Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system

Journal of Controlled Release

Volumn 168, Issue 1, 2013, Pages 28-34

  McCarthy, J ^a   O'Neill, M J ^a   Bourre, L ^a   Walsh, D ^a   Quinlan, A ^a   Hurley, G ^b   Ogier, J ^c   Shanahan, F ^b   Melgar, S ^b   Darcy, R ^c   O'Driscoll, C M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cyclodextrin siRNA delivery; Inflammatory bowel disease; Intrarectal administration; Murine model of acute colitis; TNF

Indexed keywords

CATIONIC CYCLODEXTRIN; GASTROINTESTINAL TRACT; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY RESPONSE; LIPOPOLYSACCHARIDES; MODIFIED CYCLODEXTRINS; MURINE MODEL; SIRNA DELIVERY;

ELECTROPHORESIS; GENES; GENETIC ENGINEERING; MAMMALS; POLYMERASE CHAIN REACTION; RNA;

DISEASES;

CYCLODEXTRIN; DEXTRAN SULFATE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL VIABILITY; COLITIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL ELECTROPHORESIS; GENE EXPRESSION; GENE SILENCING; GENE VECTOR; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIMULATION;

ANIMALS; BETA-CYCLODEXTRINS; CELL LINE; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; FEMALE; GENE SILENCING; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875354075     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.03.004     Document Type: Article

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