Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 20, 2014, Pages 7385-7390

  Philip, Naomi H ^a,b   Dillon, Christopher P ^c   Snyder, Annelise G ^a   Fitzgerald, Patrick ^c   Wynosky Dolfi, Meghan A ^a   Zwack, Erin E ^a   Hu, Baofeng ^a   Fitzgerald, Louise ^a   Mauldin, Elizabeth A ^a   Copenhaver, Alan M ^d   Shin, Sunny ^d   Wei, Lei ^e   Parker, Matthew ^f   Zhang, Jinghui ^f   Oberst, Andrew ^g   Green, Douglas R ^c   Brodsky, Igor E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^b Institute for Immunology   (United States)

^c Departments of Immunology   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e ROSWELL PARK CANCER INSTITUTE   (United States)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; CELL DEATH; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; YERSINIA INFECTION;

APOPTOSIS; INNATE IMMUNITY; MACROPHAGE; PROGRAMMED NECROSIS; PYROPTOSIS;

ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; CASPASE 1; CASPASE 8; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNITY, INNATE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; NF-KAPPA B; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; YERSINIA INFECTIONS; YERSINIA PSEUDOTUBERCULOSIS;

EID: 84901020402     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403477111     Document Type: Article

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