Li-Fraumeni syndrome: Cancer risk assessment and clinical management

Nature Reviews Clinical Oncology

Volumn 11, Issue 5, 2014, Pages 260-271

  McBride, Kate A ^a   Ballinger, Mandy L ^b   Killick, Emma ^d   Kirk, Judy ^a   Tattersall, Martin H N ^e   Eeles, Rosalind A ^f   Thomas, David M ^g   Mitchell, Gillian ^c  

^a WESTMEAD HOSPITAL   (Australia)

^b Research Division   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF SYDNEY   (Australia)

^f INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^g GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

ANALYTIC METHOD; CANCER INCIDENCE; CANCER LOCALIZATION; CANCER MORTALITY; CANCER PATIENT; CANCER PREVENTION; CANCER RISK; CANCER SCREENING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE REGULATION; CLINICAL EFFECTIVENESS; COPY NUMBER VARIATION; DIAGNOSTIC TEST; DNA MODIFICATION; DNA POLYMORPHISM; EVIDENCE BASED MEDICINE; FAMILIAL CANCER; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SCREENING; GENETIC VARIABILITY; GERMLINE MUTATION; HEALTH PROGRAM; HETEROZYGOTE; HIGH RISK POPULATION; INCIDENTAL FINDING; MDM2 GENE; MOLECULAR DIAGNOSIS; PATIENT CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOSOCIAL CARE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SOMATIC MUTATION; TELOMERE SHORTENING; TUMOR SUPPRESSOR GENE; ADRENAL CORTEX CARCINOMA; BRAIN CANCER; BREAST CANCER; CANCER SURVIVAL; CHROMOSOME REARRANGEMENT; CHROMOTHRIPSIS; COLONOSCOPY; COLORECTAL CANCER; EARLY DIAGNOSIS; FAMILY HISTORY; GENETIC ASSOCIATION; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MUTATIONAL ANALYSIS; OCCULT BLOOD; ONSET AGE; RADIATION EXPOSURE; SARCOMA; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SOCIAL PSYCHOLOGY; STOMACH CANCER; TUMOR CLASSIFICATION; WHOLE BODY MRI;

ADULT; AGE OF ONSET; CARRIER STATE; CHILD; DNA COPY NUMBER VARIATIONS; EARLY DETECTION OF CANCER; FEMALE; GENES, P53; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HEDGEHOG PROTEINS; HUMANS; LI-FRAUMENI SYNDROME; MALE; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MDM2; RISK; TELOMERE SHORTENING;

EID: 84899925553     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2014.41     Document Type: Review

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