Inhibition of in vitro and in vivo brown fat differentiation program by myostatin

Obesity

Volumn 21, Issue 6, 2013, Pages 1180-1188

  Braga, Melissa ^a   Pervin, Shehla ^a,b   Norris, Keith ^a   Bhasin, Shalender ^c   Singh, Rajan ^a,b  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; DEXAMETHASONE; INSULIN; METHYLISOBUTYLXANTHENE; MYOSTATIN; MYOSTATIN INHIBITOR; OSTEOGENIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PROTEIN INHIBITOR; RECOMBINANT PROTEIN; ROSIGLITAZONE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; XANTHENE DERIVATIVE;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BMP7 GENE; BROWN ADIPOSE TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; ENERGY EXPENDITURE; EPIDIDYMIS FAT; FEMALE; FIBROBLAST CULTURE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE REGULATORY NETWORK; IN VITRO STUDY; IN VIVO STUDY; ISOLATED ORGAN; KNOCKOUT MOUSE; LEVATOR ANI MUSCLE; LIPID METABOLISM; MALE; MOUSE; MST GENE; NONHUMAN; PGC1ALPHA; PGC1BETA; PRDM16 GENE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SUBCUTANEOUS FAT; TISSUE DIFFERENTIATION; UCP1 GENE; UPREGULATION; WILD TYPE;

MUS;

EID: 84881375503     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20117     Document Type: Article

References (34)

1. McPherron AC, Lawler AM, Lee SJ,. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997; 387: 83-90.
2. Lee SJ, McPherron AC,. Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci USA 2001; 98: 9306-9311.
3. McPherron AC, Lee SJ,. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 2002; 109: 595-601.
4. Schuelke M, Wagner KR, Stolz LE, et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 2004; 350: 2682-2688.
5. Choi SJ, Yablonka-Reuveni Z, Kaiyala KJ, et al. Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice. Am J Physiol Endocrinol Metab 2011; 300: E1031-E1037.
6. Bernardo BL, Wachtmann TS, Cosgrove PG, et al. Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice. PLoS One 2010; 5: e11307.
7. Zhang C, McFarlane C, Lokireddy S, et al. Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia 2012; 55: 183-193.
8. Cannon B, Nedergaard J,. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond) 2010; 34 (Suppl 1): S7-S16. Review.
9. Nedergaard J, Bengtsson T, Cannon B,. New powers of brown fat: fighting the metabolic syndrome. Cell Metab 2011; 13: 238-240.
10. Golozoubova V, Hohtola E, Matthias A, et al. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 2001; 15: 2048-2050.
11. Feldmann HM, Golozoubova V, Cannon B, et al. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 2009; 9: 203-209.
12. Lowell BB, S-Susulic V, Hamann A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993; 366: 740-742.
13. Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007; 6: 38-54.
14. Kajimura S, Seale P, Tomaru T, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008; 22: 1397-1409.
15. Schulz TJ, Huang TL, Tran TT, et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci USA 2011; 108: 143-148.
16. Almind K, Manieri M, Sivitz WI, et al. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci USA 2007; 104: 2366-2371.
17. Timmons JA, Wennmalm K, Larsson O, et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci USA 2007; 104: 4401-4406.
18. Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008; 454: 961-967.
19. Kim WK, Choi HR, Park SG, et al. Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization. Int J Biochem Cell Biol 2012; 44: 327-334.
20. Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011; 17: 200-205.
21. Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011; 121: 96-105.
22. Singh R, Artaza JN, Taylor WE, et al. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 2006; 147: 141-154.
23. Singh R, Bhasin S, Braga M, et al. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology 2009; 150: 1259-1268.
24. Braga M, Bhasin S, Jasuja R, et al. Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol 2012; 350: 39-52.
25. S. Enerback,. Brown Adipose Tissue In Humans: A New Target for Anti-Obesity Therapy. Novel Insights into Adipose Cell Functions. Research and Perspectives in Endocrine Interactions. Berlin Heidelberg: Springer-Verlag, 2010; 61-66. DOI 10.1007/978-3-642-13517-0-5.
26. Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360: 1518-1525. Erratum in: N Engl J Med 2009;361:1123.
27. Ahima RS,. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 2006; 14: 242S-249S.
28. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J,. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458: 1056-1060.
29. Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746-26749.
30. Hu E, Liang P, Spiegelman BM,. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697-10703.
31. Asterholm IW, Scherer PE,. Enhanced metabolic flexibility associated with elevated adiponectin levels. Am J Pathol 2010; 176: 1364-1376.
32. Combs TP, Pajvani UB, Berg AH, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004; 145: 367-383.
33. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83.
34. Shetty S, Ramos-Roman MA, Cho YR, et al. Enhanced fatty acid flux triggered by adiponectin overexpression. Endocrinology 2012; 153: 113-122.