Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

PLoS Pathogens

Volumn 12, Issue 10, 2016, Pages

  Philip, Naomi H ^a,b   DeLaney, Alexandra ^a   Peterson, Lance W ^a,b   Santos Marrero, Melanie ^a,b   Grier, Jennifer T ^a   Sun, Yan ^a   Wynosky Dolfi, Meghan A ^a   Zwack, Erin E ^a   Hu, Baofeng ^a   Olsen, Tayla M ^c   Rongvaux, Anthony ^d   Pope, Scott D ^e   López, Carolina B ^a,b   Oberst, Andrew ^c   Beiting, Daniel P ^a,b   Henao Mejia, Jorge ^b,f   Brodsky, Igor E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d USA   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CASPASE 8; FLICE INHIBITORY PROTEIN; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; CASP8 PROTEIN, MOUSE; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; APOPTOSIS; ARTICLE; CATALYSIS; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; YERSINIA INFECTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; GENE EXPRESSION REGULATION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; CASPASE 8; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; IMMUNITY, INNATE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; YERSINIA INFECTIONS;

EID: 84992754316     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005910     Document Type: Article

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