메뉴 건너뛰기




Volumn 40, Issue 5, 2014, Pages 459-481

Bone morphogenetic proteins: A powerful osteoinductive compound with non-negligible side effects and limitations

Author keywords

BMPs substitutes; Bone healing; Bone morphogenetic protein; Bone tissue engineering and regenerative medicine; Delivery system

Indexed keywords

BONE DENSITY CONSERVATION AGENT; BONE MORPHOGENETIC PROTEIN;

EID: 84921325005     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1177     Document Type: Review
Times cited : (127)

References (165)
  • 1
    • 84868210528 scopus 로고    scopus 로고
    • Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds
    • Lee, S. S., Huang, B. J., Kaltz, S. R., Sur, S., Newcomb, C. J., et al. (2013) Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds. Biomaterials 34, 452-459.
    • (2013) Biomaterials , vol.34 , pp. 452-459
    • Lee, S.S.1    Huang, B.J.2    Kaltz, S.R.3    Sur, S.4    Newcomb, C.J.5
  • 2
    • 84899103850 scopus 로고    scopus 로고
    • Current concerns regarding healing of bone defects
    • Oryan, A., Alidadi, S., and Moshiri, A. (2013) Current concerns regarding healing of bone defects. Hard Tissue 2, 13.
    • (2013) Hard Tissue , vol.2 , pp. 13
    • Oryan, A.1    Alidadi, S.2    Moshiri, A.3
  • 3
    • 84895924483 scopus 로고    scopus 로고
    • Biomaterial scaffolds for treating osteoporotic bone
    • Sterling, J. A. and Guelcher, S. A. (2014) Biomaterial scaffolds for treating osteoporotic bone. Curr. Osteoporos. Rep. 12, 48-54.
    • (2014) Curr. Osteoporos. Rep. , vol.12 , pp. 48-54
    • Sterling, J.A.1    Guelcher, S.A.2
  • 4
    • 84872869381 scopus 로고    scopus 로고
    • Autograft versus BMPs for the treatment of non-unions: what is the evidence?
    • Blokhuis, T. J., Calori, G. M., and Schmidmaier, G. (2013) Autograft versus BMPs for the treatment of non-unions: what is the evidence? Injury 44, S40-S42.
    • (2013) Injury , vol.44 , pp. S40-S42
    • Blokhuis, T.J.1    Calori, G.M.2    Schmidmaier, G.3
  • 6
    • 84883513756 scopus 로고    scopus 로고
    • Tendon tissue engineering and its role on healing of the experimentally induced large tendon defect model in rabbits: a comprehensive in vivo study
    • Meimandi-Parizi, A., Oryan, A., and Moshiri A. (2013) Tendon tissue engineering and its role on healing of the experimentally induced large tendon defect model in rabbits: a comprehensive in vivo study. PLoS One 8, e73016.
    • (2013) PLoS One , vol.8 , pp. e73016
    • Meimandi-Parizi, A.1    Oryan, A.2    Moshiri, A.3
  • 7
    • 84877260949 scopus 로고    scopus 로고
    • Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: current concepts, approaches and concerns
    • Moshiri, A. and Oryan, A. (2012) Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: current concepts, approaches and concerns. Hard Tissue 1, 11.
    • (2012) Hard Tissue , vol.1 , pp. 11
    • Moshiri, A.1    Oryan, A.2
  • 8
    • 84896542773 scopus 로고    scopus 로고
    • In vitro characterization of a novel tissue engineered based hybridized nano and micro structured collagen implant and its in vivo role on tenoinduction, tenoconduction, tenogenesis and tenointegration
    • Oryan, A., Moshiri, A., and Meimandi-Parizi, A. (2014) In vitro characterization of a novel tissue engineered based hybridized nano and micro structured collagen implant and its in vivo role on tenoinduction, tenoconduction, tenogenesis and tenointegration. J. Mater. Sci. Mater. Med. 25, 873-897.
    • (2014) J. Mater. Sci. Mater. Med. , vol.25 , pp. 873-897
    • Oryan, A.1    Moshiri, A.2    Meimandi-Parizi, A.3
  • 9
    • 84903982968 scopus 로고    scopus 로고
    • Tendon and ligament tissue engineering, healing and regenerative medicine
    • Moshiri, A. and Oryan, A. (2013) Tendon and ligament tissue engineering, healing and regenerative medicine. J. Sports Med. Doping Stud. 3, 126.
    • (2013) J. Sports Med. Doping Stud. , vol.3 , pp. 126
    • Moshiri, A.1    Oryan, A.2
  • 10
    • 84882890671 scopus 로고    scopus 로고
    • Role of tissue-engineered artificial tendon in healing of a large Achilles tendon defect model in rabbits
    • Moshiri, A., Oryan, A., and Meimandi-Parizi, A. (2013) Role of tissue-engineered artificial tendon in healing of a large Achilles tendon defect model in rabbits. J. Am. Coll. Surg. 217, 421-441.
    • (2013) J. Am. Coll. Surg. , vol.217 , pp. 421-441
    • Moshiri, A.1    Oryan, A.2    Meimandi-Parizi, A.3
  • 11
    • 84863663217 scopus 로고    scopus 로고
    • Shafiei-Sarvestani Z. Effects of adipose tissue stem cell concurrent with greater omentum on experimental long-bone healing in dog
    • Bigham-Sadegh, A., Mirshokraei, P., Karimi, I., Oryan, A., Aparviz, A., et al. (2012) Shafiei-Sarvestani Z. Effects of adipose tissue stem cell concurrent with greater omentum on experimental long-bone healing in dog. Connect. Tissue Res. 53, 334-342.
    • (2012) Connect. Tissue Res. , vol.53 , pp. 334-342
    • Bigham-Sadegh, A.1    Mirshokraei, P.2    Karimi, I.3    Oryan, A.4    Aparviz, A.5
  • 12
    • 84896055608 scopus 로고    scopus 로고
    • Effects of osteogenic medium on healing of the experimental critical bone defect in a rabbit model
    • Oryan, A., Bigham-Sadegh, A., and Abbasi-Teshnizi, F. (2014) Effects of osteogenic medium on healing of the experimental critical bone defect in a rabbit model. Bone 63, 53-60.
    • (2014) Bone , vol.63 , pp. 53-60
    • Oryan, A.1    Bigham-Sadegh, A.2    Abbasi-Teshnizi, F.3
  • 13
    • 84879084602 scopus 로고    scopus 로고
    • The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
    • Zhao, Y. P., Tian, Q. Y., Frenkel, S., and Liu, C. J. (2013) The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials 34, 6412-6421.
    • (2013) Biomaterials , vol.34 , pp. 6412-6421
    • Zhao, Y.P.1    Tian, Q.Y.2    Frenkel, S.3    Liu, C.J.4
  • 14
    • 84899076559 scopus 로고    scopus 로고
    • Bone regenerative medicine: classic options, novel strategies, and future directions
    • Oryan, A., Alidadi, S., Moshiri, A., and Maffulli, N. (2014) Bone regenerative medicine: classic options, novel strategies, and future directions. J. Orthop. Surg. Res. 9, 18.
    • (2014) J. Orthop. Surg. Res. , vol.9 , pp. 18
    • Oryan, A.1    Alidadi, S.2    Moshiri, A.3    Maffulli, N.4
  • 16
    • 80054921573 scopus 로고    scopus 로고
    • Structural and functional modulation of early healing of full-thickness superficial digital flexor tendon rupture in rabbits by repeated subcutaneous administration of exogenous human recombinant basic fibroblast growth factor
    • Moshiri, A. and Oryan, A. (2011) Structural and functional modulation of early healing of full-thickness superficial digital flexor tendon rupture in rabbits by repeated subcutaneous administration of exogenous human recombinant basic fibroblast growth factor. J. Foot Ankle Surg. 50, 654-662.
    • (2011) J. Foot Ankle Surg. , vol.50 , pp. 654-662
    • Moshiri, A.1    Oryan, A.2
  • 17
    • 84905752038 scopus 로고    scopus 로고
    • Recombinant fibroblast growth protein enhances healing ability of experimentally induced tendon injury in vivo
    • Oryan, A. and Moshiri, A. (2014) Recombinant fibroblast growth protein enhances healing ability of experimentally induced tendon injury in vivo. J. Tissue Eng. Regen. Med. 8, 421-431.
    • (2014) J. Tissue Eng. Regen. Med. , vol.8 , pp. 421-431
    • Oryan, A.1    Moshiri, A.2
  • 18
    • 84903987582 scopus 로고    scopus 로고
    • Tissue engineering: alternative option in managing large and massive tissue deficits
    • Oryan, A. and Moshiri, A. (2013) Tissue engineering: alternative option in managing large and massive tissue deficits. Trop. Med. Surg. 1, e101.
    • (2013) Trop. Med. Surg. , vol.1 , pp. e101
    • Oryan, A.1    Moshiri, A.2
  • 20
    • 84896486601 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: facts, challenges, and future perspectives
    • Carreira, A. C., Lojudice, F. H., Halcsik, E., Navarro, R. D., Sogayar, M. C., et al. (2014) Bone morphogenetic proteins: facts, challenges, and future perspectives. J. Dent. Res., ;93, 335-345.
    • (2014) J. Dent. Res. , vol.93 , pp. 335-345
    • Carreira, A.C.1    Lojudice, F.H.2    Halcsik, E.3    Navarro, R.D.4    Sogayar, M.C.5
  • 21
    • 43949119109 scopus 로고    scopus 로고
    • Expression and synthesis of bone morphogenetic proteins by osteoclasts: a possible path to anabolic bone remodeling
    • Garimella, R., Tague, S. E., Zhang, J., Belibi, F., Nahar, N., et al. (2008) Expression and synthesis of bone morphogenetic proteins by osteoclasts: a possible path to anabolic bone remodeling. J. Histochem. Cytochem. 56, 569-577.
    • (2008) J. Histochem. Cytochem. , vol.56 , pp. 569-577
    • Garimella, R.1    Tague, S.E.2    Zhang, J.3    Belibi, F.4    Nahar, N.5
  • 22
    • 84961291392 scopus 로고    scopus 로고
    • BMP-2 modulates expression of other growth factors in a rat fracture healing model
    • Cottrell, J. A., Keane, O., Lin, S. S., and O'Connor, J. P. (2014) BMP-2 modulates expression of other growth factors in a rat fracture healing model. J. Appl. Biomed. 12, 127-135.
    • (2014) J. Appl. Biomed. , vol.12 , pp. 127-135
    • Cottrell, J.A.1    Keane, O.2    Lin, S.S.3    O'Connor, J.P.4
  • 23
    • 84865812434 scopus 로고    scopus 로고
    • Transforming growth factor β1 inhibits bone morphogenetic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? BMC Med
    • Ehnert, S., Zhao, J., Pscherer, S., Freude, T., Dooley, S., et al. (2012) Transforming growth factor β1 inhibits bone morphogenetic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? BMC Med. 10, 101.
    • (2012) 10 , pp. 101
    • Ehnert, S.1    Zhao, J.2    Pscherer, S.3    Freude, T.4    Dooley, S.5
  • 24
    • 84893507545 scopus 로고    scopus 로고
    • Osteogenic molecules for clinical applications: improving the BMP-collagen system
    • Arrabal, P. M., Visser, R., Santos-Ruiz, L., Becerra, J., and Cifuentes, M. (2013) Osteogenic molecules for clinical applications: improving the BMP-collagen system. Biol. Res. 46, 421-429.
    • (2013) Biol. Res. , vol.46 , pp. 421-429
    • Arrabal, P.M.1    Visser, R.2    Santos-Ruiz, L.3    Becerra, J.4    Cifuentes, M.5
  • 25
    • 83455224828 scopus 로고    scopus 로고
    • The effect of BMP-4 loaded in 3D collagen-hyaluronic acid scaffolds on biocompatibility assessed with MG 63 osteoblast-like cells
    • Lungu, A., Titorencu, I., Albu, M. G., Florea, N. M., Vasile, E., et al. (2011) The effect of BMP-4 loaded in 3D collagen-hyaluronic acid scaffolds on biocompatibility assessed with MG 63 osteoblast-like cells. Digest. J. Nanomater. Biostruct. 6, 1897-1908.
    • (2011) Digest. J. Nanomater. Biostruct. , vol.6 , pp. 1897-1908
    • Lungu, A.1    Titorencu, I.2    Albu, M.G.3    Florea, N.M.4    Vasile, E.5
  • 26
    • 84939206962 scopus 로고    scopus 로고
    • Effectiveness of hybridized nano- and microstructure biodegradable
    • biocompatible, collagen-based, three-dimensional bioimplants in repair of a large tendon-defect model in rabbits.
    • Moshiri, A., Oryan, A., Meimandi-Parizi, A., Silver, I. A., Tanideh, N., et al. (2013) Effectiveness of hybridized nano- and microstructure biodegradable, biocompatible, collagen-based, three-dimensional bioimplants in repair of a large tendon-defect model in rabbits.
    • (2013)
    • Moshiri, A.1    Oryan, A.2    Meimandi-Parizi, A.3    Silver, I.A.4    Tanideh, N.5
  • 27
    • 84903696837 scopus 로고    scopus 로고
    • Composite chitosan and calcium sulfate scaffold for dual delivery of vancomycin and recombinant human bone morphogenetic protein-2
    • Doty, H. A., Leedy, M. R., Courtney, H. S., Haggard, W. O., and Bumgardner, J. D. (2014) Composite chitosan and calcium sulfate scaffold for dual delivery of vancomycin and recombinant human bone morphogenetic protein-2. J. Mater. Sci. Mater. Med. 25, 1449-1459.
    • (2014) J. Mater. Sci. Mater. Med. , vol.25 , pp. 1449-1459
    • Doty, H.A.1    Leedy, M.R.2    Courtney, H.S.3    Haggard, W.O.4    Bumgardner, J.D.5
  • 28
    • 84862782801 scopus 로고    scopus 로고
    • Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation
    • Kim, S., Kang, Y., Krueger, C. A., Sen, M., Holcomb, J. B., et al. (2012) Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation. Acta Biomater. 8, 1768-1777.
    • (2012) Acta Biomater. , vol.8 , pp. 1768-1777
    • Kim, S.1    Kang, Y.2    Krueger, C.A.3    Sen, M.4    Holcomb, J.B.5
  • 29
    • 84893832127 scopus 로고    scopus 로고
    • Evaluation of a β-calcium metaphosphate bone graft containing bone morphogenetic protein-7 in rabbit maxillary defects
    • Buranawat, B., Di Silvio, L., Deb, S., Nannmark, U., Sennerby, L., et al. (2014) Evaluation of a β-calcium metaphosphate bone graft containing bone morphogenetic protein-7 in rabbit maxillary defects. J. Periodontol. 85, 298-307.
    • (2014) J. Periodontol. , vol.85 , pp. 298-307
    • Buranawat, B.1    Di Silvio, L.2    Deb, S.3    Nannmark, U.4    Sennerby, L.5
  • 30
    • 84896715986 scopus 로고    scopus 로고
    • Osteoinductivity of gelatin/β-tricalcium phosphate sponges loaded with different concentrations of mesenchymal stem cells and bone morphogenetic protein-2 in an equine bone defect model
    • Seo, J. P., Tsuzuki, N., Haneda, K., Furuoka, H., Tabata, Y., et al. (2014) Osteoinductivity of gelatin/β-tricalcium phosphate sponges loaded with different concentrations of mesenchymal stem cells and bone morphogenetic protein-2 in an equine bone defect model. Vet. Res. Commun. 3, 73-80.
    • (2014) Vet. Res. Commun. , vol.3 , pp. 73-80
    • Seo, J.P.1    Tsuzuki, N.2    Haneda, K.3    Furuoka, H.4    Tabata, Y.5
  • 31
    • 84862794152 scopus 로고    scopus 로고
    • Gentamicin and bone morphogenic protein-2 (BMP-2)-delivering heparinized-titanium implant with enhanced antibacterial activity and osteointegration
    • Lee, D. W., Yun, Y. P., Park, K., and Kim, S. E. (2012) Gentamicin and bone morphogenic protein-2 (BMP-2)-delivering heparinized-titanium implant with enhanced antibacterial activity and osteointegration. Bone 50, 974-982.
    • (2012) Bone , vol.50 , pp. 974-982
    • Lee, D.W.1    Yun, Y.P.2    Park, K.3    Kim, S.E.4
  • 32
    • 84878355765 scopus 로고    scopus 로고
    • Evaluation of collagen/heparin coated TCP/HA granules for long-term delivery of BMP-2
    • Hannink, G., Geutjes, P. J., Daamen, W. F., and Buma, P. (2013) Evaluation of collagen/heparin coated TCP/HA granules for long-term delivery of BMP-2. J. Mater. Sci. Mater. Med. 24, 325-332.
    • (2013) J. Mater. Sci. Mater. Med. , vol.24 , pp. 325-332
    • Hannink, G.1    Geutjes, P.J.2    Daamen, W.F.3    Buma, P.4
  • 33
    • 84876253553 scopus 로고    scopus 로고
    • Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of bone defects
    • Assaf, K., Duek, E. A. R., and Oliveira, N. M. (2013) Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of bone defects. Mater. Res. 16, 215-220.
    • (2013) Mater. Res. , vol.16 , pp. 215-220
    • Assaf, K.1    Duek, E.A.R.2    Oliveira, N.M.3
  • 34
    • 84899444142 scopus 로고    scopus 로고
    • Effect of nano-hydroxyapatite coating on the osteoinductivity of porous biphasic calcium phosphate ceramics
    • Hu, J., Zhou, Y., Huang, L., Liu, J., and Lu, H. (2014) Effect of nano-hydroxyapatite coating on the osteoinductivity of porous biphasic calcium phosphate ceramics. BMC Musculoskelet. Disord. 15, 114.
    • (2014) BMC Musculoskelet. Disord. , vol.15 , pp. 114
    • Hu, J.1    Zhou, Y.2    Huang, L.3    Liu, J.4    Lu, H.5
  • 35
    • 84904307252 scopus 로고    scopus 로고
    • Thoraco-lumbar traumatic vertebral fractures augmentation by osteo-conductive and osteo-inductive bone substitute containing strontium-hydroxyapatite: our experience
    • Masala, S., Taglieri, A., Chiaravalloti, A., Calabria, E., Morini, M., et al. (2014) Thoraco-lumbar traumatic vertebral fractures augmentation by osteo-conductive and osteo-inductive bone substitute containing strontium-hydroxyapatite: our experience. Neuroradiology 56, 459-466.
    • (2014) Neuroradiology , vol.56 , pp. 459-466
    • Masala, S.1    Taglieri, A.2    Chiaravalloti, A.3    Calabria, E.4    Morini, M.5
  • 36
    • 84891547675 scopus 로고    scopus 로고
    • Gene silencing of chordin improves BMP-2 effects on osteogenic differentiation of human adipose tissue-derived stromal cells
    • Schneider, H., Sedaghati, B., Naumann, A., Hacker, M. C., and Schulz-Siegmund, M. (2014) Gene silencing of chordin improves BMP-2 effects on osteogenic differentiation of human adipose tissue-derived stromal cells. Tissue Eng. Part A 20, 335-345.
    • (2014) Tissue Eng. Part A , vol.20 , pp. 335-345
    • Schneider, H.1    Sedaghati, B.2    Naumann, A.3    Hacker, M.C.4    Schulz-Siegmund, M.5
  • 37
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • Urist, M. R. (1965) Bone: formation by autoinduction. Science 150, 893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 38
    • 0015155737 scopus 로고
    • Bone morphogenetic protein
    • Urist, M. R. and Strates, B. S. (1971) Bone morphogenetic protein, J. Dent. Res. 50, 1392-1406.
    • (1971) J. Dent. Res. , vol.50 , pp. 1392-1406
    • Urist, M.R.1    Strates, B.S.2
  • 39
    • 84885628496 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: the anomalous molecules
    • Jain, A. P., Pundir, S., and Sharma, A. (2013) Bone morphogenetic proteins: the anomalous molecules. J. Indian Soc. Periodontol. 17, 583-586.
    • (2013) J. Indian Soc. Periodontol. , vol.17 , pp. 583-586
    • Jain, A.P.1    Pundir, S.2    Sharma, A.3
  • 40
    • 0033015205 scopus 로고    scopus 로고
    • Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily
    • Davidson, A. J., Postlethwait, J. H., Yan, Y. L., Beier, D. R., van Doren, C., et al. (1999) Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily. Genome Res. 9, 121-129.
    • (1999) Genome Res. , vol.9 , pp. 121-129
    • Davidson, A.J.1    Postlethwait, J.H.2    Yan, Y.L.3    Beier, D.R.4    van Doren, C.5
  • 41
    • 38649116901 scopus 로고    scopus 로고
    • Characterization of the post-translational modification of recombinant human BMP-15 mature protein
    • Saito, S., Yano, K., Sharma, S., McMahon, H. E., and Shimasaki, S. (2008) Characterization of the post-translational modification of recombinant human BMP-15 mature protein. Protein Sci. 17, 362-370.
    • (2008) Protein Sci. , vol.17 , pp. 362-370
    • Saito, S.1    Yano, K.2    Sharma, S.3    McMahon, H.E.4    Shimasaki, S.5
  • 42
    • 84877265124 scopus 로고    scopus 로고
    • Studies on the Pinctada fucata BMP-2 gene: structural similarity and functional conservation of its osteogenic potential within the animal kingdom
    • Takami, A., Kato, H., Takagi, R., and Miyashita, T. (2013) Studies on the Pinctada fucata BMP-2 gene: structural similarity and functional conservation of its osteogenic potential within the animal kingdom. Int. J. Zool. 2013, 9.
    • (2013) Int. J. Zool. , vol.2013 , pp. 9
    • Takami, A.1    Kato, H.2    Takagi, R.3    Miyashita, T.4
  • 43
    • 0026459795 scopus 로고
    • Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis
    • Ozkaynak, E., Schnegelsberg, P. N., Jin, D. F., Clifford, G. M., Warren, F. D., et al. (1992) Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J. Biol. Chem. 267, 25220-25227.
    • (1992) J. Biol. Chem. , vol.267 , pp. 25220-25227
    • Ozkaynak, E.1    Schnegelsberg, P.N.2    Jin, D.F.3    Clifford, G.M.4    Warren, F.D.5
  • 44
  • 45
    • 35648944164 scopus 로고    scopus 로고
    • BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors
    • Allendorph, G. P., Isaacs, M. J., Kawakami, Y., Izpisua Belmonte, J. C., and Choe, S. (2007) BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry 46, 12238-12247.
    • (2007) Biochemistry , vol.46 , pp. 12238-12247
    • Allendorph, G.P.1    Isaacs, M.J.2    Kawakami, Y.3    Izpisua Belmonte, J.C.4    Choe, S.5
  • 46
    • 78751696745 scopus 로고    scopus 로고
    • Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo
    • Poli, M., Girelli, D., Campostrini, N., Maccarinelli, F., Finazzi, D., et al. (2011) Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo. Blood 117, 997-1004.
    • (2011) Blood , vol.117 , pp. 997-1004
    • Poli, M.1    Girelli, D.2    Campostrini, N.3    Maccarinelli, F.4    Finazzi, D.5
  • 47
    • 0024256133 scopus 로고
    • Novel regulators of bone formation: molecular clones and activities
    • Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242, 1528-1534.
    • (1988) Science , vol.242 , pp. 1528-1534
    • Wozney, J.M.1    Rosen, V.2    Celeste, A.J.3    Mitsock, L.M.4    Whitters, M.J.5
  • 48
    • 84882686292 scopus 로고    scopus 로고
    • Randomized clinical trial on the efficacy of Escherichia coli-derived rhBMP-2 with β-TCP/HA in extraction socket
    • Huh, J. B., Lee, H. J., Jang, J. W., Kim, M. J., Yun, P. Y., et al. (2011) Randomized clinical trial on the efficacy of Escherichia coli-derived rhBMP-2 with β-TCP/HA in extraction socket. J. Adv. Prosthodont. 3, 161-165.
    • (2011) J. Adv. Prosthodont. , vol.3 , pp. 161-165
    • Huh, J.B.1    Lee, H.J.2    Jang, J.W.3    Kim, M.J.4    Yun, P.Y.5
  • 49
    • 79960323461 scopus 로고    scopus 로고
    • Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model
    • Menendez, M. I., Clark, D. J., Carlton, M., Flanigan, D. C., Jia, G., et al. (2011) Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model. Osteoarthritis Cartilage 19, 1066-1075.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 1066-1075
    • Menendez, M.I.1    Clark, D.J.2    Carlton, M.3    Flanigan, D.C.4    Jia, G.5
  • 50
    • 33947305450 scopus 로고    scopus 로고
    • Molecular aspects of fracture healing: which are the important molecules?
    • Tsiridis, E., Upadhyay, N., and Giannoudis, P. (2007) Molecular aspects of fracture healing: which are the important molecules? Injury 38, S11-S25.
    • (2007) Injury , vol.38 , pp. S11-S25
    • Tsiridis, E.1    Upadhyay, N.2    Giannoudis, P.3
  • 51
    • 79960692785 scopus 로고    scopus 로고
    • Time kinetics of bone defect healing in response to BMP-2 and GDF-5 characterised by in vivo biomechanics
    • Wulsten, D., Glatt, V., Ellinghaus, A., Schmidt-Bleek, K., Petersen, A., et al. (2011) Time kinetics of bone defect healing in response to BMP-2 and GDF-5 characterised by in vivo biomechanics. Eur. Cell Mater. 21, 177-192.
    • (2011) Eur. Cell Mater. , vol.21 , pp. 177-192
    • Wulsten, D.1    Glatt, V.2    Ellinghaus, A.3    Schmidt-Bleek, K.4    Petersen, A.5
  • 52
    • 84862249070 scopus 로고    scopus 로고
    • Role of bone morphogenetic proteins and their antagonists during fracture healing
    • Chang, X., Lu, Y., Shibata, Y., Tsukazaki, T., and Yamaguchi, A. (2012) Role of bone morphogenetic proteins and their antagonists during fracture healing. J. Hard Tissue Biol. 21, 203-212.
    • (2012) J. Hard Tissue Biol. , vol.21 , pp. 203-212
    • Chang, X.1    Lu, Y.2    Shibata, Y.3    Tsukazaki, T.4    Yamaguchi, A.5
  • 53
    • 84871177946 scopus 로고    scopus 로고
    • Bone morphogenic protein 3 signaling in the regulation of osteogenesis
    • McMahon, M. S. (2012) Bone morphogenic protein 3 signaling in the regulation of osteogenesis. Orthopedics 35, 920.
    • (2012) Orthopedics , vol.35 , pp. 920
    • McMahon, M.S.1
  • 54
    • 79960357508 scopus 로고    scopus 로고
    • Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
    • Berasi, S. P., Varadarajan, U., Archambault, J., Cain, M., Souza, T. A., et al. (2011) Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities. Growth Factors 29, 128-139.
    • (2011) Growth Factors , vol.29 , pp. 128-139
    • Berasi, S.P.1    Varadarajan, U.2    Archambault, J.3    Cain, M.4    Souza, T.A.5
  • 55
    • 84893875436 scopus 로고    scopus 로고
    • Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration
    • Stewart, S., Gomez, A. W., Armstrong, B. E., Henner, A., and Stankunas, K. (2014) Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Rep. PII, S2211-1247(14)00011-4.
    • (2014) Cell Rep.
    • Stewart, S.1    Gomez, A.W.2    Armstrong, B.E.3    Henner, A.4    Stankunas, K.5
  • 56
    • 84892563631 scopus 로고    scopus 로고
    • VEGF and BMP-2 promote bone regeneration by facilitating bone marrow stem cell homing and differentiation
    • Zhang, W., Zhu, C., Wu, Y., Ye, D., Wang, S., et al. (2014) VEGF and BMP-2 promote bone regeneration by facilitating bone marrow stem cell homing and differentiation. Eur. Cell. Mater. 27, 1-12.
    • (2014) Eur. Cell. Mater. , vol.27 , pp. 1-12
    • Zhang, W.1    Zhu, C.2    Wu, Y.3    Ye, D.4    Wang, S.5
  • 57
    • 84875543830 scopus 로고    scopus 로고
    • Interactions between FGF21 and BMP-2 in osteogenesis
    • Ishida, K. and Haudenschild, D. R. (2013) Interactions between FGF21 and BMP-2 in osteogenesis. Biochem. Biophys. Res. Commun. 432, 677-682.
    • (2013) Biochem. Biophys. Res. Commun. , vol.432 , pp. 677-682
    • Ishida, K.1    Haudenschild, D.R.2
  • 58
    • 84879356745 scopus 로고    scopus 로고
    • Dual delivery of BMP-2 and bFGF from a new nano-composite scaffold, loaded with vascular stents for large-size mandibular defect regeneration
    • Su, J., Xu, H., Sun, J., Gong, X., and Zhao, H. (2013) Dual delivery of BMP-2 and bFGF from a new nano-composite scaffold, loaded with vascular stents for large-size mandibular defect regeneration. Int. J. Mol. Sci. 14, 12714-12728.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 12714-12728
    • Su, J.1    Xu, H.2    Sun, J.3    Gong, X.4    Zhao, H.5
  • 59
    • 84862867764 scopus 로고    scopus 로고
    • The use of bone morphogenic protein-7 (OP-1) in the management of resistant non-unions in the upper and lower limb
    • Papanna, M. C., Al-Hadithy, N., Somanchi, B. V., Sewell, M. D., Robinson, P. M., et al. (2012) The use of bone morphogenic protein-7 (OP-1) in the management of resistant non-unions in the upper and lower limb. Injury 43, 1135-1140.
    • (2012) Injury , vol.43 , pp. 1135-1140
    • Papanna, M.C.1    Al-Hadithy, N.2    Somanchi, B.V.3    Sewell, M.D.4    Robinson, P.M.5
  • 60
    • 84890494479 scopus 로고    scopus 로고
    • All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways
    • Liu, Y., Liu, Y., Zhang, R., Huang, F., Yan, Z., et al. (2014) All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways. Int. J. Biochem. Cell Biol. 47, 47-56.
    • (2014) Int. J. Biochem. Cell Biol. , vol.47 , pp. 47-56
    • Liu, Y.1    Liu, Y.2    Zhang, R.3    Huang, F.4    Yan, Z.5
  • 61
    • 0036181393 scopus 로고    scopus 로고
    • Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
    • Cho, T. J., Gerstenfeld, L. C., and Einhorn, T. A. (2002) Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J. Bone Miner. Res. 17, 513-520.
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 513-520
    • Cho, T.J.1    Gerstenfeld, L.C.2    Einhorn, T.A.3
  • 62
    • 84880059680 scopus 로고    scopus 로고
    • Reporting of industry funded study outcome data: comparison of confidential and published data on the safety and effectiveness of rhBMP-2 for spinal fusion
    • Rodgers, M. A., Brown, J. V., Heirs, M. K., Higgins, J. P., Mannion, R. J., et al. (2013) Reporting of industry funded study outcome data: comparison of confidential and published data on the safety and effectiveness of rhBMP-2 for spinal fusion. BMJ 346, f3981.
    • (2013) BMJ , vol.346 , pp. f3981
    • Rodgers, M.A.1    Brown, J.V.2    Heirs, M.K.3    Higgins, J.P.4    Mannion, R.J.5
  • 63
    • 84878558050 scopus 로고    scopus 로고
    • Revision surgery after interbody fusion with rhBMP-2: a cautionary tale for spine surgeons
    • Rodgers, S. D., Marascalchi, B. J., Grobelny, B. T., Smith, M. L., and Samadani, U. (2013) Revision surgery after interbody fusion with rhBMP-2: a cautionary tale for spine surgeons. J. Neurosurg. Spine 18, 582-587.
    • (2013) J. Neurosurg. Spine , vol.18 , pp. 582-587
    • Rodgers, S.D.1    Marascalchi, B.J.2    Grobelny, B.T.3    Smith, M.L.4    Samadani, U.5
  • 64
    • 84879165716 scopus 로고    scopus 로고
    • Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data
    • Simmonds, M. C., Brown, J. V., Heirs, M. K., Higgins, J. P., Mannion, R. J., et al. (2013) Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data. Ann. Intern. Med. 158, 877-889.
    • (2013) Ann. Intern. Med. , vol.158 , pp. 877-889
    • Simmonds, M.C.1    Brown, J.V.2    Heirs, M.K.3    Higgins, J.P.4    Mannion, R.J.5
  • 65
    • 84886258481 scopus 로고    scopus 로고
    • Manipulation of anabolic and catabolic responses with bone morphogenetic protein and zoledronic acid in a rat spinal fusion model
    • Kodera, R., Miyazaki, M., Yoshiiwa, T., Kawano, M., Kaku, N., et al. (2014) Manipulation of anabolic and catabolic responses with bone morphogenetic protein and zoledronic acid in a rat spinal fusion model. Bone 58, 26-32.
    • (2014) Bone , vol.58 , pp. 26-32
    • Kodera, R.1    Miyazaki, M.2    Yoshiiwa, T.3    Kawano, M.4    Kaku, N.5
  • 66
    • 84883509362 scopus 로고    scopus 로고
    • Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial
    • de Freitas, R. M., Susin, C., Spin-Neto, R., Marcantonio, C., Wikesjo, U. M., et al. (2013) Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial. J. Clin. Periodontol. 40, 968-975.
    • (2013) J. Clin. Periodontol. , vol.40 , pp. 968-975
    • de Freitas, R.M.1    Susin, C.2    Spin-Neto, R.3    Marcantonio, C.4    Wikesjo, U.M.5
  • 67
    • 84868642757 scopus 로고    scopus 로고
    • Recombinant human BMP-2 for the treatment of open tibial fractures
    • Wei, S., Cai, X., Huang, J., Xu, F., Liu, X., et al. (2012) Recombinant human BMP-2 for the treatment of open tibial fractures. Orthopedics 35, e847-e854.
    • (2012) Orthopedics , vol.35 , pp. e847-e854
    • Wei, S.1    Cai, X.2    Huang, J.3    Xu, F.4    Liu, X.5
  • 68
    • 84884257612 scopus 로고    scopus 로고
    • B Evaluation of a thiolated chitosan scaffold for local delivery of BMP-2 for osteogenic differentiation and ectopic bone formation
    • Bae, I. H., Jeong, B. C., Kook, M. S., Kim, S. H., and Koh, J. T. (2013) B Evaluation of a thiolated chitosan scaffold for local delivery of BMP-2 for osteogenic differentiation and ectopic bone formation. Biomed. Res. Int. 2013, 878930.
    • (2013) Biomed. Res. Int. , vol.2013 , pp. 878930
    • Bae, I.H.1    Jeong, B.C.2    Kook, M.S.3    Kim, S.H.4    Koh, J.T.5
  • 69
    • 79959579500 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation
    • Aro, H. T., Govender, S., Patel, A. D., Hernigou, P., Perera de Gregorio, A., et al. (2011) Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation. J. Bone Joint Surg. Am. 93, 801-808.
    • (2011) J. Bone Joint Surg. Am. , vol.93 , pp. 801-808
    • Aro, H.T.1    Govender, S.2    Patel, A.D.3    Hernigou, P.4    Perera de Gregorio, A.5
  • 70
    • 84875092554 scopus 로고    scopus 로고
    • Identification of small molecule activators of BMP signaling
    • Vrijens, K., Lin, W., Cui, J., Farmer, D., Low, J., et al. (2013) Identification of small molecule activators of BMP signaling. PLoS One 8, e59045.
    • (2013) PLoS One , vol.8 , pp. e59045
    • Vrijens, K.1    Lin, W.2    Cui, J.3    Farmer, D.4    Low, J.5
  • 71
    • 77649187986 scopus 로고    scopus 로고
    • Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair
    • Yu, Y. Y., Lieu, S., Lu, C., Miclau, T., Marcucio, R. S., et al. (2010) Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair. Bone 46, 841-851.
    • (2010) Bone , vol.46 , pp. 841-851
    • Yu, Y.Y.1    Lieu, S.2    Lu, C.3    Miclau, T.4    Marcucio, R.S.5
  • 72
    • 84893100174 scopus 로고    scopus 로고
    • Implantation of a novel tissue-engineered graft in a large tendon defect initiated inflammation, accelerated fibroplasia and improved remodeling of the new Achilles tendon: a comprehensive detailed study with new insights
    • Oryan, A., Moshiri, A., and Meimandi-Parizi, A. (2014) Implantation of a novel tissue-engineered graft in a large tendon defect initiated inflammation, accelerated fibroplasia and improved remodeling of the new Achilles tendon: a comprehensive detailed study with new insights. Cell Tissue Res. 355, 59-80.
    • (2014) Cell Tissue Res. , vol.355 , pp. 59-80
    • Oryan, A.1    Moshiri, A.2    Meimandi-Parizi, A.3
  • 73
    • 84931096435 scopus 로고    scopus 로고
    • Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures
    • in press.
    • Bigham-Sadegh, A. and Oryan, A. (2014) Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures. Int. Wound J., in press.
    • (2014) Int. Wound J.
    • Bigham-Sadegh, A.1    Oryan, A.2
  • 74
    • 77956023094 scopus 로고    scopus 로고
    • The role of endogenous bone morphogenetic proteins in normal skeletal repair
    • Marsell, R. and Einhorn, T. A. (2009) The role of endogenous bone morphogenetic proteins in normal skeletal repair. Injury 40, S4-S7.
    • (2009) Injury , vol.40 , pp. S4-S7
    • Marsell, R.1    Einhorn, T.A.2
  • 75
    • 84863040008 scopus 로고    scopus 로고
    • TGF-β and BMP signaling in osteoblast differentiation and bone formation
    • Chen, G., Deng, C., and Li, Y. P. (2012) TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int. J. Biol. Sci. 8, 272-288.
    • (2012) Int. J. Biol. Sci. , vol.8 , pp. 272-288
    • Chen, G.1    Deng, C.2    Li, Y.P.3
  • 76
    • 4644287292 scopus 로고    scopus 로고
    • CD44 modulates Smad1 activation in the BMP-7 signaling pathway
    • Peterson, R. S., Andhare, R. A., Rousche, K. T., Knudson, W., Wang, W., et al. (2004) CD44 modulates Smad1 activation in the BMP-7 signaling pathway. J. Cell Biol. 166, 1081-1091.
    • (2004) J. Cell Biol. , vol.166 , pp. 1081-1091
    • Peterson, R.S.1    Andhare, R.A.2    Rousche, K.T.3    Knudson, W.4    Wang, W.5
  • 77
    • 84899128750 scopus 로고    scopus 로고
    • BMP growth factor signaling in a biomechanical context
    • Kopf, J., Paarmann, P., Hiepen, C., Horbelt, D., and Knaus, P. (2014) BMP growth factor signaling in a biomechanical context. Biofactors 40, 171-187.
    • (2014) Biofactors , vol.40 , pp. 171-187
    • Kopf, J.1    Paarmann, P.2    Hiepen, C.3    Horbelt, D.4    Knaus, P.5
  • 78
    • 84860273399 scopus 로고    scopus 로고
    • Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions
    • Kloen, P., Lauzier, D., and Hamdy, R. C. (2012) Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions. Bone 51, 59-68.
    • (2012) Bone , vol.51 , pp. 59-68
    • Kloen, P.1    Lauzier, D.2    Hamdy, R.C.3
  • 79
    • 84890033223 scopus 로고    scopus 로고
    • Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling
    • Garulli, C., Kalogris, C., Pietrella, L., Bartolacci, C., Andreani, C., et al. (2014) Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling. Cell Signal 26, 352-362.
    • (2014) Cell Signal , vol.26 , pp. 352-362
    • Garulli, C.1    Kalogris, C.2    Pietrella, L.3    Bartolacci, C.4    Andreani, C.5
  • 80
    • 84904859709 scopus 로고    scopus 로고
    • BMP signaling in mesenchymal stem cell differentiation and bone formation
    • Beederman, M., Lamplot, J., Nan, G., Wang, J., Liu, X., et al. (2013) BMP signaling in mesenchymal stem cell differentiation and bone formation. J. Biomed. Sci. Eng. 6, 32-52.
    • (2013) J. Biomed. Sci. Eng. , vol.6 , pp. 32-52
    • Beederman, M.1    Lamplot, J.2    Nan, G.3    Wang, J.4    Liu, X.5
  • 81
    • 84872313111 scopus 로고    scopus 로고
    • Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
    • Shi, S., de Gorter, D. J., Hoogaars, W. M., 't Hoen, P. A., ten Dijke, P. (2013) Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy. Cell Mol Life Sci. 70, 407-423.
    • (2013) Cell Mol Life Sci. , vol.70 , pp. 407-423
    • Shi, S.1    de Gorter, D.J.2    Hoogaars, W.M.3    't Hoen, P.A.4    ten Dijke, P.5
  • 83
    • 70349085854 scopus 로고    scopus 로고
    • Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures
    • Gamer, L. W., Cox, K., Carlo, J. M., and Rosen, V. (2009) Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures. Dev Dyn. 238, 2374-2381.
    • (2009) Dev Dyn. , vol.238 , pp. 2374-2381
    • Gamer, L.W.1    Cox, K.2    Carlo, J.M.3    Rosen, V.4
  • 85
    • 84890550839 scopus 로고    scopus 로고
    • Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model
    • Bleedorn, J. A., Sullivan, R., Lu, Y., Nemke, B., Kalscheur, V., et al. (2014) Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model. J. Orthop. Res. 32, 210-216.
    • (2014) J. Orthop. Res. , vol.32 , pp. 210-216
    • Bleedorn, J.A.1    Sullivan, R.2    Lu, Y.3    Nemke, B.4    Kalscheur, V.5
  • 86
    • 84914169314 scopus 로고    scopus 로고
    • Statins, bone metabolism and treatment of bone catabolic diseases
    • in press.
    • Zhang, Y., Bradley, A. D., Wang, D., and Reinhardt, R. A. Statins, bone metabolism and treatment of bone catabolic diseases. Pharmacol. Res., in press.
    • Pharmacol. Res.
    • Zhang, Y.1    Bradley, A.D.2    Wang, D.3    Reinhardt, R.A.4
  • 87
    • 77952285581 scopus 로고    scopus 로고
    • Lin FH. Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway
    • Chen, P. Y., Sun, J. S., Tsuang, Y. H., Chen, M. H., Weng, P. W., et al. (2010) Lin FH. Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. Nutr. Res. 30, 191-199.
    • (2010) Nutr. Res. , vol.30 , pp. 191-199
    • Chen, P.Y.1    Sun, J.S.2    Tsuang, Y.H.3    Chen, M.H.4    Weng, P.W.5
  • 88
    • 84903273784 scopus 로고    scopus 로고
    • Relaxin augments BMP 2-induced osteoblast differentiation and bone formation
    • Moon, J. S., Oh, S. H., Jeong, Y. W., Kang, J. H., Park, J. C., et al. (2014) Relaxin augments BMP 2-induced osteoblast differentiation and bone formation. JBMR, 29, 1586-1596.
    • (2014) JBMR , vol.29 , pp. 1586-1596
    • Moon, J.S.1    Oh, S.H.2    Jeong, Y.W.3    Kang, J.H.4    Park, J.C.5
  • 89
    • 74249106143 scopus 로고    scopus 로고
    • Relaxin stimulates osteoclast differentiation and activation
    • Ferlin, A., Pepe, A., Facciolli, A., Gianesello, L., and Foresta, C. (2010) Relaxin stimulates osteoclast differentiation and activation. Bone 46, 504-513.
    • (2010) Bone , vol.46 , pp. 504-513
    • Ferlin, A.1    Pepe, A.2    Facciolli, A.3    Gianesello, L.4    Foresta, C.5
  • 90
    • 84861139259 scopus 로고    scopus 로고
    • Improvement in the delivery system of bone morphogenetic protein-2: a new approach to promote bone formation
    • Zhang, Q., He, Q. F., Zhang, T. H., Yu, X. L., Liu, Q., et al. (2012) Improvement in the delivery system of bone morphogenetic protein-2: a new approach to promote bone formation. Biomed. Mater. 7, 045002.
    • (2012) Biomed. Mater. , vol.7 , pp. 045002
    • Zhang, Q.1    He, Q.F.2    Zhang, T.H.3    Yu, X.L.4    Liu, Q.5
  • 91
    • 84899822379 scopus 로고    scopus 로고
    • Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats
    • Poldervaart, M. T., Wang, H., van der Stok, J., Weinans, H., Leeuwenburgh, S. C., et al. (2013) Sustained release of BMP-2 in bioprinted alginate for osteogenicity in mice and rats. PLoS One 8, e72610.
    • (2013) PLoS One , vol.8 , pp. e72610
    • Poldervaart, M.T.1    Wang, H.2    van der Stok, J.3    Weinans, H.4    Leeuwenburgh, S.C.5
  • 92
    • 84891628053 scopus 로고    scopus 로고
    • Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model
    • Rahman, C. V., Ben-David, D., Dhillon, A., Kuhn, G., Gould, T. W., et al. (2014) Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model. J. Tissue Eng. Regen. Med. 8, 59-66.
    • (2014) J. Tissue Eng. Regen. Med. , vol.8 , pp. 59-66
    • Rahman, C.V.1    Ben-David, D.2    Dhillon, A.3    Kuhn, G.4    Gould, T.W.5
  • 94
    • 84876411058 scopus 로고    scopus 로고
    • Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering
    • Jun, S. H., Lee, E. J., Jang, T. S., Kim, H. E., Jang, J. H., et al. (2013) Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering. J. Mater. Sci. Mater. Med. 24, 773-782.
    • (2013) J. Mater. Sci. Mater. Med. , vol.24 , pp. 773-782
    • Jun, S.H.1    Lee, E.J.2    Jang, T.S.3    Kim, H.E.4    Jang, J.H.5
  • 95
    • 84971459109 scopus 로고    scopus 로고
    • Effectiveness of hybridized nano- and microstructure biodegradable, biocompatible, collagen-based, three-dimensional bioimplants in repair of a large tendon-defect model in rabbits
    • in press.
    • Moshiri, A., Oryan, A., Meimandi-Parizi, A., Silver, I. A., Tanideh, N., et al. (2013) Effectiveness of hybridized nano- and microstructure biodegradable, biocompatible, collagen-based, three-dimensional bioimplants in repair of a large tendon-defect model in rabbits. J. Tissue Eng. Regen. Med., in press.
    • (2013) J. Tissue Eng. Regen. Med.
    • Moshiri, A.1    Oryan, A.2    Meimandi-Parizi, A.3    Silver, I.A.4    Tanideh, N.5
  • 96
    • 84886709732 scopus 로고    scopus 로고
    • A long-term in vivo investigation on the effects of xenogenous based, electrospun, collagen implants on the healing of experimentally-induced large tendon defects
    • Oryan, A., Moshiri, A., Parizi Meimandi, A., and Silver, I. A. (2013) A long-term in vivo investigation on the effects of xenogenous based, electrospun, collagen implants on the healing of experimentally-induced large tendon defects. J. Musculoskelet. Neuronal Interact. 13, 353-367.
    • (2013) J. Musculoskelet. Neuronal Interact. , vol.13 , pp. 353-367
    • Oryan, A.1    Moshiri, A.2    Parizi Meimandi, A.3    Silver, I.A.4
  • 97
    • 84893153887 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture: a double-blind, randomized, controlled phase-II/III trial
    • Lyon, T., Scheele, W., Bhandari, M., Koval, K. J., Sanchez, E. G., et al. (2013) Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture: a double-blind, randomized, controlled phase-II/III trial. J. Bone Joint Surg. Am. 95, 2088-2096.
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 2088-2096
    • Lyon, T.1    Scheele, W.2    Bhandari, M.3    Koval, K.J.4    Sanchez, E.G.5
  • 98
    • 73949119177 scopus 로고    scopus 로고
    • Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: current challenges in BMP delivery
    • Haidar, Z. S., Hamdy, R. C., and Tabrizian, M. (2009) Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: current challenges in BMP delivery. Biotechnol. Lett. 31, 1817-1824.
    • (2009) Biotechnol. Lett. , vol.31 , pp. 1817-1824
    • Haidar, Z.S.1    Hamdy, R.C.2    Tabrizian, M.3
  • 99
    • 84923016818 scopus 로고    scopus 로고
    • Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite
    • Sharma, A., Meyer, F., Hyvonen, M., Best, S. M., Cameron, R. E., et al. (2012) Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite. Bone Joint Res. 1, 145-151.
    • (2012) Bone Joint Res. , vol.1 , pp. 145-151
    • Sharma, A.1    Meyer, F.2    Hyvonen, M.3    Best, S.M.4    Cameron, R.E.5
  • 100
    • 84877593920 scopus 로고    scopus 로고
    • Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance
    • Meimandi-Parizi, A., Oryan, A., and Moshiri, A. (2013) Role of tissue engineered collagen based tridimensional implant on the healing response of the experimentally induced large Achilles tendon defect model in rabbits: a long term study with high clinical relevance. J. Biomed. Sci. 20, 28.
    • (2013) J. Biomed. Sci. , vol.20 , pp. 28
    • Meimandi-Parizi, A.1    Oryan, A.2    Moshiri, A.3
  • 101
    • 84878106552 scopus 로고    scopus 로고
    • Novel application of a tissue-engineered collagen-based three-dimensional bio-implant in a large tendon defect model: a broad-based study with high value in translational medicine
    • Meimandi-Parizi, A., Oryan, A., Moshiri, A., and Silver, I. A. (2013) Novel application of a tissue-engineered collagen-based three-dimensional bio-implant in a large tendon defect model: a broad-based study with high value in translational medicine. Tissue Cell 45, 282-294.
    • (2013) Tissue Cell , vol.45 , pp. 282-294
    • Meimandi-Parizi, A.1    Oryan, A.2    Moshiri, A.3    Silver, I.A.4
  • 102
    • 84877251286 scopus 로고    scopus 로고
    • A novel application of biosynthetic tissue-engineered tridimensional implant on large tendon defects: a comprehensive, detailed, in vivo investigation with significant clinical value
    • Moshiri, A., Oryan, A., and Meimandi Parizi, A. (2013) A novel application of biosynthetic tissue-engineered tridimensional implant on large tendon defects: a comprehensive, detailed, in vivo investigation with significant clinical value. Connect. Tissue Res. 54, 227-243.
    • (2013) Connect. Tissue Res. , vol.54 , pp. 227-243
    • Moshiri, A.1    Oryan, A.2    Meimandi Parizi, A.3
  • 103
    • 84895127414 scopus 로고    scopus 로고
    • Chitosan scaffolds containing calcium phosphate salts and rhBMP-2: In vitro and in vivo testing for bone tissue regeneration
    • Guzman, R., Nardecchia, S., Gutierrez, M. C., Ferrer, M. L., Ramos, V., et al. (2014) Chitosan scaffolds containing calcium phosphate salts and rhBMP-2: In vitro and in vivo testing for bone tissue regeneration. PLoS One 9, e87149.
    • (2014) PLoS One , vol.9 , pp. e87149
    • Guzman, R.1    Nardecchia, S.2    Gutierrez, M.C.3    Ferrer, M.L.4    Ramos, V.5
  • 104
    • 78349307676 scopus 로고    scopus 로고
    • Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration
    • Yilgor, P., Sousa, R. A., Reis, R. L., Hasirci, N., and Hasirci, V. (2010) Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration. J. Mater. Sci. Mater. Med. 21, 2999-3008.
    • (2010) J. Mater. Sci. Mater. Med. , vol.21 , pp. 2999-3008
    • Yilgor, P.1    Sousa, R.A.2    Reis, R.L.3    Hasirci, N.4    Hasirci, V.5
  • 105
    • 84896700451 scopus 로고    scopus 로고
    • The effect of bone morphogenic protein-2 (BMP-2)-immobilizing heparinized-chitosan scaffolds for enhanced osteoblast activity
    • Yun, Y. P., Kim, S. E., Kang, E. Y., Kim, H. J., Park, K., et al. (2013) The effect of bone morphogenic protein-2 (BMP-2)-immobilizing heparinized-chitosan scaffolds for enhanced osteoblast activity. Tissue Eng. Regen. Med. 10, 122-130.
    • (2013) Tissue Eng. Regen. Med. , vol.10 , pp. 122-130
    • Yun, Y.P.1    Kim, S.E.2    Kang, E.Y.3    Kim, H.J.4    Park, K.5
  • 106
    • 70649083100 scopus 로고    scopus 로고
    • Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery
    • Zhang, S., Kucharski, C., Doschak, M. R., Sebald, W., and Uludag, H. (2010) Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery. Biomaterials 31, 952-963.
    • (2010) Biomaterials , vol.31 , pp. 952-963
    • Zhang, S.1    Kucharski, C.2    Doschak, M.R.3    Sebald, W.4    Uludag, H.5
  • 107
    • 84893834643 scopus 로고    scopus 로고
    • Osteoinductive activity of ErhBMP-2 after anterior cervical diskectomy and fusion with a ß-TCP interbody cage in a goat model
    • Wang, H., Zhang, F., Lv, F., Jiang, J., Liu, D., et al. (2014) Osteoinductive activity of ErhBMP-2 after anterior cervical diskectomy and fusion with a ß-TCP interbody cage in a goat model. Orthopedics 37, e123-e131.
    • (2014) Orthopedics , vol.37 , pp. e123-e131
    • Wang, H.1    Zhang, F.2    Lv, F.3    Jiang, J.4    Liu, D.5
  • 108
    • 84899106934 scopus 로고    scopus 로고
    • Regeneration of calvarial defects with Escherichia coli-derived rhBMP-2 adsorbed in PLGA membrane
    • Ono, M., Sonoyama, W., Nema, K., Hara, E. S., Oida, Y., et al. (2013) Regeneration of calvarial defects with Escherichia coli-derived rhBMP-2 adsorbed in PLGA membrane. Cell Tissue Organ 198, 367-76.
    • (2013) Cell Tissue Organ , vol.198 , pp. 367-376
    • Ono, M.1    Sonoyama, W.2    Nema, K.3    Hara, E.S.4    Oida, Y.5
  • 110
    • 79953039987 scopus 로고    scopus 로고
    • In vivo comparison of the effects of rhBMP-2 and rhBMP-4 in osteochondral tissue regeneration
    • Lopiz-Morales, Y., Abarrategi, A., Ramos, V., Moreno-Vicente, C., Lopez-Duran, L., et al. (2010) In vivo comparison of the effects of rhBMP-2 and rhBMP-4 in osteochondral tissue regeneration. Eur. Cell Mater. 20, 367-378.
    • (2010) Eur. Cell Mater. , vol.20 , pp. 367-378
    • Lopiz-Morales, Y.1    Abarrategi, A.2    Ramos, V.3    Moreno-Vicente, C.4    Lopez-Duran, L.5
  • 111
    • 84904993990 scopus 로고    scopus 로고
    • Adipose derived stem cells and BMP-2 delivery in chitosan-based 3D constructs to enhance bone regeneration in a rat mandibular defect model
    • Fan, J., Park, H., Lee, M. K., Bezouglaia, O., Fartash, A., et al. (2014) Adipose derived stem cells and BMP-2 delivery in chitosan-based 3D constructs to enhance bone regeneration in a rat mandibular defect model. Tissue Eng. Part A. 20, 2169-2179.
    • (2014) Tissue Eng. Part A , vol.20 , pp. 2169-2179
    • Fan, J.1    Park, H.2    Lee, M.K.3    Bezouglaia, O.4    Fartash, A.5
  • 112
    • 84876392686 scopus 로고    scopus 로고
    • Advanced BMP gene therapies for temporal and spatial control of bone regeneration
    • Wilson, C. G., Martín-Saavedra, F. M., Vilaboa, N., and Franceschi, R. T. (2013) Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J. Dent. Res. 92, 409-417.
    • (2013) J. Dent. Res. , vol.92 , pp. 409-417
    • Wilson, C.G.1    Martín-Saavedra, F.M.2    Vilaboa, N.3    Franceschi, R.T.4
  • 113
    • 77649269524 scopus 로고    scopus 로고
    • The repair of critical-sized bone defects using expedited, autologous BMP-2 gene-activated fat implants
    • Betz, O. B., Betz, V. M., Abdulazim, A., Penzkofer, R., Schmitt, B., et al. (2010) The repair of critical-sized bone defects using expedited, autologous BMP-2 gene-activated fat implants. Tissue Eng. Part A 16, 1093-1101.
    • (2010) Tissue Eng. Part A , vol.16 , pp. 1093-1101
    • Betz, O.B.1    Betz, V.M.2    Abdulazim, A.3    Penzkofer, R.4    Schmitt, B.5
  • 114
    • 84886746212 scopus 로고    scopus 로고
    • The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor
    • Elangovan, S., D'Mello, S. R., Hong, L., Ross, R. D., Allamargot, C., et al. (2014) The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor. Biomaterials 35, 737-747.
    • (2014) Biomaterials , vol.35 , pp. 737-747
    • Elangovan, S.1    D'Mello, S.R.2    Hong, L.3    Ross, R.D.4    Allamargot, C.5
  • 115
    • 80053166656 scopus 로고    scopus 로고
    • Apatite-coated collagen scaffold for bone morphogenetic protein-2 delivery
    • Yang, H. S., La, W. G., Bhang, S. H., Lee, T. J., Lee, M., et al. (2011) Apatite-coated collagen scaffold for bone morphogenetic protein-2 delivery. Tissue Eng. Part A 17, 2153-2164.
    • (2011) Tissue Eng. Part A , vol.17 , pp. 2153-2164
    • Yang, H.S.1    La, W.G.2    Bhang, S.H.3    Lee, T.J.4    Lee, M.5
  • 116
    • 84936860165 scopus 로고    scopus 로고
    • Regenerating mandibular bone using rhBMP-2: part 1-immediate reconstruction of segmental mandibulectomies
    • in press.
    • Arzi, B., Verstraete, F. J., Huey, D. J., Cissell, D. D., and Athanasiou, K. A. (2014) Regenerating mandibular bone using rhBMP-2: part 1-immediate reconstruction of segmental mandibulectomies. Vet. Surg., in press.
    • (2014) Vet. Surg.
    • Arzi, B.1    Verstraete, F.J.2    Huey, D.J.3    Cissell, D.D.4    Athanasiou, K.A.5
  • 117
    • 79959555090 scopus 로고    scopus 로고
    • Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release
    • Brown, K. V., Li, B., Guda, T., Perrien, D. S., Guelcher, S. A., et al. (2011) Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release. Tissue Eng. Part A 17, 1735-1746.
    • (2011) Tissue Eng. Part A , vol.17 , pp. 1735-1746
    • Brown, K.V.1    Li, B.2    Guda, T.3    Perrien, D.S.4    Guelcher, S.A.5
  • 118
    • 84896696175 scopus 로고    scopus 로고
    • The effect of carrier for BMP-2 delivery on histological aspects of tissue-engineered bone
    • Jung, S. Y., KO, Y. J., Jang, H. S., Kang, S. W., and Park, J. H. (2013) The effect of carrier for BMP-2 delivery on histological aspects of tissue-engineered bone. J. Tissue Eng. Regen. Med. 10, 341-346.
    • (2013) J. Tissue Eng. Regen. Med. , vol.10 , pp. 341-346
    • Jung, S.Y.1    Ko, Y.J.2    Jang, H.S.3    Kang, S.W.4    Park, J.H.5
  • 119
    • 84886752847 scopus 로고    scopus 로고
    • Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2
    • Cao, L., Wang, J., Hou, J., Xing W., and Liu, C. (2014) Vascularization and bone regeneration in a critical sized defect using 2-N, 6-O-sulfated chitosan nanoparticles incorporating BMP-2. Biomaterials 35, 684-698.
    • (2014) Biomaterials , vol.35 , pp. 684-698
    • Cao, L.1    Wang, J.2    Hou, J.3    Xing, W.4    Liu, C.5
  • 120
    • 84897998460 scopus 로고    scopus 로고
    • Controlled-release of bone morphogenetic protein-2 from a microsphere coating applied to acid-etched Ti6AL4V implants increases biological bone growth in vivo
    • Fu, Y., Zhang, Q., Sun, Y., Liao, W., Bai, X., et al. Controlled-release of bone morphogenetic protein-2 from a microsphere coating applied to acid-etched Ti6AL4V implants increases biological bone growth in vivo. J. Orthop. Res. 32, 744-51.
    • J. Orthop. Res. , vol.32 , pp. 744-751
    • Fu, Y.1    Zhang, Q.2    Sun, Y.3    Liao, W.4    Bai, X.5
  • 121
    • 84890567432 scopus 로고    scopus 로고
    • Early inhibitory effects of zoledronic acid in tooth extraction sockets in dogs are negated by recombinant human bone morphogenetic protein
    • Gerard, D. A., Carlson, E. R., Gotcher, J. E., and Pickett, D. O. (2014) Early inhibitory effects of zoledronic acid in tooth extraction sockets in dogs are negated by recombinant human bone morphogenetic protein. J. Oral Maxillofac. Surg. 72, 61-66.
    • (2014) J. Oral Maxillofac. Surg. , vol.72 , pp. 61-66
    • Gerard, D.A.1    Carlson, E.R.2    Gotcher, J.E.3    Pickett, D.O.4
  • 122
    • 84916228233 scopus 로고    scopus 로고
    • Apatite-coated collagen sponge for the delivery of bone morphogenetic protein-2 in rabbit posterolateral lumbar fusion
    • in press.
    • Koo, K. H., Ahn, J. M., Lee, J. M., Kim, B. S., Kim, C. S., et al. (2014) Apatite-coated collagen sponge for the delivery of bone morphogenetic protein-2 in rabbit posterolateral lumbar fusion. Artif. Organs, in press.
    • (2014) Artif. Organs
    • Koo, K.H.1    Ahn, J.M.2    Lee, J.M.3    Kim, B.S.4    Kim, C.S.5
  • 123
    • 84866291403 scopus 로고    scopus 로고
    • Sustained delivery of BMP-2 and platelet-rich plasma-released growth factors contributes to osteogenesis of human adipose-derived stem cells
    • Chen, L., Lu, X., Li, S., Sun, Q., Li, W., et al. (2012) Sustained delivery of BMP-2 and platelet-rich plasma-released growth factors contributes to osteogenesis of human adipose-derived stem cells. Orthopedics 35, e1402-e1409.
    • (2012) Orthopedics , vol.35 , pp. e1402-e1409
    • Chen, L.1    Lu, X.2    Li, S.3    Sun, Q.4    Li, W.5
  • 124
    • 84892703303 scopus 로고    scopus 로고
    • Regulation of physicochemical properties, osteogenesis activity, and fibroblast growth factor-2 release ability of β-tricalcium phosphate for bone cement by calcium silicate
    • Su, C. C., Kao, C. T., Hung, C. J., Chen, Y. J., Huang, T. H., et al. (2014) Regulation of physicochemical properties, osteogenesis activity, and fibroblast growth factor-2 release ability of β-tricalcium phosphate for bone cement by calcium silicate. Mater. Sci. Eng. C Mater. Biol. Appl. 37, 156-163.
    • (2014) Mater. Sci. Eng. C Mater. Biol. Appl. , vol.37 , pp. 156-163
    • Su, C.C.1    Kao, C.T.2    Hung, C.J.3    Chen, Y.J.4    Huang, T.H.5
  • 125
    • 75749135292 scopus 로고    scopus 로고
    • Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering
    • Sohier, J., Daculsi, G., Sourice, S., de Groot, K., and Layrolle, P. (2010) Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering. J. Biomed. Mater. Res. A 92, 1105-1114.
    • (2010) J. Biomed. Mater. Res. A , vol.92 , pp. 1105-1114
    • Sohier, J.1    Daculsi, G.2    Sourice, S.3    de Groot, K.4    Layrolle, P.5
  • 126
    • 84890171521 scopus 로고    scopus 로고
    • Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway
    • Chen, Z., Wu, C., Gu, W., Klein, T., Crawford, R., et al. (2014) Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials 35, 1507-1518.
    • (2014) Biomaterials , vol.35 , pp. 1507-1518
    • Chen, Z.1    Wu, C.2    Gu, W.3    Klein, T.4    Crawford, R.5
  • 127
    • 84884804335 scopus 로고    scopus 로고
    • Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
    • Rajangam, T., and An, S. S. (2013) Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications. Int. J. Nanomed. 8, 3641-3662.
    • (2013) Int. J. Nanomed. , vol.8 , pp. 3641-3662
    • Rajangam, T.1    An, S.S.2
  • 130
    • 84887261064 scopus 로고    scopus 로고
    • Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis
    • Carragee, E.J., Chu, G., Rohatgi, R., Hurwitz, E.L., Weiner, B.K., et al. (2013) Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. J. Bone Joint Surg. Am. 95, 1537-1545.
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 1537-1545
    • Carragee, E.J.1    Chu, G.2    Rohatgi, R.3    Hurwitz, E.L.4    Weiner, B.K.5
  • 131
    • 84879113582 scopus 로고    scopus 로고
    • Transforaminal lumbar interbody fusion with rhBMP-2 in spinal deformity, spondylolisthesis, and degenerative disease-part 1: large series diagnosis related outcomes and complications with 2- to 9-year follow-up
    • Crandall, D. G., Revella, J., Patterson, J., Huish, E., Chang, M., et al. (2013) Transforaminal lumbar interbody fusion with rhBMP-2 in spinal deformity, spondylolisthesis, and degenerative disease-part 1: large series diagnosis related outcomes and complications with 2- to 9-year follow-up. Spine (Phila Pa 1976) 38, 1128-1136.
    • (2013) Spine (Phila Pa 1976) , vol.38 , pp. 1128-1136
    • Crandall, D.G.1    Revella, J.2    Patterson, J.3    Huish, E.4    Chang, M.5
  • 132
    • 84899467833 scopus 로고    scopus 로고
    • rhBMP-2/ACS grafts versus autogenous cancellous marrow grafts in large vertical defects of the maxilla: an unsponsored randomized open-label clinical trial
    • Marx, R. E., Armentano, L., Olavarria, A., and Samaniego, J. (2013) rhBMP-2/ACS grafts versus autogenous cancellous marrow grafts in large vertical defects of the maxilla: an unsponsored randomized open-label clinical trial. Int. J. Oral Maxillofac. Implants 28, e243-251.
    • (2013) Int. J. Oral Maxillofac. Implants , vol.28 , pp. e243-e251
    • Marx, R.E.1    Armentano, L.2    Olavarria, A.3    Samaniego, J.4
  • 133
    • 84893693547 scopus 로고    scopus 로고
    • Recombinant human BMP-2 increases the incidence and rate of healing in complex ankle arthrodesis
    • Fourman, M. S., Borst, E. W., Bogner, E., Rozbruch, S. R., and Fragomen, A. T. (2014) Recombinant human BMP-2 increases the incidence and rate of healing in complex ankle arthrodesis. Clin. Orthop. Relat. Res. 472, 732-739.
    • (2014) Clin. Orthop. Relat. Res. , vol.472 , pp. 732-739
    • Fourman, M.S.1    Borst, E.W.2    Bogner, E.3    Rozbruch, S.R.4    Fragomen, A.T.5
  • 135
    • 84894045351 scopus 로고    scopus 로고
    • Prospective, randomized, controlled trial of silicate-substituted calcium phosphate versus rhBMP-2 in a minimally invasive transforaminal lumbar interbody fusion
    • Nandyala, S. V., Marquez-Lara, A., Fineberg, S. J., Pelton, M., and Singh, K. (2014) Prospective, randomized, controlled trial of silicate-substituted calcium phosphate versus rhBMP-2 in a minimally invasive transforaminal lumbar interbody fusion. Spine (Phila Pa 1976) 39, 185-191.
    • (2014) Spine (Phila Pa 1976) , vol.39 , pp. 185-191
    • Nandyala, S.V.1    Marquez-Lara, A.2    Fineberg, S.J.3    Pelton, M.4    Singh, K.5
  • 136
    • 84889688900 scopus 로고    scopus 로고
    • rhBMP-2 for posterolateral instrumented lumbar fusion: a multicenter prospective randomized controlled trial
    • Hurlbert, R. J., Alexander, D., Bailey, S., Mahood, J., Abraham, E., et al. (2013) rhBMP-2 for posterolateral instrumented lumbar fusion: a multicenter prospective randomized controlled trial. Spine (Phila Pa 1976) 38, 2139-2148.
    • (2013) Spine (Phila Pa 1976) , vol.38 , pp. 2139-2148
    • Hurlbert, R.J.1    Alexander, D.2    Bailey, S.3    Mahood, J.4    Abraham, E.5
  • 137
    • 84872116582 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 versus autogenous iliac crest bone graft for lumbar fusion: a meta-analysis of ten randomized controlled trials
    • Chen, Z., Ba, G., Shen, T., and Fu, Q. (2012) Recombinant human bone morphogenetic protein-2 versus autogenous iliac crest bone graft for lumbar fusion: a meta-analysis of ten randomized controlled trials. Arch. Orthop. Trauma Surg. 132, 1725-1740.
    • (2012) Arch. Orthop. Trauma Surg. , vol.132 , pp. 1725-1740
    • Chen, Z.1    Ba, G.2    Shen, T.3    Fu, Q.4
  • 138
    • 84897437529 scopus 로고    scopus 로고
    • Buccal bone formation after flapless extraction: a randomized controlled clinical trail comparing recombinant human bone morphogenetic protein-2/absorbable collagen barrier and collagen sponge alone
    • Coomes, A. M., Mealey, B. L., Huynh-Ba, G., Barboza-Arguello, C., Moore, W. S., et al. (2014) Buccal bone formation after flapless extraction: a randomized controlled clinical trail comparing recombinant human bone morphogenetic protein-2/absorbable collagen barrier and collagen sponge alone. J. Periodontol. 85, 525-535.
    • (2014) J. Periodontol. , vol.85 , pp. 525-535
    • Coomes, A.M.1    Mealey, B.L.2    Huynh-Ba, G.3    Barboza-Arguello, C.4    Moore, W.S.5
  • 139
    • 84883867412 scopus 로고    scopus 로고
    • Clinical sequelae after rhBMP-2 use in a minimally invasive transforaminal lumbar interbody fusion
    • Singh, K., Nandyala, S. V., Marquez-Lara, A., Cha, T. D., Khan, S. N., et al. (2013) Clinical sequelae after rhBMP-2 use in a minimally invasive transforaminal lumbar interbody fusion. Spine J. 13, 1118-1125.
    • (2013) Spine J. , vol.13 , pp. 1118-1125
    • Singh, K.1    Nandyala, S.V.2    Marquez-Lara, A.3    Cha, T.D.4    Khan, S.N.5
  • 140
    • 84893924812 scopus 로고    scopus 로고
    • Rh-BMP-2 for L5-S1 arthrodesis in long fusions to the pelvis for neuromuscular spinal deformity in the pediatric age group: analysis of 11 patients
    • Gressot, L. V., Patel, A. J., Hwang, S. W., Fulkerson, D. H., and Jea, A. (2014) Rh-BMP-2 for L5-S1 arthrodesis in long fusions to the pelvis for neuromuscular spinal deformity in the pediatric age group: analysis of 11 patients. Childs Nerv. Syst. 30, 249-255.
    • (2014) Childs Nerv. Syst. , vol.30 , pp. 249-255
    • Gressot, L.V.1    Patel, A.J.2    Hwang, S.W.3    Fulkerson, D.H.4    Jea, A.5
  • 141
    • 84903178470 scopus 로고    scopus 로고
    • Ridge preservation using demineralized bone matrix gel with rhBMP-2 following tooth extraction: a randomized controlled clinical trial
    • Kim, Y. J., Lee, J. Y., Kim, J. E., Park, J. C., Shin, S. W. et al. (2014) Ridge preservation using demineralized bone matrix gel with rhBMP-2 following tooth extraction: a randomized controlled clinical trial. J. Oral Maxillofacial Surg. 72, 1281-1290.
    • (2014) J. Oral Maxillofacial Surg. , vol.72 , pp. 1281-1290
    • Kim, Y.J.1    Lee, J.Y.2    Kim, J.E.3    Park, J.C.4    Shin, S.W.5
  • 142
    • 77956013463 scopus 로고    scopus 로고
    • Treatment of tibial shaft non-unions: bone morphogenetic proteins versus autologous bone graft
    • Zimmermann, G., Wagner, C., Schmeckenbecher, K., Wentzensen, A., and Moghaddam, A. (2009) Treatment of tibial shaft non-unions: bone morphogenetic proteins versus autologous bone graft. Injury 40, S50-S53.
    • (2009) Injury , vol.40 , pp. S50-S53
    • Zimmermann, G.1    Wagner, C.2    Schmeckenbecher, K.3    Wentzensen, A.4    Moghaddam, A.5
  • 143
    • 84879177790 scopus 로고    scopus 로고
    • Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis
    • Fu, R., Selph, S., McDonagh, M., Peterson, K., Tiwari, A., et al. (2013) Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis. Ann. Intern. Med. 158, 890-902.
    • (2013) Ann. Intern. Med. , vol.158 , pp. 890-902
    • Fu, R.1    Selph, S.2    McDonagh, M.3    Peterson, K.4    Tiwari, A.5
  • 144
    • 84877945099 scopus 로고    scopus 로고
    • Transforaminal lumbar interbody fusion and posterior lumbar interbody fusion utilizing BMP-2 in treatment of degenerative spondylolisthesis: neither safe nor cost effective
    • Moatz, B. and Tortolani, P. J. (2013) Transforaminal lumbar interbody fusion and posterior lumbar interbody fusion utilizing BMP-2 in treatment of degenerative spondylolisthesis: neither safe nor cost effective. Surg. Neurol. Int. 4, S67-S73.
    • (2013) Surg. Neurol. Int. , vol.4 , pp. S67-S73
    • Moatz, B.1    Tortolani, P.J.2
  • 145
    • 84876664953 scopus 로고    scopus 로고
    • Adverse events after recombinant human BMP2 in nonspinal orthopaedic procedures
    • Woo, E. J. (2013) Adverse events after recombinant human BMP2 in nonspinal orthopaedic procedures. Clin. Orthop. Relat. Res. 471, 1707-1711.
    • (2013) Clin. Orthop. Relat. Res. , vol.471 , pp. 1707-1711
    • Woo, E.J.1
  • 146
    • 84877929075 scopus 로고    scopus 로고
    • Bone marrow enhances the performance of rhBMP-2 in spinal fusion: a rodent model
    • Bae, H.W., Zhao, L., Kanim, L.E., Wong, P., Marshall, D., et al. (2013) Bone marrow enhances the performance of rhBMP-2 in spinal fusion: a rodent model. J. Bone Joint Surg. Am. 95, 338-347.
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 338-347
    • Bae, H.W.1    Zhao, L.2    Kanim, L.E.3    Wong, P.4    Marshall, D.5
  • 147
    • 84876433078 scopus 로고    scopus 로고
    • A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair
    • Wong, E., Sangadala, S., Boden, S. D., Yoshioka, K., Hutton, W. C., et al. (2013) A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair. J. Bone Joint Surg. Am. 95, 454-461.
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 454-461
    • Wong, E.1    Sangadala, S.2    Boden, S.D.3    Yoshioka, K.4    Hutton, W.C.5
  • 148
    • 84898733886 scopus 로고    scopus 로고
    • Icariin: does it have an osteoinductive potential for bone tissue engineering? Phytother
    • Zhang, X., Liu, T., Huang, Y., Wismeijer, D., and Liu, Y. (2014) Icariin: does it have an osteoinductive potential for bone tissue engineering? Phytother. Res. 28, 498-509.
    • (2014) Res. , vol.28 , pp. 498-509
    • Zhang, X.1    Liu, T.2    Huang, Y.3    Wismeijer, D.4    Liu, Y.5
  • 149
    • 84863446613 scopus 로고    scopus 로고
    • Human platelet rich plasma plus Persian Gulf coral effects on experimental bone healing in rabbit model: radiological, histological, macroscopical and biomechanical evaluation
    • Parizi, A. M., Oryan, A., Shafiei-Sarvestani, Z., and Bigham, A. S. (2012) Human platelet rich plasma plus Persian Gulf coral effects on experimental bone healing in rabbit model: radiological, histological, macroscopical and biomechanical evaluation. J. Mater. Sci. Mater. Med. 23, 473-483.
    • (2012) J. Mater. Sci. Mater. Med. , vol.23 , pp. 473-483
    • Parizi, A.M.1    Oryan, A.2    Shafiei-Sarvestani, Z.3    Bigham, A.S.4
  • 150
    • 84857437854 scopus 로고    scopus 로고
    • The effect of hydroxyapatite-hPRP, and coral-hPRP on bone healing in rabbits: radiological, biomechanical, macroscopic and histopathologic evaluation
    • Shafiei-Sarvestani, Z., Oryan, A., Bigham, A. S., and Meimandi-Parizi, A. (2012) The effect of hydroxyapatite-hPRP, and coral-hPRP on bone healing in rabbits: radiological, biomechanical, macroscopic and histopathologic evaluation. Int. J. Surg. 10, 96-101.
    • (2012) Int. J. Surg. , vol.10 , pp. 96-101
    • Shafiei-Sarvestani, Z.1    Oryan, A.2    Bigham, A.S.3    Meimandi-Parizi, A.4
  • 151
    • 84878507876 scopus 로고    scopus 로고
    • Effects of platelet-rich plasma and recombinant human bone morphogenetic protein-2 on suture distraction osteogenesis
    • Xu, H., Ke, K., Zhang, Z., Luo, X., Jin, X., et al. (2013) Effects of platelet-rich plasma and recombinant human bone morphogenetic protein-2 on suture distraction osteogenesis. J. Craniofac. Surg. 24, 645-650.
    • (2013) J. Craniofac. Surg. , vol.24 , pp. 645-650
    • Xu, H.1    Ke, K.2    Zhang, Z.3    Luo, X.4    Jin, X.5
  • 152
    • 84897000579 scopus 로고    scopus 로고
    • Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing
    • Kim, T. H., Kim, S. H., Sandor, G. K., and Kim, Y. D. (2014) Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing. Arch. Oral Biol. 59, 550-558.
    • (2014) Arch. Oral Biol. , vol.59 , pp. 550-558
    • Kim, T.H.1    Kim, S.H.2    Sandor, G.K.3    Kim, Y.D.4
  • 153
    • 84886771627 scopus 로고    scopus 로고
    • Role of platelet rich plasma in soft and hard connective tissue healing: an evidence based review from basic to clinical application
    • Moshiri, A., and Oryan, A. (2013) Role of platelet rich plasma in soft and hard connective tissue healing: an evidence based review from basic to clinical application. Hard Tissue 2, 6.
    • (2013) Hard Tissue , vol.2 , pp. 6
    • Moshiri, A.1    Oryan, A.2
  • 154
    • 84902587074 scopus 로고    scopus 로고
    • Platelet-rich plasma (PRP): methodological aspects and clinical applications
    • in press.
    • Marques, L. F., Stessuk, T., Camargo, I. C., Sabeh Junior, N., Santos, L. D., et al. (2014) Platelet-rich plasma (PRP): methodological aspects and clinical applications. Platelets, in press.
    • (2014) Platelets
    • Marques, L.F.1    Stessuk, T.2    Camargo, I.C.3    Sabeh Junior, N.4    Santos, L.D.5
  • 155
    • 84885341323 scopus 로고    scopus 로고
    • Evaluation of bone healing in canine tibial defects filled with cortical autograft, commercial-DBM, calf fetal DBM, omentum and omentum-calf fetal DBM
    • Bigham-Sadegh, A., Karimi I., Alebouye M., Shafie-Sarvestani, Z., Oryan, A. (2013) Evaluation of bone healing in canine tibial defects filled with cortical autograft, commercial-DBM, calf fetal DBM, omentum and omentum-calf fetal DBM. J. Vet. Sci. 14, 337-343.
    • (2013) J. Vet. Sci. , vol.14 , pp. 337-343
    • Bigham-Sadegh, A.1    Karimi, I.2    Alebouye, M.3    Shafie-Sarvestani, Z.4    Oryan, A.5
  • 157
    • 84883671359 scopus 로고    scopus 로고
    • Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold
    • Jiang, L., Sun, H., Yuan, A., Zhang, K., Li, D., et al. (2013) Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold. J. Biomed. Nanotechnol. 9, 1921-1928.
    • (2013) J. Biomed. Nanotechnol. , vol.9 , pp. 1921-1928
    • Jiang, L.1    Sun, H.2    Yuan, A.3    Zhang, K.4    Li, D.5
  • 158
    • 84892565508 scopus 로고    scopus 로고
    • Evaluation of in vitro and in vivo osteogenic differentiation of nano-hydroxyapatite/chitosan/poly(lactide-co-glycolide) scaffolds with human umbilical cord mesenchymal stem cells
    • Wang, F., Zhang, Y. C., Zhou, H., Guo, Y. C., and Su, X. X. (2014) Evaluation of in vitro and in vivo osteogenic differentiation of nano-hydroxyapatite/chitosan/poly(lactide-co-glycolide) scaffolds with human umbilical cord mesenchymal stem cells. J. Biomed. Mater. Res. A. 102, 760-768.
    • (2014) J. Biomed. Mater. Res. A. , vol.102 , pp. 760-768
    • Wang, F.1    Zhang, Y.C.2    Zhou, H.3    Guo, Y.C.4    Su, X.X.5
  • 159
    • 84890312272 scopus 로고    scopus 로고
    • In vitro evaluation of bioactive strontium-based ceramic with rabbit adipose-derived stem cells for bone tissue regeneration
    • Mohan, B. G., Suresh Babu, S., Varma, H. K., and John, A. (2013) In vitro evaluation of bioactive strontium-based ceramic with rabbit adipose-derived stem cells for bone tissue regeneration. J. Mater. Sci. Mater. Med. 24, 2831-2844.
    • (2013) J. Mater. Sci. Mater. Med. , vol.24 , pp. 2831-2844
    • Mohan, B.G.1    Suresh Babu, S.2    Varma, H.K.3    John, A.4
  • 160
    • 84872848980 scopus 로고    scopus 로고
    • Monotherapy vs. polytherapy in the treatment of forearm non-unions and bone defects
    • Calori, G. M., Colomboa, M., Mazza, E., Ripamonti, C., Mazzola S., et al. (2013) Monotherapy vs. polytherapy in the treatment of forearm non-unions and bone defects. Injury S1, S63-S69.
    • (2013) Injury , vol.S1 , pp. S63-S69
    • Calori, G.M.1    Colomboa, M.2    Mazza, E.3    Ripamonti, C.4    Mazzola, S.5
  • 161
    • 84896715739 scopus 로고    scopus 로고
    • 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration
    • Inzana, J. A., Olvera, D., Fuller, S. M., Kelly, J. P., Graeve, O. A., et al. (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35, 4026-4034.
    • (2014) Biomaterials , vol.35 , pp. 4026-4034
    • Inzana, J.A.1    Olvera, D.2    Fuller, S.M.3    Kelly, J.P.4    Graeve, O.A.5
  • 162
    • 84904211382 scopus 로고    scopus 로고
    • Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect
    • Shim, J. H., Kim, S. E., Park, J. Y., Kundu, J., Kim, S. W., et al. (2014) Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect. Tissue Eng Part A 20, 1980-1992.
    • (2014) Tissue Eng Part A , vol.20 , pp. 1980-1992
    • Shim, J.H.1    Kim, S.E.2    Park, J.Y.3    Kundu, J.4    Kim, S.W.5
  • 163
    • 84877260949 scopus 로고    scopus 로고
    • Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: current concepts, approaches and concerns
    • Moshiri, A. and Oryan, A. (2012) Role of tissue engineering in tendon reconstructive surgery and regenerative medicine: current concepts, approaches and concerns. Hard Tissue 1, 11.
    • (2012) Hard Tissue , vol.1 , pp. 11
    • Moshiri, A.1    Oryan, A.2
  • 164
    • 84891750619 scopus 로고    scopus 로고
    • Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - where are we now?
    • Dawson, J. I., Kanczler, J., Tare, R., Kassem, M., and Oreffo, R. O. (2014) Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - where are we now? Stem Cells 32, 35-44.
    • (2014) Stem Cells , vol.32 , pp. 35-44
    • Dawson, J.I.1    Kanczler, J.2    Tare, R.3    Kassem, M.4    Oreffo, R.O.5
  • 165
    • 84884891747 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2
    • Song, T., Wang, W., Xu, J., Zhao, D., Dong, Q., et al. (2013) Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2. Int. J. Biochem. Cell Biol. 45, 1639-1646.
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 1639-1646
    • Song, T.1    Wang, W.2    Xu, J.3    Zhao, D.4    Dong, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.