Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Cell Research

Volumn 23, Issue 8, 2013, Pages 994-1006

  Wu, Jianfeng ^a   Huang, Zhe ^a   Ren, Junming ^a   Zhang, Zhirong ^a   He, Peng ^a   Li, Yangxin ^a   Ma, Jianhui ^a   Chen, Wanze ^a   Zhang, Yingying ^a   Zhou, Xiaojuan ^a   Yang, Zhentao ^a   Wu, Su Qin ^a   Chen, Lanfen ^a   Han, Jiahuai ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MUS;

EID: 84881184694     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2013.91     Document Type: Article

References (47)

1. Laster SM, Wood JG, Gooding LR Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis J Immunol 1988; 141:2629-2634.
2. Nakagawa T, Shimizu S, Watanabe T, et al Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death Nature 2005; 434:652- 658.
3. Baines CP, Kaiser RA, Purcell NH, et al Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death Nature 2005; 434:658-662.
4. Degterev A, Huang Z, Boyce M, et al Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Nat Chem Biol 2005; 1:112-119.
5. Huang Q, Shen HM To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage Autophagy 2009; 5:273-276
6. Sun H, Wang Y Novel Ser/Thr protein phosphatases in cell death regulation Physiology (Bethesda) 2012; 27:43-52
7. Han J, Zhong CQ, Zhang DW Programmed necrosis: backup to and competitor with apoptosis in the immune system Nat Immunol 2011; 12:1143-1149.
8. Feng S, Yang Y, Mei Y, et al Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain Cell Signal 2007; 19:2056-2067.
9. Kaiser WJ, Upton JW, Long AB, et al RIP3 mediates the embryonic lethality of caspase-8-deficient mice Nature 2011; 471:368-372
10. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM Mechanisms of necroptosis in T cells J Exp Med 2011; 208:633-641.
11. Moulin M, Anderton H, Voss AK, et al IAPs limit activation of RIP kinases by TNF receptor 1 during development EMBO J 2012; 31:1679-1691.
12. Hitomi J, Christofferson DE, Ng A, et al Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway Cell 2008; 135:1311-1323.
13. Duprez L, Takahashi N, Van Hauwermeiren F, et al RIP kinase- dependent necrosis drives lethal systemic inflammatory response syndrome Immunity 2011; 35:908-918.
14. Cho YS, Challa S, Moquin D, et al Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation Cell 2009; 137:1112-1123
15. Upton JW, Kaiser WJ, Mocarski ES DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA Cell Host Microbe 2012; 11:290-297.
16. Zhu S, Zhang Y, Bai G, Li H Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease Cell Death Dis 2011; 2:e115.
17. Linkermann A, Brasen JH, De Zen F, et al Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-alpha-induced shock Mol Med 2012; 18:577-586.
18. Zhou Z, Han V, Han J New components of the necroptotic pathway Protein Cell 2012; 3:811-817
19. Festjens N, Vanden Berghe T, Vandenabeele P Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response Biochim Biophys Acta 2006; 1757:1371-1387
20. Golstein P, Kroemer G Cell death by necrosis: towards a molecular definition Trends Biochem Sci 2007; 32:37-43
21. Wallach D, Kang TB, Kovalenko A The extrinsic cell death pathway and the elan mortel Cell Death Differ 2008; 15:1533-1541.
22. Galluzzi L, Vitale I, Abrams JM, et al Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 Cell Death Differ 2012; 19:107-120.
23. Zhang DW, Shao J, Lin J, et al RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis Science 2009; 325:332-336
24. He S, Wang L, Miao L, et al Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha Cell 2009; 137:1100-1111
25. He S, Liang Y, Shao F, Wang X Toll-like receptors activate programmed necrosis in macrophages through a receptorinteracting kinase-3-mediated pathway Proc Natl Acad Sci USA 2011; 108:20054-20059.
26. Dunai ZA, Imre G, Barna G, et al Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells PLoS One 2012; 7:e41945
27. Lin J, Li H, Yang M, et al A role of RIP3-mediated macrophage necrosis in atherosclerosis development Cell Rep 2013; 3:200-210
28. Zorde-Khvalevsky E, Abramovitch R, Barash H, et al Tolllike receptor 3 signaling attenuates liver regeneration Hepatology 2009; 50:198-206.
29. Trichonas G, Murakami Y, Thanos A, et al Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis Proc Natl Acad Sci USA 2010; 107:21695-21700
30. Li Q, Li G, Lan X, et al Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis J Biol Chem 2010; 285:9535-9544.
31. Gunther C, Martini E, Wittkopf N, et al Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis Nature 2011; 477:335-339
32. Sun L, Wang H, Wang Z, et al Mixed lineage kinase domainlike protein mediates necrosis signaling downstream of RIP3 kinase Cell 2012; 148:213-227.
33. Li J, McQuade T, Siemer AB, et al The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis Cell 2012; 150:339-350
34. Narayan N, Lee IH, Borenstein R, et al The NAD-dependent deacetylase SIRT2 is required for programmed necrosis Nature 2012; 492:199-204.
35. Wang Z, Jiang H, Chen S, Du F, Wang X The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways Cell 2012; 148:228-243.
36. Zhao J, Jitkaew S, Cai Z, et al Mixed lineage kinase domainlike is a key receptor interacting protein 3 downstream component of TNF-induced necrosis Proc Natl Acad Sci USA 2012; 109:5322-5327
37. Carlson DF, Tan W, Lillico SG, et al Efficient TALENmediated gene knockout in livestock Proc Natl Acad Sci USA 2012; 109:17382-17387.
38. Bogdanove AJ, Voytas DF TAL effectors: customizable proteins for DNA targeting Science 2011; 333:1843-1846
39. Geurts AM, Cost GJ, Freyvert Y, et al Knockout rats via embryo microinjection of zinc-finger nucleases Science 2009; 325:433
40. Mashimo T, Takizawa A, Voigt B, et al Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases PLoS One 2010; 5:e8870
41. Carbery ID, Ji D, Harrington A, et al Targeted genome modification in mice using zinc-finger nucleases Genetics 2010; 186:451-459
42. Zhang DW, Zheng M, Zhao J, et al Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes Cell Res 2011; 21:368-371.
43. Wang L, Du F, Wang X TNF-alpha induces two distinct caspase- 8 activation pathways Cell 2008; 133:693-703
44. Welz PS, Wullaert A, Vlantis K, et al FADD prevents RIP3- mediated epithelial cell necrosis and chronic intestinal inflammation Nature 2011; 477:330-334
45. Newton K, Sun X, Dixit VM Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4 Mol Cell Biol 2004; 24:1464-1469
46. Pinheiro da Silva F, Nizet V Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection Apoptosis 2009; 14:509-521
47. Gallo KA, Johnson GL Mixed-lineage kinase control of JNK and p38 MAPK pathways Nat Rev Mol Cell Biol 2002; 3:663-672.