메뉴 건너뛰기




Volumn 96, Issue 3, 2016, Pages 831-871

Parathyroid hormone-related protein, its regulation of cartilage and bone development, and role in treating bone diseases

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; KARYOPHERIN BETA; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE[1-34];

EID: 84983785852     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00031.2015     Document Type: Article
Times cited : (130)

References (397)
  • 1
    • 0035851138 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis
    • Aarts MM, Davidson D, Corluka A, Petroulakis E, Guo J, Bringhurst FR, Galipeau J, Henderson JE. Parathyroid hormone-related protein promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis. J Biol Chem 276: 37934-37943, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 37934-37943
    • Aarts, M.M.1    Davidson, D.2    Corluka, A.3    Petroulakis, E.4    Guo, J.5    Bringhurst, F.R.6    Galipeau, J.7    Henderson, J.E.8
  • 3
    • 0032852145 scopus 로고    scopus 로고
    • The nucleolar targeting signal (NTS) of parathyroid hormone related protein mediates endocytosis and nucleolar translocation
    • Aarts MM, Rix A, Guo J, Bringhurst R, Henderson JE. The nucleolar targeting signal (NTS) of parathyroid hormone related protein mediates endocytosis and nucleolar translocation. J Bone Miner Res 14: 1493-1503, 1999.
    • (1999) J Bone Miner Res , vol.14 , pp. 1493-1503
    • Aarts, M.M.1    Rix, A.2    Guo, J.3    Bringhurst, R.4    Henderson, J.E.5
  • 4
    • 0000840985 scopus 로고
    • Case Records of the Massachusetts General Hospital-Case 39061
    • Albright F. Case Records of the Massachusetts General Hospital-Case 39061. N Engl J Med 225: 789-796, 1941.
    • (1941) N Engl J Med , vol.225 , pp. 789-796
    • Albright, F.1
  • 5
    • 0021848771 scopus 로고
    • Cytochemical bioassay of parathyroid hormone in maternal and cord blood
    • Allgrove J, Adami S, Manning RM, O’Riordan JL. Cytochemical bioassay of parathyroid hormone in maternal and cord blood. Arch Dis Child 60: 110-115, 1985.
    • (1985) Arch Dis Child , vol.60 , pp. 110-115
    • Allgrove, J.1    Adami, S.2    Manning, R.M.3    O’Riordan, J.L.4
  • 6
    • 0026734658 scopus 로고
    • Parathyroid hormone-like peptide shares features with members of the early response gene family: Rapid induction by serum, growth factors, and cycloheximide
    • Allinson ET, Drucker DJ. Parathyroid hormone-like peptide shares features with members of the early response gene family: rapid induction by serum, growth factors, and cycloheximide. Cancer Res 52: 3103-3109, 1992.
    • (1992) Cancer Res , vol.52 , pp. 3103-3109
    • Allinson, E.T.1    Drucker, D.J.2
  • 7
    • 54049099247 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2
    • Alonso V, de Gortazar AR, Ardura JA, Andrade-Zapata I, Alvarez-Arroyo MV, Esbrit P. Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J Cell Physiol 217: 717-727, 2008.
    • (2008) J Cell Physiol , vol.217 , pp. 717-727
    • Alonso, V.1    de Gortazar, A.R.2    Ardura, J.A.3    Andrade-Zapata, I.4    Alvarez-Arroyo, M.V.5    Esbrit, P.6
  • 8
    • 0033890965 scopus 로고    scopus 로고
    • Inefficient function of the signal sequence of PTHrP for targeting into the secretory pathway
    • Amizuka N, Fukushi-Irie M, Sasaki T, Oda K, Ozawa H. Inefficient function of the signal sequence of PTHrP for targeting into the secretory pathway. Biochem Biophys Res Commun 273: 621-629, 2000.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 621-629
    • Amizuka, N.1    Fukushi-Irie, M.2    Sasaki, T.3    Oda, K.4    Ozawa, H.5
  • 10
    • 0027968182 scopus 로고
    • Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation
    • Amizuka N, Warshawsky H, Henderson JE, Goltzman D, Karaplis AC. Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J Cell Biol 126: 1611-1623, 1994.
    • (1994) J Cell Biol , vol.126 , pp. 1611-1623
    • Amizuka, N.1    Warshawsky, H.2    Henderson, J.E.3    Goltzman, D.4    Karaplis, A.C.5
  • 11
    • 84983741315 scopus 로고    scopus 로고
    • Osteocyte production of PTHrP is necessary for normal osteocyte differentiation and bone remodelling
    • Ansari N, Ho P, Gooi J, Martin TJ, Sims NA. Osteocyte production of PTHrP is necessary for normal osteocyte differentiation and bone remodelling. J Bone Miner Res 26: S112, 2015.
    • (2015) J Bone Miner Res , vol.26 , pp. S112
    • Ansari, N.1    Ho, P.2    Gooi, J.3    Martin, T.J.4    Sims, N.A.5
  • 14
    • 0025064842 scopus 로고
    • Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues
    • Asa SL, Henderson J, Goltzman D, Drucker DJ. Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues. J Clin Endocrinol Metab 71: 1112-1118, 1990.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1112-1118
    • Asa, S.L.1    Henderson, J.2    Goltzman, D.3    Drucker, D.J.4
  • 15
    • 0017640434 scopus 로고
    • Rat osteogenic sarcoma cells: Isolation and effects of hormones on the production of cyclic AMP and cyclic GMP
    • Atkins D, Hunt NH, Ingleton PM, Martin TJ. Rat osteogenic sarcoma cells: isolation and effects of hormones on the production of cyclic AMP and cyclic GMP. Endocrinology 101: 555-561, 1977.
    • (1977) Endocrinology , vol.101 , pp. 555-561
    • Atkins, D.1    Hunt, N.H.2    Ingleton, P.M.3    Martin, T.J.4
  • 16
    • 0017661186 scopus 로고
    • Secretion of prostaglandins as bone-resorbing agents by renal cortical carcinoma in culture
    • Atkins D, Ibbotson KJ, Hillier K, Hunt NH, Hammonds JC, Martin TJ. Secretion of prostaglandins as bone-resorbing agents by renal cortical carcinoma in culture. Br J Cancer 36: 601-607, 1977.
    • (1977) Br J Cancer , vol.36 , pp. 601-607
    • Atkins, D.1    Ibbotson, K.J.2    Hillier, K.3    Hunt, N.H.4    Hammonds, J.C.5    Martin, T.J.6
  • 17
    • 84890016169 scopus 로고    scopus 로고
    • Parathyroid hormone and parathyroid hormone-related protein analogs as therapies for osteoporosis
    • Augustine M, Horwitz MJ. Parathyroid hormone and parathyroid hormone-related protein analogs as therapies for osteoporosis. Curr Osteoporos Rep 11: 400-406, 2013.
    • (2013) Curr Osteoporos Rep , vol.11 , pp. 400-406
    • Augustine, M.1    Horwitz, M.J.2
  • 18
    • 28244477646 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy
    • Bacci G, Longhi A, Fagioli F, Briccoli A, Versari M, Picci P. Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy. Eur J Cancer 41: 2836-2845, 2005.
    • (2005) Eur J Cancer , vol.41 , pp. 2836-2845
    • Bacci, G.1    Longhi, A.2    Fagioli, F.3    Briccoli, A.4    Versari, M.5    Picci, P.6
  • 19
    • 0027186329 scopus 로고
    • NMR solution structure of human parathyroid hormone(1-34)
    • Barden JA, Kemp BE. NMR solution structure of human parathyroid hormone(1-34). Biochemistry 32: 7126-7132, 1993.
    • (1993) Biochemistry , vol.32 , pp. 7126-7132
    • Barden, J.A.1    Kemp, B.E.2
  • 20
    • 0028077042 scopus 로고
    • Stabilized NMR structure of the hypercalcemia of malignancy peptide PTHrP[Ala-26](1-34)amide
    • Barden JA, Kemp BE. Stabilized NMR structure of the hypercalcemia of malignancy peptide PTHrP[Ala-26](1-34)amide. Biochim Biophys Acta 1208: 256-262, 1994.
    • (1994) Biochim Biophys Acta , vol.1208 , pp. 256-262
    • Barden, J.A.1    Kemp, B.E.2
  • 22
    • 0000683821 scopus 로고
    • Studies of calcium phosphorus metabolism. A study of the bone trabeculae as a readily available source of calcium
    • Bauer W, Aub JC, Albright F. Studies of calcium phosphorus metabolism. A study of the bone trabeculae as a readily available source of calcium. J Exp Med 49: 145-162, 1929.
    • (1929) J Exp Med , vol.49 , pp. 145-162
    • Bauer, W.1    Aub, J.C.2    Albright, F.3
  • 23
    • 0029766811 scopus 로고    scopus 로고
    • Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes
    • Behar V, Nakamoto C, Greenberg Z, Bisello A, Suva LJ, Rosenblatt M, Chorev M. Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes. Endocrinology 137: 4217-4224, 1996.
    • (1996) Endocrinology , vol.137 , pp. 4217-4224
    • Behar, V.1    Nakamoto, C.2    Greenberg, Z.3    Bisello, A.4    Suva, L.J.5    Rosenblatt, M.6    Chorev, M.7
  • 24
  • 25
    • 0016253911 scopus 로고
    • Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism
    • Benson RC Jr, Riggs BL, Pickard BM, Arnaud CD. Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism. J Clin Invest 54: 175-181, 1974.
    • (1974) J Clin Invest , vol.54 , pp. 175-181
    • Benson Jr, R.C.1    Riggs, B.L.2    Pickard, B.M.3    Arnaud, C.D.4
  • 28
    • 0014021480 scopus 로고
    • Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma
    • Berson SA, Yalow RS. Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science 154: 907-909, 1966.
    • (1966) Science , vol.154 , pp. 907-909
    • Berson, S.A.1    Yalow, R.S.2
  • 29
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 11: R90, 2010.
    • (2010) Genome Biol , vol.11 , pp. R90
    • Betel, D.1    Koppal, A.2    Agius, P.3    Sander, C.4    Leslie, C.5
  • 31
    • 84886847538 scopus 로고    scopus 로고
    • The search for the optimal anabolic osteoporosis therapy
    • Black DM, Schafer AL. The search for the optimal anabolic osteoporosis therapy. J Bone Miner Res 28: 2263-2265, 2013.
    • (2013) J Bone Miner Res , vol.28 , pp. 2263-2265
    • Black, D.M.1    Schafer, A.L.2
  • 32
    • 0022000808 scopus 로고
    • A case of lethal congenital dwarfism with accelerated skeletal maturation
    • Blomstrand S, Claesson I, Save-Soderbergh J. A case of lethal congenital dwarfism with accelerated skeletal maturation. Pediatr Radiol 15: 141-143, 1985.
    • (1985) Pediatr Radiol , vol.15 , pp. 141-143
    • Blomstrand, S.1    Claesson, I.2    Save-Soderbergh, J.3
  • 33
    • 79251493453 scopus 로고    scopus 로고
    • The amazing osteocyte
    • Bonewald LF. The amazing osteocyte. J Bone Miner Res 26: 229-238, 2011.
    • (2011) J Bone Miner Res , vol.26 , pp. 229-238
    • Bonewald, L.F.1
  • 34
    • 0027998030 scopus 로고
    • Parathyroid hormone (PTH) and PTH-related peptide induce relaxation of smooth muscle cells from guinea pig ileum: Interaction with vasoactive intestinal peptide receptors
    • Botella A, Rekik M, Delvaux M, Davicco MJ, Barlet JP, Frexinos J, Bueno L. Parathyroid hormone (PTH) and PTH-related peptide induce relaxation of smooth muscle cells from guinea pig ileum: interaction with vasoactive intestinal peptide receptors. Endocrinology 135: 2160-2167, 1994.
    • (1994) Endocrinology , vol.135 , pp. 2160-2167
    • Botella, A.1    Rekik, M.2    Delvaux, M.3    Davicco, M.J.4    Barlet, J.P.5    Frexinos, J.6    Bueno, L.7
  • 35
    • 0021211670 scopus 로고
    • Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor
    • Brissenden JE, Ullrich A, Francke U. Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor. Nature 310: 781-784, 1984.
    • (1984) Nature , vol.310 , pp. 781-784
    • Brissenden, J.E.1    Ullrich, A.2    Francke, U.3
  • 36
    • 0021915365 scopus 로고
    • Regulation of bone mineral loss during lactation
    • Brommage R, DeLuca HF. Regulation of bone mineral loss during lactation. Am J Physiol Endocrinol Metab 248: E182-E187, 1985.
    • (1985) Am J Physiol Endocrinol Metab , vol.248 , pp. E182-E187
    • Brommage, R.1    DeLuca, H.F.2
  • 37
    • 0029116761 scopus 로고
    • Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: Implications for secretion and function
    • Bruns ME, Ferguson JE, 2nd Bruns DE, Burton DW, Brandt DW, Juppner H, Segre GV, Deftos LJ. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: implications for secretion and function. Am J Obstet Gynecol 173: 739-746, 1995.
    • (1995) Am J Obstet Gynecol , vol.173 , pp. 739-746
    • Bruns, M.E.1    Ferguson, J.E.2    Bruns, D.E.3    Burton, D.W.4    Brandt, D.W.5    Juppner, H.6    Segre, G.V.7    Deftos, L.J.8
  • 38
    • 84967956922 scopus 로고
    • Ectopic secretion of parathyroid hormone by a renal adenocarcinoma in a patient with hypercalcaemia
    • Buckle RM, McMillan M, Mallinson C. Ectopic secretion of parathyroid hormone by a renal adenocarcinoma in a patient with hypercalcaemia. Br Med J 4: 724-726, 1970.
    • (1970) Br Med J , vol.4 , pp. 724-726
    • Buckle, R.M.1    McMillan, M.2    Mallinson, C.3
  • 39
    • 84924131551 scopus 로고    scopus 로고
    • Quantifying the osteocyte network in the human skeleton
    • Buenzli PR, Sims NA. Quantifying the osteocyte network in the human skeleton. Bone 75: 144-150, 2015.
    • (2015) Bone , vol.75 , pp. 144-150
    • Buenzli, P.R.1    Sims, N.A.2
  • 40
    • 0023463127 scopus 로고
    • Constitutive and regulated secretion of proteins
    • Burgess TL, Kelly RB. Constitutive and regulated secretion of proteins. Annu Rev Cell Biol 3: 243-293, 1987.
    • (1987) Annu Rev Cell Biol , vol.3 , pp. 243-293
    • Burgess, T.L.1    Kelly, R.B.2
  • 42
    • 0026725867 scopus 로고
    • Preliminary characterization of circulating amino- and carboxy-terminal fragments of parathyroid hormonerelated peptide in humoral hypercalcemia of malignancy
    • Burtis WJ, Fodero JP, Gaich G, Debeyssey M, Stewart AF. Preliminary characterization of circulating amino- and carboxy-terminal fragments of parathyroid hormonerelated peptide in humoral hypercalcemia of malignancy. J Clin Endocrinol Metab 75: 1110-1114, 1992.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 1110-1114
    • Burtis, W.J.1    Fodero, J.P.2    Gaich, G.3    Debeyssey, M.4    Stewart, A.F.5
  • 43
    • 0023259132 scopus 로고
    • Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase- stimulating protein from a tumor associated with humoral hypercalcemia of malignancy
    • Burtis WJ,WuT, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase- stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem 262: 7151-7156, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 7151-7156
    • Burtis, W.J.1    Wu, T.2    Bunch, C.3    Wysolmerski, J.J.4    Insogna, K.L.5    Weir, E.C.6    Broadus, A.E.7    Stewart, A.F.8
  • 44
    • 0026793734 scopus 로고
    • Regulation of parathyroid hormone-related peptide (PTHrP) gene transcription: Cell- and tissue-specific promoter utilization mediated by multiple positive and negative cis-acting DNA elements
    • Campos RV, Wang C, Drucker DJ. Regulation of parathyroid hormone-related peptide (PTHrP) gene transcription: cell- and tissue-specific promoter utilization mediated by multiple positive and negative cis-acting DNA elements. Mol Endocrinol 6: 1642-1652, 1992.
    • (1992) Mol Endocrinol , vol.6 , pp. 1642-1652
    • Campos, R.V.1    Wang, C.2    Drucker, D.J.3
  • 45
    • 34548306408 scopus 로고    scopus 로고
    • Mechanisms of anabolic therapies for osteoporosis
    • Canalis E, Giustina A, Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357: 905-916, 2007.
    • (2007) N Engl J Med , vol.357 , pp. 905-916
    • Canalis, E.1    Giustina, A.2    Bilezikian, J.P.3
  • 46
    • 0025045454 scopus 로고
    • Hypercalcemia in a calcitriol-treated hypoparathyroid woman during lactation
    • Caplan RH, Beguin EA. Hypercalcemia in a calcitriol-treated hypoparathyroid woman during lactation. Obstet Gynecol 76: 485-489, 1990.
    • (1990) Obstet Gynecol , vol.76 , pp. 485-489
    • Caplan, R.H.1    Beguin, E.A.2
  • 47
    • 0025150747 scopus 로고
    • Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein
    • Care AD, Abbas SK, Pickard DW, Barri M, Drinkhill M, Findlay JB, White IR, Caple IW. Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Exp Physiol 75: 605-608, 1990.
    • (1990) Exp Physiol , vol.75 , pp. 605-608
    • Care, A.D.1    Abbas, S.K.2    Pickard, D.W.3    Barri, M.4    Drinkhill, M.5    Findlay, J.B.6    White, I.R.7    Caple, I.W.8
  • 48
    • 0014300512 scopus 로고
    • A rapid and selective vasodialtor effect of parathyroid hormone
    • Charbon GA. A rapid and selective vasodialtor effect of parathyroid hormone. Eur J Pharmacol 3: 275-278, 1968.
    • (1968) Eur J Pharmacol , vol.3 , pp. 275-278
    • Charbon, G.A.1
  • 49
    • 0016160319 scopus 로고
    • Augmentation of arterial hepatic and renal flow by extracted and synthetic parathyroid hormone
    • Charbon GA, Hulstaert PF. Augmentation of arterial hepatic and renal flow by extracted and synthetic parathyroid hormone. Endocrinology 96: 621-626, 1974.
    • (1974) Endocrinology , vol.96 , pp. 621-626
    • Charbon, G.A.1    Hulstaert, P.F.2
  • 50
    • 35348854422 scopus 로고    scopus 로고
    • Mechanical regulation of PTHrP expression in entheses
    • Chen X, Macica C, Nasiri A, Judex S, Broadus AE. Mechanical regulation of PTHrP expression in entheses. Bone 41: 752-759, 2007.
    • (2007) Bone , vol.41 , pp. 752-759
    • Chen, X.1    Macica, C.2    Nasiri, A.3    Judex, S.4    Broadus, A.E.5
  • 51
    • 22744432069 scopus 로고    scopus 로고
    • Stretch-induced PTH-related protein gene expression in osteoblasts
    • Chen X, Macica CM, Ng KW, Broadus AE. Stretch-induced PTH-related protein gene expression in osteoblasts. J Bone Miner Res 20: 1454-1461, 2005.
    • (2005) J Bone Miner Res , vol.20 , pp. 1454-1461
    • Chen, X.1    Macica, C.M.2    Ng, K.W.3    Broadus, A.E.4
  • 52
    • 0034711040 scopus 로고    scopus 로고
    • Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone
    • Chen Z, Xu P, Barbier JR, Willick G, Ni F. Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone. Biochemistry 39: 12766-12777, 2000.
    • (2000) Biochemistry , vol.39 , pp. 12766-12777
    • Chen, Z.1    Xu, P.2    Barbier, J.R.3    Willick, G.4    Ni, F.5
  • 53
    • 0032536738 scopus 로고    scopus 로고
    • Differential regulation of the parathyroid hormonerelated protein gene P1 and P3 promoters by cAMP
    • Chilco PJ, Leopold V, Zajac JD. Differential regulation of the parathyroid hormonerelated protein gene P1 and P3 promoters by cAMP. Mol Cell Endocrinol 138: 173-184, 1998.
    • (1998) Mol Cell Endocrinol , vol.138 , pp. 173-184
    • Chilco, P.J.1    Leopold, V.2    Zajac, J.D.3
  • 54
    • 0032573058 scopus 로고    scopus 로고
    • The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
    • Chung UI, Lanske B, Lee K, Li E, Kronenberg H. The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 95: 13030-13035, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13030-13035
    • Chung, U.I.1    Lanske, B.2    Lee, K.3    Li, E.4    Kronenberg, H.5
  • 55
    • 0036923972 scopus 로고    scopus 로고
    • Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta
    • Cingolani G, Bednenko J, Gillespie MT, Gerace L. Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. Mol Cell 10: 1345-1353, 2002.
    • (2002) Mol Cell , vol.10 , pp. 1345-1353
    • Cingolani, G.1    Bednenko, J.2    Gillespie, M.T.3    Gerace, L.4
  • 56
    • 0037063363 scopus 로고    scopus 로고
    • The COOH-terminus of parathyroid hormonerelated protein (PTHrP) interacts with beta-arrestin 1B
    • Conlan LA, Martin TJ, Gillespie MT. The COOH-terminus of parathyroid hormonerelated protein (PTHrP) interacts with beta-arrestin 1B. FEBS Lett 527: 71-75, 2002.
    • (2002) FEBS Lett , vol.527 , pp. 71-75
    • Conlan, L.A.1    Martin, T.J.2    Gillespie, M.T.3
  • 58
    • 0032983681 scopus 로고    scopus 로고
    • Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein
    • Cornish J, Callon KE, Lin C, Xiao C, Moseley JM, Reid IR. Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein. J Bone Miner Res 14: 915-922, 1999.
    • (1999) J Bone Miner Res , vol.14 , pp. 915-922
    • Cornish, J.1    Callon, K.E.2    Lin, C.3    Xiao, C.4    Moseley, J.M.5    Reid, I.R.6
  • 59
    • 0031046777 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo
    • Cornish J, Callon KE, Nicholson GC, Reid IR. Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo. Endocrinology 138: 1299-1304, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1299-1304
    • Cornish, J.1    Callon, K.E.2    Nicholson, G.C.3    Reid, I.R.4
  • 60
    • 0030211390 scopus 로고    scopus 로고
    • Prostate specific antigen cleaves parathyroid hormone- related protein in the PTH-like domain: Inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts
    • Cramer SD, Chen Z, Peehl DM. Prostate specific antigen cleaves parathyroid hormone- related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts. J Urol 156: 526-531, 1996.
    • (1996) J Urol , vol.156 , pp. 526-531
    • Cramer, S.D.1    Chen, Z.2    Peehl, D.M.3
  • 61
    • 0027057764 scopus 로고
    • Stretch-induced parathyroid hormone- related peptide gene expression in the rat uterus
    • Daifotis AG, Weir EC, Dreyer BE, Broadus AE. Stretch-induced parathyroid hormone- related peptide gene expression in the rat uterus. J Biol Chem 267: 23455-23458, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 23455-23458
    • Daifotis, A.G.1    Weir, E.C.2    Dreyer, B.E.3    Broadus, A.E.4
  • 66
    • 84855723440 scopus 로고    scopus 로고
    • Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice
    • De Castro LF, Lozano D, Portal-Nunez S, Maycas M, De la Fuente M, Caeiro JR, Esbrit P. Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice. J Cell Physiol 227: 1752-1760, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 1752-1760
    • De Castro, L.F.1    Lozano, D.2    Portal-Nunez, S.3    Maycas, M.4    De la Fuente, M.5    Caeiro, J.R.6    Esbrit, P.7
  • 67
    • 33845448556 scopus 로고    scopus 로고
    • Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro
    • De Gortazar AR, Alonso V, Alvarez-Arroyo MV, Esbrit P. Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. Calcif Tissue Int 79: 360-369, 2006.
    • (2006) Calcif Tissue Int , vol.79 , pp. 360-369
    • De Gortazar, A.R.1    Alonso, V.2    Alvarez-Arroyo, M.V.3    Esbrit, P.4
  • 68
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonistspecific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
    • De Lean A, Stadel JM, Lefkowitz RJ. A ternary complex model explains the agonistspecific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem 255: 7108-7117, 1980.
    • (1980) J Biol Chem , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.M.2    Lefkowitz, R.J.3
  • 69
    • 0034864296 scopus 로고    scopus 로고
    • The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells
    • De Miguel F, Fiaschi-Taesch N, Lopez-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology 142: 4096-4105, 2001.
    • (2001) Endocrinology , vol.142 , pp. 4096-4105
    • De Miguel, F.1    Fiaschi-Taesch, N.2    Lopez-Talavera, J.C.3    Takane, K.K.4    Massfelder, T.5    Helwig, J.J.6    Stewart, A.F.7
  • 70
    • 33645408784 scopus 로고    scopus 로고
    • Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: Selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations
    • Dean T, Linglart A, Mahon MJ, Bastepe M, Juppner H, Potts JT Jr, Gardella TJ. Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations. Mol Endocrinol 20: 931-943, 2006.
    • (2006) Mol Endocrinol , vol.20 , pp. 931-943
    • Dean, T.1    Linglart, A.2    Mahon, M.J.3    Bastepe, M.4    Juppner, H.5    Potts Jr, J.T.6    Gardella, T.J.7
  • 71
    • 38049086228 scopus 로고    scopus 로고
    • Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor
    • Dean T, Vilardaga JP, Potts JT Jr, Gardella TJ. Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Mol Endocrinol 22: 156-166, 2008.
    • (2008) Mol Endocrinol , vol.22 , pp. 156-166
    • Dean, T.1    Vilardaga, J.P.2    Potts Jr, J.T.3    Gardella, T.J.4
  • 72
    • 0029091836 scopus 로고
    • The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate-is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?
    • Delmas PD, Vergnaud P, Arlot ME, Pastoureau P, Meunier PJ, Nilssen MH. The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate-is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system? Bone 16: 603-610, 1995.
    • (1995) Bone , vol.16 , pp. 603-610
    • Delmas, P.D.1    Vergnaud, P.2    Arlot, M.E.3    Pastoureau, P.4    Meunier, P.J.5    Nilssen, M.H.6
  • 73
    • 0036772573 scopus 로고    scopus 로고
    • Anabolic actions of parathyroid hormone during bone growth are dependent on c-fos
    • Demiralp B, Chen HL, Koh AJ, Keller ET, McCauley LK. Anabolic actions of parathyroid hormone during bone growth are dependent on c-fos. Endocrinology 143: 4038-4047, 2002.
    • (2002) Endocrinology , vol.143 , pp. 4038-4047
    • Demiralp, B.1    Chen, H.L.2    Koh, A.J.3    Keller, E.T.4    McCauley, L.K.5
  • 77
    • 0029963567 scopus 로고    scopus 로고
    • Elimination of the carboxy-terminal sequences of parathyroid hormone-related protein 1-173 increases production and secretion of the truncated forms
    • Ditmer LS, Burton DW, Deftos LJ. Elimination of the carboxy-terminal sequences of parathyroid hormone-related protein 1-173 increases production and secretion of the truncated forms. Endocrinology 137: 1608-1617, 1996.
    • (1996) Endocrinology , vol.137 , pp. 1608-1617
    • Ditmer, L.S.1    Burton, D.W.2    Deftos, L.J.3
  • 78
    • 0027244968 scopus 로고
    • Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: Evidence for the involvement of transcription factor Ets1
    • Dittmer J, Gitlin SD, Reid RL, Brady JN. Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1. J Virol 67: 6087-6095, 1993.
    • (1993) J Virol , vol.67 , pp. 6087-6095
    • Dittmer, J.1    Gitlin, S.D.2    Reid, R.L.3    Brady, J.N.4
  • 79
    • 0031040330 scopus 로고    scopus 로고
    • Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter
    • Dittmer J, Pise-Masison CA, Clemens KE, Choi KS, Brady JN. Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter. J Biol Chem 272: 4953-4958, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 4953-4958
    • Dittmer, J.1    Pise-Masison, C.A.2    Clemens, K.E.3    Choi, K.S.4    Brady, J.N.5
  • 80
    • 0035103064 scopus 로고    scopus 로고
    • Receptors for the carboxyl-terminal region of pth(1- 84) are highly expressed in osteocytic cells
    • Divieti P, Inomata N, Chapin K, Singh R, Juppner H, Bringhurst FR. Receptors for the carboxyl-terminal region of pth(1- 84) are highly expressed in osteocytic cells. Endocrinology 142: 916-925, 2001.
    • (2001) Endocrinology , vol.142 , pp. 916-925
    • Divieti, P.1    Inomata, N.2    Chapin, K.3    Singh, R.4    Juppner, H.5    Bringhurst, F.R.6
  • 81
    • 0029736663 scopus 로고    scopus 로고
    • Insulin-like growth factor bioactivity and its modification in growth hormone resistant states
    • Donaghy AJ, Baxter RC. Insulin-like growth factor bioactivity and its modification in growth hormone resistant states. Baillieres Clin Endocrinol Metab 10: 421-446, 1996.
    • (1996) Baillieres Clin Endocrinol Metab , vol.10 , pp. 421-446
    • Donaghy, A.J.1    Baxter, R.C.2
  • 82
    • 0028118423 scopus 로고
    • Parathyroid hormone related protein (PTHrP) gene expression in fetal and extra-embryonic tissues of early pregnancy
    • Dunne FP, Ratcliffe WA, Mansour P, Heath DA. Parathyroid hormone related protein (PTHrP) gene expression in fetal and extra-embryonic tissues of early pregnancy. Hum Reprod 9: 149-156, 1994.
    • (1994) Hum Reprod , vol.9 , pp. 149-156
    • Dunne, F.P.1    Ratcliffe, W.A.2    Mansour, P.3    Heath, D.A.4
  • 83
    • 32344433290 scopus 로고    scopus 로고
    • hPTH-fragments (53- 84) and (28-48) antagonize the stimulation of calcium release and repression of alkaline phosphatase activity by hPTH-(1-34) in vitro
    • Duvos C, Scutt A, Mayer H. hPTH-fragments (53- 84) and (28-48) antagonize the stimulation of calcium release and repression of alkaline phosphatase activity by hPTH-(1-34) in vitro. FEBS Lett 580: 1509-1514, 2006.
    • (2006) FEBS Lett , vol.580 , pp. 1509-1514
    • Duvos, C.1    Scutt, A.2    Mayer, H.3
  • 84
    • 0025179577 scopus 로고
    • Comparison of the effects of parathyroid hormone (PTH) and recombinant PTH-related protein on bicarbonate excretion by the isolated perfused rat kidney
    • Ellis AG, Adam WR, Martin TJ. Comparison of the effects of parathyroid hormone (PTH) and recombinant PTH-related protein on bicarbonate excretion by the isolated perfused rat kidney. J Endocrinol 126: 403-408, 1990.
    • (1990) J Endocrinol , vol.126 , pp. 403-408
    • Ellis, A.G.1    Adam, W.R.2    Martin, T.J.3
  • 86
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 12: 861-874, 2011.
    • (2011) Nat Rev Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 88
    • 0025720469 scopus 로고
    • A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]
    • Fenton AJ, Kemp BE, Hammonds RG Jr, Mitchelhill K, Moseley JM, Martin TJ, Nicholson GC. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology 129: 3424-3426, 1991.
    • (1991) Endocrinology , vol.129 , pp. 3424-3426
    • Fenton, A.J.1    Kemp, B.E.2    Hammonds Jr, R.G.3    Mitchelhill, K.4    Moseley, J.M.5    Martin, T.J.6    Nicholson, G.C.7
  • 90
    • 0027516448 scopus 로고
    • Long-term culture of disaggregated rat osteoclasts: Inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107-139]
    • Fenton AJ, Martin TJ, Nicholson GC. Long-term culture of disaggregated rat osteoclasts: inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107-139]. J Cell Physiol 155: 1-7, 1993.
    • (1993) J Cell Physiol , vol.155 , pp. 1-7
    • Fenton, A.J.1    Martin, T.J.2    Nicholson, G.C.3
  • 94
    • 70349731659 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ
    • Fleming NI, Trivett MK, George J, Slavin JL, Murray WK, Moseley JM, Anderson RL, Thomas DM. Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ. Cancer Res 69: 7473-7479, 2009.
    • (2009) Cancer Res , vol.69 , pp. 7473-7479
    • Fleming, N.I.1    Trivett, M.K.2    George, J.3    Slavin, J.L.4    Murray, W.K.5    Moseley, J.M.6    Anderson, R.L.7    Thomas, D.M.8
  • 96
    • 0032820610 scopus 로고    scopus 로고
    • Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: A role for basal promoter and Ets-1 site
    • Foley J, Wysolmerski JJ, Missero C, King CS, Philbrick WM. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Mol Cell Endocrinol 156: 13-23, 1999.
    • (1999) Mol Cell Endocrinol , vol.156 , pp. 13-23
    • Foley, J.1    Wysolmerski, J.J.2    Missero, C.3    King, C.S.4    Philbrick, W.M.5
  • 97
    • 0030869896 scopus 로고    scopus 로고
    • Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion
    • Fox J, Miller MA, Stroup GB, Nemeth EF, Miller SC. Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion. Bone 21: 163-169, 1997.
    • (1997) Bone , vol.21 , pp. 163-169
    • Fox, J.1    Miller, M.A.2    Stroup, G.B.3    Nemeth, E.F.4    Miller, S.C.5
  • 99
    • 0042333459 scopus 로고    scopus 로고
    • Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure
    • Frolik CA, Black EC, Cain RL, Satterwhite JH, Brown-Augsburger PL, Sato M, Hock JM. Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure. Bone 33: 372-379, 2003.
    • (2003) Bone , vol.33 , pp. 372-379
    • Frolik, C.A.1    Black, E.C.2    Cain, R.L.3    Satterwhite, J.H.4    Brown-Augsburger, P.L.5    Sato, M.6    Hock, J.M.7
  • 100
    • 0001505618 scopus 로고
    • Dynamics of bone remodeling
    • Frost HM. Dynamics of bone remodeling. Bone Biodynamics 315-333, 1964.
    • (1964) Bone Biodynamics , pp. 315-333
    • Frost, H.M.1
  • 102
    • 0029816971 scopus 로고    scopus 로고
    • Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors
    • Gardella TJ, Luck MD, Jensen GS, Schipani E, Potts JT Jr, Juppner H. Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors. Endocrinology 137: 3936-3941, 1996.
    • (1996) Endocrinology , vol.137 , pp. 3936-3941
    • Gardella, T.J.1    Luck, M.D.2    Jensen, G.S.3    Schipani, E.4    Potts Jr, J.T.5    Juppner, H.6
  • 103
    • 84923341909 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors-family B G protein-coupled receptors
    • Gardella TJ, Vilardaga JP. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors-family B G protein-coupled receptors. Pharmacol Rev 67: 310-337, 2015.
    • (2015) Pharmacol Rev , vol.67 , pp. 310-337
    • Gardella, T.J.1    Vilardaga, J.P.2
  • 104
    • 13444274543 scopus 로고    scopus 로고
    • Parathyroid hormone and parathyroid hormone- related peptide, and their receptors
    • Gensure RC, Gardella TJ, Juppner H. Parathyroid hormone and parathyroid hormone- related peptide, and their receptors. Biochem Biophys Res Commun 328: 666-678, 2005.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 666-678
    • Gensure, R.C.1    Gardella, T.J.2    Juppner, H.3
  • 105
    • 0347480255 scopus 로고    scopus 로고
    • Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor
    • Gensure RC, Shimizu N, Tsang J, Gardella TJ. Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Mol Endocrinol 17: 2647-2658, 2003.
    • (2003) Mol Endocrinol , vol.17 , pp. 2647-2658
    • Gensure, R.C.1    Shimizu, N.2    Tsang, J.3    Gardella, T.J.4
  • 107
    • 73949084919 scopus 로고    scopus 로고
    • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
    • 1ra1
    • Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM. A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci Transl Med 1: 1ra1, 2009.
    • (2009) Sci Transl Med , vol.1
    • Gesty-Palmer, D.1    Flannery, P.2    Yuan, L.3    Corsino, L.4    Spurney, R.5    Lefkowitz, R.J.6    Luttrell, L.M.7
  • 109
    • 0019753095 scopus 로고
    • Malignancy-associated hypercalcemia: Evaluation with a cytochemical bioassay for parathyroid hormone
    • Goltzman D, Stewart AF, Broadus AE. Malignancy-associated hypercalcemia: evaluation with a cytochemical bioassay for parathyroid hormone. J Clin Endocrinol Metab 53: 899-904, 1981.
    • (1981) J Clin Endocrinol Metab , vol.53 , pp. 899-904
    • Goltzman, D.1    Stewart, A.F.2    Broadus, A.E.3
  • 110
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
    • Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 10: 301-312, 1996.
    • (1996) Genes Dev , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 113
    • 0015858268 scopus 로고
    • Synthesis and release of parathyroid hormone by a renal carcinoma in cell culture
    • Greenberg PB, Martin TJ, Sutcliffe HS. Synthesis and release of parathyroid hormone by a renal carcinoma in cell culture. Clin Sci Mol Med 45: 183-191, 1973.
    • (1973) Clin Sci Mol Med , vol.45 , pp. 183-191
    • Greenberg, P.B.1    Martin, T.J.2    Sutcliffe, H.S.3
  • 115
    • 0025751703 scopus 로고
    • Parathyroid hormone-related protein: Elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer
    • Grill V, Ho P, Body JJ, Johanson N, Lee SC, Kukreja SC, Moseley JM, Martin TJ. Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab 73: 1309-1315, 1991.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1309-1315
    • Grill, V.1    Ho, P.2    Body, J.J.3    Johanson, N.4    Lee, S.C.5    Kukreja, S.C.6    Moseley, J.M.7    Martin, T.J.8
  • 116
    • 84864247712 scopus 로고    scopus 로고
    • Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function
    • Gu Z, Liu Y, Zhang Y, Jin S, Chen Q, Goltzman D, Karaplis A, Miao D. Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function. PLoS One 7: e41542, 2012.
    • (2012) PLoS One , vol.7
    • Gu, Z.1    Liu, Y.2    Zhang, Y.3    Jin, S.4    Chen, Q.5    Goltzman, D.6    Karaplis, A.7    Miao, D.8
  • 117
    • 0029122715 scopus 로고
    • Evidence for the synthesis of parathyroid hormone-related protein (PTHrP) by nontransformed clonal rat osteoblastic cells in vitro
    • Guenther HL, Hofstetter W, Moseley JM, Gillespie MT, Suda N, Martin TJ. Evidence for the synthesis of parathyroid hormone-related protein (PTHrP) by nontransformed clonal rat osteoblastic cells in vitro. Bone 16: 341-347, 1995.
    • (1995) Bone , vol.16 , pp. 341-347
    • Guenther, H.L.1    Hofstetter, W.2    Moseley, J.M.3    Gillespie, M.T.4    Suda, N.5    Martin, T.J.6
  • 118
    • 79952111472 scopus 로고    scopus 로고
    • Examining the metastatic niche: Targeting the microenvironment
    • Guise T. Examining the metastatic niche: targeting the microenvironment. Semin Oncol 37 Suppl 2: -S2-14, 2010.
    • (2010) Semin Oncol , vol.37 , pp. S2-14
    • Guise, T.1
  • 119
    • 0036696005 scopus 로고    scopus 로고
    • The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C
    • Guo J, Chung UI, Kondo H, Bringhurst FR, Kronenberg HM. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell 3: 183-194, 2002.
    • (2002) Dev Cell , vol.3 , pp. 183-194
    • Guo, J.1    Chung, U.I.2    Kondo, H.3    Bringhurst, F.R.4    Kronenberg, H.M.5
  • 120
    • 77954923592 scopus 로고    scopus 로고
    • Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
    • Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, Bringhurst FR, Kronenberg HM. Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology 151: 3502-3513, 2010.
    • (2010) Endocrinology , vol.151 , pp. 3502-3513
    • Guo, J.1    Liu, M.2    Yang, D.3    Bouxsein, M.L.4    Thomas, C.C.5    Schipani, E.6    Bringhurst, F.R.7    Kronenberg, H.M.8
  • 122
    • 84954539991 scopus 로고    scopus 로고
    • Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling
    • Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ. Binding selectivity of abaloparatide for PTH-type-1-receptor conformations and effects on downstream signaling. Endocrinology 157: 141-149, 2016.
    • (2016) Endocrinology , vol.157 , pp. 141-149
    • Hattersley, G.1    Dean, T.2    Corbin, B.A.3    Bahar, H.4    Gardella, T.J.5
  • 123
    • 84983773776 scopus 로고    scopus 로고
    • BA058, a novel human PTHrP analog, restores bone mass in the aged, ovariectomized cynomolgus monkey
    • Hattersley G, Lesage E, Varela A, Mith SY. BA058, a novel human PTHrP analog, restores bone mass in the aged, ovariectomized cynomolgus monkey. J Bone Miner Res 28 Suppl 1: 34, 2013.
    • (2013) J Bone Miner Res , vol.28 , pp. 34
    • Hattersley, G.1    Lesage, E.2    Varela, A.3    Mith, S.Y.4
  • 124
    • 0000348680 scopus 로고
    • Suggested sequential mode of control of changes in cell behaviour in adult bone remodelling
    • Hattner R, Epker BN, Frost HM. Suggested sequential mode of control of changes in cell behaviour in adult bone remodelling. Nature 206: 489-490, 1965.
    • (1965) Nature , vol.206 , pp. 489-490
    • Hattner, R.1    Epker, B.N.2    Frost, H.M.3
  • 125
    • 0028930162 scopus 로고
    • Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability
    • Heath JK, Southby J, Fukumoto S, O’Keeffe LM, Martin TJ, Gillespie MT. Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability. Biochem J 307: 159-167, 1995.
    • (1995) Biochem J , vol.307 , pp. 159-167
    • Heath, J.K.1    Southby, J.2    Fukumoto, S.3    O’Keeffe, L.M.4    Martin, T.J.5    Gillespie, M.T.6
  • 126
    • 0029063164 scopus 로고
    • Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death
    • Henderson JE, Amizuka N, Warshawsky H, Biasotto D, Lanske BM, Goltzman D, Karaplis AC. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol 15: 4064-4075, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 4064-4075
    • Henderson, J.E.1    Amizuka, N.2    Warshawsky, H.3    Biasotto, D.4    Lanske, B.M.5    Goltzman, D.6    Karaplis, A.C.7
  • 129
    • 0028911715 scopus 로고
    • Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study
    • Hendy GN, Bennett HP, Gibbs BF, Lazure C, Day R, Seidah NG. Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. J Biol Chem 270: 9517-9525, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 9517-9525
    • Hendy, G.N.1    Bennett, H.P.2    Gibbs, B.F.3    Lazure, C.4    Day, R.5    Seidah, N.G.6
  • 130
    • 0031024785 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein-(1-36) is biologically active when administered subcutaneously to humans
    • Henry JG, Mitnick M, Dann PR, Stewart AF. Parathyroid hormone-related protein-(1-36) is biologically active when administered subcutaneously to humans. J Clin Endocrinol Metab 82: 900-906, 1997.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 900-906
    • Henry, J.G.1    Mitnick, M.2    Dann, P.R.3    Stewart, A.F.4
  • 132
    • 0024416113 scopus 로고
    • Comparison of the anabolic effects of synthetic parathyroid hormone-related protein (PTHrP) 1-34 and PTH 1-34 on bone in rats
    • Hock JM, Fonseca J, Gunness-Hey M, Kemp BE, Martin TJ. Comparison of the anabolic effects of synthetic parathyroid hormone-related protein (PTHrP) 1-34 and PTH 1-34 on bone in rats. Endocrinology 125: 2022-2027, 1989.
    • (1989) Endocrinology , vol.125 , pp. 2022-2027
    • Hock, J.M.1    Fonseca, J.2    Gunness-Hey, M.3    Kemp, B.E.4    Martin, T.J.5
  • 135
    • 0038022578 scopus 로고    scopus 로고
    • Direct comparison of sustained infusion of human parathyroid hormone-related protein-(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25- dihydroxyvitamin D concentrations, and fractional calcium excretion in healthy human volunteers
    • Horwitz MJ, Tedesco MB, Sereika SM, Hollis BW, Garcia-Ocana A, Stewart AF. Direct comparison of sustained infusion of human parathyroid hormone-related protein-(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25- dihydroxyvitamin D concentrations, and fractional calcium excretion in healthy human volunteers. J Clin Endocrinol Metab 88: 1603-1609, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1603-1609
    • Horwitz, M.J.1    Tedesco, M.B.2    Sereika, S.M.3    Hollis, B.W.4    Garcia-Ocana, A.5    Stewart, A.F.6
  • 137
    • 0035793055 scopus 로고    scopus 로고
    • The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones
    • Huang W, Chung UI, Kronenberg HM, de Crombrugghe B. The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci USA 98: 160-165, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 160-165
    • Huang, W.1    Chung, U.I.2    Kronenberg, H.M.3    de Crombrugghe, B.4
  • 138
    • 0025219209 scopus 로고
    • Regulation of parathyroid hormonerelated peptide gene expression by cycloheximide
    • Ikeda K, Lu C, Weir EC, Mangin M, Broadus AE. Regulation of parathyroid hormonerelated peptide gene expression by cycloheximide. J Biol Chem 265: 5398-5402, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 5398-5402
    • Ikeda, K.1    Lu, C.2    Weir, E.C.3    Mangin, M.4    Broadus, A.E.5
  • 139
    • 0023879546 scopus 로고
    • Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy
    • Ikeda K, Mangin M, Dreyer BE, Webb AC, Posillico JT, Stewart AF, Bander NH, Weir EC, Insogna KL, Broadus AE. Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. J Clin Invest 81: 2010-2014, 1988.
    • (1988) J Clin Invest , vol.81 , pp. 2010-2014
    • Ikeda, K.1    Mangin, M.2    Dreyer, B.E.3    Webb, A.C.4    Posillico, J.T.5    Stewart, A.F.6    Bander, N.H.7    Weir, E.C.8    Insogna, K.L.9    Broadus, A.E.10
  • 140
    • 0026069041 scopus 로고
    • Urinary excretion of parathyroid hormone-related protein fragments in patients with humoral hypercalcemia of malignancy and hypercalcemic tumorbearing nude mice
    • Imamura H, Sato K, Shizume K, Satoh T, Kasono K, Ozawa M, Ohmura E, Tsushima T, Demura H. Urinary excretion of parathyroid hormone-related protein fragments in patients with humoral hypercalcemia of malignancy and hypercalcemic tumorbearing nude mice. J Bone Miner Res 6: 77-84, 1991.
    • (1991) J Bone Miner Res , vol.6 , pp. 77-84
    • Imamura, H.1    Sato, K.2    Shizume, K.3    Satoh, T.4    Kasono, K.5    Ozawa, M.6    Ohmura, E.7    Tsushima, T.8    Demura, H.9
  • 144
    • 0028071526 scopus 로고
    • Nuclear signaling pathways for polypeptide ligands and their membrane receptors?
    • Jans DA. Nuclear signaling pathways for polypeptide ligands and their membrane receptors? FASEB J 8: 841-847, 1994.
    • (1994) FASEB J , vol.8 , pp. 841-847
    • Jans, D.A.1
  • 145
    • 0028802362 scopus 로고
    • The regulation of protein transport to the nucleus by phosphorylation
    • Jans DA. The regulation of protein transport to the nucleus by phosphorylation. Biochem J 311: 705-716, 1995.
    • (1995) Biochem J , vol.311 , pp. 705-716
    • Jans, D.A.1
  • 146
    • 0025919717 scopus 로고
    • p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins
    • Jans DA, Ackermann MJ, Bischoff JR, Beach DH, Peters R. p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins. J Cell Biol 115: 1203-1212, 1991.
    • (1991) J Cell Biol , vol.115 , pp. 1203-1212
    • Jans, D.A.1    Ackermann, M.J.2    Bischoff, J.R.3    Beach, D.H.4    Peters, R.5
  • 147
    • 0030806304 scopus 로고    scopus 로고
    • The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitro
    • Jans DA, Briggs LJ, Gustin SE, Jans P, Ford S, Young IG. The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitro. FEBS Lett 410: 368-372, 1997.
    • (1997) FEBS Lett , vol.410 , pp. 368-372
    • Jans, D.A.1    Briggs, L.J.2    Gustin, S.E.3    Jans, P.4    Ford, S.5    Young, I.G.6
  • 148
    • 0242413030 scopus 로고    scopus 로고
    • Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure
    • Jiang Y, Zhao JJ, Mitlak BH, Wang O, Genant HK, Eriksen EF. Recombinant human parathyroid hormone (1-34) [teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res 18: 1932-1941, 2003.
    • (2003) J Bone Miner Res , vol.18 , pp. 1932-1941
    • Jiang, Y.1    Zhao, J.J.2    Mitlak, B.H.3    Wang, O.4    Genant, H.K.5    Eriksen, E.F.6
  • 149
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40: 1434-1446, 2007.
    • (2007) Bone , vol.40 , pp. 1434-1446
    • Jilka, R.L.1
  • 153
    • 0028839011 scopus 로고
    • Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation
    • Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K. Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation. Endocrinology 136: 842-848, 1995.
    • (1995) Endocrinology , vol.136 , pp. 842-848
    • Kaji, H.1    Sugimoto, T.2    Kanatani, M.3    Fukase, M.4    Chihara, K.5
  • 154
    • 44349180840 scopus 로고    scopus 로고
    • The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis
    • Kamesh N, Aradhyam GK, Manoj N. The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis. BMC Evol Biol 8: 129, 2008.
    • (2008) BMC Evol Biol , vol.8 , pp. 129
    • Kamesh, N.1    Aradhyam, G.K.2    Manoj, N.3
  • 155
    • 0031725947 scopus 로고    scopus 로고
    • Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia
    • Karaplis AC, He B, Nguyen MT, Young ID, Semeraro D, Ozawa H, Amizuka N. Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia. Endocrinology 139: 5255-5258, 1998.
    • (1998) Endocrinology , vol.139 , pp. 5255-5258
    • Karaplis, A.C.1    He, B.2    Nguyen, M.T.3    Young, I.D.4    Semeraro, D.5    Ozawa, H.6    Amizuka, N.7
  • 156
    • 0029681280 scopus 로고    scopus 로고
    • Physiological roles for parathyroid hormone-related protein: Lessons from gene knockout mice
    • Karaplis AC, Kronenberg HM. Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice. Vitam Horm 52: 177-193, 1996.
    • (1996) Vitam Horm , vol.52 , pp. 177-193
    • Karaplis, A.C.1    Kronenberg, H.M.2
  • 158
    • 0030837522 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development
    • Karaplis AC, Vautour L. Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development. Curr Opin Nephrol Hypertens 6: 308-313, 1997.
    • (1997) Curr Opin Nephrol Hypertens , vol.6 , pp. 308-313
    • Karaplis, A.C.1    Vautour, L.2
  • 159
    • 0025373529 scopus 로고
    • Gene-encoding parathyroid hormone-like peptide: Nucleotide sequence of the rat gene and comparison with the human homologue
    • Karaplis AC, Yasuda T, Hendy GN, Goltzman D, Banville D. Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue. Mol Endocrinol 4: 441-446, 1990.
    • (1990) Mol Endocrinol , vol.4 , pp. 441-446
    • Karaplis, A.C.1    Yasuda, T.2    Hendy, G.N.3    Goltzman, D.4    Banville, D.5
  • 160
    • 0033950445 scopus 로고    scopus 로고
    • Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways
    • Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP. Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development 127: 543-548, 2000.
    • (2000) Development , vol.127 , pp. 543-548
    • Karp, S.J.1    Schipani, E.2    St-Jacques, B.3    Hunzelman, J.4    Kronenberg, H.5    McMahon, A.P.6
  • 161
    • 0030762835 scopus 로고    scopus 로고
    • Expression of the parathyroid hormone-related peptide gene in retinoic acid-induced differentiation: Involvement of ETS and Sp1
    • Karperien M, Farih-Sips H, Lowik CW, de Laat SW, Boonstra J, Defize LH. Expression of the parathyroid hormone-related peptide gene in retinoic acid-induced differentiation: involvement of ETS and Sp1. Mol Endocrinol 11: 1435-1448, 1997.
    • (1997) Mol Endocrinol , vol.11 , pp. 1435-1448
    • Karperien, M.1    Farih-Sips, H.2    Lowik, C.W.3    de Laat, S.W.4    Boonstra, J.5    Defize, L.H.6
  • 162
    • 0028108064 scopus 로고
    • Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes
    • Karperien M, van Dijk TB, Hoeijmakers T, Cremers F, Abou-Samra AB, Boonstra J, de Laat SW, Defize LH. Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes. Mech Dev 47: 29-42, 1994.
    • (1994) Mech Dev , vol.47 , pp. 29-42
    • Karperien, M.1    van Dijk, T.B.2    Hoeijmakers, T.3    Cremers, F.4    Abou-Samra, A.B.5    Boonstra, J.6    de Laat, S.W.7    Defize, L.H.8
  • 163
    • 0030687989 scopus 로고    scopus 로고
    • Temporal expression of PTHrP during endochondral bone formation in mouse and intramembranous bone formation in an in vivo rabbit model
    • Kartsogiannis V, Moseley J, McKelvie B, Chou ST, Hards DK, Ng KW, Martin TJ, Zhou H. Temporal expression of PTHrP during endochondral bone formation in mouse and intramembranous bone formation in an in vivo rabbit model. Bone 21: 385-392, 1997.
    • (1997) Bone , vol.21 , pp. 385-392
    • Kartsogiannis, V.1    Moseley, J.2    McKelvie, B.3    Chou, S.T.4    Hards, D.K.5    Ng, K.W.6    Martin, T.J.7    Zhou, H.8
  • 165
    • 21844467220 scopus 로고    scopus 로고
    • SOST is a target gene for PTH in bone
    • Keller H, Kneissel M. SOST is a target gene for PTH in bone. Bone 37: 148-158, 2005.
    • (2005) Bone , vol.37 , pp. 148-158
    • Keller, H.1    Kneissel, M.2
  • 170
    • 0027410965 scopus 로고
    • Transforming growth factor beta stimulation of parathyroid hormone-related protein (PTHrP): A paracrine regulator?
    • Kiriyama T, Gillespie MT, Glatz JA, Fukumoto S, Moseley JM, Martin TJ. Transforming growth factor beta stimulation of parathyroid hormone-related protein (PTHrP): a paracrine regulator? Mol Cell Endocrinol 92: 55-62, 1993.
    • (1993) Mol Cell Endocrinol , vol.92 , pp. 55-62
    • Kiriyama, T.1    Gillespie, M.T.2    Glatz, J.A.3    Fukumoto, S.4    Moseley, J.M.5    Martin, T.J.6
  • 172
    • 22144436249 scopus 로고    scopus 로고
    • Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
    • Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest 115: 1734-1742, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 1734-1742
    • Kobayashi, T.1    Soegiarto, D.W.2    Yang, Y.3    Lanske, B.4    Schipani, E.5    McMahon, A.P.6    Kronenberg, H.M.7
  • 173
    • 84921710537 scopus 로고    scopus 로고
    • Bone development and mineral homeostasis in the fetus and neonate: Roles of the calciotropic and phosphotropic hormones
    • Kovacs CS. Bone development and mineral homeostasis in the fetus and neonate: roles of the calciotropic and phosphotropic hormones. Physiol Rev 94: 1143-1218, 2014.
    • (2014) Physiol Rev , vol.94 , pp. 1143-1218
    • Kovacs, C.S.1
  • 174
    • 0031471679 scopus 로고    scopus 로고
    • Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation
    • Kovacs CS, Kronenberg HM. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 18: 832-872, 1997.
    • (1997) Endocr Rev , vol.18 , pp. 832-872
    • Kovacs, C.S.1    Kronenberg, H.M.2
  • 175
    • 0030465408 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor
    • Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc Natl Acad Sci USA 93: 15233-15238, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15233-15238
    • Kovacs, C.S.1    Lanske, B.2    Hunzelman, J.L.3    Guo, J.4    Karaplis, A.C.5    Kronenberg, H.M.6
  • 177
    • 70350547780 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway
    • Kozhemyakina E, Cohen T, Yao TP, Lazar AB. Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol 29: 5751-5762, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 5751-5762
    • Kozhemyakina, E.1    Cohen, T.2    Yao, T.P.3    Lazar, A.B.4
  • 178
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg HM. Developmental regulation of the growth plate. Nature 423: 332-336, 2003.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 179
    • 0035230123 scopus 로고    scopus 로고
    • The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate
    • Kronenberg HM, Chung U. The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate. Novartis Found Symp 232: 144-152, 2001.
    • (2001) Novartis Found Symp , vol.232 , pp. 144-152
    • Kronenberg, H.M.1    Chung, U.2
  • 180
    • 0025889723 scopus 로고
    • Lack of effects of neutralization of parathyroid hormone-related protein on calcium homeostasis in neonatal mice
    • Kukreja SC, D’Anza JJ, Melton ME, Wimbiscus SA, Grill V, Martin TJ. Lack of effects of neutralization of parathyroid hormone-related protein on calcium homeostasis in neonatal mice. J Bone Miner Res 6: 1197-1201, 1991.
    • (1991) J Bone Miner Res , vol.6 , pp. 1197-1201
    • Kukreja, S.C.1    D’Anza, J.J.2    Melton, M.E.3    Wimbiscus, S.A.4    Grill, V.5    Martin, T.J.6
  • 181
    • 0018943285 scopus 로고
    • Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer
    • Kukreja SC, Shemerdiak WP, Lad TE, Johnson PA. Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer. J Clin Endocrinol Metab 51: 167-169, 1980.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 167-169
    • Kukreja, S.C.1    Shemerdiak, W.P.2    Lad, T.E.3    Johnson, P.A.4
  • 182
    • 84876012965 scopus 로고    scopus 로고
    • MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein
    • Kuo PL, Liao SH, Hung JY, Huang MS, Hsu YL. MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein. Biochim Biophys Acta 1830: 3756-3766, 2013.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 3756-3766
    • Kuo, P.L.1    Liao, S.H.2    Hung, J.Y.3    Huang, M.S.4    Hsu, Y.L.5
  • 183
    • 0013907775 scopus 로고
    • Pseudohyperparathyroidism
    • Lafferty FW. Pseudohyperparathyroidism. Medicine 45: 247-260, 1966.
    • (1966) Medicine , vol.45 , pp. 247-260
    • Lafferty, F.W.1
  • 184
    • 0033548434 scopus 로고    scopus 로고
    • Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha
    • Lam MH, Briggs LJ, Hu W, Martin TJ, Gillespie MT, Jans DA. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem 274: 7391-7398, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 7391-7398
    • Lam, M.H.1    Briggs, L.J.2    Hu, W.3    Martin, T.J.4    Gillespie, M.T.5    Jans, D.A.6
  • 186
    • 0034806059 scopus 로고    scopus 로고
    • Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein
    • Lam MH, Hu W, Xiao CY, Gillespie MT, Jans DA. Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein. Biochem Biophys Res Commun 282: 629-634, 2001.
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 629-634
    • Lam, M.H.1    Hu, W.2    Xiao, C.Y.3    Gillespie, M.T.4    Jans, D.A.5
  • 187
    • 0030830560 scopus 로고    scopus 로고
    • PTHrP and cell division: Expression and localization of PTHrP in a keratinocyte cell line (HaCaT) during the cell cycle
    • Lam MH, Olsen SL, Rankin WA, Ho PW, Martin TJ, Gillespie MT, Moseley JM. PTHrP and cell division: expression and localization of PTHrP in a keratinocyte cell line (HaCaT) during the cell cycle. J Cell Physiol 173: 433-446, 1997.
    • (1997) J Cell Physiol , vol.173 , pp. 433-446
    • Lam, M.H.1    Olsen, S.L.2    Rankin, W.A.3    Ho, P.W.4    Martin, T.J.5    Gillespie, M.T.6    Moseley, J.M.7
  • 190
    • 84922553490 scopus 로고    scopus 로고
    • Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis
    • Leder BZ, O’Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G. Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 100: 697-706, 2015.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 697-706
    • Leder, B.Z.1    O’Dea, L.S.2    Zanchetta, J.R.3    Kumar, P.4    Banks, K.5    McKay, K.6    Lyttle, C.R.7    Hattersley, G.8
  • 191
    • 84899961372 scopus 로고    scopus 로고
    • Two years of Denosumab and teriparatide administration in postmenopausal women with osteoporosis (The DATA Extension Study): A randomized controlled trial
    • Leder BZ, Tsai JN, Uihlein AV, Burnett-Bowie SA, Zhu Y, Foley K, Lee H, Neer RM. Two years of Denosumab and teriparatide administration in postmenopausal women with osteoporosis (The DATA Extension Study): a randomized controlled trial. J Clin Endocrinol Metab 99: 1694-1700, 2014.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 1694-1700
    • Leder, B.Z.1    Tsai, J.N.2    Uihlein, A.V.3    Burnett-Bowie, S.A.4    Zhu, Y.5    Foley, K.6    Lee, H.7    Neer, R.M.8
  • 192
    • 0028947897 scopus 로고
    • Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats
    • Lee K, Deeds JD, Segre GV. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 136: 453-463, 1995.
    • (1995) Endocrinology , vol.136 , pp. 453-463
    • Lee, K.1    Deeds, J.D.2    Segre, G.V.3
  • 193
  • 194
    • 84875382511 scopus 로고    scopus 로고
    • Comparative genomic analysis and evolution of family-B G protein-coupled receptors from six model insect species
    • Li C, Chen M, Sang M, Liu X,WuW, Li B. Comparative genomic analysis and evolution of family-B G protein-coupled receptors from six model insect species. Gene 519: 1-12, 2013.
    • (2013) Gene , vol.519 , pp. 1-12
    • Li, C.1    Chen, M.2    Sang, M.3    Liu, X.4    Wu, W.5    Li, B.6
  • 196
    • 0027817471 scopus 로고
    • Expression of parathyroidlike protein in normal, proliferative, and neoplastic human breast tissues
    • Liapis H, Crouch EC, Grosso LE, Kitazawa S, Wick MR. Expression of parathyroidlike protein in normal, proliferative, and neoplastic human breast tissues. Am J Pathol 143: 1169-1178, 1993.
    • (1993) Am J Pathol , vol.143 , pp. 1169-1178
    • Liapis, H.1    Crouch, E.C.2    Grosso, L.E.3    Kitazawa, S.4    Wick, M.R.5
  • 197
    • 0001037775 scopus 로고
    • Nonpituitary neoplasms and Cushing’s syndrome. Ectopic "adrenocorticotropin" produced by nonpituitary neoplasms as a cause of Cushing’s syndrome
    • Liddle GW, Island DP, Ney RL, Nicholson WE, Shimizu N. Nonpituitary neoplasms and Cushing’s syndrome. Ectopic "adrenocorticotropin" produced by nonpituitary neoplasms as a cause of Cushing’s syndrome. Arch Intern Med 111: 471-475, 1963.
    • (1963) Arch Intern Med , vol.111 , pp. 471-475
    • Liddle, G.W.1    Island, D.P.2    Ney, R.L.3    Nicholson, W.E.4    Shimizu, N.5
  • 198
    • 70349985246 scopus 로고    scopus 로고
    • Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice
    • Lin PP, Pandey MK, Jin F, Raymond AK, Akiyama H, Lozano G. Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis 30: 1789-1795, 2009.
    • (2009) Carcinogenesis , vol.30 , pp. 1789-1795
    • Lin, P.P.1    Pandey, M.K.2    Jin, F.3    Raymond, A.K.4    Akiyama, H.5    Lozano, G.6
  • 199
    • 33144457259 scopus 로고    scopus 로고
    • A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: Early actions of teriparatide
    • Lindsay R, Cosman F, Zhou H, Bostrom MP, Shen VW, Cruz JD, Nieves JW, Dempster DW. A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide. J Bone Miner Res 21: 366-373, 2006.
    • (2006) J Bone Miner Res , vol.21 , pp. 366-373
    • Lindsay, R.1    Cosman, F.2    Zhou, H.3    Bostrom, M.P.4    Shen, V.W.5    Cruz, J.D.6    Nieves, J.W.7    Dempster, D.W.8
  • 201
    • 84866001590 scopus 로고    scopus 로고
    • Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
    • Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest 122: 3101-3113, 2012.
    • (2012) J Clin Invest , vol.122 , pp. 3101-3113
    • Liu, Y.1    Berendsen, A.D.2    Jia, S.3    Lotinun, S.4    Baron, R.5    Ferrara, N.6    Olsen, B.R.7
  • 202
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-1318, 2004.
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 203
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long F, Zhang XM, Karp S, Yang Y, McMahon AP. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-5108, 2001.
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 205
    • 33646871267 scopus 로고    scopus 로고
    • Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis
    • Ma YL, Zeng Q, Donley DW, Ste-Marie LG, Gallagher JC, Dalsky GP, Marcus R, Eriksen EF. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. J Bone Miner Res 21: 855-864, 2006.
    • (2006) J Bone Miner Res , vol.21 , pp. 855-864
    • Ma, Y.L.1    Zeng, Q.2    Donley, D.W.3    Ste-Marie, L.G.4    Gallagher, J.C.5    Dalsky, G.P.6    Marcus, R.7    Eriksen, E.F.8
  • 208
    • 85072144418 scopus 로고    scopus 로고
    • Bone development and remodeling
    • edited by DeGroot L, Jamieson J. New York: Elsevier Saunders
    • Maes C, Kronenberg H. Bone development and remodeling. In: Endocrinology, edited by DeGroot L, Jamieson J. New York: Elsevier Saunders, 2010, p. 1038-1072.
    • (2010) Endocrinology , pp. 1038-1072
    • Maes, C.1    Kronenberg, H.2
  • 209
    • 0017802761 scopus 로고
    • Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines
    • Majeska RJ, Rodan SB, Rodan GA. Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines. Exp Cell Res 111: 465-468, 1978.
    • (1978) Exp Cell Res , vol.111 , pp. 465-468
    • Majeska, R.J.1    Rodan, S.B.2    Rodan, G.A.3
  • 210
    • 84883184330 scopus 로고    scopus 로고
    • Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual
    • Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 154: 3031-3042, 2013.
    • (2013) Endocrinology , vol.154 , pp. 3031-3042
    • Mamillapalli, R.1    VanHouten, J.2    Dann, P.3    Bikle, D.4    Chang, W.5    Brown, E.6    Wysolmerski, J.7
  • 211
    • 54049137686 scopus 로고    scopus 로고
    • Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormonerelated protein secretion in normal versus malignant breast cells
    • Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormonerelated protein secretion in normal versus malignant breast cells. J Biol Chem 283: 24435-24447, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 24435-24447
    • Mamillapalli, R.1    VanHouten, J.2    Zawalich, W.3    Wysolmerski, J.4
  • 212
    • 0025202456 scopus 로고
    • Structure of the mouse gene encoding parathyroid hormone-related peptide
    • Mangin M, Ikeda K, Broadus AE. Structure of the mouse gene encoding parathyroid hormone-related peptide. Gene 95: 195-202, 1990.
    • (1990) Gene , vol.95 , pp. 195-202
    • Mangin, M.1    Ikeda, K.2    Broadus, A.E.3
  • 213
    • 0344608212 scopus 로고
    • Isolation and characterization of the human parathyroid hormone-like peptide gene
    • Mangin M, Ikeda K, Dreyer BE, Broadus AE. Isolation and characterization of the human parathyroid hormone-like peptide gene. Proc Natl Acad Sci USA 86: 2408-2412, 1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2408-2412
    • Mangin, M.1    Ikeda, K.2    Dreyer, B.E.3    Broadus, A.E.4
  • 214
    • 0023768337 scopus 로고
    • Two distinct tumor-derived, parathyroid hormone-like peptides result from alternative ribonucleic acid splicing
    • Mangin M, Ikeda K, Dreyer BE, Milstone L, Broadus AE. Two distinct tumor-derived, parathyroid hormone-like peptides result from alternative ribonucleic acid splicing. Mol Endocrinol 2: 1049-1055, 1988.
    • (1988) Mol Endocrinol , vol.2 , pp. 1049-1055
    • Mangin, M.1    Ikeda, K.2    Dreyer, B.E.3    Milstone, L.4    Broadus, A.E.5
  • 216
    • 24644433763 scopus 로고    scopus 로고
    • Osteoblast-derived PTHrP is a physiological regulator of bone formation
    • Martin TJ. Osteoblast-derived PTHrP is a physiological regulator of bone formation. J Clin Invest 115: 2322-2324, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2322-2324
    • Martin, T.J.1
  • 217
    • 0002643490 scopus 로고
    • Biochemical regulators of bone resorption and their significance in cancer
    • Martin TJ, Atkins DA. Biochemical regulators of bone resorption and their significance in cancer. Essays Med Biochem 4: 49-82, 1979.
    • (1979) Essays Med Biochem , vol.4 , pp. 49-82
    • Martin, T.J.1    Atkins, D.A.2
  • 218
  • 219
    • 0034473269 scopus 로고    scopus 로고
    • Mechanisms in the skeletal complications of breast cancer
    • Martin TJ, Moseley JM. Mechanisms in the skeletal complications of breast cancer. Endocr Relat Cancer 7: 271-284, 2000.
    • (2000) Endocr Relat Cancer , vol.7 , pp. 271-284
    • Martin, T.J.1    Moseley, J.M.2
  • 220
    • 0030756521 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein: Hormone and cytokine
    • Martin TJ, Moseley JM, Williams ED. Parathyroid hormone-related protein: hormone and cytokine. J Endocrinol 154 Suppl: S23-37, 1997.
    • (1997) J Endocrinol , vol.154 , pp. S23-37
    • Martin, T.J.1    Moseley, J.M.2    Williams, E.D.3
  • 221
    • 4344567903 scopus 로고    scopus 로고
    • Coupling of bone formation and resorption during bone remodeling
    • edited by Marcus FD, Kelsey J. London: Academic
    • Martin TJ, Rodan GA. Coupling of bone formation and resorption during bone remodeling. In: Osteoporosis, edited by Marcus FD, Kelsey J. London: Academic, 2001.
    • (2001) Osteoporosis
    • Martin, T.J.1    Rodan, G.A.2
  • 222
    • 13244267455 scopus 로고    scopus 로고
    • Osteoclast-derived activity in the coupling of bone formation to resorption
    • Martin TJ, Sims NA. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 11: 76-81, 2005.
    • (2005) Trends Mol Med , vol.11 , pp. 76-81
    • Martin, T.J.1    Sims, N.A.2
  • 223
    • 0024420892 scopus 로고
    • Parathyroid hormone-related protein in hypercalcaemia of malignancy
    • Martin TJ, Suva LJ. Parathyroid hormone-related protein in hypercalcaemia of malignancy. Clin Endocrinol 31: 631-647, 1989.
    • (1989) Clin Endocrinol , vol.31 , pp. 631-647
    • Martin, T.J.1    Suva, L.J.2
  • 225
    • 0034614579 scopus 로고    scopus 로고
    • Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37)
    • Marx UC, Adermann K, Bayer P, Forssmann WG, Rosch P. Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem Biophys Res Commun 267: 213-220, 2000.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 213-220
    • Marx, U.C.1    Adermann, K.2    Bayer, P.3    Forssmann, W.G.4    Rosch, P.5
  • 226
    • 0032548834 scopus 로고    scopus 로고
    • Structureactivity relation of NH2-terminal human parathyroid hormone fragments
    • Marx UC, Adermann K, Bayer P, Meyer M, Forssmann WG, Rosch P. Structureactivity relation of NH2-terminal human parathyroid hormone fragments. J Biol Chem 273: 4308-4316, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 4308-4316
    • Marx, U.C.1    Adermann, K.2    Bayer, P.3    Meyer, M.4    Forssmann, W.G.5    Rosch, P.6
  • 227
    • 0031456826 scopus 로고    scopus 로고
    • Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting
    • Massfelder T, Dann P, Wu TL, Vasavada R, Helwig JJ, Stewart AF. Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: a critical role for nuclear targeting. Proc Natl Acad Sci USA 94: 13630-13635, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13630-13635
    • Massfelder, T.1    Dann, P.2    Wu, T.L.3    Vasavada, R.4    Helwig, J.J.5    Stewart, A.F.6
  • 229
    • 65649092633 scopus 로고    scopus 로고
    • The genetic signatures of noncoding RNAs
    • Mattick JS. The genetic signatures of noncoding RNAs. PLoS Genet 5: e1000459, 2009.
    • (2009) PLoS Genet , vol.5
    • Mattick, J.S.1
  • 230
    • 0015226379 scopus 로고
    • Ectopic production of parathyroid hormone by carcinoma of the breast
    • Mavligit GM, Cohen JL, Sherwood LM. Ectopic production of parathyroid hormone by carcinoma of the breast. N Engl J Med 285: 154-156, 1971.
    • (1971) N Engl J Med , vol.285 , pp. 154-156
    • Mavligit, G.M.1    Cohen, J.L.2    Sherwood, L.M.3
  • 232
    • 84861307742 scopus 로고    scopus 로고
    • Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine
    • McCauley LK, Martin TJ. Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine. J Bone Miner Res 27: 1231-1239, 2012.
    • (2012) J Bone Miner Res , vol.27 , pp. 1231-1239
    • McCauley, L.K.1    Martin, T.J.2
  • 233
    • 0034695567 scopus 로고    scopus 로고
    • More surprises in the Hedgehog signaling pathway
    • McMahon AP. More surprises in the Hedgehog signaling pathway. Cell 100: 185-188, 2000.
    • (2000) Cell , vol.100 , pp. 185-188
    • McMahon, A.P.1
  • 235
    • 0015519538 scopus 로고
    • Parathyroid hormone production and malignancy
    • Melick RA, Martin TJ, Hicks JD. Parathyroid hormone production and malignancy. Br Med J 2: 204-205, 1972.
    • (1972) Br Med J , vol.2 , pp. 204-205
    • Melick, R.A.1    Martin, T.J.2    Hicks, J.D.3
  • 236
    • 0028355732 scopus 로고
    • Effects of transforming growth factor-beta on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell line in vitro
    • Merryman JI, DeWille JW, Werkmeister JR, Capen CC, Rosol TJ. Effects of transforming growth factor-beta on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell line in vitro. Endocrinology 134: 2424-2430, 1994.
    • (1994) Endocrinology , vol.134 , pp. 2424-2430
    • Merryman, J.I.1    DeWille, J.W.2    Werkmeister, J.R.3    Capen, C.C.4    Rosol, T.J.5
  • 238
    • 0036251217 scopus 로고    scopus 로고
    • Parathyroid hormone is essential for normal fetal bone formation
    • Miao D, He B, Karaplis AC, Goltzman D. Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109: 1173-1182, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1173-1182
    • Miao, D.1    He, B.2    Karaplis, A.C.3    Goltzman, D.4
  • 239
    • 58149481211 scopus 로고    scopus 로고
    • Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein
    • Miao D, Su H, He B, Gao J, Xia Q, Zhu M, Gu Z, Goltzman D, Karaplis AC. Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proc Natl Acad Sci USA 105: 20309-20314, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20309-20314
    • Miao, D.1    Su, H.2    He, B.3    Gao, J.4    Xia, Q.5    Zhu, M.6    Gu, Z.7    Goltzman, D.8    Karaplis, A.C.9
  • 240
    • 0036280917 scopus 로고    scopus 로고
    • Association between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activity
    • Minagawa M, Yasuda T, Watanabe T, Minamitani K, Takahashi Y, Goltzman D, White JH, Hendy GN, Kohno Y. Association between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activity. J Clin Endocrinol Metab 87: 1791-1796, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1791-1796
    • Minagawa, M.1    Yasuda, T.2    Watanabe, T.3    Minamitani, K.4    Takahashi, Y.5    Goltzman, D.6    White, J.H.7    Hendy, G.N.8    Kohno, Y.9
  • 246
    • 0029008383 scopus 로고
    • Lack of significant effect of carboxyl-terminal parathyroid hormone-related peptide fragments on isolated rat and chick osteoclasts
    • Murrills RJ, Stein LS, Dempster DW. Lack of significant effect of carboxyl-terminal parathyroid hormone-related peptide fragments on isolated rat and chick osteoclasts. Calcif Tissue Int 57: 47-51, 1995.
    • (1995) Calcif Tissue Int , vol.57 , pp. 47-51
    • Murrills, R.J.1    Stein, L.S.2    Dempster, D.W.3
  • 248
    • 84896696942 scopus 로고    scopus 로고
    • Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
    • Mutsaers AJ, Walkley CR. Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells? Bone 62: 56-63, 2014.
    • (2014) Bone , vol.62 , pp. 56-63
    • Mutsaers, A.J.1    Walkley, C.R.2
  • 249
    • 78651381799 scopus 로고    scopus 로고
    • Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signalingselective parathyroid hormone analogs
    • Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT Jr, Mahon MJ, Gardella TJ, Juppner H. Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signalingselective parathyroid hormone analogs. J Biol Chem 286: 1618-1626, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 1618-1626
    • Nagai, S.1    Okazaki, M.2    Segawa, H.3    Bergwitz, C.4    Dean, T.5    Potts Jr, J.T.6    Mahon, M.J.7    Gardella, T.J.8    Juppner, H.9
  • 252
    • 0035107369 scopus 로고    scopus 로고
    • Nuclear forms of parathyroid hormone-related peptide are translated from non-AUG start sites downstream from the initiator methionine
    • Nguyen M, He B, Karaplis A. Nuclear forms of parathyroid hormone-related peptide are translated from non-AUG start sites downstream from the initiator methionine. Endocrinology 142: 694-703, 2001.
    • (2001) Endocrinology , vol.142 , pp. 694-703
    • Nguyen, M.1    He, B.2    Karaplis, A.3
  • 253
    • 0032079521 scopus 로고    scopus 로고
    • A negative vitamin D response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D
    • Nishishita T, Okazaki T, Ishikawa T, Igarashi T, Hata K, Ogata E, Fujita T. A negative vitamin D response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D. J Biol Chem 273: 10901-10907, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 10901-10907
    • Nishishita, T.1    Okazaki, T.2    Ishikawa, T.3    Igarashi, T.4    Hata, K.5    Ogata, E.6    Fujita, T.7
  • 254
    • 0002472503 scopus 로고    scopus 로고
    • Mechanical force regulation of vascular parathyroid hormone-related peptide expression
    • Noda M, Takuwa Y, Katoh T, Kurokawa K. Mechanical force regulation of vascular parathyroid hormone-related peptide expression. Kidney Int Suppl 55: S154-155, 1996.
    • (1996) Kidney Int , pp. S154-155
    • Noda, M.1    Takuwa, Y.2    Katoh, T.3    Kurokawa, K.4
  • 255
    • 0028978685 scopus 로고
    • Desensitization of vascular tissue to parathyroid hormone and parathyroid hormone-related protein
    • Nyby MD, Hino T, Berger ME, Ormsby BL, Golub MS, Brickman AS. Desensitization of vascular tissue to parathyroid hormone and parathyroid hormone-related protein. Endocrinology 136: 2497-2504, 1995.
    • (1995) Endocrinology , vol.136 , pp. 2497-2504
    • Nyby, M.D.1    Hino, T.2    Berger, M.E.3    Ormsby, B.L.4    Golub, M.S.5    Brickman, A.S.6
  • 256
    • 0028952075 scopus 로고
    • Involvement of cell cycle and mitogen-activated pathways in induction of parathyroid hormone-related protein gene expression in rat aortic smooth muscle cells
    • Okano K, Pirola CJ, Wang HM, Forrester JS, Fagin JA, Clemens TL. Involvement of cell cycle and mitogen-activated pathways in induction of parathyroid hormone-related protein gene expression in rat aortic smooth muscle cells. Endocrinology 136: 1782-1789, 1995.
    • (1995) Endocrinology , vol.136 , pp. 1782-1789
    • Okano, K.1    Pirola, C.J.2    Wang, H.M.3    Forrester, J.S.4    Fagin, J.A.5    Clemens, T.L.6
  • 257
    • 0030016249 scopus 로고    scopus 로고
    • Conformational studies on analogs of recombinant parathyroid hormone and their interactions with phospholipids
    • Oldenburg KR, Epand RF, D’Orfani A, Vo K, Selick H, Epand RM. Conformational studies on analogs of recombinant parathyroid hormone and their interactions with phospholipids. J Biol Chem 271: 17582-17591, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 17582-17591
    • Oldenburg, K.R.1    Epand, R.F.2    D’Orfani, A.3    Vo, K.4    Selick, H.5    Epand, R.M.6
  • 258
    • 84930680391 scopus 로고    scopus 로고
    • Sustained modeling-based bone formation during adulthood in cynomolgus monkeys may contribute to continuous BMD gains with denosumab
    • Ominsky MS, Libanati C, Niu QT, Boyce RW, Kostenuik PJ, Wagman RB, Baron R, Dempster DW. Sustained modeling-based bone formation during adulthood in cynomolgus monkeys may contribute to continuous BMD gains with denosumab. J Bone Miner Res 30: 1280-1289, 2015.
    • (2015) J Bone Miner Res , vol.30 , pp. 1280-1289
    • Ominsky, M.S.1    Libanati, C.2    Niu, Q.T.3    Boyce, R.W.4    Kostenuik, P.J.5    Wagman, R.B.6    Baron, R.7    Dempster, D.W.8
  • 259
    • 0030444856 scopus 로고    scopus 로고
    • A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line
    • Orloff JJ, Ganz MB, Nathanson MH, Moyer MS, Kats Y, Mitnick M, Behal A, Gasalla-Herraiz J, Isales CM. A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line. Endocrinology 137: 5376-5385, 1996.
    • (1996) Endocrinology , vol.137 , pp. 5376-5385
    • Orloff, J.J.1    Ganz, M.B.2    Nathanson, M.H.3    Moyer, M.S.4    Kats, Y.5    Mitnick, M.6    Behal, A.7    Gasalla-Herraiz, J.8    Isales, C.M.9
  • 260
    • 0028047717 scopus 로고
    • Parathyroid hormone- related protein as a prohormone: Posttranslational processing and receptor interactions
    • Orloff JJ, Reddy D, de Papp AE, Yang KH, Soifer NE, Stewart AF. Parathyroid hormone- related protein as a prohormone: posttranslational processing and receptor interactions. Endocr Rev 15: 40-60, 1994.
    • (1994) Endocr Rev , vol.15 , pp. 40-60
    • Orloff, J.J.1    Reddy, D.2    de Papp, A.E.3    Yang, K.H.4    Soifer, N.E.5    Stewart, A.F.6
  • 261
    • 0024351517 scopus 로고
    • Parathyroid hormone-like proteins: Biochemical responses and receptor interactions
    • Orloff JJ, Wu TL, Stewart AF. Parathyroid hormone-like proteins: biochemical responses and receptor interactions. Endocr Rev 10: 476-495, 1989.
    • (1989) Endocr Rev , vol.10 , pp. 476-495
    • Orloff, J.J.1    Wu, T.L.2    Stewart, A.F.3
  • 262
    • 30944449673 scopus 로고    scopus 로고
    • A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export
    • Pache JC, Burton DW, Deftos LJ, Hastings RH. A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export. Endocrinology 147: 990-998, 2006.
    • (2006) Endocrinology , vol.147 , pp. 990-998
    • Pache, J.C.1    Burton, D.W.2    Deftos, L.J.3    Hastings, R.H.4
  • 263
    • 0016252379 scopus 로고
    • Immunochemical localization of parathyroid hormone in cancer tissue from patients with ectopic hyperparathyroidism
    • Palmieri GM, Nordquist RE, Omenn GS. Immunochemical localization of parathyroid hormone in cancer tissue from patients with ectopic hyperparathyroidism. J Clin Invest 53: 1726-1735, 1974.
    • (1974) J Clin Invest , vol.53 , pp. 1726-1735
    • Palmieri, G.M.1    Nordquist, R.E.2    Omenn, G.S.3
  • 264
    • 0002313309 scopus 로고    scopus 로고
    • Skeletal heterogeneity and the purposes of bone remodelling: Implications for the understanding of osteoporosis
    • edited by Marcus R, Feldman D, and Kelsey J. San Diego, CA: Academic
    • Parfitt AM. Skeletal heterogeneity and the purposes of bone remodelling: implications for the understanding of osteoporosis. In: Osteoporosis, edited by Marcus R, Feldman D, and Kelsey J. San Diego, CA: Academic, 1996, p. 315-339.
    • (1996) Osteoporosis , pp. 315-339
    • Parfitt, A.M.1
  • 265
  • 266
    • 0036861777 scopus 로고    scopus 로고
    • Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition
    • Pasquini GM, Davey RA, Ho PW, Michelangeli VP, Grill V, Kaczmarczyk SJ, Zajac JD. Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition. Bone 31: 598-605, 2002.
    • (2002) Bone , vol.31 , pp. 598-605
    • Pasquini, G.M.1    Davey, R.A.2    Ho, P.W.3    Michelangeli, V.P.4    Grill, V.5    Kaczmarczyk, S.J.6    Zajac, J.D.7
  • 270
    • 70350504319 scopus 로고    scopus 로고
    • Structural basis for parathyroid hormone- related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides
    • Pioszak AA, Parker NR, Gardella TJ, Xu HE. Structural basis for parathyroid hormone- related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem 284: 28382-28391, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 28382-28391
    • Pioszak, A.A.1    Parker, N.R.2    Gardella, T.J.3    Xu, H.E.4
  • 271
    • 0027444176 scopus 로고
    • Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and posttranscriptional mechanisms
    • Pirola CJ, Wang HM, Kamyar A, Wu S, Enomoto H, Sharifi B, Forrester JS, Clemens TL, Fagin JA. Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and posttranscriptional mechanisms. J Biol Chem 268: 1987-1994, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 1987-1994
    • Pirola, C.J.1    Wang, H.M.2    Kamyar, A.3    Wu, S.4    Enomoto, H.5    Sharifi, B.6    Forrester, J.S.7    Clemens, T.L.8    Fagin, J.A.9
  • 273
    • 0029012435 scopus 로고
    • Cell type-specific secretion of parathyroid hormone-related protein via the regulated versus the constitutive secretory pathway
    • Plawner LL, Philbrick WM, Burtis WJ, Broadus AE, Stewart AF. Cell type-specific secretion of parathyroid hormone-related protein via the regulated versus the constitutive secretory pathway. J Biol Chem 270: 14078-14084, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14078-14084
    • Plawner, L.L.1    Philbrick, W.M.2    Burtis, W.J.3    Broadus, A.E.4    Stewart, A.F.5
  • 274
    • 0031786497 scopus 로고    scopus 로고
    • Dissociation of bone formation from resorption during 2-week treatment with human parathyroid hormone-related peptide-(1-36) in humans: Potential as an anabolic therapy for osteoporosis
    • Plotkin H, Gundberg C, Mitnick M, Stewart AF. Dissociation of bone formation from resorption during 2-week treatment with human parathyroid hormone-related peptide-(1-36) in humans: potential as an anabolic therapy for osteoporosis. J Clin Endocrinol Metab 83: 2786-2791, 1998.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2786-2791
    • Plotkin, H.1    Gundberg, C.2    Mitnick, M.3    Stewart, A.F.4
  • 275
    • 0015936631 scopus 로고
    • Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases
    • Powell D, Singer FR, Murray TM, Minkin C, Potts JT Jr. Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases. N Engl J Med 289: 176-181, 1973.
    • (1973) N Engl J Med , vol.289 , pp. 176-181
    • Powell, D.1    Singer, F.R.2    Murray, T.M.3    Minkin, C.4    Potts Jr, J.T.5
  • 277
    • 0034732891 scopus 로고    scopus 로고
    • Genomic structure and expression of parathyroid hormone-related protein gene (PTHrP) in a teleost, Fugu rubripes
    • Power DM, Ingleton PM, Flanagan J, Canario AV, Danks J, Elgar G, Clark MS. Genomic structure and expression of parathyroid hormone-related protein gene (PTHrP) in a teleost, Fugu rubripes. Gene 250: 67-76, 2000.
    • (2000) Gene , vol.250 , pp. 67-76
    • Power, D.M.1    Ingleton, P.M.2    Flanagan, J.3    Canario, A.V.4    Danks, J.5    Elgar, G.6    Clark, M.S.7
  • 278
    • 0033019212 scopus 로고    scopus 로고
    • Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle
    • Qian J, Lorenz JN, Maeda S, Sutliff RL, Weber C, Nakayama T, Colbert MC, Paul RJ, Fagin JA, Clemens TL. Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle. Endocrinology 140: 1826-1833, 1999.
    • (1999) Endocrinology , vol.140 , pp. 1826-1833
    • Qian, J.1    Lorenz, J.N.2    Maeda, S.3    Sutliff, R.L.4    Weber, C.5    Nakayama, T.6    Colbert, M.C.7    Paul, R.J.8    Fagin, J.A.9    Clemens, T.L.10
  • 280
    • 84938970222 scopus 로고    scopus 로고
    • The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse
    • Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB. The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse. Oncogene 34: 4278-4284, 2015.
    • (2015) Oncogene , vol.34 , pp. 4278-4284
    • Quist, T.1    Jin, H.2    Zhu, J.F.3    Smith-Fry, K.4    Capecchi, M.R.5    Jones, K.B.6
  • 281
    • 0027164108 scopus 로고
    • Biosynthesis and processing of endogenous parathyroid hormone related peptide (PTHRP) by rat Leydig cell tumor H-500
    • Rabbani SA, Haq M, Goltzman D. Biosynthesis and processing of endogenous parathyroid hormone related peptide (PTHRP) by rat Leydig cell tumor H-500. Biochemistry 32: 4931-4937, 1993.
    • (1993) Biochemistry , vol.32 , pp. 4931-4937
    • Rabbani, S.A.1    Haq, M.2    Goltzman, D.3
  • 283
    • 0026576212 scopus 로고
    • Production of parathyroid hormone- related protein by the mammary gland of the goat
    • Ratcliffe WA, Thompson GE, Care AD, Peaker M. Production of parathyroid hormone- related protein by the mammary gland of the goat. J Endocrinol 133: 87-93, 1992.
    • (1992) J Endocrinol , vol.133 , pp. 87-93
    • Ratcliffe, W.A.1    Thompson, G.E.2    Care, A.D.3    Peaker, M.4
  • 286
    • 0015134841 scopus 로고
    • Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer
    • Riggs BL, Arnaud CD, Reynolds JC, Smith LH. Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer. J Clin Invest 50: 2079-2083, 1971.
    • (1971) J Clin Invest , vol.50 , pp. 2079-2083
    • Riggs, B.L.1    Arnaud, C.D.2    Reynolds, J.C.3    Smith, L.H.4
  • 287
    • 0030726118 scopus 로고    scopus 로고
    • PTHrP(107-111) inhibits in vivo resorption that was stimulated by PTHrP(1-34) when applied intermittently to neonatal mice
    • Rihani-Basharat S, Lewinson D. PTHrP(107-111) inhibits in vivo resorption that was stimulated by PTHrP(1-34) when applied intermittently to neonatal mice. Calcif Tissue Int 61: 426-428, 1997.
    • (1997) Calcif Tissue Int , vol.61 , pp. 426-428
    • Rihani-Basharat, S.1    Lewinson, D.2
  • 289
    • 0024381118 scopus 로고
    • Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: Stimulation by phorbol esters and epidermal growth factor
    • Rodan SB, Wesolowski G, Ianacone J, Thiede MA, Rodan GA. Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor. J Endocrinol 122: 219-227, 1989.
    • (1989) J Endocrinol , vol.122 , pp. 219-227
    • Rodan, S.B.1    Wesolowski, G.2    Ianacone, J.3    Thiede, M.A.4    Rodan, G.A.5
  • 290
    • 0023944150 scopus 로고
    • Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: Comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy
    • Rodda CP, Kubota M, Heath JA, Ebeling PR, Moseley JM, Care AD, Caple IW, Martin TJ. Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy. J Endocrinol 117: 261-271, 1988.
    • (1988) J Endocrinol , vol.117 , pp. 261-271
    • Rodda, C.P.1    Kubota, M.2    Heath, J.A.3    Ebeling, P.R.4    Moseley, J.M.5    Care, A.D.6    Caple, I.W.7    Martin, T.J.8
  • 291
    • 0015058210 scopus 로고
    • Some thoughts on the nature of ectopic parathyroid hormones
    • Roof BS, Carpenter B, Fink DJ, Gordan GS. Some thoughts on the nature of ectopic parathyroid hormones. Am J Med 50: 686-691, 1971.
    • (1971) Am J Med , vol.50 , pp. 686-691
    • Roof, B.S.1    Carpenter, B.2    Fink, D.J.3    Gordan, G.S.4
  • 292
    • 0029127027 scopus 로고
    • Sequences of the cDNAs encoding canine parathyroid hormone-related protein and parathyroid hormone
    • Rosol TJ, Steinmeyer CL, McCauley LK, Grone A, DeWille JW, Capen CC. Sequences of the cDNAs encoding canine parathyroid hormone-related protein and parathyroid hormone. Gene 160: 241-243, 1995.
    • (1995) Gene , vol.160 , pp. 241-243
    • Rosol, T.J.1    Steinmeyer, C.L.2    McCauley, L.K.3    Grone, A.4    DeWille, J.W.5    Capen, C.C.6
  • 293
    • 0021195776 scopus 로고
    • Postpartum resolution of hypocalcemia in a lactating hypoparathyroid patient
    • Rude RK, Haussler MR, Singer FR. Postpartum resolution of hypocalcemia in a lactating hypoparathyroid patient. Endocrinol Jpn 31: 227-233, 1984.
    • (1984) Endocrinol Jpn , vol.31 , pp. 227-233
    • Rude, R.K.1    Haussler, M.R.2    Singer, F.R.3
  • 296
    • 0034526037 scopus 로고    scopus 로고
    • Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines
    • Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, Brown EM. Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 141: 4357-4364, 2000.
    • (2000) Endocrinology , vol.141 , pp. 4357-4364
    • Sanders, J.L.1    Chattopadhyay, N.2    Kifor, O.3    Yamaguchi, T.4    Butters, R.R.5    Brown, E.M.6
  • 297
    • 0036721125 scopus 로고    scopus 로고
    • Abnormal bone architecture and biomechanical properties with near-lifetime treatment of rats with PTH
    • Sato M, Vahle J, Schmidt A, Westmore M, Smith S, Rowley E, Ma LY. Abnormal bone architecture and biomechanical properties with near-lifetime treatment of rats with PTH. Endocrinology 143: 3230-3242, 2002.
    • (2002) Endocrinology , vol.143 , pp. 3230-3242
    • Sato, M.1    Vahle, J.2    Schmidt, A.3    Westmore, M.4    Smith, S.5    Rowley, E.6    Ma, L.Y.7
  • 299
    • 0028943780 scopus 로고
    • A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
    • Schipani E, Kruse K, Juppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268: 98-100, 1995.
    • (1995) Science , vol.268 , pp. 98-100
    • Schipani, E.1    Kruse, K.2    Juppner, H.3
  • 300
    • 0029849784 scopus 로고    scopus 로고
    • Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen’s metaphyseal chondrodysplasia
    • Schipani E, Langman CB, Parfitt AM, Jensen GS, Kikuchi S, Kooh SW, Cole WG, Juppner H. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen’s metaphyseal chondrodysplasia. N Engl J Med 335: 708-714, 1996.
    • (1996) N Engl J Med , vol.335 , pp. 708-714
    • Schipani, E.1    Langman, C.B.2    Parfitt, A.M.3    Jensen, G.S.4    Kikuchi, S.5    Kooh, S.W.6    Cole, W.G.7    Juppner, H.8
  • 301
    • 0031442990 scopus 로고    scopus 로고
    • Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
    • Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM, Juppner H. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci USA 94: 13689-13694, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13689-13694
    • Schipani, E.1    Lanske, B.2    Hunzelman, J.3    Luz, A.4    Kovacs, C.S.5    Lee, K.6    Pirro, A.7    Kronenberg, H.M.8    Juppner, H.9
  • 302
    • 0034640535 scopus 로고    scopus 로고
    • Expression, release, and biological activity of parathyroid hormone-related peptide from coronary endothelial cells
    • Schluter K, Katzer C, Frischkopf K, Wenzel S, Taimor G, Piper HM. Expression, release, and biological activity of parathyroid hormone-related peptide from coronary endothelial cells. Circ Res 86: 946-951, 2000.
    • (2000) Circ Res , vol.86 , pp. 946-951
    • Schluter, K.1    Katzer, C.2    Frischkopf, K.3    Wenzel, S.4    Taimor, G.5    Piper, H.M.6
  • 303
    • 0035461379 scopus 로고    scopus 로고
    • Reconstructing the skeleton with intermittent parathyroid hormone
    • Seeman E, Delmas PD. Reconstructing the skeleton with intermittent parathyroid hormone. Trends Endocrinol Metab 12: 281-283, 2001.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 281-283
    • Seeman, E.1    Delmas, P.D.2
  • 304
    • 84927774761 scopus 로고    scopus 로고
    • Co-administration of antiresorptive and anabolic agents: A missed opportunity
    • Seeman E, Martin TJ. Co-administration of antiresorptive and anabolic agents: a missed opportunity. J Bone Miner Res 30: 753-764, 2015.
    • (2015) J Bone Miner Res , vol.30 , pp. 753-764
    • Seeman, E.1    Martin, T.J.2
  • 305
  • 306
    • 84933876926 scopus 로고
    • On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol
    • Selye H. On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol. Endocrinology 16: 547-558, 1932.
    • (1932) Endocrinology , vol.16 , pp. 547-558
    • Selye, H.1
  • 307
    • 0025829956 scopus 로고
    • Expression of parathyroid hormone-related protein mRNA in the rat before birth: Demonstration by hybridization histochemistry
    • Senior PV, Heath DA, Beck F. Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Mol Endocrinol 6: 281-290, 1991.
    • (1991) J Mol Endocrinol , vol.6 , pp. 281-290
    • Senior, P.V.1    Heath, D.A.2    Beck, F.3
  • 308
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw G, Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667, 1986.
    • (1986) Cell , vol.46 , pp. 659-667
    • Shaw, G.1    Kamen, R.2
  • 311
    • 84926635563 scopus 로고    scopus 로고
    • Coupling signals between the osteoclast and osteoblast: How are messages transmitted between these temporary visitors to the bone surface?
    • Sims NA, Martin TJ. Coupling signals between the osteoclast and osteoblast: how are messages transmitted between these temporary visitors to the bone surface? Front Endocrinol 6: 41, 2015.
    • (2015) Front Endocrinol , vol.6 , pp. 41
    • Sims, N.A.1    Martin, T.J.2
  • 312
    • 17744388606 scopus 로고    scopus 로고
    • G alpha12/ G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells
    • Singh AT, Gilchrist A, Voyno-Yasenetskaya T, Radeff-Huang JM, Stern PH. G alpha12/ G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells. Endocrinology 146: 2171-2175, 2005.
    • (2005) Endocrinology , vol.146 , pp. 2171-2175
    • Singh, A.T.1    Gilchrist, A.2    Voyno-Yasenetskaya, T.3    Radeff-Huang, J.M.4    Stern, P.H.5
  • 313
    • 0036334426 scopus 로고    scopus 로고
    • Integration of the regulation of reproductive function and energy balance: Lactation as a model
    • Smith MS, Grove KL. Integration of the regulation of reproductive function and energy balance: lactation as a model. Front Neuroendocrinol 23: 225-256, 2002.
    • (2002) Front Neuroendocrinol , vol.23 , pp. 225-256
    • Smith, M.S.1    Grove, K.L.2
  • 314
    • 34547103996 scopus 로고    scopus 로고
    • Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization
    • Sneddon WB, Friedman PA. Beta-arrestin-dependent parathyroid hormone-stimulated extracellular signal-regulated kinase activation and parathyroid hormone type 1 receptor internalization. Endocrinology 148: 4073-4079, 2007.
    • (2007) Endocrinology , vol.148 , pp. 4073-4079
    • Sneddon, W.B.1    Friedman, P.A.2
  • 317
    • 0029916853 scopus 로고    scopus 로고
    • Cell-specific and regulator-induced promoter usage and messenger ribonucleic acid splicing for parathyroid hormonerelated protein
    • Southby J, Murphy LM, Martin TJ, Gillespie MT. Cell-specific and regulator-induced promoter usage and messenger ribonucleic acid splicing for parathyroid hormonerelated protein. Endocrinology 137: 1349-1357, 1996.
    • (1996) Endocrinology , vol.137 , pp. 1349-1357
    • Southby, J.1    Murphy, L.M.2    Martin, T.J.3    Gillespie, M.T.4
  • 318
    • 0029165242 scopus 로고
    • Alternative promoter usage and mRNA splicing pathways for parathyroid hormone-related protein in normal tissues and tumours
    • Southby J, O’Keeffe LM, Martin TJ, Gillespie MT. Alternative promoter usage and mRNA splicing pathways for parathyroid hormone-related protein in normal tissues and tumours. Br J Cancer 72: 702-707, 1995.
    • (1995) Br J Cancer , vol.72 , pp. 702-707
    • Southby, J.1    O’Keeffe, L.M.2    Martin, T.J.3    Gillespie, M.T.4
  • 320
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13: 2072-2086, 1999.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 321
    • 78650304106 scopus 로고    scopus 로고
    • Advances in the biology of bone metastasis: How the skeleton affects tumor behavior
    • Sterling JA, Edwards JR, Martin TJ, Mundy GR. Advances in the biology of bone metastasis: how the skeleton affects tumor behavior. Bone 48: 6-15, 2011.
    • (2011) Bone , vol.48 , pp. 6-15
    • Sterling, J.A.1    Edwards, J.R.2    Martin, T.J.3    Mundy, G.R.4
  • 322
    • 0036233537 scopus 로고    scopus 로고
    • Hyperparathyroidism, humoral hypercalcemia of malignancy, and the anabolic actions of parathyroid hormone and parathyroid hormone-related protein on the skeleton
    • Stewart AF. Hyperparathyroidism, humoral hypercalcemia of malignancy, and the anabolic actions of parathyroid hormone and parathyroid hormone-related protein on the skeleton. J Bone Miner Res 17: 758-762, 2002.
    • (2002) J Bone Miner Res , vol.17 , pp. 758-762
    • Stewart, A.F.1
  • 323
    • 0033916327 scopus 로고    scopus 로고
    • Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: A comparison of human parathyroid hormone 1-34, parathyroid hormone- related protein 1-36, and SDZ-parathyroid hormone 893
    • Stewart AF, Cain RL, Burr DB, Jacob D, Turner CH, Hock JM. Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1-34, parathyroid hormone- related protein 1-36, and SDZ-parathyroid hormone 893. J Bone Miner Res 15: 1517-1525, 2000.
    • (2000) J Bone Miner Res , vol.15 , pp. 1517-1525
    • Stewart, A.F.1    Cain, R.L.2    Burr, D.B.3    Jacob, D.4    Turner, C.H.5    Hock, J.M.6
  • 324
    • 0019123019 scopus 로고
    • Biochemical evaluation of patients with cancer-associated hypercalcemia: Evidence for humoral and nonhumoral groups
    • Stewart AF, Horst R, Deftos LJ, Cadman EC, Lang R, Broadus AE. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med 303: 1377-1383, 1980.
    • (1980) N Engl J Med , vol.303 , pp. 1377-1383
    • Stewart, A.F.1    Horst, R.2    Deftos, L.J.3    Cadman, E.C.4    Lang, R.5    Broadus, A.E.6
  • 325
    • 0020537387 scopus 로고
    • Identification of adenylate cyclasestimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy
    • Stewart AF, Insogna KL, Goltzman D, Broadus AE. Identification of adenylate cyclasestimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 80: 1454-1458, 1983.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 1454-1458
    • Stewart, A.F.1    Insogna, K.L.2    Goltzman, D.3    Broadus, A.E.4
  • 326
    • 0023669186 scopus 로고
    • N-terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domains
    • Stewart AF, Wu T, Goumas D, Burtis WJ, Broadus AE. N-terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and parathyroid hormone-unlike domains. Biochem Biophys Res Commun 146: 672-678, 1987.
    • (1987) Biochem Biophys Res Commun , vol.146 , pp. 672-678
    • Stewart, A.F.1    Wu, T.2    Goumas, D.3    Burtis, W.J.4    Broadus, A.E.5
  • 328
    • 0020692156 scopus 로고
    • Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors
    • Strewler GJ, Williams RD, Nissenson RA. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest 71: 769-774, 1983.
    • (1983) J Clin Invest , vol.71 , pp. 769-774
    • Strewler, G.J.1    Williams, R.D.2    Nissenson, R.A.3
  • 330
    • 84942741310 scopus 로고    scopus 로고
    • Parathroid hormone-related proyein: Gene structure, biosynthesis, metabolism and regulation
    • edited by Bilezikian JP. London: Academic
    • Suva LJ, Freeman AN, Martin TJ. Parathroid hormone-related proyein: gene structure, biosynthesis, metabolism and regulation. In: The Parathyroids, edited by Bilezikian JP. London: Academic, 2015, p. 45-64.
    • (2015) The Parathyroids , pp. 45-64
    • Suva, L.J.1    Freeman, A.N.2    Martin, T.J.3
  • 334
    • 15744405759 scopus 로고    scopus 로고
    • Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling
    • Syme CA, Friedman PA, Bisello A. Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem 280: 11281-11288, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 11281-11288
    • Syme, C.A.1    Friedman, P.A.2    Bisello, A.3
  • 337
    • 33644514312 scopus 로고    scopus 로고
    • Teriparatide [human PTH(1-34)]: 25 years of experience on the use and safety of the drug for the treatment of osteoporosis
    • Tashjian AH Jr, Gagel RF. Teriparatide [human PTH(1-34)]: 25 years of experience on the use and safety of the drug for the treatment of osteoporosis. J Bone Miner Res 21: 354-365, 2006.
    • (2006) J Bone Miner Res , vol.21 , pp. 354-365
    • Tashjian Jr, A.H.1    Gagel, R.F.2
  • 338
    • 44449104186 scopus 로고    scopus 로고
    • On the interpretation of rat carcinogenicity studies for human PTH(1-34) and human PTH(1-84)
    • Tashjian AH Jr, Goltzman D. On the interpretation of rat carcinogenicity studies for human PTH(1-34) and human PTH(1-84). J Bone Miner Res 23: 803-811, 2008.
    • (2008) J Bone Miner Res , vol.23 , pp. 803-811
    • Tashjian Jr, A.H.1    Goltzman, D.2
  • 339
    • 2442741855 scopus 로고
    • Immunochemical identification of parathyroid hormone in non-parathyroid neoplasms associated with hypercalcemia
    • Tashjian AH Jr, Levine L, Munson PL. Immunochemical identification of parathyroid hormone in non-parathyroid neoplasms associated with hypercalcemia. J Exp Med 119: 467-484, 1964.
    • (1964) J Exp Med , vol.119 , pp. 467-484
    • Tashjian Jr, A.H.1    Levine, L.2    Munson, P.L.3
  • 340
    • 8744256394 scopus 로고    scopus 로고
    • Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered
    • Tazawa K, Hoshi K, Kawamoto S, Tanaka M, Ejiri S, Ozawa H. Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered. J Bone Miner Metab 22: 524-529, 2004.
    • (2004) J Bone Miner Metab , vol.22 , pp. 524-529
    • Tazawa, K.1    Hoshi, K.2    Kawamoto, S.3    Tanaka, M.4    Ejiri, S.5    Ozawa, H.6
  • 341
    • 57449116758 scopus 로고    scopus 로고
    • Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited
    • Teti A, Zallone A. Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited. Bone 44: 11-16, 2009.
    • (2009) Bone , vol.44 , pp. 11-16
    • Teti, A.1    Zallone, A.2
  • 342
    • 0024286230 scopus 로고
    • Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue
    • Thiede MA, Rodan GA. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science 242: 278-280, 1988.
    • (1988) Science , vol.242 , pp. 278-280
    • Thiede, M.A.1    Rodan, G.A.2
  • 343
    • 0023767416 scopus 로고
    • Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: Evidence for the alternative splicing of a single-copy gene
    • Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proc Natl Acad Sci USA 85: 4605-4609, 1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4605-4609
    • Thiede, M.A.1    Strewler, G.J.2    Nissenson, R.A.3    Rosenblatt, M.4    Rodan, G.A.5
  • 347
    • 0016586851 scopus 로고
    • Synthetic analogues of residues 1-34 of human parathyroid hormone: Influence of residue number 1 on biological potency in vitro
    • Tregear GW, Potts JT Jr. Synthetic analogues of residues 1-34 of human parathyroid hormone: influence of residue number 1 on biological potency in vitro. Endocr Res Commun 2: 561-570, 1975.
    • (1975) Endocr Res Commun , vol.2 , pp. 561-570
    • Tregear, G.W.1    Potts Jr, J.T.2
  • 348
    • 0021219864 scopus 로고
    • Localization of insulin-like growth factor genes to human chromosomes 11 and 12
    • Tricoli JV, Rall LB, Scott J, Bell GI, Shows TB. Localization of insulin-like growth factor genes to human chromosomes 11 and 12. Nature 310: 784-786, 1984.
    • (1984) Nature , vol.310 , pp. 784-786
    • Tricoli, J.V.1    Rall, L.B.2    Scott, J.3    Bell, G.I.4    Shows, T.B.5
  • 350
    • 0032911885 scopus 로고    scopus 로고
    • The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals
    • Truant R, Cullen BR. The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. Mol Cell Biol 19: 1210-1217, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 1210-1217
    • Truant, R.1    Cullen, B.R.2
  • 353
    • 0029862280 scopus 로고    scopus 로고
    • The expression of parathyroid hormone and parathyroid hormone-related protein in developing rat parathyroid glands
    • Tucci J, Russell A, Senior PV, Fernley R, Ferraro T, Beck F. The expression of parathyroid hormone and parathyroid hormone-related protein in developing rat parathyroid glands. J Mol Endocrinol 17: 149-157, 1996.
    • (1996) J Mol Endocrinol , vol.17 , pp. 149-157
    • Tucci, J.1    Russell, A.2    Senior, P.V.3    Fernley, R.4    Ferraro, T.5    Beck, F.6
  • 354
    • 0027171952 scopus 로고
    • Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues
    • Urena P, Kong XF, Abou-Samra AB, Juppner H, Kronenberg HM, Potts JT Jr, Segre GV. Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues. Endocrinology 133: 617-623, 1993.
    • (1993) Endocrinology , vol.133 , pp. 617-623
    • Urena, P.1    Kong, X.F.2    Abou-Samra, A.B.3    Juppner, H.4    Kronenberg, H.M.5    Potts Jr, J.T.6    Segre, G.V.7
  • 355
    • 0033789516 scopus 로고    scopus 로고
    • New members of the parathyroid hormone/parathyroid hormone receptor family: The parathyroid hormone 2 receptor and tuberoinfundibular peptide of 39 residues
    • Usdin TB, Wang T, Hoare SR, Mezey E, Palkovits M. New members of the parathyroid hormone/parathyroid hormone receptor family: the parathyroid hormone 2 receptor and tuberoinfundibular peptide of 39 residues. Front Neuroendocrinol 21: 349-383, 2000.
    • (2000) Front Neuroendocrinol , vol.21 , pp. 349-383
    • Usdin, T.B.1    Wang, T.2    Hoare, S.R.3    Mezey, E.4    Palkovits, M.5
  • 356
    • 3242887547 scopus 로고    scopus 로고
    • Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose
    • Vahle JL, Long GG, Sandusky G, Westmore M, Ma YL, Sato M. Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose. Toxicol Pathol 32: 426-438, 2004.
    • (2004) Toxicol Pathol , vol.32 , pp. 426-438
    • Vahle, J.L.1    Long, G.G.2    Sandusky, G.3    Westmore, M.4    Ma, Y.L.5    Sato, M.6
  • 357
    • 1842372716 scopus 로고    scopus 로고
    • Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells
    • Valin A, Garcia-Ocana A, De Miguel F, Sarasa JL, Esbrit P. Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells. J Cell Physiol 170: 209-215, 1997.
    • (1997) J Cell Physiol , vol.170 , pp. 209-215
    • Valin, A.1    Garcia-Ocana, A.2    De Miguel, F.3    Sarasa, J.L.4    Esbrit, P.5
  • 358
    • 0034985016 scopus 로고    scopus 로고
    • 2+ through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells
    • 2+ through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. Endocrinology 142: 2752-2759, 2001.
    • (2001) Endocrinology , vol.142 , pp. 2752-2759
    • Valin, A.1    Guillen, C.2    Esbrit, P.3
  • 360
    • 0023841795 scopus 로고
    • Pseudohyperparathyroidism secondary to gigantic mammary hypertrophy
    • Van Heerden JA, Gharib H, Jackson IT. Pseudohyperparathyroidism secondary to gigantic mammary hypertrophy. Arch Surg 123: 80-82, 1988.
    • (1988) Arch Surg , vol.123 , pp. 80-82
    • Van Heerden, J.A.1    Gharib, H.2    Jackson, I.T.3
  • 361
    • 1642363456 scopus 로고    scopus 로고
    • The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport
    • VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest 113: 598-608, 2004.
    • (2004) J Clin Invest , vol.113 , pp. 598-608
    • VanHouten, J.1    Dann, P.2    McGeoch, G.3    Brown, E.M.4    Krapcho, K.5    Neville, M.6    Wysolmerski, J.J.7
  • 363
    • 0344825793 scopus 로고    scopus 로고
    • Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice
    • VanHouten JN, Wysolmerski JJ. Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 144: 5521-5529, 2003.
    • (2003) Endocrinology , vol.144 , pp. 5521-5529
    • VanHouten, J.N.1    Wysolmerski, J.J.2
  • 364
    • 0027510537 scopus 로고
    • Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene
    • Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Mol Endocrinol 7: 273-282, 1993.
    • (1993) Mol Endocrinol , vol.7 , pp. 273-282
    • Vasavada, R.C.1    Wysolmerski, J.J.2    Broadus, A.E.3    Philbrick, W.M.4
  • 366
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273: 613-622, 1996.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 368
    • 0030466889 scopus 로고    scopus 로고
    • Bone growth: Coordinating chondrocyte differentiation
    • Wallis GA. Bone growth: coordinating chondrocyte differentiation. Curr Biol 6: 1577-1580, 1996.
    • (1996) Curr Biol , vol.6 , pp. 1577-1580
    • Wallis, G.A.1
  • 370
    • 84936997495 scopus 로고    scopus 로고
    • Periosteal PTHrP regulates cortical bone remodeling during fracture healing
    • Wang M, Nasiri AR, Broadus AE, Tommasini SM. Periosteal PTHrP regulates cortical bone remodeling during fracture healing. Bone 81: 104-111, 2015.
    • (2015) Bone , vol.81 , pp. 104-111
    • Wang, M.1    Nasiri, A.R.2    Broadus, A.E.3    Tommasini, S.M.4
  • 371
    • 84902290329 scopus 로고    scopus 로고
    • Periosteal PTHrP regulates cortical bone modeling during linear growth in mice
    • Wang M, VanHouten JN, Nasiri AR, Tommasini SM, Broadus AE. Periosteal PTHrP regulates cortical bone modeling during linear growth in mice. J Anat 225: 71-82, 2014.
    • (2014) J Anat , vol.225 , pp. 71-82
    • Wang, M.1    VanHouten, J.N.2    Nasiri, A.R.3    Tommasini, S.M.4    Broadus, A.E.5
  • 374
    • 0033974978 scopus 로고    scopus 로고
    • Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: Association with serum-induced cell proliferation
    • Watson PH, Fraher LJ, Natale BV, Kisiel M, Hendy GN, Hodsman AB. Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation. Bone 26: 221-225, 2000.
    • (2000) Bone , vol.26 , pp. 221-225
    • Watson, P.H.1    Fraher, L.J.2    Natale, B.V.3    Kisiel, M.4    Hendy, G.N.5    Hodsman, A.B.6
  • 375
    • 0024241661 scopus 로고
    • Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy
    • Weir EC, Burtis WJ, Morris CA, Brady TG, Insogna KL. Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy. Endocrinology 123: 2744-2751, 1988.
    • (1988) Endocrinology , vol.123 , pp. 2744-2751
    • Weir, E.C.1    Burtis, W.J.2    Morris, C.A.3    Brady, T.G.4    Insogna, K.L.5
  • 376
    • 0029811142 scopus 로고    scopus 로고
    • Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
    • Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci USA 93: 10240-10245, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10240-10245
    • Weir, E.C.1    Philbrick, W.M.2    Amling, M.3    Neff, L.A.4    Baron, R.5    Broadus, A.E.6
  • 378
    • 0031875955 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro
    • Werkmeister JR, Blomme EA, Weckmann MT, Grone A, McCauley LK, Wade AB, O’Rourke J, Capen CC, Rosol TJ. Effect of transforming growth factor-beta1 on parathyroid hormone-related protein secretion and mRNA expression by normal human keratinocytes in vitro. Endocrine 8: 291-299, 1998.
    • (1998) Endocrine , vol.8 , pp. 291-299
    • Werkmeister, J.R.1    Blomme, E.A.2    Weckmann, M.T.3    Grone, A.4    McCauley, L.K.5    Wade, A.B.6    O’Rourke, J.7    Capen, C.C.8    Rosol, T.J.9
  • 380
    • 0015044966 scopus 로고
    • Value of plasma chloride concentration and acid-base status in the differential diagnosis of hyperparathyroidism from other causes of hypercalcaemia
    • Wills MR. Value of plasma chloride concentration and acid-base status in the differential diagnosis of hyperparathyroidism from other causes of hypercalcaemia. J Clin Pathol 24: 219-227, 1971.
    • (1971) J Clin Pathol , vol.24 , pp. 219-227
    • Wills, M.R.1
  • 382
    • 0025787686 scopus 로고
    • Glycosylation of parathyroid hormone-related peptide secreted by human epidermal keratinocytes
    • Wu TL, Soifer NE, Burtis WJ, Milstone LM, Stewart AF. Glycosylation of parathyroid hormone-related peptide secreted by human epidermal keratinocytes. J Clin Endocrinol Metab 73: 1002-1007, 1991.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1002-1007
    • Wu, T.L.1    Soifer, N.E.2    Burtis, W.J.3    Milstone, L.M.4    Stewart, A.F.5
  • 383
    • 0029767848 scopus 로고    scopus 로고
    • Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein
    • WuTL, Vasavada RC, Yang K, Massfelder T, Ganz M, Abbas SK, Care AD, Stewart AF. Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. J Biol Chem 271: 24371-24381, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 24371-24381
    • Wu, T.L.1    Vasavada, R.C.2    Yang, K.3    Massfelder, T.4    Ganz, M.5    Abbas, S.K.6    Care, A.D.7    Stewart, A.F.8
  • 384
    • 0035035010 scopus 로고    scopus 로고
    • Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction
    • Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, Roume J, Delezoide AL, Silve C. Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction. J Clin Endocrinol Metab 86: 1788-1794, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1788-1794
    • Wysolmerski, J.J.1    Cormier, S.2    Philbrick, W.M.3    Dann, P.4    Zhang, J.P.5    Roume, J.6    Delezoide, A.L.7    Silve, C.8
  • 385
    • 0031923474 scopus 로고    scopus 로고
    • Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development
    • Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125: 1285-1294, 1998.
    • (1998) Development , vol.125 , pp. 1285-1294
    • Wysolmerski, J.J.1    Philbrick, W.M.2    Dunbar, M.E.3    Lanske, B.4    Kronenberg, H.5    Broadus, A.E.6
  • 386
    • 78149428949 scopus 로고    scopus 로고
    • Physiological actions of PTH and PTHrP; epidermal, mammary, reproductive, pancreatic tissues
    • edited by Bilezikian JP, Raisz LG, Martin TJ. New York: Academic
    • Wysolmerski JJ, Stewart AF, Kovacs CS. Physiological actions of PTH and PTHrP; epidermal, mammary, reproductive, pancreatic tissues. In: Principles of Bone Biology, edited by Bilezikian JP, Raisz LG, Martin TJ. New York: Academic, 2008, p. 713-731.
    • (2008) Principles of Bone Biology , pp. 713-731
    • Wysolmerski, J.J.1    Stewart, A.F.2    Kovacs, C.S.3
  • 389
    • 0025724012 scopus 로고
    • Sucklingmediated increases in urinary phosphate and 3',5'-cyclic adenosine monophosphate excretion in lactating rats: Possible systemic effects of parathyroid hormone-related protein
    • Yamamoto M, Duong LT, Fisher JE, Thiede MA, Caulfield MP, Rosenblatt M. Sucklingmediated increases in urinary phosphate and 3',5'-cyclic adenosine monophosphate excretion in lactating rats: possible systemic effects of parathyroid hormone-related protein. Endocrinology 129: 2614-2622, 1991.
    • (1991) Endocrinology , vol.129 , pp. 2614-2622
    • Yamamoto, M.1    Duong, L.T.2    Fisher, J.E.3    Thiede, M.A.4    Caulfield, M.P.5    Rosenblatt, M.6
  • 390
    • 0026773422 scopus 로고
    • Parathyroid hormone-related protein in the rat urinary bladder: A smooth muscle relaxant produced locally in response to mechanical stretch
    • Yamamoto M, Harm SC, Grasser WA, Thiede MA. Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch. Proc Natl Acad Sci USA 89: 5326-5330, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5326-5330
    • Yamamoto, M.1    Harm, S.C.2    Grasser, W.A.3    Thiede, M.A.4
  • 391
    • 34249075203 scopus 로고    scopus 로고
    • Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone
    • Yang D, Singh R, Divieti P, Guo J, Bouxsein ML, Bringhurst FR. Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone 40: 1453-1461, 2007.
    • (2007) Bone , vol.40 , pp. 1453-1461
    • Yang, D.1    Singh, R.2    Divieti, P.3    Guo, J.4    Bouxsein, M.L.5    Bringhurst, F.R.6
  • 394
    • 0024509993 scopus 로고
    • Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects
    • Yasuda T, Banville D, Hendy GN, Goltzman D. Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects. J Biol Chem 264: 7720-7725, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 7720-7725
    • Yasuda, T.1    Banville, D.2    Hendy, G.N.3    Goltzman, D.4
  • 396
    • 0031769483 scopus 로고    scopus 로고
    • A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia
    • Zhang P, Jobert AS, Couvineau A, Silve C. A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. J Clin Endocrinol Metab 83: 3365-3368, 1998.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3365-3368
    • Zhang, P.1    Jobert, A.S.2    Couvineau, A.3    Silve, C.4
  • 397
    • 84882594681 scopus 로고    scopus 로고
    • Endogenous parathyroid hormone-related protein compensates for the absence of parathyroid hormone in promoting bone accrual in vivo in a model of bone marrow ablation
    • Zhu Q, Zhou X, Zhu M, Wang Q, Goltzman D, Karaplis A, Miao D. Endogenous parathyroid hormone-related protein compensates for the absence of parathyroid hormone in promoting bone accrual in vivo in a model of bone marrow ablation. J Bone Miner Res 28: 1898-1911, 2013.
    • (2013) J Bone Miner Res , vol.28 , pp. 1898-1911
    • Zhu, Q.1    Zhou, X.2    Zhu, M.3    Wang, Q.4    Goltzman, D.5    Karaplis, A.6    Miao, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.