Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21

Molecular Medicine

Volumn 17, Issue 7-8, 2011, Pages 736-740

  Chartoumpekis, Dionysios V ^a   Habeos, Ioannis G ^a   Ziros, Panos G ^a   Psyrogiannis, Agathoklis I ^a   Kyriazopoulou, Venetsana E ^a   Papavassiliou, Athanasios G ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 2 ADRENERGIC RECEPTOR; CHOLESTEROL; FIBROBLAST GROWTH FACTOR 21; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRIACYLGLYCEROL;

ADIPOCYTE; ADRENERGIC STIMULATION; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; COLD EXPOSURE; CONTROLLED STUDY; GENE EXPRESSION; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; ANIMALS; CELL LINE, TRANSFORMED; COLD TEMPERATURE; DIOXOLES; FIBROBLAST GROWTH FACTORS; MALE; MICE; MICE, INBRED C57BL; OXAZOLES; PPAR ALPHA; RECEPTORS, ADRENERGIC, BETA-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THERMOGENESIS; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TYROSINE;

EID: 79960743932     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00075     Document Type: Article

References (32)

1. Itoh N, Ornitz DM. (2008) Functional evolutionary history of the mouse Fgf gene family. Dev. Dyn. 237:18-27.
2. Goetz R, et al. (2007) Molecular insights into the Klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol. Cell. Biol. 27:3417-28.
3. Nishimura T, Nakatake Y, Konishi M, Itoh N. (2000) Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta. 1492:203-6.
4. Muise ES, et al. (2008) Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator- activated receptor gamma and altered metabolic states. Mol. Pharmacol. 74:403-12.
5. Kharitonenkov A, et al. (2008) FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. J. Cell. Physiol. 215:1-7.
6. Kurosu H, et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282:26687-95.
7. Suzuki M, et al. (2008) BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol. Endocrinol. 22:1006-14.
8. Ogawa Y, et al. (2007) BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc. Natl. Acad. Sci. USA. 104:7432-7.
9. Ito S, et al. (2000) Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech. Dev. 98:115-9.
10. Badman MK, et al. (2007) Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5:426-37.
11. Coskun T, et al. (2008) Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 149:6018-27.
12. Xu J, et al. (2009) Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in dietinduced obese mice. Diabetes. 58:250-9.
13. Sarruf DA, et al. (2010) Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes. 59:1817-24.
14. Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115:1627-35.
15. Wente W, et al. (2006) Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signalregulated kinase 1/2 and Akt signaling pathways. Diabetes. 55:2470-8.
16. Xu J, et al. (2009) Acute glucose-lowering and insulin- sensitizing action of FGF21 in insulin resistant mouse models: association with liver and adipose tissue effects. Am. J. Physiol. Endocrinol. Metab. 2009, Aug 25 [Epub ahead of print].
17. van Marken Lichtenbelt WD, et al. (2009) Coldactivated brown adipose tissue in healthy men. N. Engl. J. Med. 360:1500-8.
18. Cannon B, Nedergaard J. (2004) Brown adipose tissue: function and physiological significance. Physiol. Rev. 84:277-359.
19. Lowell BB, Spiegelman BM. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404:652-60.
20. Puigserver P, et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92:829-39.
21. Boss O, et al. (1999) Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptorgamma coactivator-1. Biochem. Biophys. Res. Commun. 261:870-6.
22. Fon Tacer K, et al. (2010) Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol. Endocrinol. 24:2050-64.
23. Hondares E, et al. (2010) Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11:206-12.
24. Oishi K, et al. (2010) FGF21 is dispensable for hypothermia induced by fasting in mice. Neuro. Endocrinol. Lett. 31:198-202.
25. Klein J, et al. (1999) Beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J. Biol. Chem. 274:34795-802.
26. Bartelt A, et al. (2011) Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 17:200-5.
27. Trayhurn P, Duncan JS, Rayner DV. (1995) Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem. J. 311:729-33.
28. Gomez-Ambrosi J, Fruhbeck G, Martinez JA. (2001) Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. Mol. Cell. Endocrinol. 176:85-90.
29. Potthoff MJ, et al. (2009) FGF21 induces PGC- 1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc. Natl. Acad. Sci. U. S. A. 106:10853-8.
30. Ahima RS, et al. (1996) Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-2.
31. Kharitonenkov A, Larsen P. (2011) FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol. Metab. 22:81-6.
32. Hondares E, et al. (2011) Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J. Biol. Chem. 286:12983-90.