The apolipoprotein E-mimetic peptide COG112 inhibits NF-κB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3839-3850

  Singh, Kshipra ^a,c   Chaturvedi, Rupesh ^a,c   Barry, Daniel P ^a   Coburn, Lori A ^c   Asim, Mohammad ^a,c   Lewis, Nuruddeen D ^a,b   Piazuelo, M Blanca ^a   Washington, M Kay ^a   Vitek, Michael P ^d   Wilson, Keith T ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Optimal Screening Vehicles Division   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; APOLIPOPROTEIN E; APOLIPOPROTEINS; BODY WEIGHT; CHEMOKINES; CLINICAL PARAMETERS; COLON TISSUES; CROHN'S DISEASE; DEXTRAN SULFATE SODIUM; EPITHELIAL CELLS; IMMUNOBLOTS; IMMUNOFLUORESCENCE CONFOCAL MICROSCOPY; IMMUNOMODULATORY EFFECTS; IN-VITRO; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INFECTION MODELS; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY RESPONSE; INJURY MODELS; INTRAPERITONEAL INJECTIONS; MOUSE MODELS; MRNA EXPRESSION; MURINE MODEL; NEUROINFLAMMATION; NEW STRATEGY; NUCLEAR TRANSLOCATIONS; POTENTIAL THERAPIES; PROINFLAMMATORY CYTOKINES; RECOVERY PHASE; ULCERATIVE COLITIS;

ANTHROPOMETRY; CONFOCAL MICROSCOPY; DISEASES; GLUCOSE; PEPTIDES; SODIUM; SODIUM SULFATE;

BIOMIMETICS;

ALPHA CHEMOKINE; APOLIPOPROTEIN E; COG 112; CXCL3 CHEMOKINE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 17; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; COG112 PEPTIDE; CYTOKINE; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CITROBACTER RODENTIUM; COLITIS; COLON; COLON MUCOSA; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG EFFICACY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; MOUSE; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL RATE; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; ENTERITIS; MALE; PATHOGENICITY; PATHOLOGY;

CITROBACTER RODENTIUM; MURINAE; MUS;

ANIMALS; CELLS, CULTURED; CITROBACTER RODENTIUM; COLON; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; INFLAMMATORY BOWEL DISEASES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PEPTIDES;

EID: 79952801220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.176719     Document Type: Article

References (67)

1. Baumgart, D. C., and Carding, S. R. (2007) Lancet 369, 1627-1640
2. Baumgart, D. C., and Sandborn, W. J. (2007) Lancet 369, 1641-1657
3. Loftus, C. G., Loftus, E. V., Jr., Harmsen, W. S., Zinsmeister, A. R., Tremaine, W. J., Melton, L. J., 3rd, and Sandborn, W. J. (2007) Inflamm. Bowel Dis. 13, 254-261
4. Kojouharoff, G., Hans, W., Obermeier, F., Männel, D. N., Andus, T., Schölmerich, J., Gross, V., and Falk, W. (1997) Clin. Exp. Immunol. 107, 353-358
5. Murthy, S., Cooper, H. S., Yoshitake, H., Meyer, C., Meyer, C. J., and Murthy, N. S. (1999) Aliment. Pharmacol. Ther. 13, 251-260
6. Present, D. H. (1999) Aliment. Pharmacol. Ther. Suppl. 4, 23-28
7. Mouser, J. F., and Hyams, J. S. (1999) Clin. Ther. 21, 932-942; discussion 931
8. Present, D. H., Rutgeerts, P., Targan, S., Hanauer, S. B., Mayer, L., van Hogezand, R. A., Podolsky, D. K., Sands, B. E., Braakman, T., DeWoody, K. L., Schaible, T. F., and van Deventer, S. J. (1999) N. Engl. J. Med. 340, 1398-1405
9. Clark, M., Colombel, J. F., Feagan, B. C., Fedorak, R. N., Hanauer, S. B., Kamm, M. A., Mayer, L., Regueiro, C., Rutgeerts, P., Sandborn, W. J., Sands, B. E., Schreiber, S., Targan, S., Travis, S., and Vermeire, S. (2007) Gastroenterology 133, 312-339
10. Laskowitz, D. T., Lee, D. M., Schmechel, D., and Staats, H. F. (2000) J. Lipid Res. 41, 613-620
11. Van Oosten, M., Rensen, P. C., Van Amersfoort, E. S., Van Eck, M., Van Dam, A. M., Breve, J. J., Vogel, T., Panet, A., Van Berkel, T. J., and Kuiper, J. (2001) J. Biol. Chem. 276, 8820-8824
12. Laskowitz, D. T., Thekdi, A. D., Thekdi, S. D., Han, S. K., Myers, J. K., Pizzo, S. V., and Bennett, E. R. (2001) Exp. Neurol. 167, 74-85
13. Lynch, J. R., Tang, W., Wang, H., Vitek, M. P., Bennett, E. R., Sullivan, P. M., Warner, D. S., and Laskowitz, D. T. (2003) J. Biol. Chem. 278, 48529-48533
14. Li, F. Q., Sempowski, G. D., McKenna, S. E., Laskowitz, D. T., Colton, C. A., and Vitek, M. P. (2006) J. Pharmacol. Exp. Ther. 318, 956-965
15. Singh, K., Chaturvedi, R., Asim, M., Barry, D. P., Lewis, N. D., Vitek, M. P., and Wilson, K. T. (2008) J. Biol. Chem. 283, 16752-16761
16. Gobert, A. P., Cheng, Y., Akhtar, M., Mersey, B. D., Blumberg, D. R., Cross, R. K., Chaturvedi, R., Drachenberg, C. B., Boucher, J. L., Hacker, A., Casero, R. A., Jr., and Wilson, K. T. (2004) J. Immunol. 173, 2109-2117
17. Schreiber, S., Nikolaus, S., and Hampe, J. (1998) Gut 42, 477-484
18. Baeuerle, P. A., and Henkel, T. (1994) Annu. Rev. Immunol. 12, 141-179
19. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. (1997) Nature 388, 548-554
20. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A. (1997) Science 278, 860-866
21. Chiao, P. J., Miyamoto, S., and Verma, I. M. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 28-32
22. Vallance, B. A., Deng, W., Knodler, L. A., and Finlay, B. B. (2002) Infect. Immun. 70, 2070-2081
23. Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., and Weaver, C. T. (2006) Nature 441, 231-234
24. Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., and Nakaya, R. (1990) Gastroenterology 98, 694-702
25. Krieglstein, C. F., Cerwinka, W. H., Laroux, F. S., Salter, J. W., Russell, J. M., Schuermann, G., Grisham, M. B., Ross, C. R., and Granger, D. N. (2001) J. Exp. Med. 194, 1207-1218
26. Krieglstein, C. F., Cerwinka, W. H., Sprague, A. G., Laroux, F. S., Grisham, M. B., Koteliansky, V. E., Senninger, N., Granger, D. N., and de Fougerolles, A. R. (2002) J. Clin. Invest. 110, 1773-1782
27. Khan, M. A., Ma, C., Knodler, L. A., Valdez, Y., Rosenberger, C. M., Deng, W., Finlay, B. B., and Vallance, B. A. (2006) Infect. Immun. 74, 2522-2536
28. Theiss, A. L., Vijay-Kumar, M., Obertone, T. S., Jones, D. P., Hansen, J. M., Gewirtz, A. T., Merlin, D., and Sitaraman, S. V. (2009) Gastroenterology 137, 10
29. Sartor, R. B. (2006) Nat. Clin. Pract. Gastroenterol. Hepatol. 3, 390-407
30. Williams, K. L., Fuller, C. R., Dieleman, L. A., DaCosta, C. M., Haldeman, K. M., Sartor, R. B., and Lund, P. K. (2001) Gastroenterology 120, 925-937
31. Whitehead, R. H., VanEeden, P. E., Noble, M. D., Ataliotis, P., and Jat, P. S. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 587-591
32. Chaturvedi, R., Cheng, Y., Asim, M., Bussière, F. I., Xu, H., Gobert, A. P., Hacker, A., Casero, R. A., Jr., and Wilson, K. T. (2004) J. Biol. Chem. 279, 40161-40173
33. Cheng, Y., Chaturvedi, R., Asim, M., Bussière, F. I., Scholz, A., Xu, H., Casero, R. A., Jr., and Wilson, K. T. (2005) J. Biol. Chem. 280, 22492-22496
34. Chaturvedi, R., Asim, M., Lewis, N. D., Algood, H. M., Cover, T. L., Kim, P. Y., and Wilson, K. T. (2007) Infect. Immun. 75, 4305-4315
35. Asim, M., Chaturvedi, R., Hoge, S., Lewis, N. D., Singh, K., Barry, D. P., Algood, H. S., de Sablet, T., Gobert, A. P., and Wilson, K. T. (2010) J. Biol. Chem. 285, 20343-20357
36. Bergstrom, K. S., Guttman, J. A., Rumi, M., Ma, C., Bouzari, S., Khan, M. A., Gibson, D. L., Vogl, A. W., and Vallance, B. A. (2008) Infect. Immun. 76, 796-811
37. Wang, Y., Xiang, G. S., Kourouma, F., and Umar, S. (2006) Br. J. Pharmacol. 148, 814-824
38. Murano, M., Maemura, K., Hirata, I., Toshina, K., Nishikawa, T., Hamamoto, N., Sasaki, S., Saitoh, O., and Katsu, K. (2000) Clin. Exp. Immunol. 120, 51-58
39. Edelblum, K. L., Washington, M. K., Koyama, T., Robine, S., Baccarini, M., and Polk, D. B. (2008) Gastroenterology 135, 539-551
40. Lynch, J. R., Wang, H., Mace, B., Leinenweber, S., Warner, D. S., Bennett, E. R., Vitek, M. P., McKenna, S., and Laskowitz, D. T. (2005) Exp. Neurol. 192, 109-116
41. Wiles, S., Clare, S., Harker, J., Huett, A., Young, D., Dougan, G., and Frankel, G. (2004) Cell. Microbiol. 6, 963-972
42. Higgins, L. M., Frankel, G., Douce, G., Dougan, G., and MacDonald, T. T. (1999) Infect. Immun. 67, 3031-3039
43. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., and Weaver, C. T. (2005) Nat. Immunol. 6, 1123-1132
44. Bry, L., and Brenner, M. B. (2004) J. Immunol. 172, 433-441
45. Chalaris, A., Adam, N., Sina, C., Rosenstiel, P., Lehmann-Koch, J., Schirmacher, P., Hartmann, D., Cichy, J., Gavrilova, O., Schreiber, S., Jostock, T., Matthews, V., Häsler, R., Becker, C., Neurath, M. F., Reiss, K., Saftig, P., Scheller, J., and Rose-John, S. (2010) J. Exp. Med. 207, 1617-1624
46. MacMicking, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q. W., Sokol, K., and Hutchinson, N. (1995) Cell 81, 641-650
47. Vowinkel, T., Mori, M., Krieglstein, C. F., Russell, J., Saijo, F., Bharwani, S., Turnage, R. H., Davidson, W. S., Tso, P., Granger, D. N., and Kalogeris, T. J. (2004) J. Clin. Invest. 114, 260-269
48. Cross, R. K., and Wilson, K. T. (2003) Inflamm. Bowel Dis. 9, 179-189
49. McCafferty, D. M., Miampamba, M., Sihota, E., Sharkey, K. A., and Kubes, P. (1999) Gut 45, 864-873
50. Domek, M. J., Iwata, F., Blackman, E. I., Kao, J., Baker, M., Vidrich, A., and Leung, F. W. (1995) Scand. J. Gastroenterol. 30, 1089-1094
51. Popivanova, B. K., Kitamura, K., Wu, Y., Kondo, T., Kagaya, T., Kaneko, S., Oshima, M., Fujii, C., and Mukaida, N. (2008) J. Clin. Invest. 118, 560-570
52. D'Haens, G. R. (1999) Ital. J. Gastroenterol. Hepatol. 31, 519-520
53. Hyams, J. S., Markowitz, J., and Wyllie, R. (2000) J. Pediatr. 137, 192-196
54. Kirman, I., Whelan, R. L., and Nielsen, O. H. (2004) Eur. J. Gastroenterol. Hepatol. 16, 639-641
55. Hacker, H., and Karin, M. (2006) Sci. STKE 13,
56. Kopp, E., and Ghosh, S. (1994) Science 265, 956-959
57. Wahl, C., Liptay, S., Adler, G., and Schmid, R. M. (1998) J. Clin. Invest. 101, 1163-1174
58. Fichtner-Feigl, S., Fuss, I. J., Preiss, J. C., Strober, W., and Kitani, A. (2005) J. Clin. Invest. 115, 3057-3071
59. Kim, Y. H., Kwon, H. S., Kim, D. H., Cho, H. J., Lee, H. S., Jun, J. G., Park, J. H., and Kim, J. K. (2008) Int. Immunopharmacol. 8, 1695-1702
60. Singh, U. P., Singh, N. P., Singh, B., Hofseth, L. J., Price, R. L., Nagarkatti, M., and Nagarkatti, P. S. (2010) J. Pharmacol. Exp. Ther. 332, 829-839
61. Shibata, W., Maeda, S., Hikiba, Y., Yanai, A., Ohmae, T., Sakamoto, K., Nakagawa, H., Ogura, K., and Omata, M. (2007) J. Immunol. 179, 2681-2685
62. May, M. J., D'Acquisto, F., Madge, L. A., Glöckner, J., Pober, J. S., and Ghosh, S. (2000) Science 289, 1550-1554
63. Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z. W., Egan, L. J., Kagnoff, M. F., and Karin, M. (2004) Cell 118, 285-296
64. Nenci, A., Becker, C., Wullaert, A., Gareus, R., van Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C., Madison, B., Gumucio, D., Neurath, M. F., and Pasparakis, M. (2007) Nature 446, 557-561
65. Steinbrecher, K. A., Harmel-Laws, E., Sitcheran, R., and Baldwin, A. S. (2008) J. Immunol. 180, 2588-2599
66. Dajee, M., Lazarov, M., Zhang, J. Y., Cai, T., Green, C. L., Russell, A. J., Marinkovich, M. P., Tao, S., Lin, Q., Kubo, Y., and Khavari, P. A. (2003) Nature 421, 639-643
67. Maeda, S., Chang, L., Li, Z. W., Luo, J. L., Leffert, H., and Karin, M. (2003) Immunity 19, 725-737