Loss of the Y chromosome: An age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome?

Archives of Pathology and Laboratory Medicine

Volumn 132, Issue 8, 2008, Pages 1329-1332

  Wong, Anna K ^a   Fang, Belle ^a   Zhang, Ling ^a   Guo, Xiuqing ^a   Lee, Stephen ^a   Schreck, Rhona ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; AGING; ARTICLE; BONE MARROW BIOPSY; CHROMOSOME ABERRATION; CHROMOSOME LOSS; CYTOGENETICS; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; RETROSPECTIVE STUDY; TRISOMY; Y CHROMOSOME;

AGE FACTORS; AGED; AGED, 80 AND OVER; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, Y; CYTOGENETIC ANALYSIS; HUMANS; INCIDENCE; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; MYELODYSPLASTIC SYNDROMES; RETROSPECTIVE STUDIES;

EID: 49449102840     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Court Brown WM, Buckton KE, Jacobs PA, et al. Chromosome Studies in Adults. Eugenics Laboratory Memoirs Series XI.II. London, England: Galton Laboratory, Cambridge University Press; 1966.
2. Pierre R, Hoagland HC. Age-associated aneuploidy: loss of the Y chromosome from human bone marrow cells with aging. Cancer. 1972;30:889-894.
3. Sakurai M, Sandberg AA. The chromosomes and causation of human cancer and leukemia. Cancer. 1976;38:762-769.
4. United Kingdom Cancer Cytogenetics Group. Loss of the Y chromosome from normal and neoplastic bone marrows. Genes Chromosomes Cancer. 1992;5:83-88.
5. Holmes RI, Keating MJ, Cork A, et al. Loss of the Y chromosome in acute myelogenous leukemia: a report of 13 patients. Cancer Genet Cytogenet. 1975;17:269-278.
6. Riske CB, Morgan R, Ondreyco S, et al. X and Y chromosome loss as sole abnormality in acute non-lymphocytic leukemia (ANLL). Cancer Genet Cytogenet. 1994;72:44-47.
7. Witkor A, Rybicki BA, Piao ZS, et al. Clinical significance of Y chromosome loss in hematologic disease. Genes Chromosomes Cancer. 2000;27:11-16.
8. Herens C, Brasseur E, Jamar M, et al. Loss of the Y chromosome in bone marrow cells: results on 1907 consecutive cases of leukemia and proleukemia. Clin Lab Haem. 1999;21:17-20.
9. Abeliovich D, Yehuda O, Ben-Neriah S, et al. Loss of the Y chromosome: an age-related event or a cytogenetic marker of a malignant clone? Cancer Genet Cytogenet. 1993;78:70-71.