Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Cell Metabolism

Volumn 19, Issue 2, 2014, Pages 302-309

  Lee, Paul ^a   Linderman, Joyce D ^a   Smith, Sheila ^a   Brychta, Robert J ^a   Wang, Juan ^a   Idelson, Christopher ^a   Perron, Rachel M ^a   Werner, Charlotte D ^a   Phan, Giao Q ^b   Kammula, Udai S ^b   Kebebew, Electron ^b   Pacak, Karel ^c   Chen, Kong Y ^a   Celi, Francesco S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; FIBROBLAST GROWTH FACTOR 21; IRISIN PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; EXERCISE; GENE EXPRESSION; HUMAN; HUMAN CELL; MUSCLE; MUSCLE CONTRACTION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SHIVERING; THERMOGENESIS;

ADIPOCYTES; ADIPOKINES; ADIPOSE TISSUE, BROWN; ADULT; EXERCISE; FEMALE; FIBROBLAST GROWTH FACTORS; FIBRONECTINS; HUMANS; MALE; SHIVERING; YOUNG ADULT;

EID: 84893452569     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.12.017     Document Type: Article

References (32)

1. P.J. Atherton, and B.E. Phillips Greek goddess or Greek myth: the effects of exercise on irisin/FNDC5 in humans J. Physiol. 591 2013 5267 5268
2. N.C. Bal, S.K. Maurya, D.H. Sopariwala, S.K. Sahoo, S.C. Gupta, S.A. Shaikh, M. Pant, L.A. Rowland, E. Bombardier, and S.A. Goonasekera et al. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals Nat. Med. 18 2012 1575 1579
3. P. Boström, J. Wu, M.P. Jedrychowski, A. Korde, L. Ye, J.C. Lo, K.A. Rasbach, E.A. Boström, J.H. Choi, and J.Z. Long et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 2012 463 468
4. B. Cannon, and J. Nedergaard Brown adipose tissue: function and physiological significance Physiol. Rev. 84 2004 277 359
5. F.S. Celi, R.J. Brychta, J.D. Linderman, P.W. Butler, A.T. Alberobello, S. Smith, A.B. Courville, E.W. Lai, R. Costello, and M.C. Skarulis et al. Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults Eur. J. Endocrinol. 163 2010 863 872
6. D.V. Chartoumpekis, I.G. Habeos, P.G. Ziros, A.I. Psyrogiannis, V.E. Kyriazopoulou, and A.G. Papavassiliou Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21 Mol. Med. 17 2011 736 740
7. K.Y. Chen, R.J. Brychta, J.D. Linderman, S. Smith, A. Courville, W. Dieckmann, P. Herscovitch, C.M. Millo, A. Remaley, P. Lee, and F.S. Celi Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature J. Clin. Endocrinol. Metab. 98 2013 E1218 E1223
8. A.M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, A.B. Goldfine, F.C. Kuo, E.L. Palmer, Y.H. Tseng, and A. Doria et al. Identification and importance of brown adipose tissue in adult humans N. Engl. J. Med. 360 2009 1509 1517
9. A.M. Cypess, A.P. White, C. Vernochet, T.J. Schulz, R. Xue, C.A. Sass, T.L. Huang, C. Roberts-Toler, L.S. Weiner, and C. Sze et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat Nat. Med. 19 2013 635 639
10. T.R. Davis Chamber cold acclimatization in man J. Appl. Physiol. 16 1961 1011 1015
11. H.P. Erickson Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor? Adipocyte 2 2013 289 293
12. E. Hondares, R. Iglesias, A. Giralt, F.J. Gonzalez, M. Giralt, T. Mampel, and F. Villarroya Thermogenic activation induces FGF21 expression and release in brown adipose tissue J. Biol. Chem. 286 2011 12983 12990
13. J.Y. Huh, G. Panagiotou, V. Mougios, M. Brinkoetter, M.T. Vamvini, B.E. Schneider, and C.S. Mantzoros FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise Metabolism 61 2012 1725 1738
14. N.Z. Jespersen, T.J. Larsen, L. Peijs, S. Daugaard, P. Homøe, A. Loft, J. de Jong, N. Mathur, B. Cannon, and J. Nedergaard et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans Cell Metab. 17 2013 798 805
15. P. Lee, K.K. Ho, P. Lee, J.R. Greenfield, K.K. Ho, and J.R. Greenfield Hot fat in a cool man: infrared thermography and brown adipose tissue Diabetes Obes. Metab. 13 2011 92 93
16. P. Lee, R.J. Brychta, J. Linderman, S. Smith, K.Y. Chen, and F.S. Celi Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis J. Clin. Endocrinol. Metab. 98 2013 E98 E102
17. P. Lee, M.M. Swarbrick, and K.K. Ho Brown adipose tissue in adult humans: a metabolic renaissance Endocr. Rev. 34 2013 413 438
18. P. Lee, C.D. Werner, E. Kebebew, and F.S. Celi Functional thermogenic beige adipogenesis is inducible in human neck fat Int. J. Obes. 2013 10.1038/ijo.2013.82 Published online May 10, 2013
19. N. Petrovic, T.B. Walden, I.G. Shabalina, J.A. Timmons, B. Cannon, and J. Nedergaard Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes J. Biol. Chem. 285 2010 7153 7164
20. S. Raschke, M. Elsen, H. Gassenhuber, M. Sommerfeld, U. Schwahn, B. Brockmann, R. Jung, U. Wisløff, A.E. Tjønna, and T. Raastad et al. Evidence against a beneficial effect of irisin in humans PLoS ONE 8 2013 e73680
21. A. Roca-Rivada, C. Castelao, L.L. Senin, M.O. Landrove, J. Baltar, A. Belén Crujeiras, L.M. Seoane, F.F. Casanueva, and M. Pardo FNDC5/irisin is not only a myokine but also an adipokine PLoS ONE 8 2013 e60563
22. M. Saito, Y. Okamatsu-Ogura, M. Matsushita, K. Watanabe, T. Yoneshiro, J. Nio-Kobayashi, T. Iwanaga, M. Miyagawa, T. Kameya, and K. Nakada et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity Diabetes 58 2009 1526 1531
23. M.A. Schumacher, N. Chinnam, T. Ohashi, R.S. Shah, and H.P. Erickson The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation J. Biol. Chem. 288 2013 33738 33744
24. L.Z. Sharp, K. Shinoda, H. Ohno, D.W. Scheel, E. Tomoda, L. Ruiz, H. Hu, L. Wang, Z. Pavlova, V. Gilsanz, and S. Kajimura Human BAT possesses molecular signatures that resemble beige/brite cells PLoS ONE 7 2012 e49452
25. W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, G.J. Kemerink, N.D. Bouvy, P. Schrauwen, and G.J. Teule Cold-activated brown adipose tissue in healthy men N. Engl. J. Med. 360 2009 1500 1508
26. F. Villarroya, and A. Vidal-Puig Beyond the sympathetic tone: the new brown fat activators Cell Metab. 17 2013 638 643
27. K.A. Virtanen, M.E. Lidell, J. Orava, M. Heglind, R. Westergren, T. Niemi, M. Taittonen, J. Laine, N.J. Savisto, S. Enerbäck, and P. Nuutila Functional brown adipose tissue in healthy adults N. Engl. J. Med. 360 2009 1518 1525
28. M.S. Wen, C.Y. Wang, S.L. Lin, and K.C. Hung Decrease in irisin in patients with chronic kidney disease PLoS ONE 8 2013 e64025
29. C.D. Wrann, J.P. White, J. Salogiannnis, D. Laznik-Bogoslavski, J. Wu, D. Ma, J.D. Lin, M.E. Greenberg, and B.M. Spiegelman Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway Cell Metab. 18 2013 649 659
30. J. Wu, P. Boström, L.M. Sparks, L. Ye, J.H. Choi, A.H. Giang, M. Khandekar, K.A. Virtanen, P. Nuutila, and G. Schaart et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Cell 150 2012 366 376
31. T. Yoneshiro, S. Aita, M. Matsushita, T. Kayahara, T. Kameya, Y. Kawai, T. Iwanaga, and M. Saito Recruited brown adipose tissue as an antiobesity agent in humans J. Clin. Invest. 123 2013 3404 3408
32. H. Yu, F. Xia, K.S. Lam, Y. Wang, Y. Bao, J. Zhang, Y. Gu, P. Zhou, J. Lu, W. Jia, and A. Xu Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans Clin. Chem. 57 2011 691 700