-
1
-
-
9244236078
-
A FADD-dependent innate immune mechanism in mammalian cells
-
Balachandran S., Thomas E., Barber G.N. A FADD-dependent innate immune mechanism in mammalian cells. Nature 2004, 432:401-405.
-
(2004)
Nature
, vol.432
, pp. 401-405
-
-
Balachandran, S.1
Thomas, E.2
Barber, G.N.3
-
2
-
-
84904104369
-
Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly
-
Belz K., Schoeneberger H., Wehner S., Weigert A., Bönig H., Klingebiel T., Fichtner I., Fulda S. Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly. Blood 2014, 124:240-250.
-
(2014)
Blood
, vol.124
, pp. 240-250
-
-
Belz, K.1
Schoeneberger, H.2
Wehner, S.3
Weigert, A.4
Bönig, H.5
Klingebiel, T.6
Fichtner, I.7
Fulda, S.8
-
3
-
-
84901678314
-
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice
-
Berger S.B., Kasparcova V., Hoffman S., Swift B., Dare L., Schaeffer M., Capriotti C., Cook M., Finger J., Hughes-Earle A., et al. Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J.Immunol. 2014, 192:5476-5480.
-
(2014)
J.Immunol.
, vol.192
, pp. 5476-5480
-
-
Berger, S.B.1
Kasparcova, V.2
Hoffman, S.3
Swift, B.4
Dare, L.5
Schaeffer, M.6
Capriotti, C.7
Cook, M.8
Finger, J.9
Hughes-Earle, A.10
-
4
-
-
44949240664
-
CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand M.J.M., Milutinovic S., Dickson K.M., Ho W.C., Boudreault A., Durkin J., Gillard J.W., Jaquith J.B., Morris S.J., Barker P.A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 2008, 30:689-700.
-
(2008)
Mol. Cell
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.M.1
Milutinovic, S.2
Dickson, K.M.3
Ho, W.C.4
Boudreault, A.5
Durkin, J.6
Gillard, J.W.7
Jaquith, J.B.8
Morris, S.J.9
Barker, P.A.10
-
5
-
-
84869429707
-
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
-
Boisson B., Laplantine E., Prando C., Giliani S., Israelsson E., Xu Z., Abhyankar A., Israël L., Trevejo-Nunez G., Bogunovic D., et al. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat. Immunol. 2012, 13:1178-1186.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 1178-1186
-
-
Boisson, B.1
Laplantine, E.2
Prando, C.3
Giliani, S.4
Israelsson, E.5
Xu, Z.6
Abhyankar, A.7
Israël, L.8
Trevejo-Nunez, G.9
Bogunovic, D.10
-
6
-
-
0030011398
-
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
-
Boldin M.P., Goncharov T.M., Goltsev Y.V., Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 1996, 85:803-815.
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.P.1
Goncharov, T.M.2
Goltsev, Y.V.3
Wallach, D.4
-
7
-
-
80755132824
-
The adaptor protein FADD protects epidermal keratinocytes from necroptosis invivo and prevents skin inflammation
-
Bonnet M.C., Preukschat D., Welz P.-S., van Loo G., Ermolaeva M.A., Bloch W., Haase I., Pasparakis M. The adaptor protein FADD protects epidermal keratinocytes from necroptosis invivo and prevents skin inflammation. Immunity 2011, 35:572-582.
-
(2011)
Immunity
, vol.35
, pp. 572-582
-
-
Bonnet, M.C.1
Preukschat, D.2
Welz, P.-S.3
van Loo, G.4
Ermolaeva, M.A.5
Bloch, W.6
Haase, I.7
Pasparakis, M.8
-
8
-
-
84871125002
-
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner
-
Bossaller L., Chiang P.-I., Schmidt-Lauber C., Ganesan S., Kaiser W.J., Rathinam V.A.K., Mocarski E.S., Subramanian D., Green D.R., Silverman N., et al. Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner. J.Immunol. 2012, 189:5508-5512.
-
(2012)
J.Immunol.
, vol.189
, pp. 5508-5512
-
-
Bossaller, L.1
Chiang, P.-I.2
Schmidt-Lauber, C.3
Ganesan, S.4
Kaiser, W.J.5
Rathinam, V.A.K.6
Mocarski, E.S.7
Subramanian, D.8
Green, D.R.9
Silverman, N.10
-
9
-
-
84891343566
-
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
-
Cai Z., Jitkaew S., Zhao J., Chiang H.-C., Choksi S., Liu J., Ward Y., Wu L.-G., Liu Z.-G. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat. Cell Biol. 2014, 16:55-65.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 55-65
-
-
Cai, Z.1
Jitkaew, S.2
Zhao, J.3
Chiang, H.-C.4
Choksi, S.5
Liu, J.6
Ward, Y.7
Wu, L.-G.8
Liu, Z.-G.9
-
10
-
-
79955484750
-
Mechanisms of necroptosis in Tcells
-
Ch'en I.L., Tsau J.S., Molkentin J.D., Komatsu M., Hedrick S.M. Mechanisms of necroptosis in Tcells. J.Exp. Med. 2011, 208:633-641.
-
(2011)
J.Exp. Med.
, vol.208
, pp. 633-641
-
-
Ch'en, I.L.1
Tsau, J.S.2
Molkentin, J.D.3
Komatsu, M.4
Hedrick, S.M.5
-
11
-
-
70349472923
-
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
-
Chang M., Jin W., Sun S.-C. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 2009, 10:1089-1095.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1089-1095
-
-
Chang, M.1
Jin, W.2
Sun, S.-C.3
-
12
-
-
0037013279
-
A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation
-
Chen D., Li X., Zhai Z., Shu H.-B. A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. J.Biol. Chem. 2002, 277:15985-15991.
-
(2002)
J.Biol. Chem.
, vol.277
, pp. 15985-15991
-
-
Chen, D.1
Li, X.2
Zhai, Z.3
Shu, H.-B.4
-
13
-
-
84891739370
-
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
-
Chen X., Li W., Ren J., Huang D., He W.-T., Song Y., Yang C., Li W., Zheng X., Chen P., Han J. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2014, 24:105-121.
-
(2014)
Cell Res.
, vol.24
, pp. 105-121
-
-
Chen, X.1
Li, W.2
Ren, J.3
Huang, D.4
He, W.-T.5
Song, Y.6
Yang, C.7
Li, W.8
Zheng, X.9
Chen, P.10
Han, J.11
-
14
-
-
66449133280
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
-
Cho Y.S., Challa S., Moquin D., Genga R., Ray T.D., Guildford M., Chan F.K.-M. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123.
-
(2009)
Cell
, vol.137
, pp. 1112-1123
-
-
Cho, Y.S.1
Challa, S.2
Moquin, D.3
Genga, R.4
Ray, T.D.5
Guildford, M.6
Chan, F.K.-M.7
-
15
-
-
2442643942
-
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
-
Chuang T.-H., Ulevitch R.J. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 2004, 5:495-502.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 495-502
-
-
Chuang, T.-H.1
Ulevitch, R.J.2
-
16
-
-
84930519244
-
RIPK1- and RIPK3-induced cell death mode is determined by target availability
-
Cook W.D., Moujalled D.M., Ralph T.J., Lock P., Young S.N., Murphy J.M., Vaux D.L. RIPK1- and RIPK3-induced cell death mode is determined by target availability. Cell Death Differ. 2014, 21:1600-1612.
-
(2014)
Cell Death Differ.
, vol.21
, pp. 1600-1612
-
-
Cook, W.D.1
Moujalled, D.M.2
Ralph, T.J.3
Lock, P.4
Young, S.N.5
Murphy, J.M.6
Vaux, D.L.7
-
17
-
-
27744561393
-
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-kappaB activation but does not contribute to interferon regulatory factor 3 activation
-
Cusson-Hermance N., Khurana S., Lee T.H., Fitzgerald K.A., Kelliher M.A. Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-kappaB activation but does not contribute to interferon regulatory factor 3 activation. J.Biol. Chem. 2005, 280:36560-36566.
-
(2005)
J.Biol. Chem.
, vol.280
, pp. 36560-36566
-
-
Cusson-Hermance, N.1
Khurana, S.2
Lee, T.H.3
Fitzgerald, K.A.4
Kelliher, M.A.5
-
18
-
-
84907210946
-
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
-
Dannappel M., Vlantis K., Kumari S., Polykratis A., Kim C., Wachsmuth L., Eftychi C., Lin J., Corona T., Hermance N., et al. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 2014, 513:90-94.
-
(2014)
Nature
, vol.513
, pp. 90-94
-
-
Dannappel, M.1
Vlantis, K.2
Kumari, S.3
Polykratis, A.4
Kim, C.5
Wachsmuth, L.6
Eftychi, C.7
Lin, J.8
Corona, T.9
Hermance, N.10
-
19
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
Degterev A., Hitomi J., Germscheid M., Ch'en I.L., Korkina O., Teng X., Abbott D., Cuny G.D., Yuan C., Wagner G., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 2008, 4:313-321.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'en, I.L.4
Korkina, O.5
Teng, X.6
Abbott, D.7
Cuny, G.D.8
Yuan, C.9
Wagner, G.10
-
20
-
-
84861712290
-
Survival function of the FADD-CASPASE-8-cFLIP(L) complex
-
Dillon C.P., Oberst A., Weinlich R., Janke L.J., Kang T.-B., Ben-Moshe T., Mak T.W., Wallach D., Green D.R. Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep. 2012, 1:401-407.
-
(2012)
Cell Rep.
, vol.1
, pp. 401-407
-
-
Dillon, C.P.1
Oberst, A.2
Weinlich, R.3
Janke, L.J.4
Kang, T.-B.5
Ben-Moshe, T.6
Mak, T.W.7
Wallach, D.8
Green, D.R.9
-
21
-
-
84901386193
-
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3
-
Dillon C.P., Weinlich R., Rodriguez D.A., Cripps J.G., Quarato G., Gurung P., Verbist K.C., Brewer T.L., Llambi F., Gong Y.-N., et al. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell 2014, 157:1189-1202.
-
(2014)
Cell
, vol.157
, pp. 1189-1202
-
-
Dillon, C.P.1
Weinlich, R.2
Rodriguez, D.A.3
Cripps, J.G.4
Quarato, G.5
Gurung, P.6
Verbist, K.C.7
Brewer, T.L.8
Llambi, F.9
Gong, Y.-N.10
-
22
-
-
84901280344
-
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
-
Dondelinger Y., Declercq W., Montessuit S., Roelandt R., Goncalves A., Bruggeman I., Hulpiau P., Weber K., Sehon C.A., Marquis R.W., et al. MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep. 2014, 7:971-981.
-
(2014)
Cell Rep.
, vol.7
, pp. 971-981
-
-
Dondelinger, Y.1
Declercq, W.2
Montessuit, S.3
Roelandt, R.4
Goncalves, A.5
Bruggeman, I.6
Hulpiau, P.7
Weber, K.8
Sehon, C.A.9
Marquis, R.W.10
-
23
-
-
33646034316
-
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea C.-K., Deng L., Xia Z.-P., Pineda G., Chen Z.J. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 2006, 22:245-257.
-
(2006)
Mol. Cell
, vol.22
, pp. 245-257
-
-
Ea, C.-K.1
Deng, L.2
Xia, Z.-P.3
Pineda, G.4
Chen, Z.J.5
-
24
-
-
33845926057
-
Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding
-
Fearns C., Pan Q., Mathison J.C., Chuang T.-H. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. J.Biol. Chem. 2006, 281:34592-34600.
-
(2006)
J.Biol. Chem.
, vol.281
, pp. 34592-34600
-
-
Fearns, C.1
Pan, Q.2
Mathison, J.C.3
Chuang, T.-H.4
-
25
-
-
34548437549
-
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
-
Feng S., Yang Y., Mei Y., Ma L., Zhu D.-E., Hoti N., Castanares M., Wu M. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell. Signal. 2007, 19:2056-2067.
-
(2007)
Cell. Signal.
, vol.19
, pp. 2056-2067
-
-
Feng, S.1
Yang, Y.2
Mei, Y.3
Ma, L.4
Zhu, D.-E.5
Hoti, N.6
Castanares, M.7
Wu, M.8
-
26
-
-
79960922705
-
CIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
-
Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., Cain K., MacFarlane M., Häcker G., Leverkus M. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 2011, 43:449-463.
-
(2011)
Mol. Cell
, vol.43
, pp. 449-463
-
-
Feoktistova, M.1
Geserick, P.2
Kellert, B.3
Dimitrova, D.P.4
Langlais, C.5
Hupe, M.6
Cain, K.7
MacFarlane, M.8
Häcker, G.9
Leverkus, M.10
-
27
-
-
84880851215
-
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
-
Fiil B.K., Damgaard R.B., Wagner S.A., Keusekotten K., Fritsch M., Bekker-Jensen S., Mailand N., Choudhary C., Komander D., Gyrd-Hansen M. OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol. Cell 2013, 50:818-830.
-
(2013)
Mol. Cell
, vol.50
, pp. 818-830
-
-
Fiil, B.K.1
Damgaard, R.B.2
Wagner, S.A.3
Keusekotten, K.4
Fritsch, M.5
Bekker-Jensen, S.6
Mailand, N.7
Choudhary, C.8
Komander, D.9
Gyrd-Hansen, M.10
-
28
-
-
51049106824
-
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
-
Friedman C.S., O'Donnell M.A., Legarda-Addison D., Ng A., Cárdenas W.B., Yount J.S., Moran T.M., Basler C.F., Komuro A., Horvath C.M., et al. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep. 2008, 9:930-936.
-
(2008)
EMBO Rep.
, vol.9
, pp. 930-936
-
-
Friedman, C.S.1
O'Donnell, M.A.2
Legarda-Addison, D.3
Ng, A.4
Cárdenas, W.B.5
Yount, J.S.6
Moran, T.M.7
Basler, C.F.8
Komuro, A.9
Horvath, C.M.10
-
29
-
-
84857811063
-
CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1
-
Fujikura D., Ito M., Chiba S., Harada T., Perez F., Reed J.C., Uede T., Miyazaki T. CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1. Cell Death Dis. 2012, 3:e264.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Fujikura, D.1
Ito, M.2
Chiba, S.3
Harada, T.4
Perez, F.5
Reed, J.C.6
Uede, T.7
Miyazaki, T.8
-
30
-
-
79953906762
-
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
-
Gentle I.E., Wong W.W.-L., Evans J.M., Bankovacki A., Cook W.D., Khan N.R., Nachbur U., Rickard J., Anderton H., Moulin M., et al. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8. J.Biol. Chem. 2011, 286:13282-13291.
-
(2011)
J.Biol. Chem.
, vol.286
, pp. 13282-13291
-
-
Gentle, I.E.1
Wong, W.W.-L.2
Evans, J.M.3
Bankovacki, A.4
Cook, W.D.5
Khan, N.R.6
Nachbur, U.7
Rickard, J.8
Anderton, H.9
Moulin, M.10
-
31
-
-
79953240109
-
Linear ubiquitination prevents inflammation and regulates immune signalling
-
Gerlach B., Cordier S.M., Schmukle A.C., Emmerich C.H., Rieser E., Haas T.L., Webb A.I., Rickard J.A., Anderton H., Wong W.W.-L., et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 2011, 471:591-596.
-
(2011)
Nature
, vol.471
, pp. 591-596
-
-
Gerlach, B.1
Cordier, S.M.2
Schmukle, A.C.3
Emmerich, C.H.4
Rieser, E.5
Haas, T.L.6
Webb, A.I.7
Rickard, J.A.8
Anderton, H.9
Wong, W.W.-L.10
-
32
-
-
76149104286
-
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
-
Geserick P., Hupe M., Moulin M., Wong W.W.-L., Feoktistova M., Kellert B., Gollnick H., Silke J., Leverkus M. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J.Cell Biol. 2009, 187:1037-1054.
-
(2009)
J.Cell Biol.
, vol.187
, pp. 1037-1054
-
-
Geserick, P.1
Hupe, M.2
Moulin, M.3
Wong, W.W.-L.4
Feoktistova, M.5
Kellert, B.6
Gollnick, H.7
Silke, J.8
Leverkus, M.9
-
34
-
-
34548225362
-
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
-
Greten F.R., Arkan M.C., Bollrath J., Hsu L.-C., Goode J., Miething C., Göktuna S.I., Neuenhahn M., Fierer J., Paxian S., et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 2007, 130:918-931.
-
(2007)
Cell
, vol.130
, pp. 918-931
-
-
Greten, F.R.1
Arkan, M.C.2
Bollrath, J.3
Hsu, L.-C.4
Goode, J.5
Miething, C.6
Göktuna, S.I.7
Neuenhahn, M.8
Fierer, J.9
Paxian, S.10
-
35
-
-
84857175933
-
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
-
Gringhuis S.I., Kaptein T.M., Wevers B.A., Theelen B., van der Vlist M., Boekhout T., Geijtenbeek T.B.H. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat. Immunol. 2012, 13:246-254.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 246-254
-
-
Gringhuis, S.I.1
Kaptein, T.M.2
Wevers, B.A.3
Theelen, B.4
van der Vlist, M.5
Boekhout, T.6
Geijtenbeek, T.B.H.7
-
36
-
-
84894271641
-
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
-
Gurung P., Anand P.K., Malireddi R.K.S., Vande Walle L., Van Opdenbosch N., Dillon C.P., Weinlich R., Green D.R., Lamkanfi M., Kanneganti T.-D. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J.Immunol. 2014, 192:1835-1846.
-
(2014)
J.Immunol.
, vol.192
, pp. 1835-1846
-
-
Gurung, P.1
Anand, P.K.2
Malireddi, R.K.S.3
Vande Walle, L.4
Van Opdenbosch, N.5
Dillon, C.P.6
Weinlich, R.7
Green, D.R.8
Lamkanfi, M.9
Kanneganti, T.-D.10
-
37
-
-
79957817974
-
FLIP (Flice-likeinhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling
-
Handa P., Tupper J.C., Jordan K.C., Harlan J.M. FLIP (Flice-likeinhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling. Cell Commun. Signal. 2011, 9:16.
-
(2011)
Cell Commun. Signal.
, vol.9
, pp. 16
-
-
Handa, P.1
Tupper, J.C.2
Jordan, K.C.3
Harlan, J.M.4
-
38
-
-
0036337748
-
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat Tcells
-
He K.-L., Ting A.T. A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat Tcells. Mol. Cell. Biol. 2002, 22:6034-6045.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6034-6045
-
-
He, K.-L.1
Ting, A.T.2
-
39
-
-
84055181328
-
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway
-
He S., Liang Y., Shao F., Wang X. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc. Natl. Acad. Sci. USA 2011, 108:20054-20059.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 20054-20059
-
-
He, S.1
Liang, Y.2
Shao, F.3
Wang, X.4
-
40
-
-
57649181391
-
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
-
Hitomi J., Christofferson D.E., Ng A., Yao J., Degterev A., Xavier R.J., Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008, 135:1311-1323.
-
(2008)
Cell
, vol.135
, pp. 1311-1323
-
-
Hitomi, J.1
Christofferson, D.E.2
Ng, A.3
Yao, J.4
Degterev, A.5
Xavier, R.J.6
Yuan, J.7
-
41
-
-
5944233768
-
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
-
Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.L., Schneider P., Seed B., Tschopp J. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 2000, 1:489-495.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 489-495
-
-
Holler, N.1
Zaru, R.2
Micheau, O.3
Thome, M.4
Attinger, A.5
Valitutti, S.6
Bodmer, J.L.7
Schneider, P.8
Seed, B.9
Tschopp, J.10
-
42
-
-
0029007855
-
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
-
Hsu H., Xiong J., Goeddel D.V. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 1995, 81:495-504.
-
(1995)
Cell
, vol.81
, pp. 495-504
-
-
Hsu, H.1
Xiong, J.2
Goeddel, D.V.3
-
43
-
-
0029949257
-
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
-
Hsu H., Huang J., Shu H.B., Baichwal V., Goeddel D.V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996, 4:387-396.
-
(1996)
Immunity
, vol.4
, pp. 387-396
-
-
Hsu, H.1
Huang, J.2
Shu, H.B.3
Baichwal, V.4
Goeddel, D.V.5
-
44
-
-
0030032106
-
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
-
Hsu H., Shu H.B., Pan M.G., Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996, 84:299-308.
-
(1996)
Cell
, vol.84
, pp. 299-308
-
-
Hsu, H.1
Shu, H.B.2
Pan, M.G.3
Goeddel, D.V.4
-
45
-
-
79953239980
-
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
-
Ikeda F., Deribe Y.L., Skånland S.S., Stieglitz B., Grabbe C., Franz-Wachtel M., van Wijk S.J.L., Goswami P., Nagy V., Terzic J., et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011, 471:637-641.
-
(2011)
Nature
, vol.471
, pp. 637-641
-
-
Ikeda, F.1
Deribe, Y.L.2
Skånland, S.S.3
Stieglitz, B.4
Grabbe, C.5
Franz-Wachtel, M.6
van Wijk, S.J.L.7
Goswami, P.8
Nagy, V.9
Terzic, J.10
-
46
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schröter M., Burns K., Mattmann C., et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997, 388:190-195.
-
(1997)
Nature
, vol.388
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
Bodmer, J.L.7
Schröter, M.8
Burns, K.9
Mattmann, C.10
-
47
-
-
0032505127
-
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
-
Juo P., Kuo C.J., Yuan J., Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr. Biol. 1998, 8:1001-1008.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1001-1008
-
-
Juo, P.1
Kuo, C.J.2
Yuan, J.3
Blenis, J.4
-
48
-
-
17144413785
-
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
-
Kaiser W.J., Offermann M.K. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J.Immunol. 2005, 174:4942-4952.
-
(2005)
J.Immunol.
, vol.174
, pp. 4942-4952
-
-
Kaiser, W.J.1
Offermann, M.K.2
-
49
-
-
58749100879
-
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors
-
Kaiser W.J., Upton J.W., Mocarski E.S. Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J.Immunol. 2008, 181:6427-6434.
-
(2008)
J.Immunol.
, vol.181
, pp. 6427-6434
-
-
Kaiser, W.J.1
Upton, J.W.2
Mocarski, E.S.3
-
50
-
-
79952811804
-
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
-
Kaiser W.J., Upton J.W., Long A.B., Livingston-Rosanoff D., Daley-Bauer L.P., Hakem R., Caspary T., Mocarski E.S. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011, 471:368-372.
-
(2011)
Nature
, vol.471
, pp. 368-372
-
-
Kaiser, W.J.1
Upton, J.W.2
Long, A.B.3
Livingston-Rosanoff, D.4
Daley-Bauer, L.P.5
Hakem, R.6
Caspary, T.7
Mocarski, E.S.8
-
51
-
-
84886656964
-
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL
-
Kaiser W.J., Sridharan H., Huang C., Mandal P., Upton J.W., Gough P.J., Sehon C.A., Marquis R.W., Bertin J., Mocarski E.S. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J.Biol. Chem. 2013, 288:31268-31279.
-
(2013)
J.Biol. Chem.
, vol.288
, pp. 31268-31279
-
-
Kaiser, W.J.1
Sridharan, H.2
Huang, C.3
Mandal, P.4
Upton, J.W.5
Gough, P.J.6
Sehon, C.A.7
Marquis, R.W.8
Bertin, J.9
Mocarski, E.S.10
-
52
-
-
84901649808
-
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
-
Kaiser W.J., Daley-Bauer L.P., Thapa R.J., Mandal P., Berger S.B., Huang C., Sundararajan A., Guo H., Roback L., Speck S.H., et al. RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proc. Natl. Acad. Sci. USA 2014, 111:7753-7758.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 7753-7758
-
-
Kaiser, W.J.1
Daley-Bauer, L.P.2
Thapa, R.J.3
Mandal, P.4
Berger, S.B.5
Huang, C.6
Sundararajan, A.7
Guo, H.8
Roback, L.9
Speck, S.H.10
-
53
-
-
84872764927
-
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome
-
Kang T.-B., Yang S.-H., Toth B., Kovalenko A., Wallach D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 2013, 38:27-40.
-
(2013)
Immunity
, vol.38
, pp. 27-40
-
-
Kang, T.-B.1
Yang, S.-H.2
Toth, B.3
Kovalenko, A.4
Wallach, D.5
-
54
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Kawai T., Takahashi K., Sato S., Coban C., Kumar H., Kato H., Ishii K.J., Takeuchi O., Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 2005, 6:981-988.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
Kato, H.6
Ishii, K.J.7
Takeuchi, O.8
Akira, S.9
-
55
-
-
84912111862
-
RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis
-
Kearney C.J., Cullen S.P., Clancy D., Martin S.J. RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis. FEBS J. 2014, 281:4921-4934.
-
(2014)
FEBS J.
, vol.281
, pp. 4921-4934
-
-
Kearney, C.J.1
Cullen, S.P.2
Clancy, D.3
Martin, S.J.4
-
56
-
-
0032033132
-
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
-
Kelliher M.A., Grimm S., Ishida Y., Kuo F., Stanger B.Z., Leder P. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 1998, 8:297-303.
-
(1998)
Immunity
, vol.8
, pp. 297-303
-
-
Kelliher, M.A.1
Grimm, S.2
Ishida, Y.3
Kuo, F.4
Stanger, B.Z.5
Leder, P.6
-
57
-
-
84878862687
-
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
-
Keusekotten K., Elliott P.R., Glockner L., Fiil B.K., Damgaard R.B., Kulathu Y., Wauer T., Hospenthal M.K., Gyrd-Hansen M., Krappmann D., et al. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell 2013, 153:1312-1326.
-
(2013)
Cell
, vol.153
, pp. 1312-1326
-
-
Keusekotten, K.1
Elliott, P.R.2
Glockner, L.3
Fiil, B.K.4
Damgaard, R.B.5
Kulathu, Y.6
Wauer, T.7
Hospenthal, M.K.8
Gyrd-Hansen, M.9
Krappmann, D.10
-
58
-
-
0034744033
-
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
-
Kreuz S., Siegmund D., Scheurich P., Wajant H. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 2001, 21:3964-3973.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3964-3973
-
-
Kreuz, S.1
Siegmund, D.2
Scheurich, P.3
Wajant, H.4
-
59
-
-
0034730713
-
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
-
Lee E.G., Boone D.L., Chai S., Libby S.L., Chien M., Lodolce J.P., Ma A. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000, 289:2350-2354.
-
(2000)
Science
, vol.289
, pp. 2350-2354
-
-
Lee, E.G.1
Boone, D.L.2
Chai, S.3
Libby, S.L.4
Chien, M.5
Lodolce, J.P.6
Ma, A.7
-
60
-
-
4043136609
-
The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
-
Lee T.H., Shank J., Cusson N., Kelliher M.A. The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. J.Biol. Chem. 2004, 279:33185-33191.
-
(2004)
J.Biol. Chem.
, vol.279
, pp. 33185-33191
-
-
Lee, T.H.1
Shank, J.2
Cusson, N.3
Kelliher, M.A.4
-
61
-
-
33744951304
-
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation
-
Li H., Kobayashi M., Blonska M., You Y., Lin X. Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J.Biol. Chem. 2006, 281:13636-13643.
-
(2006)
J.Biol. Chem.
, vol.281
, pp. 13636-13643
-
-
Li, H.1
Kobayashi, M.2
Blonska, M.3
You, Y.4
Lin, X.5
-
62
-
-
84864240409
-
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
-
Li J., McQuade T., Siemer A.B., Napetschnig J., Moriwaki K., Hsiao Y.-S., Damko E., Moquin D., Walz T., McDermott A., et al. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 2012, 150:339-350.
-
(2012)
Cell
, vol.150
, pp. 339-350
-
-
Li, J.1
McQuade, T.2
Siemer, A.B.3
Napetschnig, J.4
Moriwaki, K.5
Hsiao, Y.-S.6
Damko, E.7
Moquin, D.8
Walz, T.9
McDermott, A.10
-
63
-
-
0033214236
-
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
-
Lin Y., Devin A., Rodriguez Y., Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 1999, 13:2514-2526.
-
(1999)
Genes Dev.
, vol.13
, pp. 2514-2526
-
-
Lin, Y.1
Devin, A.2
Rodriguez, Y.3
Liu, Z.G.4
-
64
-
-
38549146936
-
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
-
Lin S.-C., Chung J.Y., Lamothe B., Rajashankar K., Lu M., Lo Y.-C., Lam A.Y., Darnay B.G., Wu H. Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J.Mol. Biol. 2008, 376:526-540.
-
(2008)
J.Mol. Biol.
, vol.376
, pp. 526-540
-
-
Lin, S.-C.1
Chung, J.Y.2
Lamothe, B.3
Rajashankar, K.4
Lu, M.5
Lo, Y.-C.6
Lam, A.Y.7
Darnay, B.G.8
Wu, H.9
-
65
-
-
84878978627
-
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
-
Lukens J.R., Vogel P., Johnson G.R., Kelliher M.A., Iwakura Y., Lamkanfi M., Kanneganti T.-D. RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. Nature 2013, 498:224-227.
-
(2013)
Nature
, vol.498
, pp. 224-227
-
-
Lukens, J.R.1
Vogel, P.2
Johnson, G.R.3
Kelliher, M.A.4
Iwakura, Y.5
Lamkanfi, M.6
Kanneganti, T.-D.7
-
66
-
-
51049100571
-
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
-
Maelfait J., Vercammen E., Janssens S., Schotte P., Haegman M., Magez S., Beyaert R. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J.Exp. Med. 2008, 205:1967-1973.
-
(2008)
J.Exp. Med.
, vol.205
, pp. 1967-1973
-
-
Maelfait, J.1
Vercammen, E.2
Janssens, S.3
Schotte, P.4
Haegman, M.5
Magez, S.6
Beyaert, R.7
-
67
-
-
84912106351
-
RIP3 induces apoptosis independent of pro-necrotic kinase activity
-
this issue
-
Mandal P., Berger S.B., Pillay S., Moriwaki K., Huang C., Guo C., Lich J.D., Finger J., Kasparcova V., Votta B., et al. RIP3 induces apoptosis independent of pro-necrotic kinase activity. Mol. Cell 2014, 56:481-495. this issue.
-
(2014)
Mol. Cell
, vol.56
, pp. 481-495
-
-
Mandal, P.1
Berger, S.B.2
Pillay, S.3
Moriwaki, K.4
Huang, C.5
Guo, C.6
Lich, J.D.7
Finger, J.8
Kasparcova, V.9
Votta, B.10
-
68
-
-
84888413953
-
Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis
-
McQuade T., Cho Y., Chan F.K. Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. Biochem. J. 2013, 456:409-415.
-
(2013)
Biochem. J.
, vol.456
, pp. 409-415
-
-
McQuade, T.1
Cho, Y.2
Chan, F.K.3
-
69
-
-
2442642691
-
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
-
Meylan E., Burns K., Hofmann K., Blancheteau V., Martinon F., Kelliher M., Tschopp J. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat. Immunol. 2004, 5:503-507.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 503-507
-
-
Meylan, E.1
Burns, K.2
Hofmann, K.3
Blancheteau, V.4
Martinon, F.5
Kelliher, M.6
Tschopp, J.7
-
70
-
-
43049174990
-
TRADD protein is an essential component of the RIG-like helicase antiviral pathway
-
Michallet M.-C., Meylan E., Ermolaeva M.A., Vazquez J., Rebsamen M., Curran J., Poeck H., Bscheider M., Hartmann G., König M., et al. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 2008, 28:651-661.
-
(2008)
Immunity
, vol.28
, pp. 651-661
-
-
Michallet, M.-C.1
Meylan, E.2
Ermolaeva, M.A.3
Vazquez, J.4
Rebsamen, M.5
Curran, J.6
Poeck, H.7
Bscheider, M.8
Hartmann, G.9
König, M.10
-
71
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003, 114:181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
72
-
-
0034743199
-
NF-kappaB signals induce the expression of c-FLIP
-
Micheau O., Lens S., Gaide O., Alevizopoulos K., Tschopp J. NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol. 2001, 21:5299-5305.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5299-5305
-
-
Micheau, O.1
Lens, S.2
Gaide, O.3
Alevizopoulos, K.4
Tschopp, J.5
-
73
-
-
84884823502
-
CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis
-
Moquin D.M., McQuade T., Chan F.K.-M. CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS ONE 2013, 8:e76841.
-
(2013)
PLoS ONE
, vol.8
-
-
Moquin, D.M.1
McQuade, T.2
Chan, F.K.-M.3
-
74
-
-
84859424337
-
IAPs limit activation of RIP kinases by TNF receptor 1 during development
-
Moulin M., Anderton H., Voss A.K., Thomas T., Wong W.W.-L., Bankovacki A., Feltham R., Chau D., Cook W.D., Silke J., Vaux D.L. IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J. 2012, 31:1679-1691.
-
(2012)
EMBO J.
, vol.31
, pp. 1679-1691
-
-
Moulin, M.1
Anderton, H.2
Voss, A.K.3
Thomas, T.4
Wong, W.W.-L.5
Bankovacki, A.6
Feltham, R.7
Chau, D.8
Cook, W.D.9
Silke, J.10
Vaux, D.L.11
-
75
-
-
84884308522
-
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
-
Murphy J.M., Czabotar P.E., Hildebrand J.M., Lucet I.S., Zhang J.-G., Alvarez-Diaz S., Lewis R., Lalaoui N., Metcalf D., Webb A.I., et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013, 39:443-453.
-
(2013)
Immunity
, vol.39
, pp. 443-453
-
-
Murphy, J.M.1
Czabotar, P.E.2
Hildebrand, J.M.3
Lucet, I.S.4
Zhang, J.-G.5
Alvarez-Diaz, S.6
Lewis, R.7
Lalaoui, N.8
Metcalf, D.9
Webb, A.I.10
-
76
-
-
15844412409
-
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
-
Muzio M., Chinnaiyan A.M., Kischkel F.C., O'Rourke K., Shevchenko A., Ni J., Scaffidi C., Bretz J.D., Zhang M., Gentz R., et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996, 85:817-827.
-
(1996)
Cell
, vol.85
, pp. 817-827
-
-
Muzio, M.1
Chinnaiyan, A.M.2
Kischkel, F.C.3
O'Rourke, K.4
Shevchenko, A.5
Ni, J.6
Scaffidi, C.7
Bretz, J.D.8
Zhang, M.9
Gentz, R.10
-
77
-
-
84897088275
-
Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
-
Newton K., Dugger D.L., Wickliffe K.E., Kapoor N., de Almagro M.C., Vucic D., Komuves L., Ferrando R.E., French D.M., Webster J., et al. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science 2014, 343:1357-1360.
-
(2014)
Science
, vol.343
, pp. 1357-1360
-
-
Newton, K.1
Dugger, D.L.2
Wickliffe, K.E.3
Kapoor, N.4
de Almagro, M.C.5
Vucic, D.6
Komuves, L.7
Ferrando, R.E.8
French, D.M.9
Webster, J.10
-
78
-
-
33847251527
-
Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling
-
O'Donnell M.A., Legarda-Addison D., Skountzos P., Yeh W.C., Ting A.T. Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr. Biol. 2007, 17:418-424.
-
(2007)
Curr. Biol.
, vol.17
, pp. 418-424
-
-
O'Donnell, M.A.1
Legarda-Addison, D.2
Skountzos, P.3
Yeh, W.C.4
Ting, A.T.5
-
79
-
-
84856160569
-
Caspase 8 inhibits programmed necrosis by processing CYLD
-
O'Donnell M.A., Perez-Jimenez E., Oberst A., Ng A., Massoumi R., Xavier R., Green D.R., Ting A.T. Caspase 8 inhibits programmed necrosis by processing CYLD. Nat. Cell Biol. 2011, 13:1437-1442.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1437-1442
-
-
O'Donnell, M.A.1
Perez-Jimenez, E.2
Oberst, A.3
Ng, A.4
Massoumi, R.5
Xavier, R.6
Green, D.R.7
Ting, A.T.8
-
80
-
-
79952810024
-
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
-
Oberst A., Dillon C.P., Weinlich R., McCormick L.L., Fitzgerald P., Pop C., Hakem R., Salvesen G.S., Green D.R. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011, 471:363-367.
-
(2011)
Nature
, vol.471
, pp. 363-367
-
-
Oberst, A.1
Dillon, C.P.2
Weinlich, R.3
McCormick, L.L.4
Fitzgerald, P.5
Pop, C.6
Hakem, R.7
Salvesen, G.S.8
Green, D.R.9
-
81
-
-
84961291582
-
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
-
Orozco S., Yatim N., Werner M.R., Tran H., Gunja S.Y., Tait S.W., Albert M.L., Green D.R., Oberst A. RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ. 2014, 21:1511-1521.
-
(2014)
Cell Death Differ.
, vol.21
, pp. 1511-1521
-
-
Orozco, S.1
Yatim, N.2
Werner, M.R.3
Tran, H.4
Gunja, S.Y.5
Tait, S.W.6
Albert, M.L.7
Green, D.R.8
Oberst, A.9
-
82
-
-
84887023764
-
CFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis
-
Panayotova-Dimitrova D., Feoktistova M., Ploesser M., Kellert B., Hupe M., Horn S., Makarov R., Jensen F., Porubsky S., Schmieder A., et al. cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. Cell Rep. 2013, 5:397-408.
-
(2013)
Cell Rep.
, vol.5
, pp. 397-408
-
-
Panayotova-Dimitrova, D.1
Feoktistova, M.2
Ploesser, M.3
Kellert, B.4
Hupe, M.5
Horn, S.6
Makarov, R.7
Jensen, F.8
Porubsky, S.9
Schmieder, A.10
-
83
-
-
84905970879
-
Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis invivo
-
Polykratis A., Hermance N., Zelic M., Roderick J., Kim C., Van T.-M., Lee T.H., Chan F.K.M., Pasparakis M., Kelliher M.A. Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis invivo. J.Immunol. 2014, 193:1539-1543.
-
(2014)
J.Immunol.
, vol.193
, pp. 1539-1543
-
-
Polykratis, A.1
Hermance, N.2
Zelic, M.3
Roderick, J.4
Kim, C.5
Van, T.-M.6
Lee, T.H.7
Chan, F.K.M.8
Pasparakis, M.9
Kelliher, M.A.10
-
84
-
-
78751487532
-
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
-
Pop C., Oberst A., Drag M., Van Raam B.J., Riedl S.J., Green D.R., Salvesen G.S. FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem. J. 2011, 433:447-457.
-
(2011)
Biochem. J.
, vol.433
, pp. 447-457
-
-
Pop, C.1
Oberst, A.2
Drag, M.3
Van Raam, B.J.4
Riedl, S.J.5
Green, D.R.6
Salvesen, G.S.7
-
85
-
-
79952770123
-
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein
-
Rajput A., Kovalenko A., Bogdanov K., Yang S.-H., Kang T.-B., Kim J.-C., Du J., Wallach D. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 2011, 34:340-351.
-
(2011)
Immunity
, vol.34
, pp. 340-351
-
-
Rajput, A.1
Kovalenko, A.2
Bogdanov, K.3
Yang, S.-H.4
Kang, T.-B.5
Kim, J.-C.6
Du, J.7
Wallach, D.8
-
86
-
-
68249113997
-
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
-
Rebsamen M., Heinz L.X., Meylan E., Michallet M.-C., Schroder K., Hofmann K., Vazquez J., Benedict C.A., Tschopp J. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009, 10:916-922.
-
(2009)
EMBO Rep.
, vol.10
, pp. 916-922
-
-
Rebsamen, M.1
Heinz, L.X.2
Meylan, E.3
Michallet, M.-C.4
Schroder, K.5
Hofmann, K.6
Vazquez, J.7
Benedict, C.A.8
Tschopp, J.9
-
87
-
-
84901422731
-
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis
-
Rickard J.A., O'Donnell J.A., Evans J.M., Lalaoui N., Poh A.R., Rogers T., Vince J.E., Lawlor K.E., Ninnis R.L., Anderton H., et al. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell 2014, 157:1175-1188.
-
(2014)
Cell
, vol.157
, pp. 1175-1188
-
-
Rickard, J.A.1
O'Donnell, J.A.2
Evans, J.M.3
Lalaoui, N.4
Poh, A.R.5
Rogers, T.6
Vince, J.E.7
Lawlor, K.E.8
Ninnis, R.L.9
Anderton, H.10
-
88
-
-
0036848180
-
Exvivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart
-
Sakamaki K., Inoue T., Asano M., Sudo K., Kazama H., Sakagami J., Sakata S., Ozaki M., Nakamura S., Toyokuni S., et al. Exvivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ. 2002, 9:1196-1206.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 1196-1206
-
-
Sakamaki, K.1
Inoue, T.2
Asano, M.3
Sudo, K.4
Kazama, H.5
Sakagami, J.6
Sakata, S.7
Ozaki, M.8
Nakamura, S.9
Toyokuni, S.10
-
89
-
-
84904047854
-
Functions of caspase 8: the identified and the mysterious
-
Salvesen G.S., Walsh C.M. Functions of caspase 8: the identified and the mysterious. Semin. Immunol. 2014, 26:246-252.
-
(2014)
Semin. Immunol.
, vol.26
, pp. 246-252
-
-
Salvesen, G.S.1
Walsh, C.M.2
-
90
-
-
34547422758
-
Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis
-
Seymour R.E., Hasham M.G., Cox G.A., Shultz L.D., Hogenesch H., Roopenian D.C., Sundberg J.P. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 2007, 8:416-421.
-
(2007)
Genes Immun.
, vol.8
, pp. 416-421
-
-
Seymour, R.E.1
Hasham, M.G.2
Cox, G.A.3
Shultz, L.D.4
Hogenesch, H.5
Roopenian, D.C.6
Sundberg, J.P.7
-
91
-
-
77649225756
-
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
-
Shembade N., Ma A., Harhaj E.W. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010, 327:1135-1139.
-
(2010)
Science
, vol.327
, pp. 1135-1139
-
-
Shembade, N.1
Ma, A.2
Harhaj, E.W.3
-
92
-
-
84862907788
-
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
-
Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X., Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012, 148:213-227.
-
(2012)
Cell
, vol.148
, pp. 213-227
-
-
Sun, L.1
Wang, H.2
Wang, Z.3
He, S.4
Chen, S.5
Liao, D.6
Wang, L.7
Yan, J.8
Liu, W.9
Lei, X.10
Wang, X.11
-
93
-
-
84870570760
-
Necrostatin-1 analogues: critical issues on the specificity, activity and invivo use in experimental disease models
-
Takahashi N., Duprez L., Grootjans S., Cauwels A., Nerinckx W., DuHadaway J.B., Goossens V., Roelandt R., Van Hauwermeiren F., Libert C., et al. Necrostatin-1 analogues: critical issues on the specificity, activity and invivo use in experimental disease models. Cell Death Dis. 2012, 3:e437.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Takahashi, N.1
Duprez, L.2
Grootjans, S.3
Cauwels, A.4
Nerinckx, W.5
DuHadaway, J.B.6
Goossens, V.7
Roelandt, R.8
Van Hauwermeiren, F.9
Libert, C.10
-
94
-
-
84907197966
-
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
-
Takahashi N., Vereecke L., Bertrand M.J.M., Duprez L., Berger S.B., Divert T., Gonçalves A., Sze M., Gilbert B., Kourula S., et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature 2014, 513:95-99.
-
(2014)
Nature
, vol.513
, pp. 95-99
-
-
Takahashi, N.1
Vereecke, L.2
Bertrand, M.J.M.3
Duprez, L.4
Berger, S.B.5
Divert, T.6
Gonçalves, A.7
Sze, M.8
Gilbert, B.9
Kourula, S.10
-
95
-
-
79960921946
-
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
-
Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., Zachariou A., Lopez J., MacFarlane M., Cain K., Meier P. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 2011, 43:432-448.
-
(2011)
Mol. Cell
, vol.43
, pp. 432-448
-
-
Tenev, T.1
Bianchi, K.2
Darding, M.3
Broemer, M.4
Langlais, C.5
Wallberg, F.6
Zachariou, A.7
Lopez, J.8
MacFarlane, M.9
Cain, K.10
Meier, P.11
-
96
-
-
84882430393
-
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
-
Thapa R.J., Nogusa S., Chen P., Maki J.L., Lerro A., Andrake M., Rall G.F., Degterev A., Balachandran S. Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proc. Natl. Acad. Sci. USA 2013, 110:E3109-E3118.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E3109-E3118
-
-
Thapa, R.J.1
Nogusa, S.2
Chen, P.3
Maki, J.L.4
Lerro, A.5
Andrake, M.6
Rall, G.F.7
Degterev, A.8
Balachandran, S.9
-
97
-
-
79953237668
-
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
-
Tokunaga F., Nakagawa T., Nakahara M., Saeki Y., Taniguchi M., Sakata S.-I., Tanaka K., Nakano H., Iwai K. SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature 2011, 471:633-636.
-
(2011)
Nature
, vol.471
, pp. 633-636
-
-
Tokunaga, F.1
Nakagawa, T.2
Nakahara, M.3
Saeki, Y.4
Taniguchi, M.5
Sakata, S.-I.6
Tanaka, K.7
Nakano, H.8
Iwai, K.9
-
99
-
-
84858420051
-
DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA
-
Upton J.W., Kaiser W.J., Mocarski E.S. DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 2012, 11:290-297.
-
(2012)
Cell Host Microbe
, vol.11
, pp. 290-297
-
-
Upton, J.W.1
Kaiser, W.J.2
Mocarski, E.S.3
-
100
-
-
56349164232
-
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
-
Vallabhapurapu S., Matsuzawa A., Zhang W., Tseng P.-H., Keats J.J., Wang H., Vignali D.A.A., Bergsagel P.L., Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat. Immunol. 2008, 9:1364-1370.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1364-1370
-
-
Vallabhapurapu, S.1
Matsuzawa, A.2
Zhang, W.3
Tseng, P.-H.4
Keats, J.J.5
Wang, H.6
Vignali, D.A.A.7
Bergsagel, P.L.8
Karin, M.9
-
101
-
-
0032143986
-
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
-
Varfolomeev E.E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J.S., Mett I.L., Rebrikov D., Brodianski V.M., Kemper O.C., Kollet O., et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998, 9:267-276.
-
(1998)
Immunity
, vol.9
, pp. 267-276
-
-
Varfolomeev, E.E.1
Schuchmann, M.2
Luria, V.3
Chiannilkulchai, N.4
Beckmann, J.S.5
Mett, I.L.6
Rebrikov, D.7
Brodianski, V.M.8
Kemper, O.C.9
Kollet, O.10
-
102
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E., Blankenship J.W., Wayson S.M., Fedorova A.V., Kayagaki N., Garg P., Zobel K., Dynek J.N., Elliott L.O., Wallweber H.J.A., et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007, 131:669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
Zobel, K.7
Dynek, J.N.8
Elliott, L.O.9
Wallweber, H.J.A.10
-
103
-
-
54049155149
-
C-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
-
Varfolomeev E., Goncharov T., Fedorova A.V., Dynek J.N., Zobel K., Deshayes K., Fairbrother W.J., Vucic D. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J.Biol. Chem. 2008, 283:24295-24299.
-
(2008)
J.Biol. Chem.
, vol.283
, pp. 24295-24299
-
-
Varfolomeev, E.1
Goncharov, T.2
Fedorova, A.V.3
Dynek, J.N.4
Zobel, K.5
Deshayes, K.6
Fairbrother, W.J.7
Vucic, D.8
-
104
-
-
0032482169
-
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
-
Vercammen D., Beyaert R., Denecker G., Goossens V., Van Loo G., Declercq W., Grooten J., Fiers W., Vandenabeele P. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J.Exp. Med. 1998, 187:1477-1485.
-
(1998)
J.Exp. Med.
, vol.187
, pp. 1477-1485
-
-
Vercammen, D.1
Beyaert, R.2
Denecker, G.3
Goossens, V.4
Van Loo, G.5
Declercq, W.6
Grooten, J.7
Fiers, W.8
Vandenabeele, P.9
-
105
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince J.E., Wong W.W.-L., Khan N., Feltham R., Chau D., Ahmed A.U., Benetatos C.A., Chunduru S.K., Condon S.M., McKinlay M., et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007, 131:682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.-L.2
Khan, N.3
Feltham, R.4
Chau, D.5
Ahmed, A.U.6
Benetatos, C.A.7
Chunduru, S.K.8
Condon, S.M.9
McKinlay, M.10
-
106
-
-
72149117664
-
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-kappab and to prevent tnf-induced apoptosis
-
Vince J.E., Pantaki D., Feltham R., Mace P.D., Cordier S.M., Schmukle A.C., Davidson A.J., Callus B.A., Wong W.W.-L., Gentle I.E., et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-kappab and to prevent tnf-induced apoptosis. J.Biol. Chem. 2009, 284:35906-35915.
-
(2009)
J.Biol. Chem.
, vol.284
, pp. 35906-35915
-
-
Vince, J.E.1
Pantaki, D.2
Feltham, R.3
Mace, P.D.4
Cordier, S.M.5
Schmukle, A.C.6
Davidson, A.J.7
Callus, B.A.8
Wong, W.W.-L.9
Gentle, I.E.10
-
107
-
-
84857404572
-
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
-
Vince J.E., Wong W.W.-L., Gentle I., Lawlor K.E., Allam R., O'Reilly L., Mason K., Gross O., Ma S., Guarda G., et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 2012, 36:215-227.
-
(2012)
Immunity
, vol.36
, pp. 215-227
-
-
Vince, J.E.1
Wong, W.W.-L.2
Gentle, I.3
Lawlor, K.E.4
Allam, R.5
O'Reilly, L.6
Mason, K.7
Gross, O.8
Ma, S.9
Guarda, G.10
-
108
-
-
84898027331
-
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
-
Wang H., Sun L., Su L., Rizo J., Liu L., Wang L.-F., Wang F.-S., Wang X. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol. Cell 2014, 54:133-146.
-
(2014)
Mol. Cell
, vol.54
, pp. 133-146
-
-
Wang, H.1
Sun, L.2
Su, L.3
Rizo, J.4
Liu, L.5
Wang, L.-F.6
Wang, F.-S.7
Wang, X.8
-
109
-
-
84911192502
-
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
-
Wang X., Jiang W., Yan Y., Gong T., Han J., Tian Z., Zhou R. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat. Immunol. 2014.
-
(2014)
Nat. Immunol.
-
-
Wang, X.1
Jiang, W.2
Yan, Y.3
Gong, T.4
Han, J.5
Tian, Z.6
Zhou, R.7
-
111
-
-
84887016458
-
Protective roles for caspase-8 and cFLIP in adult homeostasis
-
Weinlich R., Oberst A., Dillon C.P., Janke L.J., Milasta S., Lukens J.R., Rodriguez D.A., Gurung P., Savage C., Kanneganti T.D., Green D.R. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep. 2013, 5:340-348.
-
(2013)
Cell Rep.
, vol.5
, pp. 340-348
-
-
Weinlich, R.1
Oberst, A.2
Dillon, C.P.3
Janke, L.J.4
Milasta, S.5
Lukens, J.R.6
Rodriguez, D.A.7
Gurung, P.8
Savage, C.9
Kanneganti, T.D.10
Green, D.R.11
-
112
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
-
Wertz I.E., O'Rourke K.M., Zhou H., Eby M., Aravind L., Seshagiri S., Wu P., Wiesmann C., Baker R., Boone D.L., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004, 430:694-699.
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
O'Rourke, K.M.2
Zhou, H.3
Eby, M.4
Aravind, L.5
Seshagiri, S.6
Wu, P.7
Wiesmann, C.8
Baker, R.9
Boone, D.L.10
-
113
-
-
76749132616
-
RIPK1 is not essential for TNFR1-induced activation of NF-kappaB
-
Wong W.W.-L., Gentle I.E., Nachbur U., Anderton H., Vaux D.L., Silke J. RIPK1 is not essential for TNFR1-induced activation of NF-kappaB. Cell Death Differ. 2010, 17:482-487.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 482-487
-
-
Wong, W.W.-L.1
Gentle, I.E.2
Nachbur, U.3
Anderton, H.4
Vaux, D.L.5
Silke, J.6
-
114
-
-
84881184694
-
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
-
Wu J., Huang Z., Ren J., Zhang Z., He P., Li Y., Ma J., Chen W., Zhang Y., Zhou X., et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 2013, 23:994-1006.
-
(2013)
Cell Res.
, vol.23
, pp. 994-1006
-
-
Wu, J.1
Huang, Z.2
Ren, J.3
Zhang, Z.4
He, P.5
Li, Y.6
Ma, J.7
Chen, W.8
Zhang, Y.9
Zhou, X.10
-
115
-
-
84932095487
-
Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis
-
Wu X.-N., Yang Z.-H., Wang X.-K., Zhang Y., Wan H., Song Y., Chen X., Shao J., Han J. Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ. 2014, 21:1709-1720.
-
(2014)
Cell Death Differ.
, vol.21
, pp. 1709-1720
-
-
Wu, X.-N.1
Yang, Z.-H.2
Wang, X.-K.3
Zhang, Y.4
Wan, H.5
Song, Y.6
Chen, X.7
Shao, J.8
Han, J.9
-
116
-
-
79960352030
-
A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage
-
Yang Y., Xia F., Hermance N., Mabb A., Simonson S., Morrissey S., Gandhi P., Munson M., Miyamoto S., Kelliher M.A. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol. Cell. Biol. 2011, 31:2774-2786.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2774-2786
-
-
Yang, Y.1
Xia, F.2
Hermance, N.3
Mabb, A.4
Simonson, S.5
Morrissey, S.6
Gandhi, P.7
Munson, M.8
Miyamoto, S.9
Kelliher, M.A.10
-
117
-
-
7144263731
-
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis
-
Yeh W.C., de la Pompa J.L., McCurrach M.E., Shu H.B., Elia A.J., Shahinian A., Ng M., Wakeham A., Khoo W., Mitchell K., et al. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 1998, 279:1954-1958.
-
(1998)
Science
, vol.279
, pp. 1954-1958
-
-
Yeh, W.C.1
de la Pompa, J.L.2
McCurrach, M.E.3
Shu, H.B.4
Elia, A.J.5
Shahinian, A.6
Ng, M.7
Wakeham, A.8
Khoo, W.9
Mitchell, K.10
-
118
-
-
56349164239
-
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
-
Zarnegar B.J., Wang Y., Mahoney D.J., Dempsey P.W., Cheung H.H., He J., Shiba T., Yang X., Yeh W.C., Mak T.W., et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat. Immunol. 2008, 9:1371-1378.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
Dempsey, P.W.4
Cheung, H.H.5
He, J.6
Shiba, T.7
Yang, X.8
Yeh, W.C.9
Mak, T.W.10
-
119
-
-
0032546387
-
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
-
Zhang J., Cado D., Chen A., Kabra N.H., Winoto A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 1998, 392:296-300.
-
(1998)
Nature
, vol.392
, pp. 296-300
-
-
Zhang, J.1
Cado, D.2
Chen, A.3
Kabra, N.H.4
Winoto, A.5
-
120
-
-
49649123561
-
Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD
-
Zhang M., Wu X., Lee A.J., Jin W., Chang M., Wright A., Imaizumi T., Sun S.-C. Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J.Biol. Chem. 2008, 283:18621-18626.
-
(2008)
J.Biol. Chem.
, vol.283
, pp. 18621-18626
-
-
Zhang, M.1
Wu, X.2
Lee, A.J.3
Jin, W.4
Chang, M.5
Wright, A.6
Imaizumi, T.7
Sun, S.-C.8
-
121
-
-
67650812332
-
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
-
Zhang D.-W., Shao J., Lin J., Zhang N., Lu B.-J., Lin S.-C., Dong M.-Q., Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.
-
(2009)
Science
, vol.325
, pp. 332-336
-
-
Zhang, D.-W.1
Shao, J.2
Lin, J.3
Zhang, N.4
Lu, B.-J.5
Lin, S.-C.6
Dong, M.-Q.7
Han, J.8
-
122
-
-
79952780505
-
Functional complementation between FADD and RIP1 in embryos and lymphocytes
-
Zhang H., Zhou X., McQuade T., Li J., Chan F.K.-M., Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011, 471:373-376.
-
(2011)
Nature
, vol.471
, pp. 373-376
-
-
Zhang, H.1
Zhou, X.2
McQuade, T.3
Li, J.4
Chan, F.K.-M.5
Zhang, J.6
-
123
-
-
84859467770
-
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
-
Zhao J., Jitkaew S., Cai Z., Choksi S., Li Q., Luo J., Liu Z.-G. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc. Natl. Acad. Sci. USA 2012, 109:5322-5327.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 5322-5327
-
-
Zhao, J.1
Jitkaew, S.2
Cai, Z.3
Choksi, S.4
Li, Q.5
Luo, J.6
Liu, Z.-G.7
-
124
-
-
84875908991
-
TRPM2 links oxidative stress to NLRP3 inflammasome activation
-
Zhong Z., Zhai Y., Liang S., Mori Y., Han R., Sutterwala F.S., Qiao L. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat. Commun. 2013, 4:1611.
-
(2013)
Nat. Commun.
, vol.4
, pp. 1611
-
-
Zhong, Z.1
Zhai, Y.2
Liang, S.3
Mori, Y.4
Han, R.5
Sutterwala, F.S.6
Qiao, L.7
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