The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis

American Journal of Pathology

Volumn 157, Issue 6, 2000, Pages 1927-1935

  Tarlton, John F ^a   Whiting, Christine V ^a   Tunmore, David ^a   Bregenholt, Soren ^b   Reimann, Jorg ^c   Claesson, Mogens H ^b   Bland, Paul W ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; SERINE PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; EPITHELIUM CELL; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; WOUND HEALING;

EID: 0033636735     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64831-6     Document Type: Article

References (37)

1. Mucosal and thymic dysregulation. Role in human intestinal inflammation
2. Disparate CD4(+) lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease - Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
3. Transforming growth-factor-β (TGF-β) in inflammation - A cause and a cure
4. Proteolytic remodeling of extracellular-matrix
5. Divergent patterns of matrix metalloproteinase activity during wound healing in ileum and colon of rats
6. Distribution of the matrix metalloproteinases stromelysin, gelatinase-A and gelatinase-B, and collagenase in Crohn's-disease and normal intestine
7. Matrix metalloproteinase levels are elevated in inflammatory bowel disease
8. Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations
9. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers
10. A major role for matrix metalloproteinases in T cell injury in the gut
11. Protease activity in a hapten-induced model of ulcerative colitis in rats
12. Guthoming CD4(+) T-cell receptor αβ (+) T-cells in the pathogenesis of murine inflammatory bowel-disease
13. Polyclonal expansion of adoptively transferred CD4(+)αβ T cells in the colonic lamina propria of scid mice with colitis
14. CD4+ T-cells that express high-levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice - Disease development is prevented by cotransfer of purified CD4+ T-cells
15. Phenotypically distinct subsets of CD4(+) T-cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice
16. Tumour necrosis factor-α (TNF-α) transcription and translation in the CD4(+) T cell-transplanted scid mouse model of colitis
17. Tumour necrosis factor-α and interferon-γ production measured at the single cell level in normal and inflamed human intestine
18. Serum concentrations of tumor-necrosis-factor-α in childhood chronic inflammatory bowel-disease
19. Characterization of the activation of latent TGF-β by cocultures of endothelial-cells and pericytes or smooth-muscle cells - A self-regulating system
20. Cytokine regulation of metalloproteinase gene-expression
21. Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease
22. Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9
23. Biomechanical and biochemical study of a standardized wound healing model
24. Prognostic value of markers of collagen remodeling in venous ulcers
25. Cytotoxic reactivity of gut lamina propria CD4(+)αβ T cells in SCID mice, with colitis
26. Relative production of tumour necrosis factor α and interleukin 10 in adult respiratory distress syndrome
27. Comparison of reflectance and transmission densitometry, using document and laser scanners, for quantitation of stained Western blots
28. Clarification of immunoblots on polyvinylidene difluoride (PVDF) membranes for transmission densitometry
29. Microscopic localization of active proteases by in-situ zymography - Detection of matrix metalloproteinase activity in vascular tissue
30. Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RB(high) subset of CD4(+) T cells
31. Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils
32. Fecal elastase reflects disease activity in active ulcerative colitis
33. The drug 5-aminosalicylic acid rescues α(1)-proteinase inhibitor from the neutrophil oxidative inactivation - A possible contribution to its therapeutic action in ulcerative-colitis
34. Membrane-type matrix metalloproteinases and cell surface-associated activation cascades for matrix metalloproteinases
35. Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation
36. TGFβ-1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence
37. Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions