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Volumn 7, Issue 11, 2012, Pages

Integrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; ENZYME;

EID: 84870322666     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049138     Document Type: Article
Times cited : (349)

References (66)
  • 1
    • 72949091232 scopus 로고    scopus 로고
    • Bacterial community variation in human body habitats across space and time
    • Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, et al. (2009) Bacterial community variation in human body habitats across space and time. Science 326: 1694-1697.
    • (2009) Science , vol.326 , pp. 1694-1697
    • Costello, E.K.1    Lauber, C.L.2    Hamady, M.3    Fierer, N.4    Gordon, J.I.5
  • 2
    • 67650047735 scopus 로고    scopus 로고
    • DNA Sudoku-harnessing high-throughput sequencing for multiplexed specimen analysis
    • Erlich Y, Chang K, Gordon A, Ronen R, Navon O, et al. (2009) DNA Sudoku-harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Research 19: 1243-1253.
    • (2009) Genome Research , vol.19 , pp. 1243-1253
    • Erlich, Y.1    Chang, K.2    Gordon, A.3    Ronen, R.4    Navon, O.5
  • 4
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin JJ, Li RQ, Raes J, Arumugam M, Burgdorf KS, et al. (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464: 59-U70.
    • (2010) Nature , vol.464 , pp. 59-70
    • Qin, J.J.1    Li, R.Q.2    Raes, J.3    Arumugam, M.4    Burgdorf, K.S.5
  • 5
    • 84862276328 scopus 로고    scopus 로고
    • Structure, Function and Diversity of the healthy human microbiome
    • Huttenhower C, Givers D, Knight R, Abubucker S, Badger JH, et al. (2012) Structure, Function and Diversity of the healthy human microbiome. Nature 486: 207-214.
    • (2012) Nature , vol.486 , pp. 207-214
    • Huttenhower, C.1    Givers, D.2    Knight, R.3    Abubucker, S.4    Badger, J.H.5
  • 10
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, et al. (2006) Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 55: 205-211.
    • (2006) Gut , vol.55 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3    Gloux, K.4    Pelletier, E.5
  • 11
    • 46749119859 scopus 로고    scopus 로고
    • Molecular analysis of the gut microbiota of identical twins with Crohn's disease
    • Dicksved J, Halfvarson J, Rosenquist M, Jarnerot G, Tysk C, et al. (2008) Molecular analysis of the gut microbiota of identical twins with Crohn's disease. ISME Journal 2: 716-727.
    • (2008) ISME Journal , vol.2 , pp. 716-727
    • Dicksved, J.1    Halfvarson, J.2    Rosenquist, M.3    Jarnerot, G.4    Tysk, C.5
  • 12
    • 66249129571 scopus 로고    scopus 로고
    • Twin Studies Reveal Specific Imbalances in the Mucosa-associated Microbiota of Patients with Ileal Crohn's Disease
    • Willing B, Halfvarson J, Dicksved J, Rosenquist M, Jarnerot G, et al. (2009) Twin Studies Reveal Specific Imbalances in the Mucosa-associated Microbiota of Patients with Ileal Crohn's Disease. Inflammatory Bowel Diseases 15: 653-660.
    • (2009) Inflammatory Bowel Diseases , vol.15 , pp. 653-660
    • Willing, B.1    Halfvarson, J.2    Dicksved, J.3    Rosenquist, M.4    Jarnerot, G.5
  • 13
    • 79953748870 scopus 로고    scopus 로고
    • Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
    • Joossens M, Huys G, Cnockaert M, De Preter V, Verbeke K, et al. (2011) Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 60: 631-637.
    • (2011) Gut , vol.60 , pp. 631-637
    • Joossens, M.1    Huys, G.2    Cnockaert, M.3    De Preter, V.4    Verbeke, K.5
  • 15
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • Willing BP, Dicksved J, Halfvarson J, Andersson AF, Lucio M, et al. (2010) A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139: 1844-1854.
    • (2010) Gastroenterology , vol.139 , pp. 1844-1854
    • Willing, B.P.1    Dicksved, J.2    Halfvarson, J.3    Andersson, A.F.4    Lucio, M.5
  • 17
  • 19
    • 81455144570 scopus 로고    scopus 로고
    • A metaproteomic approcah to study human-microbial ecosystems at the mucosal luminal interface
    • Li X, LeBlanc J, Truong A, Vuthoori R, Chen SS, et al. (2011) A metaproteomic approcah to study human-microbial ecosystems at the mucosal luminal interface. PLoS One. 6: e26542.
    • (2011) PLoS One , vol.6
    • Li, X.1    LeBlanc, J.2    Truong, A.3    Vuthoori, R.4    Chen, S.S.5
  • 20
    • 49649089054 scopus 로고    scopus 로고
    • Systems microbiology - Timeline - Molecular eco-systems biology: towards an understanding of community function
    • Raes J, Bork P, (2008) Systems microbiology - Timeline - Molecular eco-systems biology: towards an understanding of community function. Nat Rev Microbiol 6: 693-699.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 693-699
    • Raes, J.1    Bork, P.2
  • 21
    • 78650780115 scopus 로고    scopus 로고
    • An iterative workflow for mining the human intestinal metaproteome
    • Truong A, Vuthoori R, Chen SS, Lustgarten JL, Roth B, et al. (2011) A metaproteomic approach. Roojiers K, Kolmeder C, Juste C, Doré J, De Been M,et al. (2011) An iterative workflow for mining the human intestinal metaproteome. BMC Genomics 12: 6.
    • (2011) BMC Genomics , vol.12 , pp. 6
    • Truong, A.1    Vuthoori, R.2    Chen, S.S.3    Lustgarten, J.L.4    Roth, B.5
  • 22
    • 84855915896 scopus 로고    scopus 로고
    • Comparative metaproteomics and diversity analysis of human intestinal microbiota testifies for its temporal stability and expression of core functions
    • Kolmeder CA, De Been M, Nikklia J, Ritamo I, Mättö J, et al. (2012) Comparative metaproteomics and diversity analysis of human intestinal microbiota testifies for its temporal stability and expression of core functions. PLoS One. 7: e29913.
    • (2012) PLoS One , vol.7
    • Kolmeder, C.A.1    De Been, M.2    Nikklia, J.3    Ritamo, I.4    Mättö, J.5
  • 23
    • 81755176064 scopus 로고    scopus 로고
    • Strategies for Metagenomic-Guided Whole-Community Proteomics of Complex Microbial Environments
    • Cantarel BL, Erickson AR, VerBerkmoes NC, Erickson BK, Carey PA, et al. (2011) Strategies for Metagenomic-Guided Whole-Community Proteomics of Complex Microbial Environments. PLoS One 6(11): e27173.
    • (2011) PLoS One , vol.6 , Issue.11
    • Cantarel, B.L.1    Erickson, A.R.2    VerBerkmoes, N.C.3    Erickson, B.K.4    Carey, P.A.5
  • 25
    • 0033040820 scopus 로고    scopus 로고
    • Beta-1,3-galactosyl-N-acetylhexosamine phosphorylase from Bifidobacterium bifidum DSM 20082: characterization, partial purification and relation to mucin degradation
    • Derensy-Dron D, Krzewinski F, Brassart C, Bouquelet S, (1999) Beta-1,3-galactosyl-N-acetylhexosamine phosphorylase from Bifidobacterium bifidum DSM 20082: characterization, partial purification and relation to mucin degradation. Biotechnol Appl Biochem 29: 3-10.
    • (1999) Biotechnol Appl Biochem , vol.29 , pp. 3-10
    • Derensy-Dron, D.1    Krzewinski, F.2    Brassart, C.3    Bouquelet, S.4
  • 26
    • 0034284024 scopus 로고    scopus 로고
    • Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin
    • Wright DP, Rosendale DI, Robertson AM, (2000) Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin. FEMS Microbiol Lett 190: 73-79.
    • (2000) FEMS Microbiol Lett , vol.190 , pp. 73-79
    • Wright, D.P.1    Rosendale, D.I.2    Robertson, A.M.3
  • 27
    • 23044457742 scopus 로고    scopus 로고
    • TonB-dependent trans-envelope signalling: the exception or the rule?
    • Koebnik R, (2005) TonB-dependent trans-envelope signalling: the exception or the rule? Trends Microbiol 13: 343-347.
    • (2005) Trends Microbiol , vol.13 , pp. 343-347
    • Koebnik, R.1
  • 28
    • 0036056386 scopus 로고    scopus 로고
    • Outer-membrane pore-forming proteins in gram-negative anaerobic bacteria
    • Wexler HM, (2002) Outer-membrane pore-forming proteins in gram-negative anaerobic bacteria. Clin Infect Dis 35: S65-S71.
    • (2002) Clin Infect Dis , vol.35
    • Wexler, H.M.1
  • 29
    • 77952533494 scopus 로고    scopus 로고
    • OmpA variants affecting the adherence of ulcerative colitis-derived Bacteroides vulgatus
    • Sato K, Kumita W, Ode T, Ichinose S, Ando A, et al. (2010) OmpA variants affecting the adherence of ulcerative colitis-derived Bacteroides vulgatus. J Med Dent Sci 57: 55-64.
    • (2010) J Med Dent Sci , vol.57 , pp. 55-64
    • Sato, K.1    Kumita, W.2    Ode, T.3    Ichinose, S.4    Ando, A.5
  • 30
    • 0034264442 scopus 로고    scopus 로고
    • Outer membrane protein A (OmpA) binds to and activates human macrophages
    • Soulas C, Baussant T, Aubry JP, Delneste Y, Barillat N, et al. (2000) Outer membrane protein A (OmpA) binds to and activates human macrophages. J Immunol 165: 2335-2340.
    • (2000) J Immunol , vol.165 , pp. 2335-2340
    • Soulas, C.1    Baussant, T.2    Aubry, J.P.3    Delneste, Y.4    Barillat, N.5
  • 31
    • 0033201677 scopus 로고    scopus 로고
    • The rag locus of Porphyromonas gingivalis: a novel pathogenicity island
    • Curtis MA, Hanley SA, Aduse-Opoku J, (1999) The rag locus of Porphyromonas gingivalis: a novel pathogenicity island. J Periodontal Res 34: 400-405.
    • (1999) J Periodontal Res , vol.34 , pp. 400-405
    • Curtis, M.A.1    Hanley, S.A.2    Aduse-Opoku, J.3
  • 32
    • 34147167080 scopus 로고    scopus 로고
    • The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction
    • Shi XJ, Hanley SA, Faray-Kele MC, Fawell SC, Aduse-Opoku J, et al. (2007) The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction. Infect Immun 75: 2071-2074.
    • (2007) Infect Immun , vol.75 , pp. 2071-2074
    • Shi, X.J.1    Hanley, S.A.2    Faray-Kele, M.C.3    Fawell, S.C.4    Aduse-Opoku, J.5
  • 33
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: etiology and pathogenesis
    • Fiocchi C, (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205.
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 34
    • 0034213230 scopus 로고    scopus 로고
    • New therapeutic approaches to Crohn's disease
    • Sartor RB, (2000) New therapeutic approaches to Crohn's disease. N Engl J Med 342: 1664-1666.
    • (2000) N Engl J Med , vol.342 , pp. 1664-1666
    • Sartor, R.B.1
  • 35
    • 0036312998 scopus 로고    scopus 로고
    • Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation
    • Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H, (2002) Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. Carcinogenesis 23: 1139-1148.
    • (2002) Carcinogenesis , vol.23 , pp. 1139-1148
    • Okazaki, N.1    Takahashi, N.2    Kojima, S.3    Masuho, Y.4    Koga, H.5
  • 36
    • 0023766232 scopus 로고
    • Characterization of Human-Skin Fibroblast Extracellular Proteins by Two-Dimensional Polyacrylamide-Gel Electrophoresis
    • Graham CA, Mclean WHI, Hughes AE, Nevin NC, (1988) Characterization of Human-Skin Fibroblast Extracellular Proteins by Two-Dimensional Polyacrylamide-Gel Electrophoresis. Electrophoresis 9: 343-351.
    • (1988) Electrophoresis , vol.9 , pp. 343-351
    • Graham, C.A.1    Mclean, W.H.I.2    Hughes, A.E.3    Nevin, N.C.4
  • 39
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, Lopez-Boado YS, et al. (1999) Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286: 113-117.
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1    Ouellette, A.J.2    Satchell, D.P.3    Ayabe, T.4    Lopez-Boado, Y.S.5
  • 40
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
    • Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, et al. (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1: 113-118.
    • (2000) Nat Immunol , vol.1 , pp. 113-118
    • Ayabe, T.1    Satchell, D.P.2    Wilson, C.L.3    Parks, W.C.4    Selsted, M.E.5
  • 41
  • 42
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B, (1988) Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29: 990-996.
    • (1988) Gut , vol.29 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3    Floderus-Myrhed, B.4
  • 43
    • 78650097770 scopus 로고    scopus 로고
    • Genetics in Twins with Crohn's Disease: Less Pronounced than Previously Believed?
    • Halfvarson J, (2011) Genetics in Twins with Crohn's Disease: Less Pronounced than Previously Believed? Inflammatory Bowel Diseases 17: 6-12.
    • (2011) Inflammatory Bowel Diseases , vol.17 , pp. 6-12
    • Halfvarson, J.1
  • 45
    • 33750976398 scopus 로고    scopus 로고
    • MetaGene: prokaryotic gene finding from environmental genome shotgun sequences
    • Noguchi H, Park J, Takagi T, (2006) MetaGene: prokaryotic gene finding from environmental genome shotgun sequences. Nucleic Acids Research 34: 5623-5630.
    • (2006) Nucleic Acids Research , vol.34 , pp. 5623-5630
    • Noguchi, H.1    Park, J.2    Takagi, T.3
  • 46
    • 0033990061 scopus 로고    scopus 로고
    • Flexible sequence similarity searching with the FASTA3 program package
    • Pearson WR, (2000) Flexible sequence similarity searching with the FASTA3 program package. Methods Mol Biol 132: 185-219.
    • (2000) Methods Mol Biol , vol.132 , pp. 185-219
    • Pearson, W.R.1
  • 47
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    • Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3389-3402
    • Altschul, S.F.1    Madden, T.L.2    Schaffer, A.A.3    Zhang, J.4    Zhang, Z.5
  • 48
    • 0036529479 scopus 로고    scopus 로고
    • An efficient algorithm for large-scale detection of protein families
    • Enright AJ, Van Dongen S, Ouzounis CA, (2002) An efficient algorithm for large-scale detection of protein families. Nucleic Acids Research 30: 1575-1584.
    • (2002) Nucleic Acids Research , vol.30 , pp. 1575-1584
    • Enright, A.J.1    Van Dongen, S.2    Ouzounis, C.A.3
  • 49
    • 75549085495 scopus 로고    scopus 로고
    • eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations
    • Muller J, Szklarczyk D, Julien P, Letunic I, Roth A, et al. (2010) eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations. Nucleic Acids Research 38: D190-D195.
    • (2010) Nucleic Acids Research , vol.38
    • Muller, J.1    Szklarczyk, D.2    Julien, P.3    Letunic, I.4    Roth, A.5
  • 50
    • 84862200127 scopus 로고    scopus 로고
    • Complex carbohydrate utilization by the healthy human microbiome
    • Cantarel BL, Lombard V, Henrissat B, (2012) Complex carbohydrate utilization by the healthy human microbiome. PLoS One 7(6): e28742.
    • (2012) PLoS One , vol.7 , Issue.6
    • Cantarel, B.L.1    Lombard, V.2    Henrissat, B.3
  • 56
    • 58149139273 scopus 로고    scopus 로고
    • Experimental approach for deep proteome measurements from small-scale microbial biomass samples
    • Thompson MR, Chourey K, Froelich JM, Erickson BK, VerBerkmoes NC, et al. (2008) Experimental approach for deep proteome measurements from small-scale microbial biomass samples. Anal Chem 80: 9517-9525.
    • (2008) Anal Chem , vol.80 , pp. 9517-9525
    • Thompson, M.R.1    Chourey, K.2    Froelich, J.M.3    Erickson, B.K.4    VerBerkmoes, N.C.5
  • 57
    • 65249149643 scopus 로고    scopus 로고
    • Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
    • Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, et al. (2009) Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci U S A 106: 5859-5864.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5859-5864
    • Mahowald, M.A.1    Rey, F.E.2    Seedorf, H.3    Turnbaugh, P.J.4    Fulton, R.S.5
  • 58
    • 0036684101 scopus 로고    scopus 로고
    • Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT
    • McDonald WH, Ohi R, Miyamoto DT, Mitchison TJ, Yates JR, (2002) Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT. Int J Mass Spectrom 219: 245-251.
    • (2002) Int J Mass Spectrom , vol.219 , pp. 245-251
    • McDonald, W.H.1    Ohi, R.2    Miyamoto, D.T.3    Mitchison, T.J.4    Yates, J.R.5
  • 59
    • 0036399228 scopus 로고    scopus 로고
    • Shotgun proteomics and biomarker discovery
    • McDonald WH, Yates JR, (2002) Shotgun proteomics and biomarker discovery. Dis Markers 18: 99-105.
    • (2002) Dis Markers , vol.18 , pp. 99-105
    • McDonald, W.H.1    Yates, J.R.2
  • 60
    • 0000857494 scopus 로고
    • An Approach to Correlate Tandem Mass-Spectral Data of Peptides with Amino-Acid-Sequences in a Protein Database
    • Eng JK, Mccormack AL, Yates JR, (1994) An Approach to Correlate Tandem Mass-Spectral Data of Peptides with Amino-Acid-Sequences in a Protein Database. J Am Soc Mass Spectr 5: 976-989.
    • (1994) J Am Soc Mass Spectr , vol.5 , pp. 976-989
    • Eng, J.K.1    Mccormack, A.L.2    Yates, J.R.3
  • 61
    • 0036393898 scopus 로고    scopus 로고
    • DTASelect and contrast: Tools for assembling and comparing protein identifications from shotgun proteomics
    • Tabb DL, McDonald WH, Yates JR, (2002) DTASelect and contrast: Tools for assembling and comparing protein identifications from shotgun proteomics. J Proteome Res 1: 21-26.
    • (2002) J Proteome Res , vol.1 , pp. 21-26
    • Tabb, D.L.1    McDonald, W.H.2    Yates, J.R.3
  • 62
    • 33847630405 scopus 로고    scopus 로고
    • Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
    • Elias JE, Gygi SP, (2007) Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods 4: 207-214.
    • (2007) Nat Methods , vol.4 , pp. 207-214
    • Elias, J.E.1    Gygi, S.P.2
  • 63
    • 0037277179 scopus 로고    scopus 로고
    • Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: The yeast proteome
    • Peng JM, Elias JE, Thoreen CC, Licklider LJ, Gygi SP, (2003) Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: The yeast proteome. J Proteome Res 2: 43-50.
    • (2003) J Proteome Res , vol.2 , pp. 43-50
    • Peng, J.M.1    Elias, J.E.2    Thoreen, C.C.3    Licklider, L.J.4    Gygi, S.P.5
  • 64
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R, (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2


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