-
1
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408-17.
-
(2006)
N Engl J Med
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
2
-
-
22044442973
-
Tyrosine kinases as targets for cancer therapy
-
Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005;353:172-87.
-
(2005)
N Engl J Med
, vol.353
, pp. 172-187
-
-
Krause, D.S.1
Van Etten, R.A.2
-
3
-
-
77949268383
-
Chronic neutrophilic leukaemia
-
Swerdlow SH, Campo E, Lee Harris N, et al., eds. 4th ed. Lyon, France: IARC Press
-
Bain BJ, Brunning RD, Vardiman JW, Thiele J. Chronic neutrophilic leukaemia. In: Swerdlow SH, Campo E, Lee Harris N, et al., eds. WHO classification of tumors of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press, 2008:38-9.
-
(2008)
WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues
, pp. 38-39
-
-
Bain, B.J.1
Brunning, R.D.2
Vardiman, J.W.3
Thiele, J.4
-
4
-
-
68149158868
-
Atypical chronic myeloid leukaemia, BCR-ABL1 negative
-
Swerdlow SH, Campo E, Lee Harris N, et al., eds. 4th ed. Lyon, France: IARC Press
-
Vardiman JW, Bennett JM, Bain BJ, Brunning RD, Thiele J. Atypical chronic myeloid leukaemia, BCR-ABL1 negative. In: Swerdlow SH, Campo E, Lee Harris N, et al., eds. WHO classification of tumors of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press; 2008:80-1.
-
(2008)
WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues
, pp. 80-81
-
-
Vardiman, J.W.1
Bennett, J.M.2
Bain, B.J.3
Brunning, R.D.4
Thiele, J.5
-
5
-
-
0031970124
-
Demonstration of clonality in neutrophils using FISH in a case of chronic neutrophilic leukemia
-
Froberg MK, Brunning RD, Dorion P, Litz CE, Torlakovic E. Demonstration of clonality in neutrophils using FISH in a case of chronic neutrophilic leukemia. Leukemia 1998;12:623-6.
-
(1998)
Leukemia
, vol.12
, pp. 623-626
-
-
Froberg, M.K.1
Brunning, R.D.2
Dorion, P.3
Litz, C.E.4
Torlakovic, E.5
-
6
-
-
0031021384
-
Deletion of the long arm of chromosome 20 in a patient with chronic neutrophilic leukemia: Cytogenetic findings in chronic neutrophilic leukemia
-
Matano S, Nakamura S, Kobayashi K, Yoshida T, Matsuda T, Sugimoto T. Deletion of the long arm of chromosome 20 in a patient with chronic neutrophilic leukemia: cytogenetic findings in chronic neutrophilic leukemia. Am J Hematol 1997;54:72-5.
-
(1997)
Am J Hematol
, vol.54
, pp. 72-75
-
-
Matano, S.1
Nakamura, S.2
Kobayashi, K.3
Yoshida, T.4
Matsuda, T.5
Sugimoto, T.6
-
7
-
-
0343674724
-
Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemia
-
Hernández JM, del Cañizo MC, Cuneo A, et al. Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemia. Ann Oncol 2000;11:441-4.
-
(2000)
Ann Oncol
, vol.11
, pp. 441-444
-
-
Hernández, J.M.1
Del Cañizo, M.C.2
Cuneo, A.3
-
8
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Erratum, Lancet 2005;366:122
-
Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-61. [Erratum, Lancet 2005;366:122.]
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
9
-
-
21344440357
-
The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes
-
Steensma DP, Dewald GW, Lasho TL, et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood 2005;106:1207-9.
-
(2005)
Blood
, vol.106
, pp. 1207-1209
-
-
Steensma, D.P.1
Dewald, G.W.2
Lasho, T.L.3
-
10
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couédic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005;434:1144-8.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couédic, J.P.3
-
11
-
-
21344467318
-
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
-
Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005;106:2162-8.
-
(2005)
Blood
, vol.106
, pp. 2162-2168
-
-
Jones, A.V.1
Kreil, S.2
Zoi, K.3
-
12
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005;352:1779-90.
-
(2005)
N Engl J Med
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
-
13
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005;7:387-97.
-
(2005)
Cancer Cell
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
14
-
-
0009013631
-
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
-
Longley BJ, Tyrrell L, Lu SZ, et al. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet 1996;12:312-4.
-
(1996)
Nat Genet
, vol.12
, pp. 312-314
-
-
Longley, B.J.1
Tyrrell, L.2
Lu, S.Z.3
-
15
-
-
0028856070
-
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
-
Nagata H, Worobec AS, Oh CK, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A 1995;92:10560-4.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10560-10564
-
-
Nagata, H.1
Worobec, A.S.2
Oh, C.K.3
-
16
-
-
77954676938
-
G-CSF and its receptor in myeloid malignancy
-
Beekman R, Touw IP. G-CSF and its receptor in myeloid malignancy. Blood 2010;115:5131-6.
-
(2010)
Blood
, vol.115
, pp. 5131-5136
-
-
Beekman, R.1
Touw, I.P.2
-
17
-
-
0030292823
-
Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
-
Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 1996;5:491-501.
-
(1996)
Immunity
, vol.5
, pp. 491-501
-
-
Liu, F.1
Wu, H.Y.2
Wesselschmidt, R.3
Kornaga, T.4
Link, D.C.5
-
18
-
-
0029129034
-
Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
-
Dong F, Brynes RK, Tidow N, Welte K, Löwenberg B, Touw IP. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med 1995;333:487-93.
-
(1995)
N Engl J Med
, vol.333
, pp. 487-493
-
-
Dong, F.1
Brynes, R.K.2
Tidow, N.3
Welte, K.4
Löwenberg, B.5
Touw, I.P.6
-
19
-
-
0028328265
-
Identification of a nonsense mutation in the granulocyte-colony- stimulating factor receptor in severe congenital neutropenia
-
Dong F, Hoefsloot LH, Schelen AM, et al. Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia. Proc Natl Acad Sci U S A 1994;91:4480-4.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4480-4484
-
-
Dong, F.1
Hoefsloot, L.H.2
Schelen, A.M.3
-
20
-
-
33845972945
-
Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey
-
Germeshausen M, Ballmaier M, Welte K. Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey. Blood 2007;109:93-9.
-
(2007)
Blood
, vol.109
, pp. 93-99
-
-
Germeshausen, M.1
Ballmaier, M.2
Welte, K.3
-
21
-
-
84861813715
-
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
-
Beekman R, Valkhof MG, Sanders MA, et al. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood 2012;119:5071-7.
-
(2012)
Blood
, vol.119
, pp. 5071-5077
-
-
Beekman, R.1
Valkhof, M.G.2
Sanders, M.A.3
-
22
-
-
0035575765
-
The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation
-
Dong F, Qiu Y, Yi T, Touw IP, Larner AC. The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J Immunol 2001;167:6447-52.
-
(2001)
J Immunol
, vol.167
, pp. 6447-6452
-
-
Dong, F.1
Qiu, Y.2
Yi, T.3
Touw, I.P.4
Larner, A.C.5
-
23
-
-
3042741019
-
G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact
-
van de Geijn GJ, Gits J, Aarts LH, Heijmans-Antonissen C, Touw IP. G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact. Blood 2004;104:667-74.
-
(2004)
Blood
, vol.104
, pp. 667-674
-
-
Van De Geijn, G.J.1
Gits, J.2
Aarts, L.H.3
Heijmans-Antonissen, C.4
Touw, I.P.5
-
24
-
-
0033555439
-
Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia
-
Ward AC, van Aesch YM, Schelen AM, Touw IP. Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia. Blood 1999;93:447-58.
-
(1999)
Blood
, vol.93
, pp. 447-458
-
-
Ward, A.C.1
Van Aesch, Y.M.2
Schelen, A.M.3
Touw, I.P.4
-
25
-
-
0032126619
-
Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia
-
Hermans MH, Ward AC, Antonissen C, Karis A, Löwenberg B, Touw IP. Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood 1998;92:32-9.
-
(1998)
Blood
, vol.92
, pp. 32-39
-
-
Hermans, M.H.1
Ward, A.C.2
Antonissen, C.3
Karis, A.4
Löwenberg, B.5
Touw, I.P.6
-
26
-
-
0034653975
-
Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival
-
Hunter MG, Avalos BR. Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. Blood 2000;95:2132-7.
-
(2000)
Blood
, vol.95
, pp. 2132-2137
-
-
Hunter, M.G.1
Avalos, B.R.2
-
27
-
-
0038620319
-
Impaired neutrophil maturation in truncated murine G-CSF receptor-transgenic mice
-
Mitsui T, Watanabe S, Taniguchi Y, et al. Impaired neutrophil maturation in truncated murine G-CSF receptor-transgenic mice. Blood 2003;101:2990-5.
-
(2003)
Blood
, vol.101
, pp. 2990-2995
-
-
Mitsui, T.1
Watanabe, S.2
Taniguchi, Y.3
-
28
-
-
0032488908
-
Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor
-
Corey SJ, Dombrosky-Ferlan PM, Zuo S, et al. Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor. J Biol Chem 1998;273:3230-5.
-
(1998)
J Biol Chem
, vol.273
, pp. 3230-3235
-
-
Corey, S.J.1
Dombrosky-Ferlan, P.M.2
Zuo, S.3
-
29
-
-
0028364455
-
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases
-
Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A 1994;91:4683-7.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4683-4687
-
-
Corey, S.J.1
Burkhardt, A.L.2
Bolen, J.B.3
Geahlen, R.L.4
Tkatch, L.S.5
Tweardy, D.J.6
-
30
-
-
79960999868
-
G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase
-
Futami M, Zhu QS, Whichard ZL, et al. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood 2011;118:1077-86.
-
(2011)
Blood
, vol.118
, pp. 1077-1086
-
-
Futami, M.1
Zhu, Q.S.2
Whichard, Z.L.3
-
31
-
-
1942457250
-
G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses
-
Zhu QS, Robinson LJ, Roginskaya V, Corey SJ. G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses. Blood 2004;103:3305-12.
-
(2004)
Blood
, vol.103
, pp. 3305-3312
-
-
Zhu, Q.S.1
Robinson, L.J.2
Roginskaya, V.3
Corey, S.J.4
-
32
-
-
68149159772
-
An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia
-
Plo I, Zhang Y, Le Couédic JP, et al. An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J Exp Med 2009;206:1701-7.
-
(2009)
J Exp Med
, vol.206
, pp. 1701-1707
-
-
Plo, I.1
Zhang, Y.2
Le Couédic, J.P.3
-
33
-
-
84869049935
-
Crosstalk between ROR1 and the pre-B-cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia
-
Bicocca VT, Chang BH, Masouleh BK, et al. Crosstalk between ROR1 and the pre-B-cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer Cell 2012;22:656-67.
-
(2012)
Cancer Cell
, vol.22
, pp. 656-667
-
-
Bicocca, V.T.1
Chang, B.H.2
Masouleh, B.K.3
-
34
-
-
66649137944
-
RNAi screen for rapid therapeutic target identification in leukemia patients
-
Tyner JW, Deininger MW, Loriaux MM, et al. RNAi screen for rapid therapeutic target identification in leukemia patients. Proc Natl Acad Sci U S A 2009;106:8695-700.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8695-8700
-
-
Tyner, J.W.1
Deininger, M.W.2
Loriaux, M.M.3
-
35
-
-
84871982053
-
Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening
-
Tyner JW, Yang WF, Bankhead A III, et al. Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening. Cancer Res 2013;73:285-96.
-
(2013)
Cancer Res
, vol.73
, pp. 285-296
-
-
Tyner, J.W.1
Yang, W.F.2
Bankhead III, A.3
-
36
-
-
80755125575
-
Comprehensive analysis of kinase inhibitor selectivity
-
Davis MI, Hunt JP, Herrgard S, et al. Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 2011;29:1046-51.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 1046-1051
-
-
Davis, M.I.1
Hunt, J.P.2
Herrgard, S.3
-
37
-
-
0033555810
-
Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia
-
Hunter MG, Avalos BR. Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia. Blood 1999;93:440-6.
-
(1999)
Blood
, vol.93
, pp. 440-446
-
-
Hunter, M.G.1
Avalos, B.R.2
-
38
-
-
77950684805
-
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
-
Quintás-Cardama A, Vaddi K, Liu P, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010;115:3109-17.
-
(2010)
Blood
, vol.115
, pp. 3109-3117
-
-
Quintás-Cardama, A.1
Vaddi, K.2
Liu, P.3
-
39
-
-
84871988651
-
Recurrent SETBP1 mutations in atypical chronic myeloid leukemia
-
Piazza R, Valletta S, Winkelmann N, et al. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet 2013;45:18-24.
-
(2013)
Nat Genet
, vol.45
, pp. 18-24
-
-
Piazza, R.1
Valletta, S.2
Winkelmann, N.3
-
40
-
-
81155135073
-
A truncation mutant of CSF3R cooperates with PML-RARalpha to induce acute myeloid leukemia in mice
-
Kunter G, Woloszynek JR, Link DC. A truncation mutant of CSF3R cooperates with PML-RARalpha to induce acute myeloid leukemia in mice. Exp Hematol 2011;39:1136-43.
-
(2011)
Exp Hematol
, vol.39
, pp. 1136-1143
-
-
Kunter, G.1
Woloszynek, J.R.2
Link, D.C.3
|