Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity

FASEB Journal

Volumn 28, Issue 12, 2014, Pages 5361-5375

  Boon, Mariëtte R ^a,b   Kooijman, Sander ^a,b   Van Dam, Andrea D ^a,b   Pelgrom, Leonard R ^a,b   Berbée, Jimmy F P ^a,b   Visseren, Cheryl A R ^a,b   Van Aggele, Robin C ^a,b   Van Den Hoek, Anita M ^c   Sips, Hetty C M ^a,b   Lombès, Marc ^d   Havekes, Louis M ^a,b,c   Tamsma, Jouke T ^a   Guigas, Bruno ^a   Meijer, Onno C ^a,b   Jukema, J Wouter ^a   Rensen, Patrick C N ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Einthoven Laboratory for Experimental Vascular Medicine   (Netherlands)

^c TNO   (Netherlands)

^d INSERM   (France)

Author keywords

Rimonabant; Sympathetic nervous system; Uncoupling protein 1

Indexed keywords

ADRENERGIC RECEPTOR; AM 6545; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR ANTAGONIST; CYCLIC AMP; FAT DROPLET; LIPOPROTEIN; RIMONABANT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PIPERIDINE DERIVATIVE; PRIMER DNA; PYRAZOLE DERIVATIVE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPETITE; ARTICLE; BROWN ADIPOCYTE; CALORIMETRY; CONTROLLED STUDY; DIET INDUCED OBESITY; DYSLIPIDEMIA; ENERGY EXPENDITURE; ENERGY METABOLISM; FOOD INTAKE; IN VITRO STUDY; IN VIVO STUDY; LIPID ANALYSIS; LIPID STORAGE; LIPOLYSIS; LIPOPROTEIN METABOLISM; MALE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT CHANGE; WEIGHT REDUCTION; 3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; BROWN ADIPOSE TISSUE; DYSLIPIDEMIAS; METABOLISM; NUCLEOTIDE SEQUENCE; OBESITY; PHOTON ABSORPTIOMETRY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

3T3-L1 CELLS; ABSORPTIOMETRY, PHOTON; ADIPOSE TISSUE, BROWN; ANIMALS; BASE SEQUENCE; DNA PRIMERS; DYSLIPIDEMIAS; MICE; MICE, TRANSGENIC; OBESITY; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84919779595     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-247643     Document Type: Article

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