-
1
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517
-
(2009)
N Engl J Med
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
Lehman, S.2
Williams, G.3
-
2
-
-
67650242165
-
High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
-
Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity. Diabetes 2009;58:1526-1531
-
(2009)
Diabetes
, vol.58
, pp. 1526-1531
-
-
Saito, M.1
Okamatsu-Ogura, Y.2
Matsushita, M.3
-
4
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518-1525
-
(2009)
N Engl J Med
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
Lidell, M.E.2
Orava, J.3
-
5
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
Cannon B, Nedergaard J. Brown adipose tissue: Function and physiological significance. Physiol Rev 2004;84:277-359
-
(2004)
Physiol Rev
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
6
-
-
77950221998
-
Human brown adipose tissue
-
Enerbäck S. Human brown adipose tissue. Cell Metab 2010;11:248-252
-
(2010)
Cell Metab
, vol.11
, pp. 248-252
-
-
Enerbäck, S.1
-
7
-
-
79952306625
-
Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling
-
Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S. Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. PLoS One 2011;6:e17504
-
(2011)
PLoS One
, vol.6
, pp. e17504
-
-
Tajino, K.1
Hosokawa, H.2
Maegawa, S.3
Matsumura, K.4
Dhaka, A.5
Kobayashi, S.6
-
8
-
-
33846136103
-
Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue
-
Nakamura K, Morrison SF. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2007;292:R127-R136
-
(2007)
Am J Physiol Regul Integr Comp Physiol
, vol.292
, pp. 127-136
-
-
Nakamura, K.1
Morrison, S.F.2
-
9
-
-
84867564026
-
Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
-
Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 2012;151:400-413
-
(2012)
Cell
, vol.151
, pp. 400-413
-
-
Fedorenko, A.1
Lishko, P.V.2
Kirichok, Y.3
-
10
-
-
0018646453
-
A role for brown adipose tissue in diet-induced thermogenesis
-
Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979;281:31-35
-
(1979)
Nature
, vol.281
, pp. 31-35
-
-
Rothwell, N.J.1
Stock, M.J.2
-
11
-
-
77950264120
-
Brown fat and the myth of diet-induced thermogenesis
-
Kozak LP. Brown fat and the myth of diet-induced thermogenesis. Cell Metab 2010;11:263-267
-
(2010)
Cell Metab
, vol.11
, pp. 263-267
-
-
Kozak, L.P.1
-
12
-
-
84871866519
-
Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats
-
Betz MJ, Bielohuby M, Mauracher B, et al. Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats. PLoS One 2012;7:e38997
-
(2012)
PLoS One
, vol.7
, pp. e38997
-
-
Betz, M.J.1
Bielohuby, M.2
Mauracher, B.3
-
14
-
-
0035185505
-
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue
-
De Jesus LA, Carvalho SD, Ribeiro MO, et al. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 2001;108:1379-1385
-
(2001)
J Clin Invest
, vol.108
, pp. 1379-1385
-
-
De Jesus, L.A.1
Carvalho, S.D.2
Ribeiro, M.O.3
-
15
-
-
33745966038
-
Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
-
Atit R, Sgaier SK, Mohamed OA, et al. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol 2006;296: 164-176
-
(2006)
Dev Biol
, vol.296
, pp. 164-176
-
-
Atit, R.1
Sgaier, S.K.2
Mohamed, O.A.3
-
16
-
-
0027051199
-
Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization
-
Cousin B, Cinti S, Morroni M, et al. Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization. J Cell Sci 1992;103:931-942
-
(1992)
J Cell Sci
, vol.103
, pp. 931-942
-
-
Cousin, B.1
Cinti, S.2
Morroni, M.3
-
17
-
-
0032528169
-
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
-
Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 1998;102:412-420
-
(1998)
J Clin Invest
, vol.102
, pp. 412-420
-
-
Guerra, C.1
Koza, R.A.2
Yamashita, H.3
Walsh, K.4
Kozak, L.P.5
-
18
-
-
84896710569
-
Functional thermogenic beige adipogenesis is inducible in human neck fat
-
Lond
-
Lee P, Werner CD, Kebebew E, Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond) 2014;38:170-176
-
(2014)
Int J Obes
, vol.38
, pp. 170-176
-
-
Lee, P.1
Werner, C.D.2
Kebebew, E.3
Celi, F.S.4
-
19
-
-
50049122271
-
PRDM16 controls a brown fat/skeletal muscle switch
-
Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008;454:961-967
-
(2008)
Nature
, vol.454
, pp. 961-967
-
-
Seale, P.1
Bjork, B.2
Yang, W.3
-
20
-
-
83455198397
-
Recruited vs. Nonrecruited molecular signatures of brown, "brite," and white adipose tissues
-
Waldén TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J. Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues. Am J Physiol Endocrinol Metab 2012;302:E19-E31
-
(2012)
Am J Physiol Endocrinol Metab
, vol.302
, pp. 19-31
-
-
Waldén, T.B.1
Hansen, I.R.2
Timmons, J.A.3
Cannon, B.4
Nedergaard, J.5
-
21
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999;98:115-124
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
-
22
-
-
0032549811
-
A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998;92:829-839
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
23
-
-
33646124709
-
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
-
Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab 2006;3:333-341
-
(2006)
Cell Metab
, vol.3
, pp. 333-341
-
-
Uldry, M.1
Yang, W.2
St-Pierre, J.3
Lin, J.4
Seale, P.5
Spiegelman, B.M.6
-
24
-
-
34347326271
-
Transcriptional control of brown fat determination by PRDM16
-
Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007;6:38-54
-
(2007)
Cell Metab
, vol.6
, pp. 38-54
-
-
Seale, P.1
Kajimura, S.2
Yang, W.3
-
25
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011;121: 96-105
-
(2011)
J Clin Invest
, vol.121
, pp. 96-105
-
-
Seale, P.1
Conroe, H.M.2
Estall, J.3
-
26
-
-
0016042975
-
Growth and distribution of human fetal brown fat
-
Merklin RJ. Growth and distribution of human fetal brown fat. Anat Rec 1974;178:637-645
-
(1974)
Anat Rec
, vol.178
, pp. 637-645
-
-
Merklin, R.J.1
-
27
-
-
0027249271
-
Type II iodothyronine 59-deiodinase and uncoupling protein in brown adipose tissue of human newborns
-
Houstk J, Vízek K, Pavelka S, et al. Type II iodothyronine 59-deiodinase and uncoupling protein in brown adipose tissue of human newborns. J Clin Endocrinol Metab 1993;77:382-387
-
(1993)
J Clin Endocrinol Metab
, vol.77
, pp. 382-387
-
-
Houstk, J.1
Vízek, K.2
Pavelka, S.3
-
28
-
-
0015332110
-
The distribution of brown adipose tissue in the human
-
Heaton JM. The distribution of brown adipose tissue in the human. J Anat 1972;112:35-39
-
(1972)
J Anat
, vol.112
, pp. 35-39
-
-
Heaton, J.M.1
-
29
-
-
0026562272
-
Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans
-
Garruti G, Ricquier D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int J Obes Relat Metab Disord 1992;16: 383-390
-
(1992)
Int J Obes Relat Metab Disord
, vol.16
, pp. 383-390
-
-
Garruti, G.1
Ricquier, D.2
-
30
-
-
0027456304
-
Immunohistochemical detection of human brown adipose tissue uncoupling protein in an autopsy series
-
Kortelainen ML, Pelletier G, Ricquier D, Bukowiecki LJ. Immunohistochemical detection of human brown adipose tissue uncoupling protein in an autopsy series. J Histochem Cytochem 1993;41:759-764
-
(1993)
J Histochem Cytochem
, vol.41
, pp. 759-764
-
-
Kortelainen, M.L.1
Pelletier, G.2
Ricquier, D.3
Bukowiecki, L.J.4
-
31
-
-
0022499231
-
Brown adipose tissue uncoupling protein content in human infants, children and adults
-
Lond
-
Lean ME, James WP, Jennings G, Trayhurn P. Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin Sci (Lond) 1986;71:291-297
-
(1986)
Clin Sci
, vol.71
, pp. 291-297
-
-
Lean, M.E.1
James, W.P.2
Jennings, G.3
Trayhurn, P.4
-
32
-
-
0021844412
-
Enhanced thermogenic responsiveness during chronic ephedrine treatment in man
-
Astrup A, Lundsgaard C, Madsen J, Christensen NJ. Enhanced thermogenic responsiveness during chronic ephedrine treatment in man. Am J Clin Nutr 1985;42:83-94
-
(1985)
Am J Clin Nutr
, vol.42
, pp. 83-94
-
-
Astrup, A.1
Lundsgaard, C.2
Madsen, J.3
Christensen, N.J.4
-
33
-
-
0023902522
-
Metabolic and thyroidal responses to mild cold are abnormal in obese diabetic women
-
Oxf
-
Lean ME, Murgatroyd PR, Rothnie I, Reid IW, Harvey R. Metabolic and thyroidal responses to mild cold are abnormal in obese diabetic women. Clin Endocrinol (Oxf) 1988;28:665-673
-
(1988)
Clin Endocrinol
, vol.28
, pp. 665-673
-
-
Lean, M.E.1
Murgatroyd, P.R.2
Rothnie, I.3
Reid, I.W.4
Harvey, R.5
-
34
-
-
0024691070
-
Brown adipose tissue in humans
-
Lean ME. Brown adipose tissue in humans. Proc Nutr Soc 1989;48:243-256
-
(1989)
Proc Nutr Soc
, vol.48
, pp. 243-256
-
-
Lean, M.E.1
-
35
-
-
0022065787
-
Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man
-
Astrup A, Bülow J, Madsen J, Christensen NJ. Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am J Physiol 1985;248:E507-E515
-
(1985)
Am J Physiol
, vol.248
, pp. 507-515
-
-
Astrup, A.1
Bülow, J.2
Madsen, J.3
Christensen, N.J.4
-
36
-
-
0027487922
-
Effects of acclimatization to cold baths on men's responses to whole-body cooling in air
-
Budd GM, Brotherhood JR, Beasley FA, et al. Effects of acclimatization to cold baths on men's responses to whole-body cooling in air. Eur J Appl Physiol Occup Physiol 1993;67:438-449
-
(1993)
Eur J Appl Physiol Occup Physiol
, vol.67
, pp. 438-449
-
-
Budd, G.M.1
Brotherhood, J.R.2
Beasley, F.A.3
-
37
-
-
0022007439
-
The characterization and energetic potential of brown adipose tissue in man
-
Lond
-
Cunningham S, Leslie P, Hopwood D, et al. The characterization and energetic potential of brown adipose tissue in man. Clin Sci (Lond) 1985;69:343-348
-
(1985)
Clin Sci
, vol.69
, pp. 343-348
-
-
Cunningham, S.1
Leslie, P.2
Hopwood, D.3
-
38
-
-
0141781299
-
USA-Fat prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT
-
Cohade C, Mourtzikos KA, Wahl RL. "USA-Fat": Prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT. J Nucl Med 2003;44:1267-1270
-
(2003)
J Nucl Med
, vol.44
, pp. 1267-1270
-
-
Cohade, C.1
Mourtzikos, K.A.2
Wahl, R.L.3
-
40
-
-
84856529575
-
Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
-
Ouellet V, Labbé SM, Blondin DP, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 2012;122:545-552
-
(2012)
J Clin Invest
, vol.122
, pp. 545-552
-
-
Ouellet, V.1
Labbé, S.M.2
Blondin, D.P.3
-
41
-
-
78650676545
-
Brown adipose tissue, wholebody energy expenditure, and thermogenesis in healthy adult men
-
Silver Spring
-
Yoneshiro T, Aita S, Matsushita M, et al. Brown adipose tissue, wholebody energy expenditure, and thermogenesis in healthy adult men. Obesity (Silver Spring) 2011;19:13-16
-
(2011)
Obesity
, vol.19
, pp. 13-16
-
-
Yoneshiro, T.1
Aita, S.2
Matsushita, M.3
-
42
-
-
78650098848
-
Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
-
Ouellet V, Routhier-Labadie A, Bellemare W, et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011;96:192-199
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 192-199
-
-
Ouellet, V.1
Routhier-Labadie, A.2
Bellemare, W.3
-
43
-
-
79961233289
-
High prevalence of brown adipose tissue in adult humans
-
Lee P, Zhao JT, Swarbrick MM, et al. High prevalence of brown adipose tissue in adult humans. J Clin Endocrinol Metab 2011;96:2450-2455
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 2450-2455
-
-
Lee, P.1
Zhao, J.T.2
Swarbrick, M.M.3
-
44
-
-
80053154065
-
Inducible brown adipogenesis of supraclavicular fat in adult humans
-
Lee P, Swarbrick MM, Zhao JT, Ho KK. Inducible brown adipogenesis of supraclavicular fat in adult humans. Endocrinology 2011;152:3597-3602
-
(2011)
Endocrinology
, vol.152
, pp. 3597-3602
-
-
Lee, P.1
Swarbrick, M.M.2
Zhao, J.T.3
Ho, K.K.4
-
45
-
-
77954303930
-
Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans
-
Pfannenberg C, Werner MK, Ripkens S, et al. Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes 2010;59:1789-1793
-
(2010)
Diabetes
, vol.59
, pp. 1789-1793
-
-
Pfannenberg, C.1
Werner, M.K.2
Ripkens, S.3
-
46
-
-
77957577776
-
A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans
-
Lee P, Greenfield JR, Ho KK, Fulham MJ. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2010;299:E601-E606
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
, pp. 601-606
-
-
Lee, P.1
Greenfield, J.R.2
Ho, K.K.3
Fulham, M.J.4
-
47
-
-
84855661101
-
The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT
-
Jacene HA, Cohade CC, Zhang Z, Wahl RL. The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT. Mol Imaging Biol 2011;13:1278-1283
-
(2011)
Mol Imaging Biol
, vol.13
, pp. 1278-1283
-
-
Jacene, H.A.1
Cohade, C.C.2
Zhang, Z.3
Wahl, R.L.4
-
48
-
-
70349334680
-
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
-
Zingaretti MC, Crosta F, Vitali A, et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009;23:3113-3120
-
(2009)
FASEB J
, vol.23
, pp. 3113-3120
-
-
Zingaretti, M.C.1
Crosta, F.2
Vitali, A.3
-
49
-
-
84869233588
-
Human BAT possesses molecular signatures that resemble beige/brite cells
-
Sharp LZ, Shinoda K, Ohno H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One 2012;7:e49452
-
(2012)
PLoS One
, vol.7
, pp. e49452
-
-
Sharp, L.Z.1
Shinoda, K.2
Ohno, H.3
-
50
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366-376
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
Boström, P.2
Sparks, L.M.3
-
51
-
-
84895792999
-
Increased brown adipose tissue oxidative capacity in cold-acclimated humans
-
Blondin DP, Labbé SM, Tingelstad HC, et al. Increased brown adipose tissue oxidative capacity in cold-acclimated humans. J Clin Endocrinol Metab 2014;99:E438-E446
-
(2014)
J Clin Endocrinol Metab
, vol.99
, pp. 438-446
-
-
Blondin, D.P.1
Labbé, S.M.2
Tingelstad, H.C.3
-
52
-
-
84881221754
-
Recruited brown adipose tissue as an antiobesity agent in humans
-
Yoneshiro T, Aita S, Matsushita M, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 2013;123:3404-3408
-
(2013)
J Clin Invest
, vol.123
, pp. 3404-3408
-
-
Yoneshiro, T.1
Aita, S.2
Matsushita, M.3
-
53
-
-
84885232033
-
Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: Relationship with outdoor temperature
-
Betz MJ, Slawik M, Lidell ME, et al. Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: Relationship with outdoor temperature. J Clin Endocrinol Metab 2013;98:4097-4104
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 4097-4104
-
-
Betz, M.J.1
Slawik, M.2
Lidell, M.E.3
-
54
-
-
84877340732
-
Evidence for two types of brown adipose tissue in humans
-
Lidell ME, Betz MJ, Dahlqvist Leinhard O, et al. Evidence for two types of brown adipose tissue in humans. Nat Med 2013;19:631-634
-
(2013)
Nat Med
, vol.19
, pp. 631-634
-
-
Lidell, M.E.1
Betz, M.J.2
Dahlqvist Leinhard, O.3
-
55
-
-
84877331455
-
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
-
Cypess AM, White AP, Vernochet C, et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013;19:635-639
-
(2013)
Nat Med
, vol.19
, pp. 635-639
-
-
Cypess, A.M.1
White, A.P.2
Vernochet, C.3
-
56
-
-
84877263632
-
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
-
Jespersen NZ, Larsen TJ, Peijs L, et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013;17:798-805
-
(2013)
Cell Metab
, vol.17
, pp. 798-805
-
-
Jespersen, N.Z.1
Larsen, T.J.2
Peijs, L.3
-
57
-
-
84902097377
-
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
-
Rao RR, Long JZ, White JP, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 2014; 157:1279-1291
-
(2014)
Cell
, vol.157
, pp. 1279-1291
-
-
Rao, R.R.1
Long, J.Z.2
White, J.P.3
-
58
-
-
84902094655
-
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
-
Qiu Y, Nguyen KD, Odegaard JI, et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 2014;157:1292-1308
-
(2014)
Cell
, vol.157
, pp. 1292-1308
-
-
Qiu, Y.1
Nguyen, K.D.2
Odegaard, J.I.3
-
59
-
-
78651094465
-
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
-
Schulz TJ, Huang TL, Tran TT, et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci USA 2011;108:143-148
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 143-148
-
-
Schulz, T.J.1
Huang, T.L.2
Tran, T.T.3
-
60
-
-
84894558872
-
Metabolically active human brown adipose tissue derived stem cells
-
Silva FJ, Holt DJ, Vargas V, et al. Metabolically active human brown adipose tissue derived stem cells. Stem Cells 2014;32:572-581
-
(2014)
Stem Cells
, vol.32
, pp. 572-581
-
-
Silva, F.J.1
Holt, D.J.2
Vargas, V.3
-
61
-
-
84855658897
-
Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle
-
Lond
-
Russell AP, Crisan M, Léger B, et al. Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle. Int J Obes (Lond) 2012; 36:155-158
-
(2012)
Int J Obes
, vol.36
, pp. 155-158
-
-
Russell, A.P.1
Crisan, M.2
Léger, B.3
-
62
-
-
79952089254
-
Brown adipose tissue in morbidly obese subjects
-
Vijgen GH, Bouvy ND, Teule GJ, Brans B, Schrauwen P, Van Marken Lichtenbelt WD. Brown adipose tissue in morbidly obese subjects. PLoS One 2011;6:e17247
-
(2011)
PLoS One
, vol.6
, pp. e17247
-
-
Vijgen, G.H.1
Bouvy, N.D.2
Teule, G.J.3
Brans, B.4
Schrauwen, P.5
Van Marken Lichtenbelt, W.D.6
-
63
-
-
84862495484
-
Increase in brown adipose tissue activity after weight loss in morbidly obese subjects
-
Vijgen GH, Bouvy ND, Teule GJ, et al. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. J Clin Endocrinol Metab 2012;97:E1229-E1233
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 1229-1233
-
-
Vijgen, G.H.1
Bouvy, N.D.2
Teule, G.J.3
-
64
-
-
0028865142
-
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
-
Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995;96:2914-2923
-
(1995)
J Clin Invest
, vol.96
, pp. 2914-2923
-
-
Kopecky, J.1
Clarke, G.2
Enerbäck, S.3
Spiegelman, B.4
Kozak, L.P.5
-
65
-
-
17944377509
-
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
-
Cederberg A, Grønning LM, Ahrén B, Taskén K, Carlsson P, Enerbäck S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 2001;106:563-573
-
(2001)
Cell
, vol.106
, pp. 563-573
-
-
Cederberg, A.1
Grønning, L.M.2
Ahrén, B.3
Taskén, K.4
Carlsson, P.5
Enerbäck, S.6
-
66
-
-
20044386339
-
Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance
-
Kim JK, Kim HJ, Park SY, et al. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance. Diabetes 2005;54:1657-1663
-
(2005)
Diabetes
, vol.54
, pp. 1657-1663
-
-
Kim, J.K.1
Kim, H.J.2
Park, S.Y.3
-
67
-
-
0031025546
-
Strain-specific response to b 3-adrenergic receptor agonist treatment of diet-induced obesity in mice
-
Collins S, Daniel KW, Petro AE, Surwit RS. Strain-specific response to b 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 1997;138:405-413
-
(1997)
Endocrinology
, vol.138
, pp. 405-413
-
-
Collins, S.1
Daniel, K.W.2
Petro, A.E.3
Surwit, R.S.4
-
68
-
-
0028281432
-
Impaired expression and functional activity of the beta 3-and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice
-
Collins S, Daniel KW, Rohlfs EM, Ramkumar V, Taylor IL, Gettys TW. Impaired expression and functional activity of the beta 3-and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 1994;8:518-527
-
(1994)
Mol Endocrinol
, vol.8
, pp. 518-527
-
-
Collins, S.1
Daniel, K.W.2
Rohlfs, E.M.3
Ramkumar, V.4
Taylor, I.L.5
Gettys, T.W.6
-
69
-
-
84880272552
-
Impact of UCP1 and b3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans
-
Lond
-
Yoneshiro T, Ogawa T, Okamoto N, et al. Impact of UCP1 and b3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obes (Lond) 2013;37:993-998
-
(2013)
Int J Obes
, vol.37
, pp. 993-998
-
-
Yoneshiro, T.1
Ogawa, T.2
Okamoto, N.3
-
70
-
-
84884549617
-
Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults
-
Nakayama K, Miyashita H, Yanagisawa Y, Iwamoto S. Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults. PLoS One 2013;8:e74720
-
(2013)
PLoS One
, vol.8
, pp. e74720
-
-
Nakayama, K.1
Miyashita, H.2
Yanagisawa, Y.3
Iwamoto, S.4
-
71
-
-
79960945989
-
Different metabolic responses of human brown adipose tissue to activation by cold and insulin
-
Orava J, Nuutila P, Lidell ME, et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011; 14:272-279
-
(2011)
Cell Metab
, vol.14
, pp. 272-279
-
-
Orava, J.1
Nuutila, P.2
Lidell, M.E.3
-
72
-
-
84911896533
-
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans
-
Chondronikola M, Volpi E, Børsheim E, et al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes 2014;63:4089-4099
-
(2014)
Diabetes
, vol.63
, pp. 4089-4099
-
-
Chondronikola, M.1
Volpi, E.2
Børsheim, E.3
-
73
-
-
84887168000
-
Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans
-
Silver Spring
-
Orava J, Nuutila P, Noponen T, et al. Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans. Obesity (Silver Spring) 2013;21:2279-2287
-
(2013)
Obesity
, vol.21
, pp. 2279-2287
-
-
Orava, J.1
Nuutila, P.2
Noponen, T.3
-
74
-
-
84907973405
-
Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
-
Lee P, Smith S, Linderman J, et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes 2014;63:3686-3698
-
(2014)
Diabetes
, vol.63
, pp. 3686-3698
-
-
Lee, P.1
Smith, S.2
Linderman, J.3
-
75
-
-
79751503329
-
Brown adipose tissue activity controls triglyceride clearance
-
Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011;17:200-205
-
(2011)
Nat Med
, vol.17
, pp. 200-205
-
-
Bartelt, A.1
Bruns, O.T.2
Reimer, R.3
-
76
-
-
84894412290
-
Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice
-
Geerling JJ, Boon MR, Van Der Zon GC, et al. Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice. Diabetes 2014;63:880-891
-
(2014)
Diabetes
, vol.63
, pp. 880-891
-
-
Geerling, J.J.1
Boon, M.R.2
Van Der Zon, G.C.3
-
77
-
-
0031011161
-
Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats
-
Ghorbani M, Himms-Hagen J. Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 1997;21:465-475
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
, pp. 465-475
-
-
Ghorbani, M.1
Himms-Hagen, J.2
-
78
-
-
0030976887
-
Anti-obesity and anti-diabetic effects of CL316, 243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: Induction of uncoupling protein and activation of glucose transporter 4 in white fat
-
Umekawa T, Yoshida T, Sakane N, Saito M, Kumamoto K, Kondo M. Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: Induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol 1997;136:429-437
-
(1997)
Eur J Endocrinol
, vol.136
, pp. 429-437
-
-
Umekawa, T.1
Yoshida, T.2
Sakane, N.3
Saito, M.4
Kumamoto, K.5
Kondo, M.6
-
79
-
-
0031661901
-
Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
-
Weyer C, Tataranni PA, Snitker S, Danforth E Jr, Ravussin E. Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans. Diabetes 1998;47:1555-1561
-
(1998)
Diabetes
, vol.47
, pp. 1555-1561
-
-
Weyer, C.1
Tataranni, P.A.2
Snitker, S.3
Danforth, E.4
Ravussin, E.5
-
80
-
-
0036224375
-
Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men
-
Van Baak MA, Hul GB, Toubro S, et al. Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men. Clin Pharmacol Ther 2002;71:272-279
-
(2002)
Clin Pharmacol Ther
, vol.71
, pp. 272-279
-
-
Van Baak, M.A.1
Hul, G.B.2
Toubro, S.3
-
81
-
-
0036783754
-
Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men
-
Larsen TM, Toubro S, Van Baak MA, et al. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr 2002;76:780-788
-
(2002)
Am J Clin Nutr
, vol.76
, pp. 780-788
-
-
Larsen, T.M.1
Toubro, S.2
Van Baak, M.A.3
-
82
-
-
84920627180
-
Activation of human brown adipose tissue by a b3-adrenergic receptor agonist
-
Cypess AM, Weiner LS, Roberts-Toler C, et al. Activation of human brown adipose tissue by a b3-adrenergic receptor agonist. Cell Metab 2015;21:33-38
-
(2015)
Cell Metab
, vol.21
, pp. 33-38
-
-
Cypess, A.M.1
Weiner, L.S.2
Roberts-Toler, C.3
-
83
-
-
84871611304
-
Ephedrine activates brown adipose tissue in lean but not obese humans
-
Carey AL, Formosa MF, Van Every B, et al. Ephedrine activates brown adipose tissue in lean but not obese humans. Diabetologia 2013;56:147-155
-
(2013)
Diabetologia
, vol.56
, pp. 147-155
-
-
Carey, A.L.1
Formosa, M.F.2
Van Every, B.3
-
84
-
-
84862515329
-
Cold but not sympathomimetics activates human brown adipose tissue in vivo
-
Cypess AM, Chen YC, Sze C, et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci USA 2012;109: 10001-10005
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 10001-10005
-
-
Cypess, A.M.1
Chen, Y.C.2
Sze, C.3
-
85
-
-
84939951899
-
Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: Implications for obesity
-
Carey AL, Pajtak R, Formosa MF, et al. Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: Implications for obesity. Diabetologia 2015;58:1045-1054
-
(2015)
Diabetologia
, vol.58
, pp. 1045-1054
-
-
Carey, A.L.1
Pajtak, R.2
Formosa, M.F.3
-
87
-
-
70449421916
-
A TRbeta-selective agonist confers resistance to diet-induced obesity
-
Amorim BS, Ueta CB, Freitas BC, et al. A TRbeta-selective agonist confers resistance to diet-induced obesity. J Endocrinol 2009;203:291-299
-
(2009)
J Endocrinol
, vol.203
, pp. 291-299
-
-
Amorim, B.S.1
Ueta, C.B.2
Freitas, B.C.3
-
88
-
-
34247344167
-
Thyroid hormone receptor betaspecific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats
-
Villicev CM, Freitas FR, Aoki MS, et al. Thyroid hormone receptor betaspecific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol 2007;193:21-29
-
(2007)
J Endocrinol
, vol.193
, pp. 21-29
-
-
Villicev, C.M.1
Freitas, F.R.2
Aoki, M.S.3
-
89
-
-
84865603263
-
Bile acid binding resin improves metabolic control through the induction of energy expenditure
-
Watanabe M, Morimoto K, Houten SM, et al. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS One 2012;7:e38286
-
(2012)
PLoS One
, vol.7
, pp. e38286
-
-
Watanabe, M.1
Morimoto, K.2
Houten, S.M.3
-
90
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
Watanabe M, Houten SM, Mataki C, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439:484-489
-
(2006)
Nature
, vol.439
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
-
91
-
-
84862776702
-
A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
Boström P, Wu J, Jedrychowski MP, et al. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463-468
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Boström, P.1
Wu, J.2
Jedrychowski, M.P.3
-
92
-
-
84904417022
-
Browning of white fat does irisin play a role in humans?
-
Elsen M, Raschke S, Eckel J. Browning of white fat: Does irisin play a role in humans? J Endocrinol 2014;222:R25-R38
-
(2014)
J Endocrinol
, vol.222
, pp. 25-38
-
-
Elsen, M.1
Raschke, S.2
Eckel, J.3
-
93
-
-
84893452569
-
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
-
Lee P, Linderman JD, Smith S, et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab 2014;19:302-309
-
(2014)
Cell Metab
, vol.19
, pp. 302-309
-
-
Lee, P.1
Linderman, J.D.2
Smith, S.3
-
94
-
-
84893064752
-
Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling
-
Zhang Y, Li R, Meng Y, et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 2014;63:514-525
-
(2014)
Diabetes
, vol.63
, pp. 514-525
-
-
Zhang, Y.1
Li, R.2
Meng, Y.3
-
95
-
-
84891840977
-
B-Aminoisobutyric acid induces browning of white fat and hepatic b-oxidation and is inversely correlated with cardiometabolic risk factors
-
Roberts LD, Boström P, O'Sullivan JF, et al. b-Aminoisobutyric acid induces browning of white fat and hepatic b-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab 2014;19:96-108
-
(2014)
Cell Metab
, vol.19
, pp. 96-108
-
-
Roberts, L.D.1
Boström, P.2
O'Sullivan, J.F.3
-
96
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008;454: 1000-1004
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
Kokkotou, E.2
Schulz, T.J.3
-
97
-
-
84884183691
-
BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
-
Boon MR, Van Den Berg SA, Wang Y, et al. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS One 2013;8:e74083
-
(2013)
PLoS One
, vol.8
, pp. e74083
-
-
Boon, M.R.1
Van Den Berg, S.A.2
Wang, Y.3
-
98
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
Whittle AJ, Carobbio S, Martins L, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012;149: 871-885
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.J.1
Carobbio, S.2
Martins, L.3
-
99
-
-
79953886306
-
Thermogenic activation induces FGF21 expression and release in brown adipose tissue
-
Hondares E, Iglesias R, Giralt A, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem 2011;286: 12983-12990
-
(2011)
J Biol Chem
, vol.286
, pp. 12983-12990
-
-
Hondares, E.1
Iglesias, R.2
Giralt, A.3
-
100
-
-
84925857018
-
White-to-brown metabolic conversion of human adipocytes by JAK inhibition
-
Moisan A, Lee YK, Zhang JD, et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol 2015;17:57-67
-
(2015)
Nat Cell Biol
, vol.17
, pp. 57-67
-
-
Moisan, A.1
Lee, Y.K.2
Zhang, J.D.3
-
101
-
-
84879993961
-
Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature
-
Chen KY, Brychta RJ, Linderman JD, et al. Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature. J Clin Endocrinol Metab 2013;98:E1218-E1223
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 1218-1223
-
-
Chen, K.Y.1
Brychta, R.J.2
Linderman, J.D.3
|