CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

Blood

Volumn 121, Issue 6, 2013, Pages 975-983

  McNerney, Megan E ^a,b   Brown, Christopher D ^a,c   Wang, Xiaoyue ^a,c   Bartom, Elizabeth T ^d   Karmakar, Subhradip ^a   Bandlamudi, Chaitanya ^a,c   Yu, Shan ^a,c   Ko, Jinkyung ^e   Sandall, Barry P ^e   Stricker, Thomas ^f   Anastasi, John ^b   Grossman, Robert L ^a,d   Cunningham, John M ^e   Le Beau, Michelle M ^a,c   White, Kevin P ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d University of Chicago   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CUX1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CHROMOSOME 7Q; CHROMOSOME DELETION; DROSOPHILA MELANOGASTER; GENE SEQUENCE; HAPLOINSUFFICIENCY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

EID: 84873579853     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-04-426965     Document Type: Article

References (50)

1. Rowley JD. Deletions of chromosome 7 in haematological disorders [letter]. Lancet. 1973; 2(7842):1385-1386.
2. Byrd JC, Mrozek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100(13):4325-4336. (Pubitemid 35429670)
3. Smith SM, Le Beau MM, Huo D, et al. Clinicalcytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102(1):43-52. (Pubitemid 36759634)
4. Bejar R, Levine R, Ebert BL. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol. 2011;29(5):504-515.
5. Preiss BS, Bergmann OJ, Friis LS, et al. Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML. Cancer Genet Cytogenet. 2010;202(2):108-122.
6. Luna-Fineman S, Shannon KM, Lange BJ. Childhood monosomy 7: epidemiology, biology, and mechanistic implications. Blood. 1995;85(8): 1985-1999.
7. Klampfl T, Harutyunyan A, Berg T, et al. Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression. Blood. 2011;118(1):167-176.
8. Mitelman F. The cytogenetic scenario of chronic myeloid leukemia. Leuk Lymphoma. 1993; 11(Suppl 1):11-15. (Pubitemid 23274129)
9. Niemeyer CM, Arico M, Basso G, et al. Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS). Blood. 1997;89(10): 3534-3543. (Pubitemid 27227076)
10. Wetzler M, Dodge RK, Mrozek K, et al. Additional cytogenetic abnormalities in adults with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a study of the Cancer and Leukaemia Group B. Br J Haematol. 2004;124(3):275-288. (Pubitemid 38167977)
11. Le Beau MM, Espinosa R 3rd, Davis EM, Eisenbart JD, Larson RA, Green ED. Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood. 1996;88(6):1930-1935. (Pubitemid 26307892)
12. Tosi S, Scherer SW, Giudici G, Czepulkowski B, Biondi A, Kearney L. Delineation of multiple deleted regions in 7q in myeloid disorders. Genes Chromosomes Cancer. 1999;25(4):384-392. (Pubitemid 29326146)
13. Fischer K, Frohling S, Scherer SW, et al. Molecular cytogenetic delineation of deletions and translocations involving chromosome band 7q22 in myeloid leukemias. Blood. 1997;89(6):2036-2041. (Pubitemid 27132119)
14. Wong JC, Zhang Y, Lieuw KH, et al. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood. 2010;115(22):4524-4532.
15. Liang H, Fairman J, Claxton DF, Nowell PC, Green ED, Nagarajan L. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci. Proc Natl Acad Sci U S A. 1998;95(7):3781-3785. (Pubitemid 28173206)
16. Jerez A, Sugimoto Y, Makishima H, et al. Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis. Blood. 2012;119(25):6109-6117.
17. Sun W, Wright FA, Tang Z, et al. Integrated study of copy number states and genotype calls using high-density SNP arrays. Nucleic Acids Res. 2009;37(16):5365-5377.
18. Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25(9):1105-1111.
19. Li H, Handsaker B, Wysoker A, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009;25(16):2078-2079.
20. McKenna A, Hanna M, Banks E, et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 2010;20(9):1297-1303.
21. Trapnell C, Williams BA, Pertea G, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010;28(5):511-515.
22. McPherson A, Hormozdiari F, Zayed A, et al. de- Fuse: an algorithm for gene fusion discovery in tumor RNA-Seq data. PLoS Comput Biol. 2011; 7(5):e1001138.
23. Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009;25(14):1754-1760.
24. Sinenko SA, Mathey-Prevot B. Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. Oncogene. 2004;23(56):9120-9128. (Pubitemid 40013079)
25. Yasothornsrikul S, Davis WJ, Cramer G, Kimbrell DA, Dearolf CR. viking: identification and characterization of a second type IV collagen in Drosophila. Gene. 1997;198(1):17-25.
26. Pau G, Fuchs F, Sklyar O, Boutros M, Huber W. EBImage: an R package for image processing with applications to cellular phenotypes. Bioinformatics. 2010;26(7):979-981.
27. Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321(5897):1801-1806.
28. Storey JD. A direct approach to false discovery rates. J R Stat Soc B. 2002;64(3):479-498.
29. Palanisamy N. Chromosomal translocations in AML: detection and prognostic significance. Cancer Treat Res. 2010;145:41-58.
30. Thoennissen NH, Lasho T, Thoennissen GB, Ogawa S, Tefferi A, Koeffler HP. Novel CUX1 missense mutation in association with 7q- at leukemic transformation of MPN. Am J Hematol. 2011; 86(8):703-705.
31. Hulea L, Nepveu A. CUX1 transcription factors: From biochemical activities and cell-based assays to mouse models and human diseases. Gene. 2012;497(1):18-26.
32. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44-57.
33. Novershtern N, Subramanian A, Lawton LN, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
34. Harada R, Vadnais C, Sansregret L, et al. Genomewide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes. Nucleic Acids Res. 2008; 36(1):189-202.
35. Crozatier M, Vincent A. Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias. Dis Model Mech. 2011;4(4):439-445.
36. Neufeld EJ, Skalnik DG, Lievens PM, Orkin SH. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat Genet. 1992;1(1):50-55.
37. Ludlow C, Choy R, Blochlinger K. Functional analysis of Drosophila and mammalian cut proteins in files. Dev Biol. 1996;178(1):149-159. (Pubitemid 26297247)
38. Jung SH, Evans CJ, Uemura C, Banerjee U. The Drosophila lymph gland as a developmental model of hematopoiesis. Development. 2005; 132(11):2521-2533. (Pubitemid 40883253)
39. Asha H, Nagy I, Kovacs G, Stetson D, Ando I, Dearolf CR. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics. 2003; 163(1):203-215. (Pubitemid 36222665)
40. Lewis S, Abrahamson G, Boultwood J, Fidler C, Potter A, Wainscoat JS. Molecular characterization of the 7q deletion in myeloid disorders. Br J Haematol. 1996;93(1):75-80. (Pubitemid 26132389)
41. Thoennissen NH, Krug UO, Lee DH, et al. Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms. Blood. 2010;115(14):2882-2890.
42. Hindersin S, Niemeyer CM, Germing U, Gobel U, Kratz CP. Mutation analysis of CUTL1 in childhood myeloid neoplasias with monosomy 7. Leuk Res. 2007;31(9):1323-1324.
43. Sinclair AM, Lee JA, Goldstein A, et al. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood. 2001; 98(13):3658-3667.
44. Cadieux C, Fournier S, Peterson AC, Bedard C, Bedell BJ, Nepveu A. Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia. Cancer Res. 2006;66(19):9492-9501. (Pubitemid 44623647)
45. Hammerman PS, Hayes DN, Wilkerson MD, et al. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012; 489(7417):519-525.
46. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487(7407):330-337.
47. Zhai Z, Ha N, Papagiannouli F, et al. Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumorsuppressing mechanism in Drosophila. PLoS Genet. 2012;8(3):e1002582.
48. Rosenbauer F, Koschmieder S, Steidl U, Tenen DG. Effect of transcription-factor concentrations on leukemic stem cells. Blood. 2005;106(5):1519-1524. (Pubitemid 41208560)
49. Grueber WB, Jan LY, Jan YN. Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell. 2003;112(6):805-818. (Pubitemid 36378883)
50. Robinson JT, Thorvaldsdottir H, Winckler W, et al. Integrative genomics viewer. Nat Biotechnol. 2011;29(1):24-26.