Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

Science

Volumn 343, Issue 6177, 2014, Pages 1357-1360

  Newton, Kim ^a   Dugger, Debra L ^a   Wickliffe, Katherine E ^a   Kapoor, Neeraj ^a   De Almagro, M Cristina ^a   Vucic, Domagoj ^a   Komuves, Laszlo ^a   Ferrando, Ronald E ^a   French, Dorothy M ^a,b   Webster, Joshua ^a   Roose Girma, Merone ^a   Warming, Søren ^a   Dixit, Vishva M ^a  

^a GENENTECH INC   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 3; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CASP8 PROTEIN, MOUSE; FADD PROTEIN, MOUSE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, MOUSE; RIPK3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CELL ORGANELLE; ENZYME ACTIVITY; INHIBITOR; PATHOLOGY; PROTEIN; RODENT; SIGNALING; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENZYME INACTIVATION; ENZYME MECHANISM; GENE; GENETIC TRANSCRIPTION; HYPOTHERMIA; MOUSE; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENTERITIS; GENE TARGETING; GENETICS; LARGE INTESTINE; METABOLISM; NECROSIS; PATHOLOGY; SMALL INTESTINE;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; CASPASE 8; CELL SURVIVAL; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; ENTERITIS; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE KNOCK-IN TECHNIQUES; INTESTINE, LARGE; INTESTINE, SMALL; MICE; NECROSIS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84897088275     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1249361     Document Type: Article

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