Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

Science

Volumn 340, Issue 6132, 2013, Pages 622-626

  Wang, Fang ^a   Travins, Jeremy ^a   DeLaBarre, Byron ^a   Penard Lacronique, Virginie ^b,c,d   Schalm, Stefanie ^a   Hansen, Erica ^a   Straley, Kimberly ^a   Kernytsky, Andrew ^a   Liu, Wei ^a   Gliser, Camelia ^a   Yang, Hua ^a   Gross, Stefan ^a   Artin, Erin ^a   Saada, Veronique ^c   Mylonas, Elena ^b,c,d   Quivoron, Cyril ^b,c,d   Popovici Muller, Janeta ^a   Saunders, Jeffrey O ^a,h   Salituro, Francesco G ^a,i   Yan, Shunqi ^e   Murray, Stuart ^a   Wei, Wentao ^f   Gao, Yi ^g   Dang, Lenny ^a   Dorsch, Marion ^a   Agresta, Sam ^a   Schenkein, David P ^a   Biller, Scott A ^a   Su, Shinsan M ^a   De Botton, Stephane ^b,c,d   Yen, Katharine E ^a   more..

^a AGIOS PHARMACEUTICALS   (United States)

^b INSERM   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e SCHRÖDINGER INC   (United States)

^f Viva Biotech Zhangjiang High tech Park   (China)

^g Shanghai ChemPartner Co Ltd   (China)

^h Ember Therapeutics   (United States)

ⁱ Sage Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGI 6780; ANTINEOPLASTIC AGENT; CD11B ANTIGEN; CD15 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOGLOBIN C; ISOCITRATE DEHYDROGENASE 2; UNCLASSIFIED DRUG; VIMENTIN;

ACCUMULATION; CANCER; CRYSTAL STRUCTURE; DATA ACQUISITION; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; MUTATION; SECRETION;

ARTICLE; BINDING SITE; CANCER INHIBITION; CARBON SOURCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURFACE; CHELATION; CRYSTAL STRUCTURE; DECARBOXYLATION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ERYTHROLEUKEMIA; ERYTHROPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; LEUKEMIA CELL; PRIORITY JOURNAL; STEADY STATE;

EID: 84877620952     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1234769     Document Type: Article

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