Expression of nitric oxide synthase in ulcerative colitis

European Journal of Clinical Investigation

Volumn 26, Issue 10, 1996, Pages 867-872

  Godkin, A J ^a,d   De Belder, A J ^b   Villa, L ^c   Wong, A ^c   Beesley, J E ^c   Kane, S P ^a   Martin, J F ^c  

^a WEST MIDDLESEX UNIVERSITY HOSPITAL   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c WELLCOME RESEARCH LABORATORIES   (United Kingdom)

^d RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Inducible nitric oxide synthase; Ulcerative colitis

Indexed keywords

NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0029848602     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.1996.tb02131.x     Document Type: Article

References (32)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43:109-42.
2. Förstermann U, Pollock JS, Nakane M. Nitric oxide synthases in the cardiovascular system. Trends Cardiovasc Med 1993; 3:104-10.
3. Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand 1992;145:201-27.
4. Schmidt HHHW, Gagne GD, Nakane M, Pollock JS, Miller MF, Murad F. Mapping of neural nitric oxide synthase in the rat suggests frequent co-localisation with NADPH diaphorase, but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J Histochem Cytochem 1992;40:1439-56.
5. Bult H, Boeckxstaens GE, Pelckmans PA, Jordaens FH, van Maercke YM, Herman AG. Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 1990; 345:346-7.
6. Stark ME, Szurszewski JH. Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 1992;103:1928-49.
7. Vanderwinden J-M, Mailleux P, Schiffmann SN, Vanderhaeghen J-J, De Laet M-H. Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis. N Engl J Med 1992; 327:511-5.
8. Mearin F, Mourelle M, Guarner F et al. Patients with achalasia lack nitric oxide synthase in the gastro-oesophageal junction. Eur J Clin Invest 1993;23:724-8.
9. Stuehr DJ, Marletta MA. Induction of nitrite nitrate biosynthesis in murine macrophages by BCG infection, lymphokines and interferon. J Immunol 1987;139:518-25.
10. Radomski MW, Palmer RMJ, Moncada S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive nitrix oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990;87:10043-7.
11. Rees DD, Cellek S, Palmer RMJ, Moncada S. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the unwanted effects on vascular tone. An insight into the endotoxin shock. Biochem Biophys Res Commun 1990; 173:541-7.
12. 2+-independent nitric oxide synthasein the myocardium. Br J Pharmacol 1992;105:575-80.
13. de Belder AJ, Radomski MW, Why HJF et al. Nitric oxide synthase activities in human myocardium. Lancet 1993;341:84-5.
14. Hamid Q, Springall DR, Riverso-Morenos V et al. Induction of nitric oxide synthase in asthma. Lancet 1993;342:1510-3.
15. Sartor RB. Cytokines in intestinal inflammation pathophysiological and clinical considerations. Gastroenterology 1994; 106:533-9.
16. Middleton SJ, Shorthouse M, Hunter JD. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993;341:465-6.
17. Boughton-Smith NK, Evans SM, Hawkey CJ et al. Nitric oxide synthase activity in ulcerative colitis. Lancet 1993;342:338-40.
18. 2+-independent nitric oxide synthases. FEBS Lett 1991; 291:145-9.
19. Radomski MW, Vallane P, Whitlay G, Foxwell N, Moncada S. Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovas Res 1993;27:1380-3.
20. Riveros-Morenos V, Beddell C, Moncada S. Nitric oxide synthase. Structural studies using anti-peptide antibodies. Eur J Biochem 1993;215:801-8.
21. Shu S, Ju G, Fan L. The glucose oxidase DAB nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 1988;85:169-71.
22. Isaacs KL, Sartor RB, Haskill S. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 1992;103:1587-95.
23. Youngman KR, Simon PL, West GA et al. Localisation of intestinal interletikin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 1993;104:749-58.
24. Mitsuyama K, Sata M, Tanikawa K. Significance of interleukin-6 in patients with inflammatory bowel disease. Gastroenterologica Japonica 26:20-8.
25. Marletta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS. Macrophage oxidation of L-arginine to nitrite and nitrate : nitric oxide is an intermediate. Biochemistry 1988;27:8706-11.
26. Shanahan F. Pathogenesis of ulcerative colitis. Lancet 1993; 342:407-11.
27. Barnard JA, Beauchamp RD, Coffey RJ, Moses HL. Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci USA 1989;865:1578-82.
28. Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role for transforming growth factor beta. Gastroenterology 1993;105:1323-32.
29. Lamas S, Michel T, Brenner BM, Marsden PA. Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha. Am J Physiol 1991;C634-41.
30. Yoshizumi M, Perrella MA, Burnett JC Jr, Lee M-E. Tumor necrosis factor down-regulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993; 73:205-9.
31. Lelchuk R, Radomski MW, Martin JE, Moncada S. Constitutive and inducible nitric oxide synthases in human megakaryoblastic cells. J Pharmacol Exp Ther 1992; 262:12200-4.
32. Conde M, Andrade J. Inhibitory effect of cyclosporin A and FK 506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. Immunology 1995;84:476-81.