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Volumn 13, Issue 1, 2017, Pages 26-35

Brown adipose tissue as a secretory organ

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; BATOKINE; BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR 21; INTERLEUKIN 6; NEU DIFFERENTIATION FACTOR; NEUREGULIN 4; UNCLASSIFIED DRUG;

EID: 84987667575     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2016.136     Document Type: Review
Times cited : (513)

References (132)
  • 1
    • 0034668852 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins: From mitochondria to the regulation of energy balance
    • Ricquier, D. & Bouillaud, F. Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. J. Physiol. 15, 3-10 (2000).
    • (2000) J. Physiol. , vol.15 , pp. 3-10
    • Ricquier, D.1    Bouillaud, F.2
  • 2
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 3
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.B.1
  • 4
    • 84946611387 scopus 로고    scopus 로고
    • Human brown adipose tissue: What we have learned so far
    • Bletz, M. J. & Enerback, S. Human brown adipose tissue: what we have learned so far. Diabetes 64, 2352-2360 (2015).
    • (2015) Diabetes , vol.64 , pp. 2352-2360
    • Bletz, M.J.1    Enerback, S.2
  • 5
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor (PPAR) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic, N. et al. Chronic peroxisome proliferator-activated receptor (PPAR) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 7153-7164
    • Petrovic, N.1
  • 6
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012).
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1
  • 7
    • 84890234667 scopus 로고    scopus 로고
    • UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
    • Shabalina, I. G. et al. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep. 5, 1196-1203 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 1196-1203
    • Shabalina, I.G.1
  • 8
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
    • Guerra, C., Koza, R. A., Yamashita, H., Walsh, K. & Kozak, L. P. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 9
    • 84975757439 scopus 로고    scopus 로고
    • A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
    • Kazak, L. et al. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell 163, 643-655 (2015).
    • (2015) Cell , vol.163 , pp. 643-655
    • Kazak, L.1
  • 10
    • 84983749205 scopus 로고    scopus 로고
    • Metabolic activity of brown, "beige" and white adipose tissues in response to chronic adrenergic stimulation in male mice
    • Labbe, S. M. et al. Metabolic activity of brown, "beige" and white adipose tissues in response to chronic adrenergic stimulation in male mice. Am. J. Physiol. Endocrinol. Metab. 311, E260-E268 (2016).
    • (2016) Am. J. Physiol. Endocrinol. Metab. , vol.311 , pp. E260-E268
    • Labbe, S.M.1
  • 11
    • 84913586856 scopus 로고    scopus 로고
    • The browning of white adipose tissue: Some burning issues
    • Nedergaard, J. & Cannon, B. The browning of white adipose tissue: some burning issues. Cell Metab. 20, 396-407 (2014).
    • (2014) Cell Metab. , vol.20 , pp. 396-407
    • Nedergaard, J.1    Cannon, B.2
  • 12
    • 84907862142 scopus 로고    scopus 로고
    • 20 Years of leptin: Leptin at 20: An overview
    • Friedman, J. 20 Years of leptin: leptin at 20: an overview. J. Endocrinol. 223, T1-T8 (2014).
    • (2014) J. Endocrinol , vol.223 , pp. T1-T8
    • Friedman, J.1
  • 13
    • 80052373417 scopus 로고    scopus 로고
    • Evaluation of macrophage plasticity in brown and white adipose tissue
    • Ortega, M. T., Xie, L., Mora, S. & Chapes, S. K. Evaluation of macrophage plasticity in brown and white adipose tissue. Cell. Immunol. 271, 124-133 (2011).
    • (2011) Cell. Immunol. , vol.271 , pp. 124-133
    • Ortega, M.T.1    Xie, L.2    Mora, S.3    Chapes, S.K.4
  • 14
    • 0028153775 scopus 로고
    • Production of nerve growth factor by brown fat in culture: Relation with the in vivo developmental stage of the tissue
    • Nechad, M., Ruka, E. & Thibault, J. Production of nerve growth factor by brown fat in culture: relation with the in vivo developmental stage of the tissue. Comp. Biochem. Physiol. Comp. Physiol. 107, 381-388 (1994).
    • (1994) Comp. Biochem. Physiol. Comp. Physiol. , vol.107 , pp. 381-388
    • Nechad, M.1    Ruka, E.2    Thibault, J.3
  • 15
    • 0030062369 scopus 로고    scopus 로고
    • Expression of nerve growth factor in brown adipose tissue: Implications for thermogenesis and obesity
    • Nisoli, E., Tonello, C., Benarese, M., Liberini, P. & Carruba, M O. Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity. Endocrinology 137, 495-503 (1996).
    • (1996) Endocrinology , vol.137 , pp. 495-503
    • Nisoli, E.1    Tonello, C.2    Benarese, M.3    Liberini, P.4    Carruba, M.O.5
  • 16
    • 0027956923 scopus 로고
    • Basic fibroblast growth factor (bFGF) contributes to the enlargement of brown adipose tissue during cold acclimation
    • Yamashita, H. et al. Basic fibroblast growth factor (bFGF) contributes to the enlargement of brown adipose tissue during cold acclimation. Pflugers Arch. 428, 352-356 (1994).
    • (1994) Pflugers Arch. , vol.428 , pp. 352-356
    • Yamashita, H.1
  • 17
    • 78449285575 scopus 로고    scopus 로고
    • Sympathetic and sensory innervation of brown adipose tissue
    • Bartness, T. J., Vaughan, C. H. & Song, C. K. Sympathetic and sensory innervation of brown adipose tissue. Int. J. Obes. (Lond.). 34 (Suppl. 1), S36-S42 (2010).
    • (2010) Int. J. Obes. (Lond.). , vol.34 , pp. S36-S42
    • Bartness, T.J.1    Vaughan, C.H.2    Song, C.K.3
  • 18
    • 0000143140 scopus 로고
    • Brown adipose tissue hyperplasia: A fundamental mechanism of adaptation to cold and hyperphagia
    • Bukowiecki, L., Collet, A. J., Follea, N., Guay, G. & Jahjah, L. Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia. Am. J. Physiol. 242, E353-E359 (1982).
    • (1982) Am. J. Physiol. , vol.242 , pp. E353-E359
    • Bukowiecki, L.1    Collet, A.J.2    Follea, N.3    Guay, G.4    Jahjah, L.5
  • 19
    • 0033113716 scopus 로고    scopus 로고
    • Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue
    • Asano, A., Kimura, K. & Saito, M. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. J. Vet. Med. Sci. 61, 403-409 (1999).
    • (1999) J. Vet. Med. Sci. , vol.61 , pp. 403-409
    • Asano, A.1    Kimura, K.2    Saito, M.3
  • 20
    • 57849153917 scopus 로고    scopus 로고
    • Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
    • Xue, Y. et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 9, 99-109 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 99-109
    • Xue, Y.1
  • 21
    • 0018348872 scopus 로고
    • Tissue distribution of cold-induced thermogenesis in conscious warm-or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis
    • Foster, D. O. & Frydman, M. L. Tissue distribution of cold-induced thermogenesis in conscious warm-or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can. J. Physiol. Pharmacol. 57, 257-270 (1979).
    • (1979) Can. J. Physiol. Pharmacol. , vol.57 , pp. 257-270
    • Foster, D.O.1    Frydman, M.L.2
  • 22
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava, J. et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab. 14, 272-279 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 272-279
    • Orava, J.1
  • 23
    • 84902356732 scopus 로고    scopus 로고
    • Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure
    • Sun, K. et al. Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure. Mol. Metab. 3, 474-483 (2014).
    • (2014) Mol. Metab. , vol.3 , pp. 474-483
    • Sun, K.1
  • 24
    • 84949681360 scopus 로고    scopus 로고
    • Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes
    • Mahdaviani, K., Chess, D., Wu, Y., Shirihai, O. & Aprahamian, T. R. Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metabolism 65, 26-35 (2016).
    • (2016) Metabolism , vol.65 , pp. 26-35
    • Mahdaviani, K.1    Chess, D.2    Wu, Y.3    Shirihai, O.4    Aprahamian, T.R.5
  • 25
    • 84908546317 scopus 로고    scopus 로고
    • Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues
    • Hansen, I. R., Jansson, K. M., Cannon, B. & Nedergaard, J. Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues. Biochim. Biophys. Acta 1841, 1691-1699 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 1691-1699
    • Hansen, I.R.1    Jansson, K.M.2    Cannon, B.3    Nedergaard, J.4
  • 26
    • 84905715172 scopus 로고    scopus 로고
    • Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice
    • Rourke, J. L., Muruganandan, S., Dranse, H. J., McMullen, N. M. & Sinal, C. J. Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice. J. Endocrinol. 222, 201-215 (2014).
    • (2014) J. Endocrinol. , vol.222 , pp. 201-215
    • Rourke, J.L.1    Muruganandan, S.2    Dranse, H.J.3    McMullen, N.M.4    Sinal, C.J.5
  • 27
    • 84893765411 scopus 로고    scopus 로고
    • Processing, signaling, and physiological function of chemerin
    • Mattern, A., Zellmann, T. & Beck-Sickinger, A. G. Processing, signaling, and physiological function of chemerin. IUBMB Life 66, 19-26 (2014).
    • (2014) IUBMB Life , vol.66 , pp. 19-26
    • Mattern, A.1    Zellmann, T.2    Beck-Sickinger, A.G.3
  • 28
    • 77952970098 scopus 로고    scopus 로고
    • Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
    • Vegiopoulos, A. et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328, 1158-1161 (2010).
    • (2010) Science , vol.328 , pp. 1158-1161
    • Vegiopoulos, A.1
  • 29
    • 84870330258 scopus 로고    scopus 로고
    • A new role for lipocalin prostaglandin D synthase in the regulation of brown adipose tissue substrate utilization
    • Virtue, S. et al. A new role for lipocalin prostaglandin D synthase in the regulation of brown adipose tissue substrate utilization. Diabetes 61, 3139-3147 (2012).
    • (2012) Diabetes , vol.61 , pp. 3139-3147
    • Virtue, S.1
  • 30
    • 0030953217 scopus 로고    scopus 로고
    • Lipocalin-type prostaglandin D synthase (-trace) is a newly recognized type of retinoid transporter
    • Tanaka, T. et al. Lipocalin-type prostaglandin D synthase (-trace) is a newly recognized type of retinoid transporter. J. Biol. Chem. 272, 15789-15795 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 15789-15795
    • Tanaka, T.1
  • 31
    • 84975234589 scopus 로고    scopus 로고
    • Prostaglandin E2 signals white-to-brown adipogenic differentiation
    • Garcia-Alonso, V. & Claria, J. Prostaglandin E2 signals white-to-brown adipogenic differentiation. Adipocyte 3, 290-296 (2014).
    • (2014) Adipocyte , vol.3 , pp. 290-296
    • Garcia-Alonso, V.1    Claria, J.2
  • 32
    • 0031040056 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase in rat brown adipocytes: Implications for blood flow to brown adipose tissue
    • Nisoli, E., Tonello, C., Briscini, L. & Carruba, M. O. Inducible nitric oxide synthase in rat brown adipocytes: implications for blood flow to brown adipose tissue. Endocrinology 138, 676-682 (1997).
    • (1997) Endocrinology , vol.138 , pp. 676-682
    • Nisoli, E.1    Tonello, C.2    Briscini, L.3    Carruba, M.O.4
  • 33
    • 84921924044 scopus 로고    scopus 로고
    • Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway
    • Roberts, L. D. et al. Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway. Diabetes 64, 471-484 (2015).
    • (2015) Diabetes , vol.64 , pp. 471-484
    • Roberts, L.D.1
  • 34
    • 84920052826 scopus 로고    scopus 로고
    • Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
    • Gnad, T. et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 516, 395-399 (2014).
    • (2014) Nature , vol.516 , pp. 395-399
    • Gnad, T.1
  • 35
    • 84867564026 scopus 로고    scopus 로고
    • Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
    • Fedorenko, A., Lishko, P. V. & Kirichok, Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 151, 400-413 (2012).
    • (2012) Cell , vol.151 , pp. 400-413
    • Fedorenko, A.1    Lishko, P.V.2    Kirichok, Y.3
  • 36
    • 84947718853 scopus 로고    scopus 로고
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
    • Whittle, A. J. et al. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat. Commun. 6, 8951 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8951
    • Whittle, A.J.1
  • 37
    • 84963946899 scopus 로고    scopus 로고
    • Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation
    • Krott, L. M. et al. Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation. J. Lipid Res. 57, 464-473 (2016).
    • (2016) J. Lipid Res. , vol.57 , pp. 464-473
    • Krott, L.M.1
  • 38
    • 84919779595 scopus 로고    scopus 로고
    • Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity
    • Boon, M. R. et al. Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity. FASEB J. 28, 5361-5375 (2014).
    • (2014) FASEB J. , vol.28 , pp. 5361-5375
    • Boon, M.R.1
  • 39
    • 84960510127 scopus 로고    scopus 로고
    • The Gq signalling pathway inhibits brown and beige adipose tissue
    • Klepac, K. et al. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat. Commun. 7, 10895 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10895
    • Klepac, K.1
  • 40
    • 84875867013 scopus 로고    scopus 로고
    • Bone morphogenic proteins signaling in adipogenesis and energy homeostasis
    • Modica, S. & Wolfrum, C. Bone morphogenic proteins signaling in adipogenesis and energy homeostasis. Biochim. Biophys. Acta 1831, 915-923 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 915-923
    • Modica, S.1    Wolfrum, C.2
  • 41
    • 50049127055 scopus 로고    scopus 로고
    • New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    • Tseng, Y. H. et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008).
    • (2008) Nature , vol.454 , pp. 1000-1004
    • Tseng, Y.H.1
  • 42
    • 84874450879 scopus 로고    scopus 로고
    • BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
    • Qian, S. W. et al. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc. Natl Acad. Sci. USA 110, E798-E807 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E798-E807
    • Qian, S.W.1
  • 43
    • 79958242398 scopus 로고    scopus 로고
    • Emerging roles for the transforming growth factor-superfamily in regulating adiposity and energy expenditure
    • Zamani, N. & Brown, C. W. Emerging roles for the transforming growth factor-superfamily in regulating adiposity and energy expenditure. Endocr. Rev. 32, 387-403 (2011).
    • (2011) Endocr. Rev. , vol.32 , pp. 387-403
    • Zamani, N.1    Brown, C.W.2
  • 44
    • 84881511710 scopus 로고    scopus 로고
    • Regulation of brown adipogenesis by the Tgf-family: Involvement of Srebp1c in Tgf-and Activin-induced inhibition of adipogenesis
    • Yoshida, H. et al. Regulation of brown adipogenesis by the Tgf-family: involvement of Srebp1c in Tgf-and Activin-induced inhibition of adipogenesis. Biochim. Biophys. Acta 1830, 5027-5035 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 5027-5035
    • Yoshida, H.1
  • 45
    • 84891826484 scopus 로고    scopus 로고
    • Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio
    • Schleinitz, D. et al. Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio. Int. J. Obes. (Lond.) 38, 120-125 (2014).
    • (2014) Int. J. Obes. (Lond.) , vol.38 , pp. 120-125
    • Schleinitz, D.1
  • 46
    • 84875367849 scopus 로고    scopus 로고
    • Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
    • Schulz, T. J. et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 495, 379-383 (2013).
    • (2013) Nature , vol.495 , pp. 379-383
    • Schulz, T.J.1
  • 47
    • 78651094465 scopus 로고    scopus 로고
    • Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
    • Schulz, T. J. et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc. Natl Acad. Sci. USA 108, 143-148 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 143-148
    • Schulz, T.J.1
  • 48
    • 64349121056 scopus 로고    scopus 로고
    • Transcriptional control of brown adipocyte development and physiological function-of mice and men
    • Seale, P., Kajimura, S. & Spiegelman, B. M. Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev. 23, 788-797 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 788-797
    • Seale, P.1    Kajimura, S.2    Spiegelman, B.M.3
  • 49
    • 84879548972 scopus 로고    scopus 로고
    • Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1-and CD36-mediated fatty acid uptake
    • Townsend, K. L. et al. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1-and CD36-mediated fatty acid uptake. Antioxid. Redox Signal 19, 243-257 (2013).
    • (2013) Antioxid. Redox Signal , vol.19 , pp. 243-257
    • Townsend, K.L.1
  • 50
    • 84860897594 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
    • Townsend, K. L. et al. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J. 26, 2187-2196 (2012).
    • (2012) FASEB J. , vol.26 , pp. 2187-2196
    • Townsend, K.L.1
  • 51
    • 33847773447 scopus 로고    scopus 로고
    • A role for bone morphogenetic protein-4 in adipocyte development
    • Bowers, R. R. & Lane, M. D. A role for bone morphogenetic protein-4 in adipocyte development. Cell Cycle 6, 385-389 (2007).
    • (2007) Cell Cycle , vol.6 , pp. 385-389
    • Bowers, R.R.1    Lane, M.D.2
  • 52
    • 84894030350 scopus 로고    scopus 로고
    • Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes
    • Xue, R. et al. Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes. Am. J. Physiol. Endocrinol. Metab. 306, E363-E372 (2014).
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E363-E372
    • Xue, R.1
  • 53
    • 84899461858 scopus 로고    scopus 로고
    • BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells
    • Elsen, M. et al. BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells. Am. J. Physiol. Cell Physiol. 306, C431-C440 (2014).
    • (2014) Am. J. Physiol. Cell Physiol. , vol.306 , pp. C431-C440
    • Elsen, M.1
  • 54
    • 84929657663 scopus 로고    scopus 로고
    • BMP4 and BMP antagonists regulate human white and beige adipogenesis
    • Gustafson, B. et al. BMP4 and BMP antagonists regulate human white and beige adipogenesis. Diabetes 64, 1670-1681 (2015).
    • (2015) Diabetes , vol.64 , pp. 1670-1681
    • Gustafson, B.1
  • 56
    • 84921325005 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: A powerful osteoinductive compound with non-negligible side effects and limitations
    • Oryan, A., Alidadi, S., Moshiri, A. & Bigham-Sadegh, A. Bone morphogenetic proteins: a powerful osteoinductive compound with non-negligible side effects and limitations. Biofactors 40, 459-481 (2014).
    • (2014) Biofactors , vol.40 , pp. 459-481
    • Oryan, A.1    Alidadi, S.2    Moshiri, A.3    Bigham-Sadegh, A.4
  • 57
    • 84860850964 scopus 로고    scopus 로고
    • BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
    • Whittle, A. J. et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149, 871-885 (2012).
    • (2012) Cell , vol.149 , pp. 871-885
    • Whittle, A.J.1
  • 58
    • 84926632666 scopus 로고    scopus 로고
    • Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice
    • Grefhorst, A. et al. Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice. Biol. Sex. Differ. 6, 7 (2015).
    • (2015) Biol. Sex. Differ. , vol.6 , pp. 7
    • Grefhorst, A.1
  • 59
    • 84891783225 scopus 로고    scopus 로고
    • Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure
    • Hinoi, E. et al. Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure. Diabetes 63, 162-175 (2014).
    • (2014) Diabetes , vol.63 , pp. 162-175
    • Hinoi, E.1
  • 60
    • 84893711097 scopus 로고    scopus 로고
    • BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity
    • Kuo, M. M. et al. BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity. Biomaterials 35, 3172-3179 (2014).
    • (2014) Biomaterials , vol.35 , pp. 3172-3179
    • Kuo, M.M.1
  • 61
    • 84862740881 scopus 로고    scopus 로고
    • A novel therapeutic approach to treating obesity through modulation of TGF signaling
    • Koncarevic, A. et al. A novel therapeutic approach to treating obesity through modulation of TGF signaling. Endocrinology 153, 3133-3146 (2012).
    • (2012) Endocrinology , vol.153 , pp. 3133-3146
    • Koncarevic, A.1
  • 62
    • 79959933148 scopus 로고    scopus 로고
    • Protection from obesity and diabetes by blockade of TGF-/Smad3 signaling
    • Yadav, H. et al. Protection from obesity and diabetes by blockade of TGF-/Smad3 signaling. Cell Metab. 14, 67-79 (2011).
    • (2011) Cell Metab. , vol.14 , pp. 67-79
    • Yadav, H.1
  • 63
    • 84863992227 scopus 로고    scopus 로고
    • Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism
    • Fournier, B. et al. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol. Cell. Biol. 32, 2871-2879 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 2871-2879
    • Fournier, B.1
  • 64
    • 84961792763 scopus 로고    scopus 로고
    • AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue
    • Steculorum, S. M. et al. AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue. Cell 165, 125-138 (2016).
    • (2016) Cell , vol.165 , pp. 125-138
    • Steculorum, S.M.1
  • 65
    • 84881375503 scopus 로고    scopus 로고
    • Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
    • Braga, M., Pervin, S., Norris, K., Bhasin, S. & Singh, R. Inhibition of in vitro and in vivo brown fat differentiation program by myostatin. Obesity (Silver Spring) 21, 1180-1188 (2013).
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 1180-1188
    • Braga, M.1    Pervin, S.2    Norris, K.3    Bhasin, S.4    Singh, R.5
  • 66
    • 84894734673 scopus 로고    scopus 로고
    • Follistatin promotes adipocyte differentiation, browning, and energy metabolism
    • Braga, M. et al. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J. Lipid Res. 55, 375-384 (2014).
    • (2014) J. Lipid Res. , vol.55 , pp. 375-384
    • Braga, M.1
  • 68
    • 82555186955 scopus 로고    scopus 로고
    • Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    • Nguyen, K. D. et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480, 104-108 (2011).
    • (2011) Nature , vol.480 , pp. 104-108
    • Nguyen, K.D.1
  • 69
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda, H. et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116, 1494-1505 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1494-1505
    • Kanda, H.1
  • 70
    • 0034608894 scopus 로고    scopus 로고
    • Tumor necrosis factor mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity
    • Nisoli, E. et al. Tumor necrosis factor mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc. Natl Acad. Sci. USA 97, 8033-8038 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 8033-8038
    • Nisoli, E.1
  • 71
    • 84946550475 scopus 로고    scopus 로고
    • Proinflammatory cytokine interleukin-1 suppresses cold-induced thermogenesis in adipocytes
    • Goto, T. et al. Proinflammatory cytokine interleukin-1 suppresses cold-induced thermogenesis in adipocytes. Cytokine 77, 107-114 (2016).
    • (2016) Cytokine , vol.77 , pp. 107-114
    • Goto, T.1
  • 72
    • 0033521694 scopus 로고    scopus 로고
    • Tumor necrosis factor-regulates in vivo expression of the rat UCP family differentially
    • Masaki, T. et al. Tumor necrosis factor-regulates in vivo expression of the rat UCP family differentially. Biochim. Biophys. Acta 1436, 585-592 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1436 , pp. 585-592
    • Masaki, T.1
  • 73
    • 73649094118 scopus 로고    scopus 로고
    • Deletion of tumor necrosis factor-receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
    • Romanatto, T. et al. Deletion of tumor necrosis factor-receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J. Biol. Chem. 284, 36213-36222 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 36213-36222
    • Romanatto, T.1
  • 74
    • 0343035670 scopus 로고    scopus 로고
    • Adrenergic stimulation of interleukin-1 and interleukin-6 expression in mouse brown adipocytes
    • Burysek, L. & Houstek, J.-Adrenergic stimulation of interleukin-1 and interleukin-6 expression in mouse brown adipocytes. FEBS Lett. 411, 83-86 (1997).
    • (1997) FEBS Lett , vol.411 , pp. 83-86
    • Burysek, L.1    Houstek, J.2
  • 75
    • 84907896485 scopus 로고    scopus 로고
    • Nuclear factor-B is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate
    • Hinoi, E., Iezaki, T., Ozaki, K. & Yoneda, Y. Nuclear factor-B is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate. Biochem. Biophys. Res. Commun. 452, 974-979 (2014).
    • (2014) Biochem. Biophys. Res. Commun. , vol.452 , pp. 974-979
    • Hinoi, E.1    Iezaki, T.2    Ozaki, K.3    Yoneda, Y.4
  • 76
    • 84924969384 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    • Brestoff, J. R. et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015).
    • (2015) Nature , vol.519 , pp. 242-246
    • Brestoff, J.R.1
  • 77
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu, Y. et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308 (2014).
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1
  • 78
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu, D. et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243-247 (2011).
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1
  • 79
    • 84920940721 scopus 로고    scopus 로고
    • Activated type 2 innate lymphoid cells regulate beige fat biogenesis
    • Lee, M. W. et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015).
    • (2015) Cell , vol.160 , pp. 74-87
    • Lee, M.W.1
  • 80
    • 84902097377 scopus 로고    scopus 로고
    • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
    • Rao, R. R. et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157, 1279-1291 (2014).
    • (2014) Cell , vol.157 , pp. 1279-1291
    • Rao, R.R.1
  • 81
    • 84938747174 scopus 로고    scopus 로고
    • Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation
    • Hui, X. et al. Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation. Cell Metab. 22, 279-290 (2015).
    • (2015) Cell Metab. , vol.22 , pp. 279-290
    • Hui, X.1
  • 82
    • 0022366443 scopus 로고
    • Potential of brown adipose tissue type II thyroxine 5-deiodinase as a local and systemic source of triiodothyronine in rats
    • Silva, J. E. & Larsen, P. R. Potential of brown adipose tissue type II thyroxine 5-deiodinase as a local and systemic source of triiodothyronine in rats. J. Clin. Invest. 76, 2296-2305 (1985).
    • (1985) J. Clin. Invest. , vol.76 , pp. 2296-2305
    • Silva, J.E.1    Larsen, P.R.2
  • 83
    • 0020509014 scopus 로고
    • Adrenergic activation of triiodothyronine production in brown adipose tissue
    • Silva, J. E. & Larsen, P. R. Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305, 712-713 (1983).
    • (1983) Nature , vol.305 , pp. 712-713
    • Silva, J.E.1    Larsen, P.R.2
  • 84
    • 0023628919 scopus 로고
    • Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation
    • Bianco, A. C. & Silva, J. E. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am. J. Physiol. 253, E255-E263 (1987).
    • (1987) Am. J. Physiol. , vol.253 , pp. E255-E263
    • Bianco, A.C.1    Silva, J.E.2
  • 85
    • 0023113587 scopus 로고
    • Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat
    • Fernandez, J. A., Mampel, T., Villarroya, F. & Iglesias, R. Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat. Biochem. J. 243, 281-284 (1987).
    • (1987) Biochem. J. , vol.243 , pp. 281-284
    • Fernandez, J.A.1    Mampel, T.2    Villarroya, F.3    Iglesias, R.4
  • 86
    • 84857408775 scopus 로고    scopus 로고
    • Reversal of type 1 diabetes in mice by brown adipose tissue transplant
    • Gunawardana, S. C. & Piston, D. W. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 61, 674-682 (2012).
    • (2012) Diabetes , vol.61 , pp. 674-682
    • Gunawardana, S.C.1    Piston, D.W.2
  • 87
    • 84931045954 scopus 로고    scopus 로고
    • Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant
    • Gunawardana, S. C. & Piston, D. W. Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant. Am. J. Physiol. Endocrinol. Metab. 308, E1043-E1055 (2015).
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.308 , pp. E1043-E1055
    • Gunawardana, S.C.1    Piston, D.W.2
  • 88
    • 84878678150 scopus 로고    scopus 로고
    • Brown adipose tissue transplantation improves whole-body energy metabolism
    • Liu, X. et al. Brown adipose tissue transplantation improves whole-body energy metabolism. Cell Res. 23, 851-854 (2013).
    • (2013) Cell Res. , vol.23 , pp. 851-854
    • Liu, X.1
  • 89
    • 84873854027 scopus 로고    scopus 로고
    • Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
    • Stanford, K. I. et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J. Clin. Invest. 123, 215-223 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 215-223
    • Stanford, K.I.1
  • 90
    • 84937567570 scopus 로고    scopus 로고
    • Brown adipose tissue transplantation reverses obesity in ob/ob mice
    • Liu, X. et al. Brown adipose tissue transplantation reverses obesity in ob/ob mice. Endocrinology 156, 2461-2469 (2015).
    • (2015) Endocrinology , vol.156 , pp. 2461-2469
    • Liu, X.1
  • 91
    • 84889674445 scopus 로고    scopus 로고
    • Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation)
    • Zhu, Z. et al. Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation). Physiol. Behav 125, 21-29 (2014).
    • (2014) Physiol. Behav , vol.125 , pp. 21-29
    • Zhu, Z.1
  • 92
    • 84940707952 scopus 로고    scopus 로고
    • A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis
    • Stanford, K. I. et al. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes 64, 2002-2014 (2015).
    • (2015) Diabetes , vol.64 , pp. 2002-2014
    • Stanford, K.I.1
  • 93
    • 84955587698 scopus 로고    scopus 로고
    • Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice
    • Min, S. Y. et al. Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat. Med. 22, 312-318 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 312-318
    • Min, S.Y.1
  • 94
    • 84930201353 scopus 로고    scopus 로고
    • Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy
    • Thoonen, R. et al. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. J. Mol. Cell. Cardiol. 84, 202-211 (2015).
    • (2015) J. Mol. Cell. Cardiol. , vol.84 , pp. 202-211
    • Thoonen, R.1
  • 95
    • 84960922284 scopus 로고    scopus 로고
    • Brown adipose tissue transplantation ameliorates polycystic ovary syndrome
    • Yuan, X. et al. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proc. Natl Acad. Sci. USA 113, 2708-2713 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 2708-2713
    • Yuan, X.1
  • 97
    • 84911917697 scopus 로고    scopus 로고
    • Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
    • Markan, K. R. et al. Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Diabetes 63, 4057-4066 (2014).
    • (2014) Diabetes , vol.63 , pp. 4057-4066
    • Markan, K.R.1
  • 98
    • 79960743932 scopus 로고    scopus 로고
    • Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
    • Chartoumpekis, D. V. et al. Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol. Med. 17, 736-740 (2011).
    • (2011) Mol. Med. , vol.17 , pp. 736-740
    • Chartoumpekis, D.V.1
  • 99
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares, E. et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 286, 12983-12990 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 12983-12990
    • Hondares, E.1
  • 100
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
    • Fisher, F. M. et al. FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 271-281
    • Fisher, F.M.1
  • 101
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPAR in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares, E. et al. Hepatic FGF21 expression is induced at birth via PPAR in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11, 206-212 (2010).
    • (2010) Cell Metab. , vol.11 , pp. 206-212
    • Hondares, E.1
  • 102
    • 84931577787 scopus 로고    scopus 로고
    • Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
    • Keipert, S. et al. Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion. Mol. Metab. 4, 537-542 (2015).
    • (2015) Mol. Metab. , vol.4 , pp. 537-542
    • Keipert, S.1
  • 103
    • 84929708081 scopus 로고    scopus 로고
    • Discrete aspects of FGF21 in vivo pharmacology do not require UCP1
    • Samms, R. J. et al. Discrete aspects of FGF21 in vivo pharmacology do not require UCP1. Cell Rep. 11, 991-999 (2015).
    • (2015) Cell Rep. , vol.11 , pp. 991-999
    • Samms, R.J.1
  • 104
    • 84899516860 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
    • Keipert, S. et al. Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am. J. Physiol. Endocrinol. Metab. 306, E469-E482 (2014).
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E469-E482
    • Keipert, S.1
  • 105
    • 84907211065 scopus 로고    scopus 로고
    • FGF21 expression and release in muscle cells: Involvement of MyoD and regulation by mitochondria-driven signalling
    • Ribas, F., Villarroya, J., Hondares, E., Giralt, M. & Villarroya, F. FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. Biochem. J. 463, 191-199 (2014).
    • (2014) Biochem. J. , vol.463 , pp. 191-199
    • Ribas, F.1    Villarroya, J.2    Hondares, E.3    Giralt, M.4    Villarroya, F.5
  • 106
    • 80051667626 scopus 로고    scopus 로고
    • FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: A diagnostic study
    • Suomalainen, A. et al. FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol. 10, 806-818 (2011).
    • (2011) Lancet Neurol. , vol.10 , pp. 806-818
    • Suomalainen, A.1
  • 107
    • 84930579383 scopus 로고    scopus 로고
    • Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue
    • Veniant, M. M. et al. Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue. Cell Metab. 21, 731-738 (2015).
    • (2015) Cell Metab. , vol.21 , pp. 731-738
    • Veniant, M.M.1
  • 108
    • 84962741845 scopus 로고    scopus 로고
    • Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle
    • Ikeda, S. I. et al. Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem. Biophys. Res. Commun. 473, 947-952 (2016).
    • (2016) Biochem. Biophys. Res. Commun. , vol.473 , pp. 947-952
    • Ikeda, S.I.1
  • 109
    • 84899124414 scopus 로고    scopus 로고
    • Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
    • Mauer, J. et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat. Immunol. 15, 423-430 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 423-430
    • Mauer, J.1
  • 110
    • 84897042421 scopus 로고    scopus 로고
    • Role of IL-6 in exercise training-and cold-induced UCP1 expression in subcutaneous white adipose tissue
    • Knudsen, J. G. et al. Role of IL-6 in exercise training-and cold-induced UCP1 expression in subcutaneous white adipose tissue. PLoS ONE 9, e84910 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e84910
    • Knudsen, J.G.1
  • 111
    • 84900554165 scopus 로고    scopus 로고
    • Brown and white adipose tissues: Intrinsic differences in gene expression and response to cold exposure in mice
    • Rosell, M. et al. Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice. Am. J. Physiol. Endocrinol. Metab. 306, E945-E964 (2014).
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.306 , pp. E945-E964
    • Rosell, M.1
  • 112
    • 84920617544 scopus 로고    scopus 로고
    • The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
    • Wang, G. X. et al. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nat. Med. 20, 1436-1443 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1436-1443
    • Wang, G.X.1
  • 113
    • 84880652296 scopus 로고    scopus 로고
    • Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton
    • Rahman, S. et al. Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton. Endocrinology 154, 2687-2701 (2013).
    • (2013) Endocrinology , vol.154 , pp. 2687-2701
    • Rahman, S.1
  • 114
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • Yang, Q. et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436, 356-362 (2005).
    • (2005) Nature , vol.436 , pp. 356-362
    • Yang, Q.1
  • 115
    • 84857410594 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors-and-, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue
    • Rosell, M. et al. Peroxisome proliferator-activated receptors-and-, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue. Endocrinology 153, 1162-1173 (2012).
    • (2012) Endocrinology , vol.153 , pp. 1162-1173
    • Rosell, M.1
  • 116
    • 85027909934 scopus 로고    scopus 로고
    • Adipose tissue browning and metabolic health
    • Bartelt, A. & Heeren, J. Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 10, 24-36 (2014).
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 24-36
    • Bartelt, A.1    Heeren, J.2
  • 117
    • 84872493616 scopus 로고    scopus 로고
    • Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family
    • Fu, Z., Yao, F., Abou-Samra, A. B. & Zhang, R. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem. Biophys. Res. Commun. 430, 1126-1131 (2013).
    • (2013) Biochem. Biophys. Res. Commun. , vol.430 , pp. 1126-1131
    • Fu, Z.1    Yao, F.2    Abou-Samra, A.B.3    Zhang, R.4
  • 118
    • 84874976157 scopus 로고    scopus 로고
    • Emerging roles of lipasin as a critical lipid regulator
    • Zhang, R. & Abou-Samra, A. B. Emerging roles of lipasin as a critical lipid regulator. Biochem. Biophys. Res. Commun. 432, 401-405 (2013).
    • (2013) Biochem. Biophys. Res. Commun. , vol.432 , pp. 401-405
    • Zhang, R.1    Abou-Samra, A.B.2
  • 119
    • 84877707122 scopus 로고    scopus 로고
    • Betatrophin: A hormone that controls pancreatic cell proliferation
    • Yi, P., Park, J. S. & Melton, D. A. Betatrophin: a hormone that controls pancreatic cell proliferation. Cell 153, 747-758 (2013).
    • (2013) Cell , vol.153 , pp. 747-758
    • Yi, P.1    Park, J.S.2    Melton, D.A.3
  • 120
    • 84908331466 scopus 로고    scopus 로고
    • ANGPTL8/betatrophin does not control pancreatic cell expansion
    • Gusarova, V. et al. ANGPTL8/betatrophin does not control pancreatic cell expansion. Cell 159, 691-696 (2014).
    • (2014) Cell , vol.159 , pp. 691-696
    • Gusarova, V.1
  • 121
    • 84954180388 scopus 로고    scopus 로고
    • Brown adipose YY1 deficiency activates expression of secreted proteins linked to energy expenditure and prevents diet-induced obesity
    • Verdeguer, F. et al. Brown adipose YY1 deficiency activates expression of secreted proteins linked to energy expenditure and prevents diet-induced obesity. Mol. Cell. Biol. 36, 184-196 (2015).
    • (2015) Mol. Cell. Biol. , vol.36 , pp. 184-196
    • Verdeguer, F.1
  • 122
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • Sharp, L. Z. et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 7, e49452 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e49452
    • Sharp, L.Z.1
  • 124
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 125
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • Dushay, J. et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139, 456-463 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 456-463
    • Dushay, J.1
  • 126
    • 84894058844 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue
    • Hondares, E. et al. Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. Metabolism 63, 312-317 (2014).
    • (2014) Metabolism , vol.63 , pp. 312-317
    • Hondares, E.1
  • 127
    • 84959510077 scopus 로고    scopus 로고
    • Searching for classical brown fat in humans: Development of a novel human fetal brown stem cell model
    • Di Franco, A. et al. Searching for classical brown fat in humans: development of a novel human fetal brown stem cell model. Stem Cells 34, 1679-1691 (2016).
    • (2016) Stem Cells , vol.34 , pp. 1679-1691
    • Di Franco, A.1
  • 128
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee, P. et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 19, 302-309 (2014).
    • (2014) Cell Metab. , vol.19 , pp. 302-309
    • Lee, P.1
  • 129
    • 84929415426 scopus 로고    scopus 로고
    • Serum FGF21 levels are associated with brown adipose tissue activity in humans
    • Hanssen, M. J. et al. Serum FGF21 levels are associated with brown adipose tissue activity in humans. Sci. Rep. 5, 10275 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 10275
    • Hanssen, M.J.1
  • 130
    • 84877263632 scopus 로고    scopus 로고
    • A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
    • Jespersen, N. Z. et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab. 17, 798-805 (2013).
    • (2013) Cell Metab. , vol.17 , pp. 798-805
    • Jespersen, N.Z.1
  • 131
    • 77950296018 scopus 로고    scopus 로고
    • Transplantation of adipose tissue and stem cells: Role in metabolism and disease
    • Tran, T. T. & Kahn, C. R. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat. Rev. Endocrinol. 6, 195-213 (2010).
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 195-213
    • Tran, T.T.1    Kahn, C.R.2
  • 132
    • 84960895375 scopus 로고    scopus 로고
    • A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function
    • Svensson, K. J. et al. A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function. Cell Metab. 23, 454-466 (2016).
    • (2016) Cell Metab. , vol.23 , pp. 454-466
    • Svensson, K.J.1


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