Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

Molecular Metabolism

Volumn 3, Issue 4, 2014, Pages 474-483

  Sun, Kai ^a   Kusminski, Christine M ^a   Luby Phelps, Kate ^b   Spurgin, Stephen B ^a   An, Yu A ^a   Wang, Qiong A ^a   Holland, William L ^a   Scherer, Philipp E ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

BAT; Cold tolerance; Energy expenditure; VEGF A

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCOUPLING PROTEIN 1; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CAPILLARY; CAPILLARY RAREFACTION; COLD TOLERANCE; CONTROLLED STUDY; DIET; ENERGY EXPENDITURE; ENERGY METABOLISM; FATTY LIVER; GENE OVEREXPRESSION; GLUCOSE METABOLISM; LIPID DIET; LIPID METABOLISM; MITOCHONDRIAL GENE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THERMOGENESIS; TISSUE EXPANSION; TRANSGENIC MOUSE; UPREGULATION; VASCULARIZATION; WEIGHT GAIN;

MUS; MUS MUSCULUS;

EID: 84902356732     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.03.010     Document Type: Article

References (44)

1. Cao Y. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nature Reviews Drug Discovery 2010, 9:107-115.
2. Sun K., Wernstedt-Asterholm I., Kusminski C.M., Bueno A.C., Wang Z.V., Pollard J.W., et al. Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:5874-5879.
3. Cao Y. Angiogenesis modulates adipogenesis and obesity. The Journal of Clinical Investigation 2007, 117:2362-2368.
4. Sun K., Kusminski C.M., Scherer P.E. Adipose tissue remodeling and obesity. The Journal of Clinical Investigation 2011, 121:2094-2101.
5. Sung H.K., Doh K.O., Son J.E., Park J.G., Bae Y., Choi S., et al. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metabolism 2013, 17:61-72.
6. Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. Federation of American Societies for Experimental Biology Journal 1999, 13:9-22.
7. Elias I., Franckhauser S., Ferre T., Vila L., Tafuro S., Munoz S., et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 2012, 61:1801-1813.
8. Yilmaz M., Hotamisligil G.S. Damned if you do, damned if you don't: the conundrum of adipose tissue vascularization. Cell Metabolism 2013, 17:7-9.
9. Elias I., Franckhauser S., Bosch F. New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance. Adipocyte 2013, 2:109-112.
10. Nedergaard J., Cannon B. UCP1 mRNA does not produce heat. Biochimica et Biophysica Acta 2013, 1831:943-949.
11. Rosen E.D., Spiegelman B.M. What we talk about when we talk about fat. Cell 2014, 156:20-44.
12. Xue Y., Petrovic N., Cao R., Larsson O., Lim S., Chen S., et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metabolism 2009, 9:99-109.
13. Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiological Reviews 2004, 84:277-359.
14. Bartelt A., Bruns O.T., Reimer R., Hohenberg H., Ittrich H., Peldschus K., et al. Brown adipose tissue activity controls triglyceride clearance. Nature Medicine 2011, 17:200-205.
15. Nedergaard J., Bengtsson T., Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. American Journal of Physiology. Endocrinology Metabolism 2007, 293:E444-E452.
16. Muzzin P. The uncoupling proteins. Annales d'endocrinologie (Paris) 2002, 63:106-110.
17. Golozoubova V., Cannon B., Nedergaard J. UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. American Journal of Physiology. Endocrinology and Metabolism 2006, 291:E350-E357.
18. Nedergaard J., Golozoubova V., Matthias A., Asadi A., Jacobsson A., Cannon B. UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochimica et Biophysica Acta 2001, 1504:82-106.
19. Rim J.S., Kozak L.P. Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene. Journal of Biological Chemistry 2002, 277:34589-34600.
20. Halberg N., Khan T., Trujillo M.E., Wernstedt-Asterholm I., Attie A.D., Sherwani S., et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Molecular and Cellular Biology 2009, 29:4467-4483.
21. Sun K., Halberg N., Khan M., Magalang U.J., Scherer P.E. Selective inhibition of hypoxia-inducible factor 1alpha ameliorates adipose tissue dysfunction. Molecular and Cellular Biology 2013, 33:904-917.
22. Lin E.Y., Li J.F., Bricard G., Wang W., Deng Y., Sellers R., et al. Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages. Molecular Oncology 2007, 1:288-302.
23. Kusminski C.M., Holland W.L., Sun K., Park J., Spurgin S.B., Lin Y., et al. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nature Medicine 2012, 18:1539-1549.
24. Rogers G.W., Brand M.D., Petrosyan S., Ashok D., Elorza A.A., Ferrick D.A., et al. High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One 2011, 6:e21746.
25. Tonello C., Giordano A., Cozzi V., Cinti S., Stock M.J., Carruba M.O., et al. Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats. FEBS Letters 1999, 442:167-172.
26. Asano A., Kimura K., Saito M. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. The Journal of Veterinary Medicine Science 1999, 61:403-409.
27. Asano A., Morimatsu M., Nikami H., Yoshida T., Saito M. Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: implication in cold-induced angiogenesis. The Biochemical Journal 1997, 328(Pt 1):179-183.
28. Fredriksson J.M., Lindquist J.M., Bronnikov G.E., Nedergaard J. Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta-adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. Journal of Biological Chemistry 2000, 275:13802-13811.
29. Fredriksson J.M., Nikami H., Nedergaard J. Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption. FEBS Letters 2005, 579:5680-5684.
30. Bagchi M., Kim L.A., Boucher J., Walshe T.E., Kahn C.R., D'Amore P.A., et al. Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. Federation of American Societies for Experimental Biology Journal 2013, 27:3257-3271.
31. Zhang Q.X., Magovern C.J., Mack C.A., Budenbender K.T., Ko W., Rosengart T.K., et al. Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. The Journal of Surgical Research 1997, 67:147-154.
32. Fukumura D., Ushiyama A., Duda D.G., Xu L., Tam J., Krishna V., et al. Paracrine regulation of angiogenesis and adipocyte differentiation during invivo adipogenesis. Circulation Research 2003, 93:e88-e97.
33. Smith R.E. Thermoregulatory and adaptive behavior of brown adipose tissue. Science 1964, 146:1686-1689.
34. Spiegelman B.M. Transcriptional control of energy homeostasis through the PGC1 coactivators. Novartis Foundation Symposium 2007, 286:3-6. [discussion: 6-12, 162-163, 196-203].
35. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. Acold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839.
36. Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocrine Reviews 2003, 24:78-90.
37. Kozak L.P. Brown fat and the myth of diet-induced thermogenesis. Cell Metabolism 2010, 11:263-267.
38. Wang Q.A., Tao C., Gupta R.K., Scherer P.E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nature Medicine 2013, 19:1338-1344.
39. Golozoubova V., Hohtola E., Matthias A., Jacobsson A., Cannon B., Nedergaard J. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. Federation of American Societies for Experimental Biology Journal 2001, 15:2048-2050.
40. Guerra C., Koza R.A., Yamashita H., Walsh K., Kozak L.P. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. The Journal of Clinical Investigation 1998, 102:412-420.
41. Ghorbani M., Claus T.H., Himms-Hagen J. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. Biochemical Pharmacology 1997, 54:121-131.
42. Sun K., Scherer P.E. Adipose tissue dysfunction: a multistep process 2010, Springer-Verlag, Berlin Heidelberg.
43. Unger R.H., Clark G.O., Scherer P.E., Orci L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochimica et Biophysica Acta 2010, 1801:209-214.
44. Unger R.H., Scherer P.E. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends in Endocrinology and Metabolism 2010, 21:345-352.