Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 20054-20059

  He, Sudan ^a   Liang, Yuqiong ^b   Shao, Feng ^b   Wang, Xiaodong ^b  

^a SOOCHOW UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

Bone marrow derived macrophage; Necroptosis

Indexed keywords

PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING KINASE 3; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; CELL DEATH; CELL LOSS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CYTOKINES; ENZYME ACTIVATION; INFLAMMATION MEDIATORS; INTERFERON REGULATORY FACTOR-3; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; NECROSIS; NF-KAPPA B; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 84055181328     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116302108     Document Type: Article

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