Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

Arthritis Research and Therapy

Volumn 17, Issue 1, 2015, Pages

  Cuda, Carla M ^a   Misharin, Alexander V ^a   Khare, Sonal ^a   Saber, Rana ^a   Tsai, FuNien ^a   Archer, Amy M ^a   Homan, Philip J ^a   Haines, G Kenneth ^b   Hutcheson, Jack ^c   Dorfleutner, Andrea ^a   Budinger, G R Scott ^a   Stehlik, Christian ^a   Perlman, Harris ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CASPASE 8; IMIQUIMOD; IMMUNOGLOBULIN; INTERLEUKIN 1BETA; METRONIDAZOLE; NEOMYCIN; PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VANCOMYCIN; CD11B ANTIGEN; CD86 ANTIGEN; DIFFERENTIATION ANTIGEN; LY ANTIGEN; LY-6C ANTIGEN, MOUSE; LYSOZYME; LYSOZYME M, MOUSE; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INJURY; LYMPHADENOPATHY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SPLEEN CELL; SPLENOMEGALY; UPREGULATION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; ENZYMOLOGY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; SPLEEN; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; ANTIGENS, LY; BLOTTING, WESTERN; CASPASE 8; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MURAMIDASE; MYELOID CELLS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SPLEEN; TOLL-LIKE RECEPTORS;

EID: 84944877351     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0794-z     Document Type: Article

References (26)

1. Hutcheson J, Perlman H. BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention. Oncogene. 2008;27 Suppl 1:S168-75.
2. L complex inhibits RIPK3-dependent necrosis. Nature. 2011;471:363-7.
3. Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, et al. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity. 2011;34:340-51.
4. Sears N, Sen GC, Stark GR, Chattopadhyay S. Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J Biol Chem. 2011;286:33037-33044.
5. Kang TB, Yang SH, Toth B, Kovalenko A, Wallach D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity. 2013;38:27-40.
6. Vince JE, Wong WW, Gentle I, Lawlor KE, Allam R, O'Reilly L, et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity. 2012;36:215-27.
7. Gurung P, Anand PK, Malireddi RK, Vande Walle L, Van Opdenbosch N, Dillon CP, et al. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol. 2014;192:1835-46.
8. Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell. 2011;43:449-63.
9. Cuda CM, Agrawal H, Misharin AV, Haines 3rd GK, Hutcheson J, Weber E, et al. Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice. Arthritis Rheum. 2012;64:808-20.
10. Cuda CM, Misharin AV, Gierut AK, Saber R, Haines 3rd GK, Hutcheson J, et al. Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol. 2014;192:5548-60.
11. Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005;175:3469-73.
12. Hutcheson J, Scatizzi JC, Siddiqui AM, Haines 3rd GK, Wu T, Li QZ, et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity. 2008;28:206-17.
13. Rose S, Misharin A, Perlman H. A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment. Cytometry A. 2011;81:343-50.
14. Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, et al. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol. 2004;173:2976-84.
15. Cohen PL, Eisenberg RA. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol. 1991;9:243-69.
16. Pawar RD, Ramanjaneyulu A, Kulkarni OP, Lech M, Segerer S, Anders HJ. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol. 2007;18:1721-31.
17. Thomas TJ, Gunnia UB, Seibold JR, Thomas T. Defective signal-transduction pathways in T-cells from autoimmune MRL-lpr/lpr mice are associated with increased polyamine concentrations. Biochem J. 1995;311:175-82.
18. Littman DR, Pamer EG. Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe. 2011;10:311-23.
19. Mathis D, Benoist C. Microbiota and autoimmune disease: the hosted self. Cell Host Microbe. 2011;10:297-301.
20. - monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014;9:591-604.
21. Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, et al. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 2003;17:883-95.
22. Young JA, He TH, Reizis B, Winoto A. Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep. 2013;3:1932-44.
23. Kalai M, Van Loo G, Vanden Berghe T, Meeus A, Burm W, Saelens X, et al. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Differ. 2002;9:981-94.
24. Schock SN, Young JA, He TH, Sun Y, Winoto A. Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88-dependent systemic inflammation. PLoS One. 2015;10:e0124391.
25. Rébé C, Cathelin S, Launay S, Filomenko R, Prévotat L, L'Ollivier C, et al. Caspase-8 prevents sustained activation of NF-κB in monocytes undergoing macrophagic differentiation. Blood. 2007;109:1442-50.
26. Sordet O, Rébé C, Plenchette S, Zermati Y, Hermine O, Vainchenker W, et al. Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood. 2002;100:4446-53.