Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate

Biochemical and Biophysical Research Communications

Volumn 452, Issue 4, 2014, Pages 974-979

  Hinoi, Eiichi ^a   Iezaki, Takashi ^a   Ozaki, Kakeru ^a   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Brown adipocytes; GDF5; NF B; Obesity; Palmitate; Pro inflammatory cytokines

Indexed keywords

CYTOKINE; FATTY ACID; GROWTH DIFFERENTIATION FACTOR 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LEPTIN; PALMITIC ACID; TUMOR NECROSIS FACTOR ALPHA; GDF5 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; BINDING SITE; BROWN ADIPOSE TISSUE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA FLANKING REGION; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; UPREGULATION; ANIMAL; BROWN ADIPOCYTE; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; INFLAMMATION; METABOLISM;

ADIPOCYTES, BROWN; ANIMALS; CELLS, CULTURED; CYTOKINES; GROWTH DIFFERENTIATION FACTOR 5; INFLAMMATION; MICE; MICE, INBRED C57BL; NF-KAPPA B; OBESITY; PALMITIC ACID;

EID: 84907896485     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.022     Document Type: Article

References (25)

1. P.G. Kopelman Obesity as a medical problem Nature 404 2000 635 643
2. E.E. Kershaw, and J.S. Flier Adipose tissue as an endocrine organ J. Clin. Endocrinol. Metab. 89 2004 2548 2556
3. E.D. Rosen, and B.M. Spiegelman Adipocytes as regulators of energy balance and glucose homeostasis Nature 444 2006 847 853
4. S.R. Farmer Molecular determinants of brown adipocyte formation and function Genes Dev. 22 2008 1269 1275
5. A.M. Cypess, S. Lehman, G. Williams, I. Tal, and D. Rodman Identification and importance of brown adipose tissue in adult humans N. Engl. J. Med. 360 2009 1509 1517
6. W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, and G.J. Kemerink Cold-activated brown adipose tissue in healthy men N. Engl. J. Med. 360 2009 1500 1508
7. K.A. Virtanen, M.E. Lidell, J. Orava, M. Heglind, and R. Westergren Functional brown adipose tissue in healthy adults N. Engl. J. Med. 360 2009 1518 1525
8. S.C. Chang, B. Hoang, J.T. Thomas, S. Vukicevic, and F.P. Luyten Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development J. Biol. Chem. 269 1994 28227 28234
9. J.T. Thomas, K. Lin, M. Nandedkar, M. Camargo, and J. Cervenka A human chondrodysplasia due to a mutation in a TGF-beta superfamily member Nat. Genet. 12 1996 315 317
10. Y. Miyamoto, A. Mabuchi, D. Shi, T. Kubo, and Y. Takatori A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis Nat. Genet. 39 2007 529 533
11. E. Hinoi, Y. Nakamura, S. Takada, H. Fujita, and T. Iezaki Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure Diabetes 63 2014 162 175
12. E. Hinoi, T. Iezaki, H. Fujita, T. Watanabe, and Y. Odaka PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway Biochem. Biophys. Res. Commun. 450 2014 255 260
13. Y.H. Tseng, E. Kokkotou, T.J. Schulz, T.L. Huang, and J.N. Winnay New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure Nature 454 2008 1000 1004
14. E. Hinoi, H. Ochi, T. Takarada, E. Nakatani, and T. Iezaki Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia J. Bone Miner. Res. 27 2012 938 949
15. Y. Nakamura, E. Hinoi, T. Iezaki, S. Takada, and S. Hashizume Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia Biochim. Biophys. Acta 2013 1832 1117 1128
16. T. Kan, A. Ikeda, T. Fukai, T. Nakagawa, and K. Nakamura SOX11 contributes to the regulation of GDF5 in joint maintenance BMC Dev. Biol. 13 2013 4
17. V. Baud, and M. Karin Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls Nat. Rev. Drug Discov. 8 2009 33 40
18. H. Carlsen, F. Haugen, S. Zadelaar, R. Kleemann, and T. Kooistra Diet-induced obesity increases NF-kappaB signaling in reporter mice Genes Nutr. 4 2009 215 222
19. T. Tang, J. Zhang, J. Yin, J. Staszkiewicz, and B. Gawronska-Kozak Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure J. Biol. Chem. 285 2010 4637 4644
20. G.M. Reaven, C. Hollenbeck, C.Y. Jeng, M.S. Wu, and Y.D. Chen Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM Diabetes 37 1988 1020 1024
21. G.I. Shulman Cellular mechanisms of insulin resistance J. Clin. Invest. 106 2000 171 176
22. H. Shi, M.V. Kokoeva, K. Inouye, I. Tzameli, and H. Yin TLR4 links innate immunity and fatty acid-induced insulin resistance J. Clin. Invest. 116 2006 3015 3025
23. T. Coll, E. Eyre, R. Rodríguez-Calvo, X. Palomer, and R.M. Sánchez Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells J. Biol. Chem. 283 2008 11107 11116
24. T. Kadowaki, and T. Yamauchi Adiponectin and adiponectin receptors Endocr. Rev. 26 2005 439 451
25. N. Ouchi, A. Higuchi, K. Ohashi, Y. Oshima, and N. Gokce Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity Science 329 2010 454 457