메뉴 건너뛰기




Volumn 176, Issue , 2016, Pages 38-68

Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; ANTIINFLAMMATORY AGENT; CD98 ANTIGEN; CHEMOKINE RECEPTOR CCR1 ANTAGONIST; CXCL1 CHEMOKINE; ENZYME INHIBITOR; IMMUNOMODULATING AGENT; INTERLEUKIN 1 DERIVATIVE; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 21; INTERLEUKIN 6; MICRORNA; NATURAL KILLER CELL RECEPTOR NKG2D; NUTRACEUTICAL; PROBIOTIC AGENT; TRANSCRIPTION FACTOR GATA 3; TUMOR NECROSIS FACTOR INHIBITOR; BIOLOGICAL PRODUCT;

EID: 84991387611     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2016.04.009     Document Type: Review
Times cited : (147)

References (270)
  • 1
    • 30344445931 scopus 로고    scopus 로고
    • Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities
    • 1 Hanauer, S.B., Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 12 (2006), S3–S9.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. S3-S9
    • Hanauer, S.B.1
  • 2
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • 2 Bouma, G., Strober, W., The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3 (2003), 521–533.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 3
    • 84867825504 scopus 로고    scopus 로고
    • Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease
    • 3 Xiao, B., Merlin, D., Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opin Drug Deliv 9 (2012), 1393–1407.
    • (2012) Expert Opin Drug Deliv , vol.9 , pp. 1393-1407
    • Xiao, B.1    Merlin, D.2
  • 4
    • 2942557091 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease with corticosteroids
    • vii
    • 4 Katz, J.A., Treatment of inflammatory bowel disease with corticosteroids. Gastroenterol Clin North Am 33 (2004), 171–189 vii.
    • (2004) Gastroenterol Clin North Am , vol.33 , pp. 171-189
    • Katz, J.A.1
  • 5
    • 84959517229 scopus 로고    scopus 로고
    • Gastrointestinal stability of therapeutic anti-TNF alpha IgG1 monoclonal antibodies
    • 5 Yadav, V., Varum, F., Bravo, R., Furrer, E., Basit, A.W., Gastrointestinal stability of therapeutic anti-TNF alpha IgG1 monoclonal antibodies. Int J Pharm 502 (2016), 181–187.
    • (2016) Int J Pharm , vol.502 , pp. 181-187
    • Yadav, V.1    Varum, F.2    Bravo, R.3    Furrer, E.4    Basit, A.W.5
  • 8
    • 54349118972 scopus 로고    scopus 로고
    • The role of IL-13 and NK T cells in experimental and human ulcerative colitis
    • 8 Fuss, I.J., Strober, W., The role of IL-13 and NK T cells in experimental and human ulcerative colitis. Mucosal Immunol 1 (2008), S31–S33.
    • (2008) Mucosal Immunol , vol.1 , pp. S31-S33
    • Fuss, I.J.1    Strober, W.2
  • 9
    • 79952532799 scopus 로고    scopus 로고
    • Suppression of inflammation in ulcerative colitis by interferon-beta-1a is accompanied by inhibition of IL-13 production
    • 9 Mannon, P.J., Hornung, R.L., Yang, Z., et al. Suppression of inflammation in ulcerative colitis by interferon-beta-1a is accompanied by inhibition of IL-13 production. Gut 60 (2011), 449–455.
    • (2011) Gut , vol.60 , pp. 449-455
    • Mannon, P.J.1    Hornung, R.L.2    Yang, Z.3
  • 10
    • 84899424860 scopus 로고    scopus 로고
    • Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis
    • 10 Okamura, M., Yoh, K., Ojima, M., Morito, N., Takahashi, S., Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis. Exp Anim 63 (2014), 133–140.
    • (2014) Exp Anim , vol.63 , pp. 133-140
    • Okamura, M.1    Yoh, K.2    Ojima, M.3    Morito, N.4    Takahashi, S.5
  • 11
    • 77955797125 scopus 로고    scopus 로고
    • Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis
    • 11 Ohtani, K., Ohtsuka, Y., Ikuse, T., et al. Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. Pediatr Int 52 (2010), 584–589.
    • (2010) Pediatr Int , vol.52 , pp. 584-589
    • Ohtani, K.1    Ohtsuka, Y.2    Ikuse, T.3
  • 12
    • 0032976657 scopus 로고    scopus 로고
    • Increased intraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmental perfusion
    • 12 Carlson, M., Raab, Y., Peterson, C., Hallgren, R., Venge, P., Increased intraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmental perfusion. Am J Gastroenterol 94 (1999), 1876–1883.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1876-1883
    • Carlson, M.1    Raab, Y.2    Peterson, C.3    Hallgren, R.4    Venge, P.5
  • 13
    • 28144452006 scopus 로고    scopus 로고
    • The role of eosinophils in inflammatory bowel disease
    • 13 Al-Haddad, S., Riddell, R.H., The role of eosinophils in inflammatory bowel disease. Gut 54 (2005), 1674–1675.
    • (2005) Gut , vol.54 , pp. 1674-1675
    • Al-Haddad, S.1    Riddell, R.H.2
  • 15
    • 84897985897 scopus 로고    scopus 로고
    • Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation
    • 15 Vivinus-Nebot, M., Frin-Mathy, G., Bzioueche, H., et al. Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation. Gut 63 (2014), 744–752.
    • (2014) Gut , vol.63 , pp. 744-752
    • Vivinus-Nebot, M.1    Frin-Mathy, G.2    Bzioueche, H.3
  • 16
    • 43549120052 scopus 로고    scopus 로고
    • Role of gastrointestinal eosinophils in inflammatory bowel disease and intestinal tumours
    • 16 Wedemeyer, J., Vosskuhl, K., Role of gastrointestinal eosinophils in inflammatory bowel disease and intestinal tumours. Best Pract Res Clin Gastroenterol 22 (2008), 537–549.
    • (2008) Best Pract Res Clin Gastroenterol , vol.22 , pp. 537-549
    • Wedemeyer, J.1    Vosskuhl, K.2
  • 17
    • 0031047320 scopus 로고    scopus 로고
    • Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls
    • 17 Bischoff, S.C., Grabowsky, J., Manns, M.P., Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls. Dig Dis Sci 42 (1997), 394–403.
    • (1997) Dig Dis Sci , vol.42 , pp. 394-403
    • Bischoff, S.C.1    Grabowsky, J.2    Manns, M.P.3
  • 18
    • 22644444207 scopus 로고    scopus 로고
    • Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2
    • 18 Cario, E., Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut 54 (2005), 1182–1193.
    • (2005) Gut , vol.54 , pp. 1182-1193
    • Cario, E.1
  • 19
    • 2442519456 scopus 로고    scopus 로고
    • Genetic variation in DLG5 is associated with inflammatory bowel disease
    • 19 Stoll, M., Corneliussen, B., Costello, C.M., et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 36 (2004), 476–480.
    • (2004) Nat Genet , vol.36 , pp. 476-480
    • Stoll, M.1    Corneliussen, B.2    Costello, C.M.3
  • 20
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • 20 Panwala, C.M., Jones, J.C., Viney, J.L., A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 161 (1998), 5733–5744.
    • (1998) J Immunol , vol.161 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 21
    • 0033916388 scopus 로고    scopus 로고
    • Epigenetics of inflammatory bowel disease
    • 21 Petronis, A., Petroniene, R., Epigenetics of inflammatory bowel disease. Gut 47 (2000), 302–306.
    • (2000) Gut , vol.47 , pp. 302-306
    • Petronis, A.1    Petroniene, R.2
  • 22
    • 84943240073 scopus 로고    scopus 로고
    • Genetics of inflammatory bowel diseases
    • 22 McGovern, D.P., Kugathasan, S., Cho, J.H., Genetics of inflammatory bowel diseases. Gastroenterology 149 (2015), 1163–1176 e2.
    • (2015) Gastroenterology , vol.149 , pp. 1163-1176 e2
    • McGovern, D.P.1    Kugathasan, S.2    Cho, J.H.3
  • 23
    • 84949558017 scopus 로고    scopus 로고
    • Inflammatory bowel disease: genetics, epigenetics, and pathogenesis
    • 23 Loddo, I., Romano, C., Inflammatory bowel disease: genetics, epigenetics, and pathogenesis. Front Immunol, 6, 2015, 551.
    • (2015) Front Immunol , vol.6 , pp. 551
    • Loddo, I.1    Romano, C.2
  • 24
    • 84868526965 scopus 로고    scopus 로고
    • Role of commensal gut bacteria in inflammatory bowel diseases
    • 24 Loh, G., Blaut, M., Role of commensal gut bacteria in inflammatory bowel diseases. Gut Microbes 3 (2012), 544–555.
    • (2012) Gut Microbes , vol.3 , pp. 544-555
    • Loh, G.1    Blaut, M.2
  • 25
    • 84946734733 scopus 로고    scopus 로고
    • Microbiota in inflammatory bowel disease pathogenesis and therapy: is it all about diet?
    • 25 Serban, D.E., Microbiota in inflammatory bowel disease pathogenesis and therapy: is it all about diet?. Nutr Clin Pract 30 (2015), 760–779.
    • (2015) Nutr Clin Pract , vol.30 , pp. 760-779
    • Serban, D.E.1
  • 26
    • 84896725333 scopus 로고    scopus 로고
    • The role of the innate immune system in granulomatous disorders
    • 26 Petersen, H.J., Smith, A.M., The role of the innate immune system in granulomatous disorders. Front Immunol, 4, 2013, 120.
    • (2013) Front Immunol , vol.4 , pp. 120
    • Petersen, H.J.1    Smith, A.M.2
  • 27
    • 79957576822 scopus 로고    scopus 로고
    • Chronic granulomatous disease: a review of the infectious and inflammatory complications
    • 27 Song, E., Jaishankar, G.B., Saleh, H., et al. Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy, 9, 2011, 10.
    • (2011) Clin Mol Allergy , vol.9 , pp. 10
    • Song, E.1    Jaishankar, G.B.2    Saleh, H.3
  • 28
    • 0035082973 scopus 로고    scopus 로고
    • Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice
    • 28 Rath, H.C., Schultz, M., Freitag, R., et al. Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice. Infect Immun 69 (2001), 2277–2285.
    • (2001) Infect Immun , vol.69 , pp. 2277-2285
    • Rath, H.C.1    Schultz, M.2    Freitag, R.3
  • 29
    • 79956078164 scopus 로고    scopus 로고
    • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
    • 29 Bloom, S.M., Bijanki, V.N., Nava, G.M., et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 9 (2011), 390–403.
    • (2011) Cell Host Microbe , vol.9 , pp. 390-403
    • Bloom, S.M.1    Bijanki, V.N.2    Nava, G.M.3
  • 30
    • 34249886868 scopus 로고    scopus 로고
    • CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
    • 30 Barnich, N., Carvalho, F.A., Glasser, A.L., et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest 117 (2007), 1566–1574.
    • (2007) J Clin Invest , vol.117 , pp. 1566-1574
    • Barnich, N.1    Carvalho, F.A.2    Glasser, A.L.3
  • 31
    • 0035026232 scopus 로고    scopus 로고
    • The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo
    • 31 Atuma, C., Strugala, V., Allen, A., Holm, L., The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol 280 (2001), G922–G929.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280 , pp. G922-G929
    • Atuma, C.1    Strugala, V.2    Allen, A.3    Holm, L.4
  • 34
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    • 34 Johansson, M.E., Gustafsson, J.K., Holmen-Larsson, J., et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63 (2014), 281–291.
    • (2014) Gut , vol.63 , pp. 281-291
    • Johansson, M.E.1    Gustafsson, J.K.2    Holmen-Larsson, J.3
  • 35
    • 34447099136 scopus 로고    scopus 로고
    • Induction of secretory immunity and memory at mucosal surfaces
    • 35 Brandtzaeg, P., Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25 (2007), 5467–5484.
    • (2007) Vaccine , vol.25 , pp. 5467-5484
    • Brandtzaeg, P.1
  • 36
    • 0025031856 scopus 로고
    • Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis
    • 36 Takahasi, F., Shah, H.S., Wise, L.S., Das, K.M., Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis. Gut 31 (1990), 1016–1020.
    • (1990) Gut , vol.31 , pp. 1016-1020
    • Takahasi, F.1    Shah, H.S.2    Wise, L.S.3    Das, K.M.4
  • 37
    • 4043072255 scopus 로고    scopus 로고
    • Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease
    • 37 Olson, T.S., Bamias, G., Naganuma, M., et al. Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest 114 (2004), 389–398.
    • (2004) J Clin Invest , vol.114 , pp. 389-398
    • Olson, T.S.1    Bamias, G.2    Naganuma, M.3
  • 38
    • 70349640926 scopus 로고    scopus 로고
    • Hyperactivated B cells in human inflammatory bowel disease
    • 38 Noronha, A.M., Liang, Y., Hetzel, J.T., et al. Hyperactivated B cells in human inflammatory bowel disease. J Leukoc Biol 86 (2009), 1007–1016.
    • (2009) J Leukoc Biol , vol.86 , pp. 1007-1016
    • Noronha, A.M.1    Liang, Y.2    Hetzel, J.T.3
  • 39
    • 77249139158 scopus 로고    scopus 로고
    • Selective IgA deficiency
    • 39 Yel, L., Selective IgA deficiency. J Clin Immunol 30 (2010), 10–16.
    • (2010) J Clin Immunol , vol.30 , pp. 10-16
    • Yel, L.1
  • 40
    • 84907300008 scopus 로고    scopus 로고
    • Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
    • 40 Palm, N.W., de Zoete, M.R., Cullen, T.W., et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158 (2014), 1000–1010.
    • (2014) Cell , vol.158 , pp. 1000-1010
    • Palm, N.W.1    de Zoete, M.R.2    Cullen, T.W.3
  • 41
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • 41 Khor, B., Gardet, A., Xavier, R.J., Genetics and pathogenesis of inflammatory bowel disease. Nature 474 (2011), 307–317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 42
    • 79851479595 scopus 로고    scopus 로고
    • Immunopathogenesis of inflammatory bowel disease
    • 42 Matricon, J., Barnich, N., Ardid, D., Immunopathogenesis of inflammatory bowel disease. Self Nonself 1 (2010), 299–309.
    • (2010) Self Nonself , vol.1 , pp. 299-309
    • Matricon, J.1    Barnich, N.2    Ardid, D.3
  • 43
    • 77956646451 scopus 로고    scopus 로고
    • Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
    • 43 Ferreira, R.C., Pan-Hammarstrom, Q., Graham, R.R., et al. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet 42 (2010), 777–780.
    • (2010) Nat Genet , vol.42 , pp. 777-780
    • Ferreira, R.C.1    Pan-Hammarstrom, Q.2    Graham, R.R.3
  • 44
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • 44 Macpherson, A., Khoo, U.Y., Forgacs, I., Philpott-Howard, J., Bjarnason, I., Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38 (1996), 365–375.
    • (1996) Gut , vol.38 , pp. 365-375
    • Macpherson, A.1    Khoo, U.Y.2    Forgacs, I.3    Philpott-Howard, J.4    Bjarnason, I.5
  • 45
    • 0022545059 scopus 로고
    • Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls
    • 45 Scott, M.G., Nahm, M.H., Macke, K., Nash, G.S., Bertovich, M.J., MacDermott, R.P., Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls. Clin Exp Immunol 66 (1986), 209–215.
    • (1986) Clin Exp Immunol , vol.66 , pp. 209-215
    • Scott, M.G.1    Nahm, M.H.2    Macke, K.3    Nash, G.S.4    Bertovich, M.J.5    MacDermott, R.P.6
  • 46
    • 70350093622 scopus 로고    scopus 로고
    • An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice
    • 46 Kobayashi, K., Qiao, S.W., Yoshida, M., Baker, K., Lencer, W.I., Blumberg, R.S., An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology 137 (2009), 1746–1756.e1.
    • (2009) Gastroenterology , vol.137 , pp. 1746-1756.e1
    • Kobayashi, K.1    Qiao, S.W.2    Yoshida, M.3    Baker, K.4    Lencer, W.I.5    Blumberg, R.S.6
  • 47
    • 84921574597 scopus 로고    scopus 로고
    • Environmental risk factors for inflammatory bowel diseases: a review
    • 47 Ananthakrishnan, A.N., Environmental risk factors for inflammatory bowel diseases: a review. Dig Dis Sci 60 (2015), 290–298.
    • (2015) Dig Dis Sci , vol.60 , pp. 290-298
    • Ananthakrishnan, A.N.1
  • 48
    • 84904504746 scopus 로고    scopus 로고
    • Smoking in inflammatory bowel disease: impact on disease course and insights into the aetiology of its effect
    • 48 Parkes, G.C., Whelan, K., Lindsay, J.O., Smoking in inflammatory bowel disease: impact on disease course and insights into the aetiology of its effect. J Crohns Colitis 8 (2014), 717–725.
    • (2014) J Crohns Colitis , vol.8 , pp. 717-725
    • Parkes, G.C.1    Whelan, K.2    Lindsay, J.O.3
  • 49
    • 84862303080 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis
    • 49 Monteleone, I., MacDonald, T.T., Pallone, F., Monteleone, G., The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis. Curr Opin Gastroenterol 28 (2012), 310–313.
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 310-313
    • Monteleone, I.1    MacDonald, T.T.2    Pallone, F.3    Monteleone, G.4
  • 50
    • 0026583866 scopus 로고
    • Diet and inflammatory bowel disease: a case-control study
    • 50 Persson, P.G., Ahlbom, A., Hellers, G., Diet and inflammatory bowel disease: a case-control study. Epidemiology 3 (1992), 47–52.
    • (1992) Epidemiology , vol.3 , pp. 47-52
    • Persson, P.G.1    Ahlbom, A.2    Hellers, G.3
  • 51
    • 0030794276 scopus 로고    scopus 로고
    • Pre-illness dietary factors in inflammatory bowel disease
    • 51 Reif, S., Klein, I., Lubin, F., Farbstein, M., Hallak, A., Gilat, T., Pre-illness dietary factors in inflammatory bowel disease. Gut 40 (1997), 754–760.
    • (1997) Gut , vol.40 , pp. 754-760
    • Reif, S.1    Klein, I.2    Lubin, F.3    Farbstein, M.4    Hallak, A.5    Gilat, T.6
  • 52
    • 0030799019 scopus 로고    scopus 로고
    • Colonic sulfide in pathogenesis and treatment of ulcerative colitis
    • 52 Roediger, W.E., Moore, J., Babidge, W., Colonic sulfide in pathogenesis and treatment of ulcerative colitis. Dig Dis Sci 42 (1997), 1571–1579.
    • (1997) Dig Dis Sci , vol.42 , pp. 1571-1579
    • Roediger, W.E.1    Moore, J.2    Babidge, W.3
  • 53
    • 15444376177 scopus 로고    scopus 로고
    • Past and current theories of etiology of IBD: toothpaste, worms, and refrigerators
    • 53 Korzenik, J.R., Past and current theories of etiology of IBD: toothpaste, worms, and refrigerators. J Clin Gastroenterol 39 (2005), S59–S65.
    • (2005) J Clin Gastroenterol , vol.39 , pp. S59-S65
    • Korzenik, J.R.1
  • 54
    • 84904636678 scopus 로고    scopus 로고
    • Oral peptide and protein delivery: intestinal obstacles and commercial prospects
    • 54 Smart, A.L., Gaisford, S., Basit, A.W., Oral peptide and protein delivery: intestinal obstacles and commercial prospects. Expert Opin Drug Deliv 11 (2014), 1323–1335.
    • (2014) Expert Opin Drug Deliv , vol.11 , pp. 1323-1335
    • Smart, A.L.1    Gaisford, S.2    Basit, A.W.3
  • 55
    • 43249121029 scopus 로고    scopus 로고
    • Gut instincts: explorations in intestinal physiology and drug delivery
    • 55 McConnell, E.L., Fadda, H.M., Basit, A.W., Gut instincts: explorations in intestinal physiology and drug delivery. Int J Pharm 364 (2008), 213–226.
    • (2008) Int J Pharm , vol.364 , pp. 213-226
    • McConnell, E.L.1    Fadda, H.M.2    Basit, A.W.3
  • 56
    • 0035084176 scopus 로고    scopus 로고
    • Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs
    • 56 Nugent, S.G., Kumar, D., Rampton, D.S., Evans, D.F., Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48 (2001), 571–577.
    • (2001) Gut , vol.48 , pp. 571-577
    • Nugent, S.G.1    Kumar, D.2    Rampton, D.S.3    Evans, D.F.4
  • 57
    • 0032801475 scopus 로고    scopus 로고
    • Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease
    • 57 Ewe, K., Schwartz, S., Petersen, S., Press, A.G., Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease. Dig Dis Sci 44 (1999), 1434–1439.
    • (1999) Dig Dis Sci , vol.44 , pp. 1434-1439
    • Ewe, K.1    Schwartz, S.2    Petersen, S.3    Press, A.G.4
  • 58
    • 0031817515 scopus 로고    scopus 로고
    • Gastrointestinal pH profiles in patients with inflammatory bowel disease
    • 58 Press, A.G., Hauptmann, I.A., Hauptmann, L., et al. Gastrointestinal pH profiles in patients with inflammatory bowel disease. Aliment Pharmacol Ther 12 (1998), 673–678.
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 673-678
    • Press, A.G.1    Hauptmann, I.A.2    Hauptmann, L.3
  • 59
    • 0242361674 scopus 로고    scopus 로고
    • Intestinal performance of two mesalamine formulations in patients with active ulcerative colitis as assessed by gamma scintigraphy
    • 59 Sinha, A., Ball, D.J., Connor, A.L., Nightingale, J., Wilding, I.R., Intestinal performance of two mesalamine formulations in patients with active ulcerative colitis as assessed by gamma scintigraphy. Pract Gastrotenterol 27 (2003), 56–69.
    • (2003) Pract Gastrotenterol , vol.27 , pp. 56-69
    • Sinha, A.1    Ball, D.J.2    Connor, A.L.3    Nightingale, J.4    Wilding, I.R.5
  • 60
    • 0031946095 scopus 로고    scopus 로고
    • Small intestinal transit time and intraluminal pH in ileocecal resected patients with Crohn's disease
    • 60 Fallingborg, J., Pedersen, P., Jacobsen, B.A., Small intestinal transit time and intraluminal pH in ileocecal resected patients with Crohn's disease. Dig Dis Sci 43 (1998), 702–705.
    • (1998) Dig Dis Sci , vol.43 , pp. 702-705
    • Fallingborg, J.1    Pedersen, P.2    Jacobsen, B.A.3
  • 61
    • 0033950973 scopus 로고    scopus 로고
    • Limited exposure of the healthy distal colon to orally-dosed formulation is further exaggerated in active left-sided ulcerative colitis
    • 61 Hebden, J.M., Blackshaw, P.E., Perkins, A.C., Wilson, C.G., Spiller, R.C., Limited exposure of the healthy distal colon to orally-dosed formulation is further exaggerated in active left-sided ulcerative colitis. Aliment Pharmacol Ther 14 (2000), 155–161.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 155-161
    • Hebden, J.M.1    Blackshaw, P.E.2    Perkins, A.C.3    Wilson, C.G.4    Spiller, R.C.5
  • 62
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • 62 Sartor, R.B., Microbial influences in inflammatory bowel diseases. Gastroenterology 134 (2008), 577–594.
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 63
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • 63 Willing, B.P., Dicksved, J., Halfvarson, J., et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139 (2010), 1844–1854.e1.
    • (2010) Gastroenterology , vol.139 , pp. 1844-1854.e1
    • Willing, B.P.1    Dicksved, J.2    Halfvarson, J.3
  • 64
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • 64 Sokol, H., Pigneur, B., Watterlot, L., et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 105 (2008), 16731–16736.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3
  • 65
    • 76149128701 scopus 로고    scopus 로고
    • What should be considered on design of a colon-specific prodrug?
    • 65 Jung, Y., Kim, Y.M., What should be considered on design of a colon-specific prodrug?. Expert Opin Drug Deliv 7 (2010), 245–258.
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 245-258
    • Jung, Y.1    Kim, Y.M.2
  • 66
    • 84865140623 scopus 로고    scopus 로고
    • Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice
    • 66 Im, E., Riegler, F.M., Pothoulakis, C., Rhee, S.H., Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice. Am J Physiol Gastrointest Liver Physiol 303 (2012), G490–G497.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G490-G497
    • Im, E.1    Riegler, F.M.2    Pothoulakis, C.3    Rhee, S.H.4
  • 67
    • 0016254051 scopus 로고
    • The origin of human fecal alkaline phosphatase
    • 67 Horrigan, F.D., Danovitch, S.H., The origin of human fecal alkaline phosphatase. Am J Dig Dis 19 (1974), 603–608.
    • (1974) Am J Dig Dis , vol.19 , pp. 603-608
    • Horrigan, F.D.1    Danovitch, S.H.2
  • 68
    • 61649122881 scopus 로고    scopus 로고
    • Role of alkaline phosphatase in colitis in man and rats
    • 68 Tuin, A., Poelstra, K., de Jager-Krikken, A., et al. Role of alkaline phosphatase in colitis in man and rats. Gut 58 (2009), 379–387.
    • (2009) Gut , vol.58 , pp. 379-387
    • Tuin, A.1    Poelstra, K.2    de Jager-Krikken, A.3
  • 70
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor
    • 70 Hollander, D., Vadheim, C.M., Brettholz, E., Petersen, G.M., Delahunty, T., Rotter, J.I., Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann Intern Med 105 (1986), 883–885.
    • (1986) Ann Intern Med , vol.105 , pp. 883-885
    • Hollander, D.1    Vadheim, C.M.2    Brettholz, E.3    Petersen, G.M.4    Delahunty, T.5    Rotter, J.I.6
  • 71
    • 58849084704 scopus 로고    scopus 로고
    • Defensins and inflammation: the role of defensins in inflammatory bowel disease
    • 71 Ramasundara, M., Leach, S.T., Lemberg, D.A., Day, A.S., Defensins and inflammation: the role of defensins in inflammatory bowel disease. J Gastroenterol Hepatol 24 (2009), 202–208.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 202-208
    • Ramasundara, M.1    Leach, S.T.2    Lemberg, D.A.3    Day, A.S.4
  • 72
    • 17944383049 scopus 로고    scopus 로고
    • Intestinal permeability in Crohn's disease patients and their first degree relatives
    • 72 Secondulfo, M., de Magistris, L., Fiandra, R., et al. Intestinal permeability in Crohn's disease patients and their first degree relatives. Dig Liver Dis 33 (2001), 680–685.
    • (2001) Dig Liver Dis , vol.33 , pp. 680-685
    • Secondulfo, M.1    de Magistris, L.2    Fiandra, R.3
  • 73
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • 73 Wehkamp, J., Salzman, N.H., Porter, E., et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 102 (2005), 18129–18134.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.H.2    Porter, E.3
  • 74
    • 0000295520 scopus 로고
    • Mast cells in nonspecific ulcerative colitis
    • 74 McAulfy, R.L., Sommers, S.C., Mast cells in nonspecific ulcerative colitis. Am J Dig Dis 6 (1961), 233–236.
    • (1961) Am J Dig Dis , vol.6 , pp. 233-236
    • McAulfy, R.L.1    Sommers, S.C.2
  • 75
    • 0019060557 scopus 로고
    • Crohn's disease: transmission electron microscopic studies. I. Barrier function. Possible changes related to alterations of cell coat, mucous coat, epithelial cells, and Paneth cells
    • 75 Dvorak, A.M., Dickersin, G.R., Crohn's disease: transmission electron microscopic studies. I. Barrier function. Possible changes related to alterations of cell coat, mucous coat, epithelial cells, and Paneth cells. Hum Pathol 11 (1980), 561–571.
    • (1980) Hum Pathol , vol.11 , pp. 561-571
    • Dvorak, A.M.1    Dickersin, G.R.2
  • 76
    • 68249087581 scopus 로고    scopus 로고
    • Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa
    • 76 Tirosh, B., Khatib, N., Barenholz, Y., Nissan, A., Rubinstein, A., Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa. Mol Pharm 6 (2009), 1083–1091.
    • (2009) Mol Pharm , vol.6 , pp. 1083-1091
    • Tirosh, B.1    Khatib, N.2    Barenholz, Y.3    Nissan, A.4    Rubinstein, A.5
  • 77
    • 38449100939 scopus 로고    scopus 로고
    • NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences
    • 77 Liu, X., Ye, L., Christianson, G.J., Yang, J.Q., Roopenian, D.C., Zhu, X., NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences. J Immunol 179 (2007), 2999–3011.
    • (2007) J Immunol , vol.179 , pp. 2999-3011
    • Liu, X.1    Ye, L.2    Christianson, G.J.3    Yang, J.Q.4    Roopenian, D.C.5    Zhu, X.6
  • 78
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • 78 Yen, D., Cheung, J., Scheerens, H., et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116 (2006), 1310–1316.
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 79
    • 68949144958 scopus 로고    scopus 로고
    • High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD
    • 79 Leon, A.J., Gomez, E., Garrote, J.A., et al. High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD. Mediators Inflamm 2009 (2009), 1–10.
    • (2009) Mediators Inflamm , vol.2009 , pp. 1-10
    • Leon, A.J.1    Gomez, E.2    Garrote, J.A.3
  • 80
    • 0031409459 scopus 로고    scopus 로고
    • Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease
    • 80 Levy, A.M., Gleich, G.J., Sandborn, W.J., Tremaine, W.J., Steiner, B.L., Phillips, S.F., Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease. Mayo Clin Proc 72 (1997), 117–123.
    • (1997) Mayo Clin Proc , vol.72 , pp. 117-123
    • Levy, A.M.1    Gleich, G.J.2    Sandborn, W.J.3    Tremaine, W.J.4    Steiner, B.L.5    Phillips, S.F.6
  • 81
    • 0032788099 scopus 로고    scopus 로고
    • Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis
    • 81 Uguccioni, M., Gionchetti, P., Robbiani, D.F., et al. Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis. Am J Pathol 155 (1999), 331–336.
    • (1999) Am J Pathol , vol.155 , pp. 331-336
    • Uguccioni, M.1    Gionchetti, P.2    Robbiani, D.F.3
  • 82
    • 84893725774 scopus 로고    scopus 로고
    • Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study
    • 82 Mayer, L., Sandborn, W.J., Stepanov, Y., et al. Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study. Gut 63 (2014), 442–450.
    • (2014) Gut , vol.63 , pp. 442-450
    • Mayer, L.1    Sandborn, W.J.2    Stepanov, Y.3
  • 83
    • 0141762545 scopus 로고    scopus 로고
    • TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis
    • 83 Del Zotto, B., Mumolo, G., Pronio, A.M., Montesani, C., Tersigni, R., Boirivant, M., TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis. Clin Exp Immunol 134 (2003), 120–126.
    • (2003) Clin Exp Immunol , vol.134 , pp. 120-126
    • Del Zotto, B.1    Mumolo, G.2    Pronio, A.M.3    Montesani, C.4    Tersigni, R.5    Boirivant, M.6
  • 84
    • 0029936899 scopus 로고    scopus 로고
    • Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity
    • 84 West, G.A., Matsuura, T., Levine, A.D., Klein, J.S., Fiocchi, C., Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity. Gastroenterology 110 (1996), 1683–1695.
    • (1996) Gastroenterology , vol.110 , pp. 1683-1695
    • West, G.A.1    Matsuura, T.2    Levine, A.D.3    Klein, J.S.4    Fiocchi, C.5
  • 85
    • 63849189696 scopus 로고    scopus 로고
    • Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers
    • 85 Haas, S.L., Abbatista, M., Brade, J., Singer, M.V., Bocker, U., Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers. Swiss Med Wkly 139 (2009), 140–145.
    • (2009) Swiss Med Wkly , vol.139 , pp. 140-145
    • Haas, S.L.1    Abbatista, M.2    Brade, J.3    Singer, M.V.4    Bocker, U.5
  • 86
    • 0033778054 scopus 로고    scopus 로고
    • Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice
    • 86 Keates, A.C., Castagliuolo, I., Cruickshank, W.W., et al. Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice. Gastroenterology 119 (2000), 972–982.
    • (2000) Gastroenterology , vol.119 , pp. 972-982
    • Keates, A.C.1    Castagliuolo, I.2    Cruickshank, W.W.3
  • 87
    • 80051737824 scopus 로고    scopus 로고
    • Vitamin D status and cytokine levels in patients with Crohn's disease
    • 87 Kelly, P., Suibhne, T.N., O'Morain, C., O'Sullivan, M., Vitamin D status and cytokine levels in patients with Crohn's disease. Int J Vitam Nutr Res 81 (2011), 205–210.
    • (2011) Int J Vitam Nutr Res , vol.81 , pp. 205-210
    • Kelly, P.1    Suibhne, T.N.2    O'Morain, C.3    O'Sullivan, M.4
  • 88
    • 84876420115 scopus 로고    scopus 로고
    • Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal toll-like receptor 3 stimulation
    • 88 Ostvik, A.E., Granlund, A.V., Bugge, M., et al. Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal toll-like receptor 3 stimulation. Inflamm Bowel Dis 19 (2013), 265–274.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 265-274
    • Ostvik, A.E.1    Granlund, A.V.2    Bugge, M.3
  • 89
    • 34249983431 scopus 로고    scopus 로고
    • CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions
    • 89 Allez, M., Tieng, V., Nakazawa, A., et al. CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions. Gastroenterology 132 (2007), 2346–2358.
    • (2007) Gastroenterology , vol.132 , pp. 2346-2358
    • Allez, M.1    Tieng, V.2    Nakazawa, A.3
  • 90
    • 0033923293 scopus 로고    scopus 로고
    • The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis)
    • 90 Stuber, E., Buschenfeld, A., Luttges, J., Von Freier, A., Arendt, T., Folsch, U.R., The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis). Eur J Clin Invest 30 (2000), 594–599.
    • (2000) Eur J Clin Invest , vol.30 , pp. 594-599
    • Stuber, E.1    Buschenfeld, A.2    Luttges, J.3    Von Freier, A.4    Arendt, T.5    Folsch, U.R.6
  • 91
    • 84937144703 scopus 로고    scopus 로고
    • The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
    • 91 Brenna, O., Bruland, T., Furnes, M.W., et al. The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease. Scand J Gastroenterol 50 (2015), 1241–1252.
    • (2015) Scand J Gastroenterol , vol.50 , pp. 1241-1252
    • Brenna, O.1    Bruland, T.2    Furnes, M.W.3
  • 92
    • 0029848602 scopus 로고    scopus 로고
    • Expression of nitric oxide synthase in ulcerative colitis
    • 92 Godkin, A.J., De Belder, A.J., Villa, L., et al. Expression of nitric oxide synthase in ulcerative colitis. Eur J Clin Invest 26 (1996), 867–872.
    • (1996) Eur J Clin Invest , vol.26 , pp. 867-872
    • Godkin, A.J.1    De Belder, A.J.2    Villa, L.3
  • 93
    • 0033636735 scopus 로고    scopus 로고
    • The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis
    • 93 Tarlton, J.F., Whiting, C.V., Tunmore, D., et al. The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis. Am J Pathol 157 (2000), 1927–1935.
    • (2000) Am J Pathol , vol.157 , pp. 1927-1935
    • Tarlton, J.F.1    Whiting, C.V.2    Tunmore, D.3
  • 94
    • 34447318899 scopus 로고    scopus 로고
    • Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype
    • 94 Meijer, M.J., Mieremet-Ooms, M.A., van der Zon, A.M., et al. Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype. Dig Liver Dis 39 (2007), 733–739.
    • (2007) Dig Liver Dis , vol.39 , pp. 733-739
    • Meijer, M.J.1    Mieremet-Ooms, M.A.2    van der Zon, A.M.3
  • 95
    • 84880245794 scopus 로고    scopus 로고
    • IL-23/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: immunomodulatory effect of retinoic acid
    • 95 Rafa, H., Saoula, H., Belkhelfa, M., et al. IL-23/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: immunomodulatory effect of retinoic acid. J Interferon Cytokine Res 33 (2013), 355–368.
    • (2013) J Interferon Cytokine Res , vol.33 , pp. 355-368
    • Rafa, H.1    Saoula, H.2    Belkhelfa, M.3
  • 96
    • 0031613754 scopus 로고    scopus 로고
    • Colonic proteinases: increased activity in patients with ulcerative colitis
    • 96 Bustos, D., Negri, G., De Paula, J.A., et al. Colonic proteinases: increased activity in patients with ulcerative colitis. Medicina (B Aires) 58 (1998), 262–264.
    • (1998) Medicina (B Aires) , vol.58 , pp. 262-264
    • Bustos, D.1    Negri, G.2    De Paula, J.A.3
  • 97
    • 84879258302 scopus 로고    scopus 로고
    • Increase of faecal tryptic activity relates to changes in the intestinal microbiome: analysis of Crohn's disease with a multidisciplinary platform
    • 97 Midtvedt, T., Zabarovsky, E., Norin, E., et al. Increase of faecal tryptic activity relates to changes in the intestinal microbiome: analysis of Crohn's disease with a multidisciplinary platform. PLoS One, 8, 2013, e66074.
    • (2013) PLoS One , vol.8 , pp. e66074
    • Midtvedt, T.1    Zabarovsky, E.2    Norin, E.3
  • 98
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • 98 Cario, E., Podolsky, D.K., Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68 (2000), 7010–7017.
    • (2000) Infect Immun , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 99
    • 22344448660 scopus 로고    scopus 로고
    • Characteristics of intestinal dendritic cells in inflammatory bowel diseases
    • 99 Hart, A.L., Al-Hassi, H.O., Rigby, R.J., et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 129 (2005), 50–65.
    • (2005) Gastroenterology , vol.129 , pp. 50-65
    • Hart, A.L.1    Al-Hassi, H.O.2    Rigby, R.J.3
  • 100
    • 36549058329 scopus 로고    scopus 로고
    • Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation
    • 100 Hu, S., Ciancio, M.J., Lahav, M., et al. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology 133 (2007), 1893–1904.
    • (2007) Gastroenterology , vol.133 , pp. 1893-1904
    • Hu, S.1    Ciancio, M.J.2    Lahav, M.3
  • 101
    • 84872060066 scopus 로고    scopus 로고
    • Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective
    • 101 Vincent, F.B., Morand, E.F., Murphy, K., Mackay, F., Mariette, X., Marcelli, C., Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective. Ann Rheum Dis 72 (2013), 165–178.
    • (2013) Ann Rheum Dis , vol.72 , pp. 165-178
    • Vincent, F.B.1    Morand, E.F.2    Murphy, K.3    Mackay, F.4    Mariette, X.5    Marcelli, C.6
  • 102
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • 102 Fuss, I.J., Heller, F., Boirivant, M., et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 113 (2004), 1490–1497.
    • (2004) J Clin Invest , vol.113 , pp. 1490-1497
    • Fuss, I.J.1    Heller, F.2    Boirivant, M.3
  • 103
    • 0028265506 scopus 로고
    • Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis
    • 103 Pullan, R.D., Thomas, G.A., Rhodes, M., et al. Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut 35 (1994), 353–359.
    • (1994) Gut , vol.35 , pp. 353-359
    • Pullan, R.D.1    Thomas, G.A.2    Rhodes, M.3
  • 104
    • 84886951355 scopus 로고    scopus 로고
    • Targets for new immunomodulation strategies in inflammatory bowel disease
    • 104 Monteleone, G., Caruso, R., Pallone, F., Targets for new immunomodulation strategies in inflammatory bowel disease. Autoimmun Rev 13 (2014), 11–14.
    • (2014) Autoimmun Rev , vol.13 , pp. 11-14
    • Monteleone, G.1    Caruso, R.2    Pallone, F.3
  • 105
    • 84920942417 scopus 로고    scopus 로고
    • Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study
    • 105 Danese, S., Rudzinski, J., Brandt, W., et al. Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study. Gut 64 (2015), 243–249.
    • (2015) Gut , vol.64 , pp. 243-249
    • Danese, S.1    Rudzinski, J.2    Brandt, W.3
  • 106
    • 84935030329 scopus 로고    scopus 로고
    • Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study
    • 106 Reinisch, W., Panes, J., Khurana, S., et al. Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study. Gut 64 (2015), 894–900.
    • (2015) Gut , vol.64 , pp. 894-900
    • Reinisch, W.1    Panes, J.2    Khurana, S.3
  • 107
    • 38649120825 scopus 로고    scopus 로고
    • CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(−/−) mice, which can be abrogated by anti-CXCL10 antibody inhibition
    • 107 Singh, U.P., Singh, S., Singh, R., Cong, Y., Taub, D.D., Lillard, J.W. Jr., CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(−/−) mice, which can be abrogated by anti-CXCL10 antibody inhibition. J Interferon Cytokine Res 28 (2008), 31–43.
    • (2008) J Interferon Cytokine Res , vol.28 , pp. 31-43
    • Singh, U.P.1    Singh, S.2    Singh, R.3    Cong, Y.4    Taub, D.D.5    Lillard, J.W.6
  • 109
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • 109 Guo, H., Ingolia, N.T., Weissman, J.S., Bartel, D.P., Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466 (2010), 835–840.
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 110
    • 84858722006 scopus 로고    scopus 로고
    • MicroRNAs, new effectors and regulators of NF-kappaB
    • 110 Boldin, M.P., Baltimore, D., MicroRNAs, new effectors and regulators of NF-kappaB. Immunol Rev 246 (2012), 205–220.
    • (2012) Immunol Rev , vol.246 , pp. 205-220
    • Boldin, M.P.1    Baltimore, D.2
  • 111
    • 55249119513 scopus 로고    scopus 로고
    • MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha
    • 111 Wu, F., Zikusoka, M., Trindade, A., et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 135 (2008), 1624–1635.e24.
    • (2008) Gastroenterology , vol.135 , pp. 1624-1635.e24
    • Wu, F.1    Zikusoka, M.2    Trindade, A.3
  • 112
    • 84884373262 scopus 로고    scopus 로고
    • MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis
    • 112 Koukos, G., Polytarchou, C., Kaplan, J.L., et al. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology 145 (2013), 842–852.e2.
    • (2013) Gastroenterology , vol.145 , pp. 842-852.e2
    • Koukos, G.1    Polytarchou, C.2    Kaplan, J.L.3
  • 113
    • 84942365747 scopus 로고    scopus 로고
    • MicroRNA214 is associated with progression of ulcerative colitis, and inhibition reduces development of colitis and colitis-associated cancer in mice
    • 113 Polytarchou, C., Hommes, D.W., Palumbo, T., et al. MicroRNA214 is associated with progression of ulcerative colitis, and inhibition reduces development of colitis and colitis-associated cancer in mice. Gastroenterology 149 (2015), 981–992.e11.
    • (2015) Gastroenterology , vol.149 , pp. 981-992.e11
    • Polytarchou, C.1    Hommes, D.W.2    Palumbo, T.3
  • 114
    • 34249066486 scopus 로고    scopus 로고
    • PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
    • 114 Tanaka, T., Grusby, M.J., Kaisho, T., PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol 8 (2007), 584–591.
    • (2007) Nat Immunol , vol.8 , pp. 584-591
    • Tanaka, T.1    Grusby, M.J.2    Kaisho, T.3
  • 115
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • 115 Romashkova, J.A., Makarov, S.S., NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401 (1999), 86–90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 116
    • 84906553545 scopus 로고    scopus 로고
    • Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(−/−) mice
    • 116 Im, E., Jung, J., Pothoulakis, C., Rhee, S.H., Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(−/−) mice. Gastroenterology 147 (2014), 667–679.e10.
    • (2014) Gastroenterology , vol.147 , pp. 667-679.e10
    • Im, E.1    Jung, J.2    Pothoulakis, C.3    Rhee, S.H.4
  • 117
    • 79951955176 scopus 로고    scopus 로고
    • Oral TNF-alpha gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease
    • 117 Kriegel, C., Amiji, M., Oral TNF-alpha gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease. J Control Release 150 (2011), 77–86.
    • (2011) J Control Release , vol.150 , pp. 77-86
    • Kriegel, C.1    Amiji, M.2
  • 118
    • 77958494386 scopus 로고    scopus 로고
    • Orally delivered thioketal nanoparticles loaded with TNF-alpha-siRNA target inflammation and inhibit gene expression in the intestines
    • 118 Wilson, D.S., Dalmasso, G., Wang, L., Sitaraman, S.V., Merlin, D., Murthy, N., Orally delivered thioketal nanoparticles loaded with TNF-alpha-siRNA target inflammation and inhibit gene expression in the intestines. Nat Mater 9 (2010), 923–928.
    • (2010) Nat Mater , vol.9 , pp. 923-928
    • Wilson, D.S.1    Dalmasso, G.2    Wang, L.3    Sitaraman, S.V.4    Merlin, D.5    Murthy, N.6
  • 119
    • 84875354075 scopus 로고    scopus 로고
    • Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system
    • 119 McCarthy, J., O'Neill, M.J., Bourre, L., et al. Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system. J Control Release 168 (2013), 28–34.
    • (2013) J Control Release , vol.168 , pp. 28-34
    • McCarthy, J.1    O'Neill, M.J.2    Bourre, L.3
  • 120
    • 84863873036 scopus 로고    scopus 로고
    • The role of CD98hc in mouse macrophage functions
    • 120 Tsumura, H., Ito, M., Li, X.K., et al. The role of CD98hc in mouse macrophage functions. Cell Immunol 276 (2012), 128–134.
    • (2012) Cell Immunol , vol.276 , pp. 128-134
    • Tsumura, H.1    Ito, M.2    Li, X.K.3
  • 121
    • 0024374428 scopus 로고
    • Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen, and the transferrin receptor. Studies in inflammatory bowel disease and after in vitro exposure to different stimuli
    • 121 Fais, S., Pallone, F., Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen, and the transferrin receptor. Studies in inflammatory bowel disease and after in vitro exposure to different stimuli. Gastroenterology 97 (1989), 1435–1441.
    • (1989) Gastroenterology , vol.97 , pp. 1435-1441
    • Fais, S.1    Pallone, F.2
  • 122
    • 22544447648 scopus 로고    scopus 로고
    • Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation
    • 122 Kucharzik, T., Lugering, A., Yan, Y., et al. Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation. Lab Invest 85 (2005), 932–941.
    • (2005) Lab Invest , vol.85 , pp. 932-941
    • Kucharzik, T.1    Lugering, A.2    Yan, Y.3
  • 123
    • 74049088187 scopus 로고    scopus 로고
    • MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation
    • 123 Nguyen, H.T., Dalmasso, G., Yan, Y., et al. MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation. J Biol Chem 285 (2010), 1479–1489.
    • (2010) J Biol Chem , vol.285 , pp. 1479-1489
    • Nguyen, H.T.1    Dalmasso, G.2    Yan, Y.3
  • 124
    • 79955485553 scopus 로고    scopus 로고
    • CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
    • 124 Nguyen, H.T., Dalmasso, G., Torkvist, L., et al. CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice. J Clin Invest 121 (2011), 1733–1747.
    • (2011) J Clin Invest , vol.121 , pp. 1733-1747
    • Nguyen, H.T.1    Dalmasso, G.2    Torkvist, L.3
  • 125
    • 84891830156 scopus 로고    scopus 로고
    • Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles
    • 125 Laroui, H., Geem, D., Xiao, B., et al. Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles. Mol Ther 22 (2014), 69–80.
    • (2014) Mol Ther , vol.22 , pp. 69-80
    • Laroui, H.1    Geem, D.2    Xiao, B.3
  • 126
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    • 126 Sugamura, K., Ishii, N., Weinberg, A.D., Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 4 (2004), 420–431.
    • (2004) Nat Rev Immunol , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 127
    • 0029895222 scopus 로고    scopus 로고
    • The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells
    • 127 Imura, A., Hori, T., Imada, K., et al. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Med 183 (1996), 2185–2195.
    • (1996) J Exp Med , vol.183 , pp. 2185-2195
    • Imura, A.1    Hori, T.2    Imada, K.3
  • 128
    • 0032955192 scopus 로고    scopus 로고
    • Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein
    • 128 Higgin, L.M., McDonald, S.A., Whittle, N., Crockett, N., Shields, J.G., MacDonald, T.T., Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J Immunol 162 (1999), 486–493.
    • (1999) J Immunol , vol.162 , pp. 486-493
    • Higgin, L.M.1    McDonald, S.A.2    Whittle, N.3    Crockett, N.4    Shields, J.G.5    MacDonald, T.T.6
  • 129
    • 0037378345 scopus 로고    scopus 로고
    • Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis
    • 129 Totsuka, T., Kanai, T., Uraushihara, K., et al. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 284 (2003), G595–G603.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284 , pp. G595-G603
    • Totsuka, T.1    Kanai, T.2    Uraushihara, K.3
  • 131
    • 84876460077 scopus 로고    scopus 로고
    • Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis
    • 131 Pitari, G.M., Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis. Drug Des Devel Ther 7 (2013), 351–360.
    • (2013) Drug Des Devel Ther , vol.7 , pp. 351-360
    • Pitari, G.M.1
  • 132
    • 7044269199 scopus 로고    scopus 로고
    • Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics
    • 132 Forte, L.R. Jr., Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics. Pharmacol Ther 104 (2004), 137–162.
    • (2004) Pharmacol Ther , vol.104 , pp. 137-162
    • Forte, L.R.1
  • 133
    • 79551650331 scopus 로고    scopus 로고
    • Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
    • 133 Han, X., Mann, E., Gilbert, S., et al. Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier. PLoS One, 6, 2011, e16139.
    • (2011) PLoS One , vol.6 , pp. e16139
    • Han, X.1    Mann, E.2    Gilbert, S.3
  • 134
    • 84959167060 scopus 로고    scopus 로고
    • Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
    • 134 Shailubhai, K., Palejwala, V., Arjunan, K.P., et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther 6 (2015), 213–222.
    • (2015) World J Gastrointest Pharmacol Ther , vol.6 , pp. 213-222
    • Shailubhai, K.1    Palejwala, V.2    Arjunan, K.P.3
  • 135
    • 0033152023 scopus 로고    scopus 로고
    • IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells
    • 135 Pizarro, T.T., Michie, M.H., Bentz, M., et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 162 (1999), 6829–6835.
    • (1999) J Immunol , vol.162 , pp. 6829-6835
    • Pizarro, T.T.1    Michie, M.H.2    Bentz, M.3
  • 136
    • 0034795561 scopus 로고    scopus 로고
    • Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    • 136 Siegmund, B., Fantuzzi, G., Rieder, F., et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 281 (2001), R1264–R1273.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281 , pp. R1264-R1273
    • Siegmund, B.1    Fantuzzi, G.2    Rieder, F.3
  • 137
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: regulator of Treg/Th17 balance
    • 137 Kimura, A., Kishimoto, T., IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40 (2010), 1830–1835.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 138
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo
    • 138 Atreya, R., Mudter, J., Finotto, S., et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 6 (2000), 583–588.
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3
  • 139
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • discussion 947
    • 139 Ito, H., Takazoe, M., Fukuda, Y., et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126 (2004), 989–996 discussion 947.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 140
    • 84871153584 scopus 로고    scopus 로고
    • Interleukin-13 and transforming growth factor beta synergise in the pathogenesis of human intestinal fistulae
    • 140 Scharl, M., Frei, S., Pesch, T., et al. Interleukin-13 and transforming growth factor beta synergise in the pathogenesis of human intestinal fistulae. Gut 62 (2013), 63–72.
    • (2013) Gut , vol.62 , pp. 63-72
    • Scharl, M.1    Frei, S.2    Pesch, T.3
  • 141
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • 141 Wynn, T.A., IL-13 effector functions. Annu Rev Immunol 21 (2003), 425–456.
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 143
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    • 143 Monteleone, G., Monteleone, I., Fina, D., et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 128 (2005), 687–694.
    • (2005) Gastroenterology , vol.128 , pp. 687-694
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3
  • 144
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and th17 cell response by interleukin-21
    • 144 Fina, D., Sarra, M., Fantini, M.C., et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 134 (2008), 1038–1048.
    • (2008) Gastroenterology , vol.134 , pp. 1038-1048
    • Fina, D.1    Sarra, M.2    Fantini, M.C.3
  • 146
    • 38349134786 scopus 로고    scopus 로고
    • Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis
    • 146 Ito, Y., Kanai, T., Totsuka, T., et al. Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol 294 (2008), G199–G207.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G199-G207
    • Ito, Y.1    Kanai, T.2    Totsuka, T.3
  • 147
    • 34250367967 scopus 로고    scopus 로고
    • Inhibition of NKG2D receptor function by antibody therapy attenuates transfer-induced colitis in SCID mice
    • 147 Kjellev, S., Haase, C., Lundsgaard, D., Urso, B., Tornehave, D., Markholst, H., Inhibition of NKG2D receptor function by antibody therapy attenuates transfer-induced colitis in SCID mice. Eur J Immunol 37 (2007), 1397–1406.
    • (2007) Eur J Immunol , vol.37 , pp. 1397-1406
    • Kjellev, S.1    Haase, C.2    Lundsgaard, D.3    Urso, B.4    Tornehave, D.5    Markholst, H.6
  • 149
    • 84857774124 scopus 로고    scopus 로고
    • The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases
    • 149 Toussirot, E., The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases. Inflamm Allergy Drug Targets 11 (2012), 159–168.
    • (2012) Inflamm Allergy Drug Targets , vol.11 , pp. 159-168
    • Toussirot, E.1
  • 150
    • 84929027304 scopus 로고    scopus 로고
    • IL12p40 regulates functional development of human CD4+ T cells: enlightenment by the elevated expressions of IL12p40 in patients with inflammatory bowel diseases
    • 150 Wang, X., Wu, T., Zhou, F., et al. IL12p40 regulates functional development of human CD4+ T cells: enlightenment by the elevated expressions of IL12p40 in patients with inflammatory bowel diseases. Medicine (Baltimore), 94, 2015, e613.
    • (2015) Medicine (Baltimore) , vol.94 , pp. e613
    • Wang, X.1    Wu, T.2    Zhou, F.3
  • 151
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • 151 Neurath, M.F., Fuss, I., Kelsall, B.L., Stuber, E., Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 182 (1995), 1281–1290.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 153
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • 153 Sandborn, W.J., Feagan, B.G., Fedorak, R.N., et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 135 (2008), 1130–1141.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 154
    • 84929910457 scopus 로고    scopus 로고
    • Briakinumab for treatment of Crohn's disease: results of a randomized trial
    • 154 Panaccione, R., Sandborn, W.J., Gordon, G.L., et al. Briakinumab for treatment of Crohn's disease: results of a randomized trial. Inflamm Bowel Dis 21 (2015), 1329–1340.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 1329-1340
    • Panaccione, R.1    Sandborn, W.J.2    Gordon, G.L.3
  • 155
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    • 155 Elson, C.O., Cong, Y., Weaver, C.T., et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132 (2007), 2359–2370.
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1    Cong, Y.2    Weaver, C.T.3
  • 157
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • 157 Gaffen, S.L., Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 9 (2009), 556–567.
    • (2009) Nat Rev Immunol , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 158
    • 84945385596 scopus 로고    scopus 로고
    • Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease
    • 158 Khanna, R., Preiss, J.C., MacDonald, J.K., Timmer, A., Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease. Cochrane Database Syst Rev, 5, 2015, CD007572.
    • (2015) Cochrane Database Syst Rev , vol.5 , pp. CD007572
    • Khanna, R.1    Preiss, J.C.2    MacDonald, J.K.3    Timmer, A.4
  • 159
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
    • 159 Hueber, W., Sands, B.E., Lewitzky, S., et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61 (2012), 1693–1700.
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 160
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • 160 Ogawa, A., Andoh, A., Araki, Y., Bamba, T., Fujiyama, Y., Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol 110 (2004), 55–62.
    • (2004) Clin Immunol , vol.110 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3    Bamba, T.4    Fujiyama, Y.5
  • 161
    • 84875846364 scopus 로고    scopus 로고
    • Secukinumab failure in Crohn's disease: the yeast connection?
    • 161 Colombel, J.F., Sendid, B., Jouault, T., Poulain, D., Secukinumab failure in Crohn's disease: the yeast connection?. Gut 62 (2013), 800–801.
    • (2013) Gut , vol.62 , pp. 800-801
    • Colombel, J.F.1    Sendid, B.2    Jouault, T.3    Poulain, D.4
  • 162
    • 0027441514 scopus 로고
    • Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • 162 Breese, E., Braegger, C.P., Corrigan, C.J., Walker-Smith, J.A., MacDonald, T.T., Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 78 (1993), 127–131.
    • (1993) Immunology , vol.78 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3    Walker-Smith, J.A.4    MacDonald, T.T.5
  • 163
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • 163 Fuss, I.J., Neurath, M., Boirivant, M., et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157 (1996), 1261–1270.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 164
    • 33746176176 scopus 로고    scopus 로고
    • Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
    • 164 Hommes, D.W., Mikhajlova, T.L., Stoinov, S., et al. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut 55 (2006), 1131–1137.
    • (2006) Gut , vol.55 , pp. 1131-1137
    • Hommes, D.W.1    Mikhajlova, T.L.2    Stoinov, S.3
  • 165
    • 0021380968 scopus 로고
    • The mucosal mast cell and its role in gastrointestinal allergic diseases
    • 165 Barrett, K.E., Metcalfe, D.D., The mucosal mast cell and its role in gastrointestinal allergic diseases. Clin Rev Allergy 2 (1984), 39–53.
    • (1984) Clin Rev Allergy , vol.2 , pp. 39-53
    • Barrett, K.E.1    Metcalfe, D.D.2
  • 167
    • 0036016660 scopus 로고    scopus 로고
    • Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease
    • 167 Nishida, Y., Murase, K., Isomoto, H., et al. Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease. Hepatogastroenterology 49 (2002), 678–682.
    • (2002) Hepatogastroenterology , vol.49 , pp. 678-682
    • Nishida, Y.1    Murase, K.2    Isomoto, H.3
  • 168
    • 44349101991 scopus 로고    scopus 로고
    • Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
    • 168 Galli, S.J., Grimbaldeston, M., Tsai, M., Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 8 (2008), 478–486.
    • (2008) Nat Rev Immunol , vol.8 , pp. 478-486
    • Galli, S.J.1    Grimbaldeston, M.2    Tsai, M.3
  • 169
    • 1142263309 scopus 로고    scopus 로고
    • Key role of mast cells and their major secretory products in inflammatory bowel disease
    • 169 He, S.H., Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol 10 (2004), 309–318.
    • (2004) World J Gastroenterol , vol.10 , pp. 309-318
    • He, S.H.1
  • 170
    • 0031841290 scopus 로고    scopus 로고
    • Ketotifen treatment of active colitis in patients with 5-aminosalicylate intolerance
    • 170 Marshall, J.K., Irvine, E.J., Ketotifen treatment of active colitis in patients with 5-aminosalicylate intolerance. Can J Gastroenterol 12 (1998), 273–275.
    • (1998) Can J Gastroenterol , vol.12 , pp. 273-275
    • Marshall, J.K.1    Irvine, E.J.2
  • 172
    • 0034020873 scopus 로고    scopus 로고
    • Secretion and tissue content of eosinophil cationic protein in Crohn's disease
    • 172 Winterkamp, S., Raithel, M., Hahn, E.G., Secretion and tissue content of eosinophil cationic protein in Crohn's disease. J Clin Gastroenterol 30 (2000), 170–175.
    • (2000) J Clin Gastroenterol , vol.30 , pp. 170-175
    • Winterkamp, S.1    Raithel, M.2    Hahn, E.G.3
  • 174
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
    • 174 Singh, S., Aggarwal, B.B., Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem 270 (1995), 24995–25000.
    • (1995) J Biol Chem , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 175
    • 0032537814 scopus 로고    scopus 로고
    • Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin
    • 175 Chen, Y.R., Tan, T.H., Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 17 (1998), 173–178.
    • (1998) Oncogene , vol.17 , pp. 173-178
    • Chen, Y.R.1    Tan, T.H.2
  • 176
    • 34247281580 scopus 로고    scopus 로고
    • Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling
    • 176 Suh, H.W., Kang, S., Kwon, K.S., Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling. Mol Cell Biochem 298 (2007), 187–194.
    • (2007) Mol Cell Biochem , vol.298 , pp. 187-194
    • Suh, H.W.1    Kang, S.2    Kwon, K.S.3
  • 177
    • 84939127091 scopus 로고    scopus 로고
    • Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy
    • 177 Xiao, B., Si, X., Zhang, M., Merlin, D., Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy. Colloids Surf B Biointerfaces 135 (2015), 379–385.
    • (2015) Colloids Surf B Biointerfaces , vol.135 , pp. 379-385
    • Xiao, B.1    Si, X.2    Zhang, M.3    Merlin, D.4
  • 178
    • 84908157739 scopus 로고    scopus 로고
    • Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis
    • 178 Mascaraque, C., Aranda, C., Ocon, B., et al. Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis. Pharmacol Res 90 (2014), 48–57.
    • (2014) Pharmacol Res , vol.90 , pp. 48-57
    • Mascaraque, C.1    Aranda, C.2    Ocon, B.3
  • 179
    • 67651100698 scopus 로고    scopus 로고
    • Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice
    • 179 Wu, S.L., Chen, J.C., Li, C.C., Lo, H.Y., Ho, T.Y., Hsiang, C.Y., Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice. J Pharmacol Exp Ther 330 (2009), 370–376.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 370-376
    • Wu, S.L.1    Chen, J.C.2    Li, C.C.3    Lo, H.Y.4    Ho, T.Y.5    Hsiang, C.Y.6
  • 180
    • 34247108064 scopus 로고    scopus 로고
    • Therapeutic effect of a new immunosuppressive agent, everolimus, on interleukin-10 gene-deficient mice with colitis
    • 180 Matsuda, C., Ito, T., Song, J., et al. Therapeutic effect of a new immunosuppressive agent, everolimus, on interleukin-10 gene-deficient mice with colitis. Clin Exp Immunol 148 (2007), 348–359.
    • (2007) Clin Exp Immunol , vol.148 , pp. 348-359
    • Matsuda, C.1    Ito, T.2    Song, J.3
  • 181
    • 84899774975 scopus 로고    scopus 로고
    • Protective effect of 7-O-succinyl macrolactin A against intestinal inflammation is mediated through PI3-kinase/Akt/mTOR and NF-kappaB signaling pathways
    • 181 Park, S., Regmi, S.C., Park, S.Y., et al. Protective effect of 7-O-succinyl macrolactin A against intestinal inflammation is mediated through PI3-kinase/Akt/mTOR and NF-kappaB signaling pathways. Eur J Pharmacol 735 (2014), 184–192.
    • (2014) Eur J Pharmacol , vol.735 , pp. 184-192
    • Park, S.1    Regmi, S.C.2    Park, S.Y.3
  • 182
    • 84888384534 scopus 로고    scopus 로고
    • Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis
    • 182 Xiao, H.T., Lin, C.Y., Ho, D.H., et al. Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. J Nat Prod 76 (2013), 2120–2125.
    • (2013) J Nat Prod , vol.76 , pp. 2120-2125
    • Xiao, H.T.1    Lin, C.Y.2    Ho, D.H.3
  • 183
    • 84871918454 scopus 로고    scopus 로고
    • Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor
    • 183 Terajima, M., Inoue, T., Magari, K., Yamazaki, H., Higashi, Y., Mizuhara, H., Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor. Eur J Pharmacol 698 (2013), 455–462.
    • (2013) Eur J Pharmacol , vol.698 , pp. 455-462
    • Terajima, M.1    Inoue, T.2    Magari, K.3    Yamazaki, H.4    Higashi, Y.5    Mizuhara, H.6
  • 184
    • 0037299903 scopus 로고    scopus 로고
    • Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis
    • 184 Kankuri, E., Hamalainen, M., Hukkanen, M., et al. Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis. Scand J Gastroenterol 38 (2003), 186–192.
    • (2003) Scand J Gastroenterol , vol.38 , pp. 186-192
    • Kankuri, E.1    Hamalainen, M.2    Hukkanen, M.3
  • 185
    • 79952801220 scopus 로고    scopus 로고
    • The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis
    • 185 Singh, K., Chaturvedi, R., Barry, D.P., et al. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem 286 (2011), 3839–3850.
    • (2011) J Biol Chem , vol.286 , pp. 3839-3850
    • Singh, K.1    Chaturvedi, R.2    Barry, D.P.3
  • 186
    • 79960999678 scopus 로고    scopus 로고
    • Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-kappaB down-regulation and caspase-3 activation
    • 186 Singer, M., Trugnan, G., Chelbi-Alix, M.K., Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-kappaB down-regulation and caspase-3 activation. Innate Immun 17 (2011), 365–374.
    • (2011) Innate Immun , vol.17 , pp. 365-374
    • Singer, M.1    Trugnan, G.2    Chelbi-Alix, M.K.3
  • 187
    • 84910672931 scopus 로고    scopus 로고
    • Novel synthetic biscoumarins target tumor necrosis factor-alpha in hepatocellular carcinoma in vitro and in vivo
    • 187 Keerthy, H.K., Mohan, C.D., Siveen, K.S., et al. Novel synthetic biscoumarins target tumor necrosis factor-alpha in hepatocellular carcinoma in vitro and in vivo. J Biol Chem 289 (2014), 31879–31890.
    • (2014) J Biol Chem , vol.289 , pp. 31879-31890
    • Keerthy, H.K.1    Mohan, C.D.2    Siveen, K.S.3
  • 188
    • 77953703822 scopus 로고    scopus 로고
    • A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease
    • 188 Dotan, I., Rachmilewitz, D., Schreiber, S., et al. A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease. Gut 59 (2010), 760–766.
    • (2010) Gut , vol.59 , pp. 760-766
    • Dotan, I.1    Rachmilewitz, D.2    Schreiber, S.3
  • 189
    • 84901362590 scopus 로고    scopus 로고
    • Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease
    • 189 Arab, H.H., Al-Shorbagy, M.Y., Abdallah, D.M., Nassar, N.N., Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease. PLoS One, 9, 2014, e97193.
    • (2014) PLoS One , vol.9 , pp. e97193
    • Arab, H.H.1    Al-Shorbagy, M.Y.2    Abdallah, D.M.3    Nassar, N.N.4
  • 190
    • 33847021973 scopus 로고    scopus 로고
    • Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth
    • 190 Yan, F., Cao, H., Cover, T.L., Whitehead, R., Washington, M.K., Polk, D.B., Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132 (2007), 562–575.
    • (2007) Gastroenterology , vol.132 , pp. 562-575
    • Yan, F.1    Cao, H.2    Cover, T.L.3    Whitehead, R.4    Washington, M.K.5    Polk, D.B.6
  • 191
    • 25444512029 scopus 로고    scopus 로고
    • A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease
    • 191 Bousvaros, A., Guandalini, S., Baldassano, R.N., et al. A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease. Inflamm Bowel Dis 11 (2005), 833–839.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 833-839
    • Bousvaros, A.1    Guandalini, S.2    Baldassano, R.N.3
  • 192
    • 66149090738 scopus 로고    scopus 로고
    • Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
    • 192 Mennigen, R., Nolte, K., Rijcken, E., et al. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 296 (2009), G1140–G1149.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G1140-G1149
    • Mennigen, R.1    Nolte, K.2    Rijcken, E.3
  • 193
    • 77957831387 scopus 로고    scopus 로고
    • Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study
    • 193 Tursi, A., Brandimarte, G., Papa, A., et al. Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 105 (2010), 2218–2227.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2218-2227
    • Tursi, A.1    Brandimarte, G.2    Papa, A.3
  • 195
    • 4644239296 scopus 로고    scopus 로고
    • Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    • 195 Kruis, W., Fric, P., Pokrotnieks, J., et al. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53 (2004), 1617–1623.
    • (2004) Gut , vol.53 , pp. 1617-1623
    • Kruis, W.1    Fric, P.2    Pokrotnieks, J.3
  • 196
    • 77249133143 scopus 로고    scopus 로고
    • Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
    • 196 Vandenbroucke, K., de Haard, H., Beirnaert, E., et al. Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis. Mucosal Immunol 3 (2010), 49–56.
    • (2010) Mucosal Immunol , vol.3 , pp. 49-56
    • Vandenbroucke, K.1    de Haard, H.2    Beirnaert, E.3
  • 197
    • 33744933432 scopus 로고    scopus 로고
    • A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease
    • 197 Braat, H., Rottiers, P., Hommes, D.W., et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol 4 (2006), 754–759.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 754-759
    • Braat, H.1    Rottiers, P.2    Hommes, D.W.3
  • 198
    • 84879109909 scopus 로고    scopus 로고
    • A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice
    • 198 Hayashi, A., Sato, T., Kamada, N., et al. A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe 13 (2013), 711–722.
    • (2013) Cell Host Microbe , vol.13 , pp. 711-722
    • Hayashi, A.1    Sato, T.2    Kamada, N.3
  • 199
    • 82455175811 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis
    • 199 Thomas, S., Metzke, D., Schmitz, J., Dorffel, Y., Baumgart, D.C., Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis. Am J Physiol Gastrointest Liver Physiol 301 (2011), G1083–G1092.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G1083-G1092
    • Thomas, S.1    Metzke, D.2    Schmitz, J.3    Dorffel, Y.4    Baumgart, D.C.5
  • 200
    • 65549118300 scopus 로고    scopus 로고
    • Effect of Bacillus subtilis PB6, a natural probiotic on colon mucosal inflammation and plasma cytokines levels in inflammatory bowel disease
    • 200 Selvam, R., Maheswari, P., Kavitha, P., Ravichandran, M., Sas, B., Ramchand, C.N., Effect of Bacillus subtilis PB6, a natural probiotic on colon mucosal inflammation and plasma cytokines levels in inflammatory bowel disease. Indian J Biochem Biophys 46 (2009), 79–85.
    • (2009) Indian J Biochem Biophys , vol.46 , pp. 79-85
    • Selvam, R.1    Maheswari, P.2    Kavitha, P.3    Ravichandran, M.4    Sas, B.5    Ramchand, C.N.6
  • 201
    • 84907484487 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats
    • 201 Zhang, M., Qiu, X., Zhang, H., et al. Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats. PLoS One, 9, 2014, e109146.
    • (2014) PLoS One , vol.9 , pp. e109146
    • Zhang, M.1    Qiu, X.2    Zhang, H.3
  • 202
    • 70349422112 scopus 로고    scopus 로고
    • Lactococcus lactis subsp. Cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice
    • 202 Nishitani, Y., Tanoue, T., Yamada, K., et al. Lactococcus lactis subsp. Cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice. Int Immunopharmacol 9 (2009), 1444–1451.
    • (2009) Int Immunopharmacol , vol.9 , pp. 1444-1451
    • Nishitani, Y.1    Tanoue, T.2    Yamada, K.3
  • 203
    • 58549106111 scopus 로고    scopus 로고
    • Lactobacillus suntoryeus inhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis
    • 203 Lee, J.H., Lee, B., Lee, H.S., et al. Lactobacillus suntoryeus inhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis. Int J Colorectal Dis 24 (2009), 231–237.
    • (2009) Int J Colorectal Dis , vol.24 , pp. 231-237
    • Lee, J.H.1    Lee, B.2    Lee, H.S.3
  • 204
    • 68249158102 scopus 로고    scopus 로고
    • A component of polysaccharide peptidoglycan complex on lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer
    • 204 Matsumoto, S., Hara, T., Nagaoka, M., et al. A component of polysaccharide peptidoglycan complex on lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer. Immunology 128 (2009), e170–e180.
    • (2009) Immunology , vol.128 , pp. e170-e180
    • Matsumoto, S.1    Hara, T.2    Nagaoka, M.3
  • 205
    • 84856969539 scopus 로고    scopus 로고
    • Fecal microbiota transplantation and emerging applications
    • 205 Borody, T.J., Khoruts, A., Fecal microbiota transplantation and emerging applications. Nat Rev Gastroenterol Hepatol 9 (2012), 88–96.
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , pp. 88-96
    • Borody, T.J.1    Khoruts, A.2
  • 206
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • 206 van Nood, E., Vrieze, A., Nieuwdorp, M., et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 368 (2013), 407–415.
    • (2013) N Engl J Med , vol.368 , pp. 407-415
    • van Nood, E.1    Vrieze, A.2    Nieuwdorp, M.3
  • 208
    • 84919624382 scopus 로고    scopus 로고
    • Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and efficacy trial results
    • 208 Cui, B., Feng, Q., Wang, H., et al. Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol 30 (2015), 51–58.
    • (2015) J Gastroenterol Hepatol , vol.30 , pp. 51-58
    • Cui, B.1    Feng, Q.2    Wang, H.3
  • 209
    • 84925595618 scopus 로고    scopus 로고
    • The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy
    • 209 Cammarota, G., Ianiro, G., Cianci, R., Bibbo, S., Gasbarrini, A., Curro, D., The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy. Pharmacol Ther 149 (2015), 191–212.
    • (2015) Pharmacol Ther , vol.149 , pp. 191-212
    • Cammarota, G.1    Ianiro, G.2    Cianci, R.3    Bibbo, S.4    Gasbarrini, A.5    Curro, D.6
  • 210
    • 84931469899 scopus 로고    scopus 로고
    • Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial
    • 210 Moayyedi, P., Surette, M.G., Kim, P.T., et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149 (2015), 102–109.e6.
    • (2015) Gastroenterology , vol.149 , pp. 102-109.e6
    • Moayyedi, P.1    Surette, M.G.2    Kim, P.T.3
  • 211
    • 84966293687 scopus 로고    scopus 로고
    • Donor species richness determines faecal microbiota transplantation success in inflammatory bowel disease
    • 211 Vermeire, S., Joossens, M., Verbeke, K., et al. Donor species richness determines faecal microbiota transplantation success in inflammatory bowel disease. J Crohns Colitis 10 (2016), 387–394.
    • (2016) J Crohns Colitis , vol.10 , pp. 387-394
    • Vermeire, S.1    Joossens, M.2    Verbeke, K.3
  • 212
    • 84870322666 scopus 로고    scopus 로고
    • Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease
    • 212 Erickson, A.R., Cantarel, B.L., Lamendella, R., et al. Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease. PLoS One, 7, 2012, e49138.
    • (2012) PLoS One , vol.7 , pp. e49138
    • Erickson, A.R.1    Cantarel, B.L.2    Lamendella, R.3
  • 213
    • 0024970366 scopus 로고
    • Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?
    • 213 Borody, T.J., George, L., Andrews, P., et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?. Med J Aust, 150, 1989, 604.
    • (1989) Med J Aust , vol.150 , pp. 604
    • Borody, T.J.1    George, L.2    Andrews, P.3
  • 214
    • 84865507246 scopus 로고    scopus 로고
    • Sa1922 pilot study on the safety and efficacy of faecal microbiota transplantation in refractory Crohn's disease
    • 214 Vermeire, S., Joossens, M., Verbeke, K., et al. Sa1922 pilot study on the safety and efficacy of faecal microbiota transplantation in refractory Crohn's disease. Gastroenterology 142 (2012), S–360.
    • (2012) Gastroenterology , vol.142 , pp. S-360
    • Vermeire, S.1    Joossens, M.2    Verbeke, K.3
  • 215
    • 0036212849 scopus 로고    scopus 로고
    • Innate immune recognition
    • 215 Janeway, C.A. Jr., Medzhitov, R., Innate immune recognition. Annu Rev Immunol 20 (2002), 197–216.
    • (2002) Annu Rev Immunol , vol.20 , pp. 197-216
    • Janeway, C.A.1    Medzhitov, R.2
  • 216
    • 0034650930 scopus 로고    scopus 로고
    • Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors
    • 216 Cario, E., Rosenberg, I.M., Brandwein, S.L., Beck, P.L., Reinecker, H.C., Podolsky, D.K., Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors. J Immunol 164 (2000), 966–972.
    • (2000) J Immunol , vol.164 , pp. 966-972
    • Cario, E.1    Rosenberg, I.M.2    Brandwein, S.L.3    Beck, P.L.4    Reinecker, H.C.5    Podolsky, D.K.6
  • 217
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • 217 Cario, E., Gerken, G., Podolsky, D.K., Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132 (2007), 1359–1374.
    • (2007) Gastroenterology , vol.132 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 218
    • 29744448927 scopus 로고    scopus 로고
    • Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases
    • 218 Pierik, M., Joossens, S., Van Steen, K., et al. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis 12 (2006), 1–8.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1-8
    • Pierik, M.1    Joossens, S.2    Van Steen, K.3
  • 219
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • 219 Park, B.S., Song, D.H., Kim, H.M., Choi, B.S., Lee, H., Lee, J.O., The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458 (2009), 1191–1195.
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.S.4    Lee, H.5    Lee, J.O.6
  • 220
    • 67049095880 scopus 로고    scopus 로고
    • A novel toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
    • 220 Ungaro, R., Fukata, M., Hsu, D., et al. A novel toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol 296 (2009), G1167–G1179.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G1167-G1179
    • Ungaro, R.1    Fukata, M.2    Hsu, D.3
  • 222
    • 33845647693 scopus 로고    scopus 로고
    • Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
    • 222 Boirivant, M., Pallone, F., Di Giacinto, C., et al. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 131 (2006), 1786–1798.
    • (2006) Gastroenterology , vol.131 , pp. 1786-1798
    • Boirivant, M.1    Pallone, F.2    Di Giacinto, C.3
  • 223
    • 84925064199 scopus 로고    scopus 로고
    • Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease
    • 223 Monteleone, G., Neurath, M.F., Ardizzone, S., et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med 372 (2015), 1104–1113.
    • (2015) N Engl J Med , vol.372 , pp. 1104-1113
    • Monteleone, G.1    Neurath, M.F.2    Ardizzone, S.3
  • 225
    • 0034463305 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The interleukin 10 inflammatory bowel disease cooperative study group
    • 225 Fedorak, R.N., Gangl, A., Elson, C.O., et al. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The interleukin 10 inflammatory bowel disease cooperative study group. Gastroenterology 119 (2000), 1473–1482.
    • (2000) Gastroenterology , vol.119 , pp. 1473-1482
    • Fedorak, R.N.1    Gangl, A.2    Elson, C.O.3
  • 226
    • 84982273080 scopus 로고    scopus 로고
    • IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites
    • 226 Wadwa, M., Klopfleisch, R., Adamczyk, A., et al. IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites. Mucosal Immunol, 2016.
    • (2016) Mucosal Immunol
    • Wadwa, M.1    Klopfleisch, R.2    Adamczyk, A.3
  • 227
    • 84889027555 scopus 로고    scopus 로고
    • Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis
    • 227 Xiong, J., Lin, Y.H., Bi, L.H., Wang, J.D., Bai, Y., Liu, S.D., Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis. BMC Gastroenterol, 13, 2013, 165.
    • (2013) BMC Gastroenterol , vol.13 , pp. 165
    • Xiong, J.1    Lin, Y.H.2    Bi, L.H.3    Wang, J.D.4    Bai, Y.5    Liu, S.D.6
  • 228
    • 84879920950 scopus 로고    scopus 로고
    • Stem cell therapy in inflammatory bowel disease: which, when and how?
    • 228 van Deen, W.K., Oikonomopoulos, A., Hommes, D.W., Stem cell therapy in inflammatory bowel disease: which, when and how?. Curr Opin Gastroenterol 29 (2013), 384–390.
    • (2013) Curr Opin Gastroenterol , vol.29 , pp. 384-390
    • van Deen, W.K.1    Oikonomopoulos, A.2    Hommes, D.W.3
  • 229
    • 0038350648 scopus 로고    scopus 로고
    • Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation
    • 229 Ditschkowski, M., Einsele, H., Schwerdtfeger, R., et al. Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation. Transplantation 75 (2003), 1745–1747.
    • (2003) Transplantation , vol.75 , pp. 1745-1747
    • Ditschkowski, M.1    Einsele, H.2    Schwerdtfeger, R.3
  • 230
    • 84950111817 scopus 로고    scopus 로고
    • Autologous hematopoetic stem cell transplantation for refractory Crohn disease: a randomized clinical trial
    • 230 Hawkey, C.J., Allez, M., Clark, M.M., et al. Autologous hematopoetic stem cell transplantation for refractory Crohn disease: a randomized clinical trial. JAMA 314 (2015), 2524–2534.
    • (2015) JAMA , vol.314 , pp. 2524-2534
    • Hawkey, C.J.1    Allez, M.2    Clark, M.M.3
  • 231
    • 77957221364 scopus 로고    scopus 로고
    • Review article: stem cell therapies for inflammatory bowel disease—efficacy and safety
    • 231 Garcia-Bosch, O., Ricart, E., Panes, J., Review article: stem cell therapies for inflammatory bowel disease—efficacy and safety. Aliment Pharmacol Ther 32 (2010), 939–952.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 939-952
    • Garcia-Bosch, O.1    Ricart, E.2    Panes, J.3
  • 232
    • 64049104052 scopus 로고    scopus 로고
    • Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial
    • 232 Garcia-Olmo, D., Herreros, D., Pascual, I., et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum 52 (2009), 79–86.
    • (2009) Dis Colon Rectum , vol.52 , pp. 79-86
    • Garcia-Olmo, D.1    Herreros, D.2    Pascual, I.3
  • 233
    • 84879459518 scopus 로고    scopus 로고
    • Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial
    • 233 de la Portilla, F., Alba, F., Garcia-Olmo, D., Herrerias, J.M., Gonzalez, F.X., Galindo, A., Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis 28 (2013), 313–323.
    • (2013) Int J Colorectal Dis , vol.28 , pp. 313-323
    • de la Portilla, F.1    Alba, F.2    Garcia-Olmo, D.3    Herrerias, J.M.4    Gonzalez, F.X.5    Galindo, A.6
  • 236
    • 80051532073 scopus 로고    scopus 로고
    • Remestemcel-L: human mesenchymal stem cells as an emerging therapy for Crohn's disease
    • 236 Mannon, P.J., Remestemcel-L: human mesenchymal stem cells as an emerging therapy for Crohn's disease. Expert Opin Biol Ther 11 (2011), 1249–1256.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1249-1256
    • Mannon, P.J.1
  • 238
    • 84874200497 scopus 로고    scopus 로고
    • Application of multiStem((R)) allogeneic cells for immunomodulatory therapy: clinical progress and pre-clinical challenges in prophylaxis for graft versus host disease
    • 238 Vaes, B., Van't Hof, W., Deans, R., Pinxteren, J., Application of multiStem((R)) allogeneic cells for immunomodulatory therapy: clinical progress and pre-clinical challenges in prophylaxis for graft versus host disease. Front Immunol, 3, 2012, 345.
    • (2012) Front Immunol , vol.3 , pp. 345
    • Vaes, B.1    Van't Hof, W.2    Deans, R.3    Pinxteren, J.4
  • 240
    • 0037308263 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • 240 Bonen, D.K., Cho, J.H., The genetics of inflammatory bowel disease. Gastroenterology 124 (2003), 521–536.
    • (2003) Gastroenterology , vol.124 , pp. 521-536
    • Bonen, D.K.1    Cho, J.H.2
  • 241
    • 33947304185 scopus 로고    scopus 로고
    • Bone marrow stem cell-mediated regeneration in IBD: where do we go from here?
    • 241 Brittan, M., Alison, M.R., Schier, S., Wright, N.A., Bone marrow stem cell-mediated regeneration in IBD: where do we go from here?. Gastroenterology 132 (2007), 1171–1173.
    • (2007) Gastroenterology , vol.132 , pp. 1171-1173
    • Brittan, M.1    Alison, M.R.2    Schier, S.3    Wright, N.A.4
  • 242
    • 33744990181 scopus 로고    scopus 로고
    • Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells
    • 242 Ochi, H., Abraham, M., Ishikawa, H., et al. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells. Nat Med 12 (2006), 627–635.
    • (2006) Nat Med , vol.12 , pp. 627-635
    • Ochi, H.1    Abraham, M.2    Ishikawa, H.3
  • 243
    • 84868110120 scopus 로고    scopus 로고
    • An oral CD3-specific antibody suppresses T-cell-induced colitis and alters cytokine responses to T-cell activation in mice
    • 243 Forster, K., Goethel, A., Chan, C.W., Zanello, G., Streutker, C., Croitoru, K., An oral CD3-specific antibody suppresses T-cell-induced colitis and alters cytokine responses to T-cell activation in mice. Gastroenterology 143 (2012), 1298–1307.
    • (2012) Gastroenterology , vol.143 , pp. 1298-1307
    • Forster, K.1    Goethel, A.2    Chan, C.W.3    Zanello, G.4    Streutker, C.5    Croitoru, K.6
  • 247
    • 78049514932 scopus 로고    scopus 로고
    • Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis
    • 247 Sandborn, W.J., Colombel, J.F., Frankel, M., et al. Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis. Gut 59 (2010), 1485–1492.
    • (2010) Gut , vol.59 , pp. 1485-1492
    • Sandborn, W.J.1    Colombel, J.F.2    Frankel, M.3
  • 248
    • 47949115543 scopus 로고    scopus 로고
    • Therapeutic benefit of pentostatin in severe IL-10−/− colitis
    • 248 Brown, J.B., Lee, G., Grimm, G.R., Barrett, T.A., Therapeutic benefit of pentostatin in severe IL-10−/− colitis. Inflamm Bowel Dis 14 (2008), 880–887.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 880-887
    • Brown, J.B.1    Lee, G.2    Grimm, G.R.3    Barrett, T.A.4
  • 249
    • 0034900527 scopus 로고    scopus 로고
    • Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages
    • 249 Hausmann, M., Spöttl, T., Andus, T., et al. Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages. Clin Exp Immunol 125 (2001), 48–55.
    • (2001) Clin Exp Immunol , vol.125 , pp. 48-55
    • Hausmann, M.1    Spöttl, T.2    Andus, T.3
  • 250
    • 34247116009 scopus 로고    scopus 로고
    • In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis
    • 250 Hausmann, M., Obermeier, F., Paper, D.H., et al. In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis. Clin Exp Immunol 148 (2007), 373–381.
    • (2007) Clin Exp Immunol , vol.148 , pp. 373-381
    • Hausmann, M.1    Obermeier, F.2    Paper, D.H.3
  • 251
    • 84900542521 scopus 로고    scopus 로고
    • Protective effect of Acacia ferruginea against ulcerative colitis via modulating inflammatory mediators, cytokine profile and NF-kappaB signal transduction pathways
    • 251 Sakthivel, K.M., Guruvayoorappan, C., Protective effect of Acacia ferruginea against ulcerative colitis via modulating inflammatory mediators, cytokine profile and NF-kappaB signal transduction pathways. J Environ Pathol Toxicol Oncol 33 (2014), 83–98.
    • (2014) J Environ Pathol Toxicol Oncol , vol.33 , pp. 83-98
    • Sakthivel, K.M.1    Guruvayoorappan, C.2
  • 252
    • 84888813530 scopus 로고    scopus 로고
    • Protective effect of marine mangrove Rhizophora apiculata on acetic acid induced experimental colitis by regulating anti-oxidant enzymes, inflammatory mediators and nuclear factor-kappa B subunits
    • 252 V, V.P., C, G., Protective effect of marine mangrove Rhizophora apiculata on acetic acid induced experimental colitis by regulating anti-oxidant enzymes, inflammatory mediators and nuclear factor-kappa B subunits. Int Immunopharmacol 18 (2014), 124–134.
    • (2014) Int Immunopharmacol , vol.18 , pp. 124-134
    • V, V.P.1    C, G.2
  • 253
    • 84902481395 scopus 로고    scopus 로고
    • Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats
    • 253 Kumar, V.S., Rajmane, A.R., Adil, M., Kandhare, A.D., Ghosh, P., Bodhankar, S.L., Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res 28 (2014), 132–145.
    • (2014) J Biomed Res , vol.28 , pp. 132-145
    • Kumar, V.S.1    Rajmane, A.R.2    Adil, M.3    Kandhare, A.D.4    Ghosh, P.5    Bodhankar, S.L.6
  • 254
    • 84886020874 scopus 로고    scopus 로고
    • Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-kappaB signal transduction pathways in rats with ulcerative colitis
    • 254 Sakthivel, K.M., Guruvayoorappan, C., Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-kappaB signal transduction pathways in rats with ulcerative colitis. Int Immunopharmacol 17 (2013), 907–916.
    • (2013) Int Immunopharmacol , vol.17 , pp. 907-916
    • Sakthivel, K.M.1    Guruvayoorappan, C.2
  • 255
    • 84879027507 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats
    • 255 Nagib, M.M., Tadros, M.G., ElSayed, M.I., Khalifa, A.E., Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats. Toxicol Appl Pharmacol 271 (2013), 106–113.
    • (2013) Toxicol Appl Pharmacol , vol.271 , pp. 106-113
    • Nagib, M.M.1    Tadros, M.G.2    ElSayed, M.I.3    Khalifa, A.E.4
  • 256
    • 84873921287 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis
    • 256 Philippe, D., Brahmbhatt, V., Foata, F., et al. Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis. World J Gastroenterol 18 (2012), 5351–5359.
    • (2012) World J Gastroenterol , vol.18 , pp. 5351-5359
    • Philippe, D.1    Brahmbhatt, V.2    Foata, F.3
  • 257
    • 77954651225 scopus 로고    scopus 로고
    • Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis
    • 257 Yao, J., Wang, J.Y., Liu, L., et al. Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis. Arch Med Res 41 (2010), 288–294.
    • (2010) Arch Med Res , vol.41 , pp. 288-294
    • Yao, J.1    Wang, J.Y.2    Liu, L.3
  • 258
    • 84925792536 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel diseases: is there a place for nutritional supplementation?
    • 258 Lan, A., Blachier, F., Benamouzig, R., et al. Mucosal healing in inflammatory bowel diseases: is there a place for nutritional supplementation?. Inflamm Bowel Dis 21 (2015), 198–207.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 198-207
    • Lan, A.1    Blachier, F.2    Benamouzig, R.3
  • 259
    • 84893772723 scopus 로고    scopus 로고
    • Beneficial effects of an amino acid mixture on colonic mucosal healing in rats
    • 259 Liu, X., Beaumont, M., Walker, F., et al. Beneficial effects of an amino acid mixture on colonic mucosal healing in rats. Inflamm Bowel Dis 19 (2013), 2895–2905.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2895-2905
    • Liu, X.1    Beaumont, M.2    Walker, F.3
  • 260
    • 84901785045 scopus 로고    scopus 로고
    • Glutamine supplementation attenuates expressions of adhesion molecules and chemokine receptors on T cells in a murine model of acute colitis
    • 260 Hou, Y.C., Wu, J.M., Wang, M.Y., et al. Glutamine supplementation attenuates expressions of adhesion molecules and chemokine receptors on T cells in a murine model of acute colitis. Mediators Inflamm, 2014, 2014, 837107.
    • (2014) Mediators Inflamm , vol.2014 , pp. 837107
    • Hou, Y.C.1    Wu, J.M.2    Wang, M.Y.3
  • 261
    • 79954613654 scopus 로고    scopus 로고
    • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models
    • 261 Xue, H., Sufit, A.J., Wischmeyer, P.E., Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. JPEN J Parenter Enteral Nutr 35 (2011), 188–197.
    • (2011) JPEN J Parenter Enteral Nutr , vol.35 , pp. 188-197
    • Xue, H.1    Sufit, A.J.2    Wischmeyer, P.E.3
  • 262
    • 84870335319 scopus 로고    scopus 로고
    • Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis
    • 262 Crespo, I., San-Miguel, B., Prause, C., et al. Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis. PLoS One, 7, 2012, e50407.
    • (2012) PLoS One , vol.7 , pp. e50407
    • Crespo, I.1    San-Miguel, B.2    Prause, C.3
  • 263
    • 59249095410 scopus 로고    scopus 로고
    • Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis
    • 263 Kretzmann, N.A., Fillmann, H., Mauriz, J.L., et al. Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Inflamm Bowel Dis 14 (2008), 1504–1513.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1504-1513
    • Kretzmann, N.A.1    Fillmann, H.2    Mauriz, J.L.3
  • 264
    • 69949105948 scopus 로고    scopus 로고
    • L-cysteine supplementation attenuates local inflammation and restores gut homeostasis in a porcine model of colitis
    • 264 Kim, C.J., Kovacs-Nolan, J., Yang, C., Archbold, T., Fan, M.Z., Mine, Y., L-cysteine supplementation attenuates local inflammation and restores gut homeostasis in a porcine model of colitis. Biochim Biophys Acta 1790 (2009), 1161–1169.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 1161-1169
    • Kim, C.J.1    Kovacs-Nolan, J.2    Yang, C.3    Archbold, T.4    Fan, M.Z.5    Mine, Y.6
  • 265
    • 84858040869 scopus 로고    scopus 로고
    • L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
    • 265 Coburn, L.A., Gong, X., Singh, K., et al. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One, 7, 2012, e33546.
    • (2012) PLoS One , vol.7 , pp. e33546
    • Coburn, L.A.1    Gong, X.2    Singh, K.3
  • 266
    • 45249108440 scopus 로고    scopus 로고
    • Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanisms involving downregulation of interleukin 17
    • 266 Requena, P., Daddaoua, A., Martinez-Plata, E., et al. Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanisms involving downregulation of interleukin 17. Br J Pharmacol 154 (2008), 825–832.
    • (2008) Br J Pharmacol , vol.154 , pp. 825-832
    • Requena, P.1    Daddaoua, A.2    Martinez-Plata, E.3
  • 267
    • 84919664233 scopus 로고    scopus 로고
    • Anti-apoptotic effects of milk-derived casein glycomacropeptide on mice with ulcerative colitis
    • 267 Chen, Q., Wang, H., Zhu, C., Yan, Y., Pang, G., Anti-apoptotic effects of milk-derived casein glycomacropeptide on mice with ulcerative colitis. Food and Agricultural Immunology 25 (2014), 453–466.
    • (2014) Food and Agricultural Immunology , vol.25 , pp. 453-466
    • Chen, Q.1    Wang, H.2    Zhu, C.3    Yan, Y.4    Pang, G.5
  • 268
    • 85022227909 scopus 로고    scopus 로고
    • MON-PP058: randomised clinical trial: casein glycomacropeptide for active distal ulcerative colitis—a pilot study
    • 268 Wernlund, P.G., Hvas, C.L., Christensen, L.A., et al. MON-PP058: randomised clinical trial: casein glycomacropeptide for active distal ulcerative colitis—a pilot study. Clinical Nutrition, 34, 2015, S149.
    • (2015) Clinical Nutrition , vol.34 , pp. S149
    • Wernlund, P.G.1    Hvas, C.L.2    Christensen, L.A.3
  • 269
    • 33745504056 scopus 로고    scopus 로고
    • Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor
    • 269 Gallowitsch-Puerta, M., Tracey, K.J., Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor. Ann N Y Acad Sci 1062 (2005), 209–219.
    • (2005) Ann N Y Acad Sci , vol.1062 , pp. 209-219
    • Gallowitsch-Puerta, M.1    Tracey, K.J.2
  • 270
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    • 270 Borovikova, L.V., Ivanova, S., Zhang, M., et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405 (2000), 458–462.
    • (2000) Nature , vol.405 , pp. 458-462
    • Borovikova, L.V.1    Ivanova, S.2    Zhang, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.