FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

Biochemical Journal

Volumn 433, Issue 3, 2011, Pages 447-457

  Pop, Cristina ^a   Oberst, Andrew ^b   Drag, Marcin ^a,c   Van Raam, Bram J ^a   Riedl, Stefan J ^a   Green, Douglas R ^b   Salvesen, Guy S ^a  

^a BURNHAM INSTITUTE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Activation mechanism; Apoptosis; Caspase 8; Protein dimerization

Indexed keywords

CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CATALYSIS; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; DIMERIZATION; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HYDROLYSIS; MICE; MICE, KNOCKOUT; SUBSTRATE SPECIFICITY;

MUS;

EID: 78751487532     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101738     Document Type: Article

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