Role of nucleophosmin in embryonic development and tumorigenesis

Nature

Volumn 437, Issue 7055, 2005, Pages 147-153

  Grisendi, Silvia ^a   Bernardi, Rosa ^a   Rossi, Marco ^a   Cheng, Ke ^a   Khandker, Luipa ^a   Manova, Katia ^a   Pandolfi, Pier Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; GENES; TUMORS;

CANCER PATHOGENESIS; EMBRYONIC DEVELOPMENT; NUCLEOPHOSMIN;

PROTEINS;

MUTANT PROTEIN; NUCLEOPHOSMIN; NUCLEAR PROTEIN;

MEDICINE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CENTROSOME; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; EMBRYO DEVELOPMENT; GENOMIC INSTABILITY; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HETEROZYGOSITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYELODYSPLASTIC SYNDROME; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; APOPTOSIS; CELL CULTURE; CELL CYCLE; CELL TRANSFORMATION; EMBRYO DEATH; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETICS; METABOLISM; MOUSE MUTANT; NEOPLASM; PATHOLOGY;

ANIMALIA;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CENTROSOME; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; FIBROBLASTS; GENE DELETION; GENOMIC INSTABILITY; HEMATOPOIESIS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, KNOCKOUT; MYELODYSPLASTIC SYNDROMES; NEOPLASMS; NUCLEAR PROTEINS;

EID: 24344437303     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature03915     Document Type: Article

References (30)

1. Redner, R. L., Rush, E. A., Faas, S., Rudert, W. A. & Corey, S. J. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 87, 882-886 (1996).
2. Morris, S. W. et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263, 1281-1284 (1994).
3. Yoneda-Kato, N. et al. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene 12, 265-275 (1996).
4. Falini, B. et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N. Engl. J. Med. 352, 254-266 (2005).
5. Grisendi, S. & Pandolfi, P. P. NPM mutations in acute myelogenous leukemia. N. Engl. J. Med. 352, 291-292 (2005).
6. Van den Berghe, H. & Michaux, L. 5q-, twenty-five years later: a synopsis. Cancer Genet. Cytogenet. 94, 1-7 (1997).
7. Westbrook, C. A. et al. Cytogenetic and molecular diagnosis of chromosome 5 deletions in myelodysplasia. Br. J. Haematol. 110, 847-855 (2000).
8. Giagounidis, A. A. N. et al. Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplatic syndromes and del(5q) including band q31. Leukemia 18, 113-119 (2004).
9. List, A. F., Vardiman, J., Issa, J. P. & DeWitte, T. M. Myelodysplastic syndromes. Hematology (Am. Soc. Hematol. Educ. Program), 297-317 (2004).
10. Olney, H. J. & Le Beau, M. M. in The Myelodysplastic Syndromes, Pathobiology and Clinical Management (ed. Bennet, J. M.) 89-120 (Marcel Dekker, New York, 2002).
11. Hingorani, K., Szebeni, A. & Olson, M. O. Mapping the functional domains of nucleolar protein B23. J. Biol. Chem. 275, 24451-24457 (2000).
12. Savkur, R. S. & Olson, M. O. Preferential cleavage in pre-ribosomal RNA by protein B23 endoribonuclease. Nucleic Acids Res. 26, 4508-4515 (1998).
13. Wu, M. H. & Yung, B. Y. UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA. J. Biol. Chem. 277, 48234-48240 (2002).
14. Zhang, H. et al. B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1. J. Biol. Chem. 279, 35726-35734 (2004).
15. Okuda, M. et al. Nucleophosmin/B23 is a target of CDK2/cydin E in centrosome duplication. Cell 103, 127-140 (2000).
16. Kondo, T. et al. Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity. Oncogene 15, 1275-1281 (1997).
17. Bertwistle, D., Sugimoto, M. & Sherr, C. J. Physical and functional interactions of the Arf tumour suppressor protein with nucleophosmin/823. Mol. Cell. Biol. 24, 985-996 (2004).
18. Colombo, E., Marine, J. C., Danovi, D., Falini, B. & Pelicci, P. G. Nucleophosmin regulates the stability and transcriptional activity of p53. Nature Cell Biol. 4, 529-533 (2002).
19. Kurki, S. et al. Nucleolar protein NPM interacts with HDM2 and protects tumour suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 5, 465-475 (2004).
20. Mendes-da-Silva, P., Moreira, A., Duro-da-Costa, J., Matias, D. & Monteiro, C. Frequent loss of heterozygosity on chromosome 5 in non-small cell lung carcinoma. Mol. Pathol. 53, 184-187 (2000).
21. Korgaonkar, C. et al. Nucleophosmin (823) targets Arf to nucleoli and inhibits its function. Mol. Cell. Biol. 25, 1258-1271 (2005).
22. Li, J., Zhang, X., Sejas, D. P., Bagby, G. C. & Pang, Q. Hypoxia-induced Nucleophosmin protects cell death through inhibition of p53. J. Biol. Chem. 279, 41275-41279 (2004).
23. Lanni, J. S. & Jacks, T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18, 1055-1064 (1998).
24. Khan, S. H. & Whal, G. M. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. Cancer Res. 58, 369-401 (1998).
25. Stewart, Z. A., Leach, S. D. & Pietenpol, J. A. p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell. Biol. 19, 205-215 (1999).
26. Spike, B. T. et al. The Rb tumour suppressor is required for stress erythropoiesis. EMBO J. 23, 4319-4329 (2004).
27. Lerch-Gagg, A. et al. Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J. Biol. Chem. 277, 45347-45355 (2002).
28. Bunting, M., Bernstein, K. E., Greer, J. M., Capecchi, M. R. & Thomas, K. R. Targeting genes for self-excision in the germ line. Genes Dev. 13, 1524-1528 (1999).
29. Bardeesy, N. et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419, 162-167 (2002).
30. Chung, Y. J. et al. A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Res. 14, 188-196 (2004).