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Volumn 7, Issue , 2016, Pages

The G q signalling pathway inhibits brown and beige adipose tissue

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN; G PROTEIN COUPLED RECEPTOR; UNCOUPLING PROTEIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; ION CHANNEL; MITOCHONDRIAL PROTEIN; UCP1 PROTEIN, HUMAN; UCP1 PROTEIN, MOUSE;

EID: 84960510127     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10895     Document Type: Article
Times cited : (96)

References (45)
  • 1
    • 84920841451 scopus 로고    scopus 로고
    • Brown beige, and white: The new color code of fat and its pharmacological implications
    • Pfeifer, A. & Hoffmann, L. S. Brown, beige, and white: the new color code of fat and its pharmacological implications. Annu. Rev. Pharmacol. Toxicol. 55, 207-227 (2015).
    • (2015) Annu. Rev. Pharmacol. Toxicol , vol.55 , pp. 207-227
    • Pfeifer, A.1    Hoffmann, L.S.2
  • 2
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • Rosen, E. D. & Spiegelman, B. M. What we talk about when we talk about fat. Cell 156, 20-44 (2014).
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 3
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: Development, function and therapeutic potential
    • Harms, M. & Seale, P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252-1263 (2013).
    • (2013) Nat. Med , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 4
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
    • (2004) Physiol. Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 5
    • 84894132767 scopus 로고    scopus 로고
    • A new era in brown adipose tissue biology: Molecular control of brown fat development and energy homeostasis
    • Kajimura, S. & Saito, M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu. Rev. Physiol. 76, 225-249 (2013).
    • (2013) Annu. Rev. Physiol , vol.76 , pp. 225-249
    • Kajimura, S.1    Saito, M.2
  • 6
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen, K. A., et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 7
    • 64349095231 scopus 로고    scopus 로고
    • Cold-Activated brown adipose tissue in healthy men
    • Van Marken Lichtenbelt, W. D., et al. Cold-Activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 1500-1508
    • Van Marken Lichtenbelt, W.D.1
  • 9
    • 70350443275 scopus 로고    scopus 로고
    • Transdifferentiation properties of adipocytes in the adipose organ
    • Cinti, S. Transdifferentiation properties of adipocytes in the adipose organ. Am. J. Physiol. Endocrinol. Metab. 297, E977-E986 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297 , pp. E977-E986
    • Cinti, S.1
  • 10
    • 77950190436 scopus 로고    scopus 로고
    • Distribution and development of brown adipocytes in the murine and human adipose organ
    • Frontini, A. & Cinti, S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell. Metab. 11, 253-256 (2010).
    • (2010) Cell. Metab , vol.11 , pp. 253-256
    • Frontini, A.1    Cinti, S.2
  • 11
    • 79954425389 scopus 로고    scopus 로고
    • Structural insights into adrenergic receptor function and pharmacology
    • Kobilka, B. K. Structural insights into adrenergic receptor function and pharmacology. Trends. Pharmacol. Sci. 32, 213-218 (2011).
    • (2011) Trends. Pharmacol. Sci , vol.32 , pp. 213-218
    • Kobilka, B.K.1
  • 12
    • 34147137118 scopus 로고    scopus 로고
    • Seven transmembrane receptors: Something old, something new
    • Lefkowitz, R. J. Seven transmembrane receptors: something old, something new. Acta Physiol. (Oxf.) 190, 9-19 (2007).
    • (2007) Acta Physiol. (Oxf , vol.190 , pp. 9-19
    • Lefkowitz, R.J.1
  • 14
    • 25444482429 scopus 로고    scopus 로고
    • Mammalian G proteins and their cell type specific functions
    • Wettschureck, N. & Offermanns, S. Mammalian G proteins and their cell type specific functions. Physiol. Rev. 85, 1159-1204 (2005).
    • (2005) Physiol. Rev , vol.85 , pp. 1159-1204
    • Wettschureck, N.1    Offermanns, S.2
  • 15
    • 0037205055 scopus 로고    scopus 로고
    • G protein pathways
    • Neves, S. R., Ram, P. T. & Iyengar, R. G protein pathways. Science 296, 1636-1639 (2002).
    • (2002) Science , vol.296 , pp. 1636-1639
    • Neves, S.R.1    Ram, P.T.2    Iyengar, R.3
  • 16
    • 0028973505 scopus 로고
    • G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
    • Buhl, A. M., Johnson, N. L., Dhanasekaran, N. & Johnson, G. L. G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J. Biol. Chem. 270, 24631-24634 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 24631-24634
    • Buhl, A.M.1    Johnson, N.L.2    Dhanasekaran, N.3    Johnson, G.L.4
  • 17
    • 84885336217 scopus 로고    scopus 로고
    • In brown adipocytes, adrenergically induced beta 1)-/beta 3)-(Gs)-, alpha(2)-(Gi)- and alpha(1)-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation
    • Wang, Y., Falting, J. M., Mattsson, C. L., Holmstrom, T. E. & Nedergaard, J. In brown adipocytes, adrenergically induced beta(1)-/beta(3)-(Gs)-, alpha(2)-(Gi)- and alpha(1)-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation. Exp. Cell Res. 319, 2718-2727 (2013).
    • (2013) Exp. Cell Res. , vol.319 , pp. 2718-2727
    • Wang, Y.1    Falting, J.M.2    Mattsson, C.L.3    Holmstrom, T.E.4    Nedergaard, J.5
  • 18
    • 84920052826 scopus 로고    scopus 로고
    • Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
    • Gnad, T., et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 516, 395-399 (2014).
    • (2014) Nature , vol.516 , pp. 395-399
    • Gnad, T.1
  • 19
    • 84876350392 scopus 로고    scopus 로고
    • IUPHAR-DB: Updated database content and new features
    • Sharman, J. L., et al. IUPHAR-DB: updated database content and new features. Nucleic Acids Res. 41, D1083-D1088 (2013).
    • (2013) Nucleic Acids Res , vol.41 , pp. D1083-D1088
    • Sharman, J.L.1
  • 20
    • 84984911801 scopus 로고    scopus 로고
    • The experimental power of FR900359 to study Gq-regulated biological processes
    • Schrage, R., et al. The experimental power of FR900359 to study Gq-regulated biological processes. Nat. Commun. 6, 10156 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 10156
    • Schrage, R.1
  • 21
    • 48449105746 scopus 로고    scopus 로고
    • Engineering GPCR signalling pathways with RASSLs
    • Conklin, B. R., et al. Engineering GPCR signalling pathways with RASSLs. Nat. Methods 5, 673-678 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 673-678
    • Conklin, B.R.1
  • 22
    • 34247640671 scopus 로고    scopus 로고
    • Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
    • Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S. & Roth, B. L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl Acad. Sci. USA 104, 5163-5168 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5163-5168
    • Armbruster, B.N.1    Li, X.2    Pausch, M.H.3    Herlitze, S.4    Roth, B.L.5
  • 24
    • 0028981870 scopus 로고
    • Endothelin-1, but not endothelin-3, suppresses lipoprotein lipase gene expression in brown adipocytes differentiated in culture
    • Uchida, Y., et al. Endothelin-1, but not endothelin-3, suppresses lipoprotein lipase gene expression in brown adipocytes differentiated in culture. Eur. J. Pharmacol. 291, 33-41 (1995).
    • (1995) Eur. J. Pharmacol , vol.291 , pp. 33-41
    • Uchida, Y.1
  • 25
    • 0026630131 scopus 로고
    • Regulation of expression of the lipoprotein lipase gene in brown adipose tissue
    • Mitchell, J. R., et al. Regulation of expression of the lipoprotein lipase gene in brown adipose tissue. Am. J. Physiol. 263, E500-E506 (1992).
    • (1992) Am. J. Physiol , vol.263 , pp. E500-E506
    • Mitchell, J.R.1
  • 26
    • 77950361100 scopus 로고    scopus 로고
    • Protein kinase g controls brown fat cell differentiation and mitochondrial biogenesis
    • Haas, B., et al. Protein kinase g controls brown fat cell differentiation and mitochondrial biogenesis. Sci. Signal. 2, ra78 (2009).
    • (2009) Sci. Signal , vol.2 , pp. ra78
    • Haas, B.1
  • 27
    • 84920945954 scopus 로고    scopus 로고
    • Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes
    • McDonald, M. E., et al. Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Cell 160, 105-118 (2015).
    • (2015) Cell , vol.160 , pp. 105-118
    • McDonald, M.E.1
  • 28
    • 84899755491 scopus 로고    scopus 로고
    • Vascular rarefaction mediates whitening of brown fat in obesity
    • Shimizu, I., et al. Vascular rarefaction mediates whitening of brown fat in obesity. J. Clin. Invest. 124, 2099-2112 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 2099-2112
    • Shimizu, I.1
  • 29
    • 84921296654 scopus 로고    scopus 로고
    • An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue
    • Amisten, S., et al. An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue. Pharmacol. Ther. 146, 61-93 (2015).
    • (2015) Pharmacol. Ther , vol.146 , pp. 61-93
    • Amisten, S.1
  • 30
    • 54549087794 scopus 로고    scopus 로고
    • Anatomical profiling of G protein-coupled receptor expression
    • Regard, J. B., Sato, I. T. & Coughlin, S. R. Anatomical profiling of G protein-coupled receptor expression. Cell 135, 561-571 (2008).
    • (2008) Cell , vol.135 , pp. 561-571
    • Regard, J.B.1    Sato, I.T.2    Coughlin, S.R.3
  • 31
    • 84936773588 scopus 로고    scopus 로고
    • Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes
    • Xue, R., et al. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat. Med. 21, 760-768 (2015).
    • (2015) Nat. Med , vol.21 , pp. 760-768
    • Xue, R.1
  • 32
    • 84867582084 scopus 로고    scopus 로고
    • New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus
    • Pernow, J., Shemyakin, A. & Bohm, F. New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus. Life Sci. 91, 507-516 (2012).
    • (2012) Life Sci , vol.91 , pp. 507-516
    • Pernow, J.1    Shemyakin, A.2    Bohm, F.3
  • 33
    • 84900542024 scopus 로고    scopus 로고
    • Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats
    • Crissey, J. M., et al. Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306, R596-R606 (2014).
    • (2014) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.306 , pp. R596-R606
    • Crissey, J.M.1
  • 34
    • 84859465056 scopus 로고    scopus 로고
    • In vivo identification of bipotential adipocyte progenitors recruited by beta3-Adrenoceptor activation and high-fat feeding
    • Lee, Y. H., Petkova, A. P., Mottillo, E. P. & Granneman, J. G. In vivo identification of bipotential adipocyte progenitors recruited by beta3-Adrenoceptor activation and high-fat feeding. Cell Metab. 15, 480-491 (2012).
    • (2012) Cell Metab , vol.15 , pp. 480-491
    • Lee, Y.H.1    Petkova, A.P.2    Mottillo, E.P.3    Granneman, J.G.4
  • 35
    • 84956650447 scopus 로고    scopus 로고
    • Gq/11alpha and Gsalpha mediate distinct physiological responses to central melanocortins
    • Li, Y. Q., et al. Gq/11alpha and Gsalpha mediate distinct physiological responses to central melanocortins. J. Clin. Invest. 126, 40-49 (2015).
    • (2015) J. Clin. Invest , vol.126 , pp. 40-49
    • Li, Y.Q.1
  • 36
    • 84865693713 scopus 로고    scopus 로고
    • A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes
    • Jennissen, K., et al. A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes. Sci. Signal. 5, ra62 (2012).
    • (2012) Sci. Signal , vol.5 , pp. ra62
    • Jennissen, K.1
  • 37
    • 84877747920 scopus 로고    scopus 로고
    • Mir-155 regulates differentiation of brown and beige adipocytes via a bistable circuit
    • Chen, Y., et al. miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat. Commun. 4, 1769 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 1769
    • Chen, Y.1
  • 38
    • 70350434580 scopus 로고    scopus 로고
    • Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes
    • Elabd, C., et al. Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells 27, 2753-2760 (2009).
    • (2009) Stem Cells , vol.27 , pp. 2753-2760
    • Elabd, C.1
  • 39
    • 84930225128 scopus 로고    scopus 로고
    • Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue
    • Hoffmann, L. S., et al. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat. Commun. 6, 7235 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 7235
    • Hoffmann, L.S.1
  • 40
    • 84885232033 scopus 로고    scopus 로고
    • Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: Relationship with outdoor temperature
    • Betz, M. J., et al. Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature. J. Clin. Endocrinol. Metab. 98, 4097-4104 (2013).
    • (2013) J. Clin. Endocrinol. Metab , vol.98 , pp. 4097-4104
    • Betz, M.J.1
  • 41
    • 84940206953 scopus 로고    scopus 로고
    • G protein-coupled receptor (GPCR) expression in native cells novel endoGPCRs as physiologic regulators and therapeutic targets
    • Insel, P. A., et al. G protein-coupled receptor (GPCR) expression in native cells: navel endoGPCRs as physiologic regulators and therapeutic targets. Mol. Pharmacol. 88, 181-187 (2015).
    • (2015) Mol. Pharmacol , vol.88 , pp. 181-187
    • Insel, P.A.1
  • 42
    • 0026725897 scopus 로고
    • Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells
    • Kalinec, G., Nazarali, A. J., Hermouet, S., Xu, N. & Gutkind, J. S. Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol. Cell. Biol. 12, 4687-4693 (1992).
    • (1992) Mol. Cell. Biol , vol.12 , pp. 4687-4693
    • Kalinec, G.1    Nazarali, A.J.2    Hermouet, S.3    Xu, N.4    Gutkind, J.S.5
  • 43
    • 77956657852 scopus 로고    scopus 로고
    • Deconvolution of complex G protein-coupled receptor signalling in live cells using dynamic mass redistribution measurements
    • Schroder, R., et al. Deconvolution of complex G protein-coupled receptor signalling in live cells using dynamic mass redistribution measurements. Nat. Biotechnol. 28, 943-949 (2010).
    • (2010) Nat. Biotechnol , vol.28 , pp. 943-949
    • Schroder, R.1
  • 44
    • 10344245101 scopus 로고    scopus 로고
    • Lentiviral transgenesis
    • Pfeifer, A. Lentiviral transgenesis. Transgenic. Res. 13, 513-522 (2004).
    • (2004) Transgenic. Res , vol.13 , pp. 513-522
    • Pfeifer, A.1


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