Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis

Pharmacological Research

Volumn 90, Issue , 2014, Pages 48-57

  Mascaraque, Cristina ^a   Aranda, Carlos ^a   Ocón, Borja ^a   Monte, María Jesús ^b   Suárez, María Dolores ^a   Zarzuelo, Antonio ^a   Marín, José Juan García ^b   Martínez Augustin, Olga ^a   De Medina, Fermín Sánchez ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

CD4+ CD62L+ T cell transfer colitis; Epithelial transport; Flavonoid; Rutin

Indexed keywords

AGLYCONE; ALKALINE PHOSPHATASE; BUDESONIDE; CALGRANULIN A; CXCL1 CHEMOKINE; CYTOKINE; FLAVONOID; GAMMA INTERFERON; INTERLEUKIN 1BETA; L SELECTIN; MYELOPEROXIDASE; QUERCETIN; RUTOSIDE; STAT4 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PEROXIDASE; RAG-1 PROTEIN; STAT4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOTRANSFORMATION; CD4+ T LYMPHOCYTE; CELL TRANSFER; COLITIS; CONTROLLED STUDY; DISEASE ACTIVITY; ENTERITIS; ENZYME ACTIVITY; EX VIVO STUDY; FEEDING; FEMALE; GENE EXPRESSION; IN VITRO STUDY; INFLAMMATORY BOWEL DISEASE; LYMPH NODE; LYMPHOCYTE; MESENTERY LYMPH NODE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; T LYMPHOCYTE; WEIGHT REDUCTION; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CELL LINE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; LARGE INTESTINE; METABOLISM; PATHOLOGY; SPLEEN; WISTAR RAT;

ALKALINE PHOSPHATASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELLS, CULTURED; COLITIS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HOMEODOMAIN PROTEINS; INTESTINE, LARGE; LYMPH NODES; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PEROXIDASE; QUERCETIN; RATS, WISTAR; RNA, MESSENGER; RUTIN; SPLEEN; STAT4 TRANSCRIPTION FACTOR; T-LYMPHOCYTES;

EID: 84908157739     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.09.005     Document Type: Article

References (43)

1. A. Schirbel, and C. Fiocchi Inflammatory bowel disease: established and evolving considerations on its etiopathogenesis and therapy J Dig Dis 11 2010 266 276
2. A. Kaser, S. Zeissig, and R.S. Blumberg Inflammatory bowel disease Annu Rev Immunol 28 2010 573 621
3. R. González, I. Ballester, R. López-Posadas, M.D. Suárez, A. Zarzuelo, and O. Martínez-Augustin Effects of flavonoids and other polyphenols on inflammation Crit Rev Food Sci Nutr 51 2011 331 362
4. E. Middleton Jr., C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol Rev 52 2000 673 751
5. I. Ballester, D. Camuesco, J. Gálvez, F. Sánchez de Medina, and A. Zarzuelo Flavonoids and inflammatory bowel disease ARS Pharmaceutica 47 2006 5 21
6. H. Shapiro, P. Singer, Z. Halpern, and R. Bruck Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis Gut 56 2007 426 435
7. J. Galvez, T. Cruz, E. Crespo, M.A. Ocete, M.D. Lorente, and F. Sanchez de Medina Rutoside as mucosal protective in acetic acid-induced rat colitis Planta Med 63 1997 409 414
8. T. Cruz, J. Galvez, M.A. Ocete, M.E. Crespo, L.H.F. Sanchez de Medina, and A. Zarzuelo Oral administration of rutoside can ameliorate inflammatory bowel disease in rats Life Sci 62 1998 687 695
9. K.H. Kwon, A. Murakami, T. Tanaka, and H. Ohigashi Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression Biochem Pharmacol 69 2005 395 406
10. M. Comalada, D. Camuesco, S. Sierra, I. Ballester, J. Xaus, and J. Galvez In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway Eur J Immunol 35 2005 584 592
11. F. Sanchez de Medina, B. Vera, J. Galvez, and A. Zarzuelo Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat Life Sci 70 2002 3097 3108
12. F. Sanchez de Medina, J. Galvez, J.A. Romero, and A. Zarzuelo Effect of quercitrin on acute and chronic experimental colitis in the rat J Pharmacol Exp Ther 278 1996 771 779
13. S. Fiorucci, J.L. Wallace, A. Mencarelli, E. Distrutti, G. Rizzo, and S. Farneti A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction Proc Natl Acad Sci U S A 101 2004 15736 15741
14. L.A. Dieleman, B.U. Ridwan, G.S. Tennyson, K.W. Beagley, R.P. Bucy, and C.O. Elson Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice Gastroenterology 107 1994 1643 1652
15. J.C. Hoffmann, K. Peters, S. Henschke, B. Herrmann, K. Pfister, and J. Westermann Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after gammadelta T cell depletion and no effect of alphabeta T cell depletion Gut 48 2001 489 495
16. I. Koboziev, F. Karlsson, S. Zhang, and M.B. Grisham Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies Inflamm Bowel Dis 17 2011 1229 1245
17. K. Nones, Y.E. Dommels, S. Martell, C. Butts, W.C. McNabb, and Z.A. Park The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases Br J Nutr 101 2009 169 181
18. F. Sanchez de Medina, O. Martinez-Augustin, R. Gonzalez, I. Ballester, A. Nieto, and J. Galvez Induction of alkaline phosphatase in the inflamed intestine: a novel pharmacological target for inflammatory bowel disease Biochem Pharmacol 68 2004 2317 2326
19. O.A. Bessey, O.H. Lowry, and M.J. Brook Rapid colorimetric method for the determination of alkaline phosphatase in five cubic mililiters of serum J Biol Chem 164 1946 321 329
20. J.E. Krawisz, P. Sharon, and W.F. Stenson Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models Gastroenterology 87 1984 1344 1350
21. I. Romero-Calvo, B. Ocon, P. Martinez-Moya, M.D. Suarez, A. Zarzuelo, and O. Martinez-Augustin Reversible ponceau staining as a loading control alternative to actin in Western blots Anal Biochem 401 2010 318 320
22. M. Comalada, I. Ballester, E. Bailon, S. Sierra, J. Xaus, and J. Galvez Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship Biochem Pharmacol 72 2006 1010 1021
23. S. Ding, E. Dudley, S. Plummer, J. Tang, R.P. Newton, and A.G. Brenton Quantitative determination of major active components in ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry Rapid Commun Mass Spectrom 20 2006 2753 2760
24. P. Martinez-Moya, M. Ortega-Gonzalez, R. Gonzalez, A. Anzola, B. Ocon, and C. Hernandez-Chirlaque Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats Pharmacol Res 66 2012 144 153
25. R. Lopez-Posadas, R. Gonzalez, I. Ballester, P. Martinez-Moya, I. Romero-Calvo, and M.D. Suarez Tissue-nonspecific alkaline phosphatase is activated in enterocytes by oxidative stress via changes in glycosylation Inflamm Bowel Dis 17 2011 543 556
26. D.V. Ostanin, J. Bao, I. Koboziev, L. Gray, S.A. Robinson-Jackson, and M. Kosloski-Davidson T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade Am J Physiol Gastrointest Liver Physiol 296 2009 G135 G146
27. M. Barbier, C. Cherbut, A.C. Aube, H.M. Blottiere, and J.P. Galmiche Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats Gut 43 1998 783 790
28. A. Ballinger, T. El-Haj, D. Perrett, J. Turvill, O. Obeid, and S. Dryden The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis Gastroenterology 118 2000 544 553
29. P. Martinez-Moya, I. Romero-Calvo, P. Requena, C. Hernandez-Chirlaque, C.J. Aranda, and R. Gonzalez Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis Int Immunopharmacol 15 2013 372 380
30. H. Kim, H. Kong, B. Choi, Y. Yang, Y. Kim, and M.J. Lim Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease Pharm Res 22 2005 1499 1509
31. P.A. Ruiz, A. Braune, G. Holzlwimmer, L. Quintanilla-Fend, and D. Haller Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells J Nutr 137 2007 1208 1215
32. J.M. Gee, M.S. DuPont, M.J. Rhodes, and I.T. Johnson Quercetin glucosides interact with the intestinal glucose transport pathway Free Radic Biol Med 25 1998 19 25
33. G. Kottra, and H. Daniel Flavonoid glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake J Pharmacol Exp Ther 322 2007 829 835
34. R.E. Steinert, B. Ditscheid, M. Netzel, and G. Jahreis Absorption of black currant anthocyanins by monolayers of human intestinal epithelial Caco-2 cells mounted in ussing type chambers J Agric Food Chem 56 2008 4995 5001
35. J.Y. Dai, J.L. Yang, and C. Li Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers Acta Pharmacol Sin 29 2008 1086 1093
36. W. Brand, P.A. van der Wel, M.J. Rein, D. Barron, G. Williamson, and P.J. van Bladeren Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers Drug Metab Dispos 36 2008 1794 1802
37. J.P. Spencer, G. Chowrimootoo, R. Choudhury, E.S. Debnam, S.K. Srai, and C. Rice-Evans The small intestine can both absorb and glucuronidate luminal flavonoids FEBS Lett 458 1999 224 230
38. W. Andlauer, C. Stumpf, and P. Furst Intestinal absorption of rutin in free and conjugated forms Biochem Pharmacol 62 2001 369 374
39. T. Fukao, D.M. Frucht, G. Yap, M. Gadina, J.J. O'Shea, and S. Koyasu Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses J Immunol 166 2001 4446 4455
40. R. López-Posadas, I. Ballester, A. Abadía, M.D. Suárez, A. Zarzuelo, and O. Martínez-Augustin Effect of flavonoids on rat splenocytes, a structure-activity relationship study Biochem Pharmacol 76 2008 495 506
41. G. Muthian, and J.J. Bright Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte J Clin Immunol 24 2004 542 552
42. J.S. Choi, S.W. Kang, J. Li, J.L. Kim, J.Y. Bae, and D.S. Kim Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2 J Agric Food Chem 57 2009 2079 2086
43. L. Senggunprai, V. Kukongviriyapan, A. Prawan, and U. Kukongviriyapan Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK/STAT signaling pathway Phytother Res 28 2014 841 848