메뉴 건너뛰기




Volumn 137, Issue 9, 1996, Pages 3936-3941

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MUTANT PROTEIN; PARATHYROID HORMONE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE[1-34]; SECRETIN;

EID: 0029816971     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.9.8756569     Document Type: Article
Times cited : (73)

References (40)
  • 2
    • 0026592357 scopus 로고
    • Constitutive activation of the α1B-adrenergic receptor by all amino acid substitutions at a single site
    • Kjelsberg MA, Cotecchia S, Ostrowski J, Caron MG, Lefkowitz RJ 1992 Constitutive activation of the α1B-adrenergic receptor by all amino acid substitutions at a single site. J Biol Chem 1942:1430-1433
    • (1992) J Biol Chem , vol.1942 , pp. 1430-1433
    • Kjelsberg, M.A.1    Cotecchia, S.2    Ostrowski, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 3
    • 0028209348 scopus 로고
    • Negative antagonists promote an inactive conformation of the β2-adrenergic receptor
    • Samama P, Pei G, Costa T, Cotecchia S, Lefkowitz RJ 1994 Negative antagonists promote an inactive conformation of the β2-adrenergic receptor. Mol Pharmacol 45:390-394
    • (1994) Mol Pharmacol , vol.45 , pp. 390-394
    • Samama, P.1    Pei, G.2    Costa, T.3    Cotecchia, S.4    Lefkowitz, R.J.5
  • 4
    • 0001169515 scopus 로고
    • Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins
    • Costa T, Herz A 1989 Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proc Natl Acad Sci USA 86:7321-7325
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7321-7325
    • Costa, T.1    Herz, A.2
  • 5
    • 0026608113 scopus 로고
    • Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand
    • Costa T, Ogino Y, Munson PJ, Onaran O, Rodbard D 1992 Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol Pharmacol 41:549-560
    • (1992) Mol Pharmacol , vol.41 , pp. 549-560
    • Costa, T.1    Ogino, Y.2    Munson, P.J.3    Onaran, O.4    Rodbard, D.5
  • 6
    • 0028180127 scopus 로고
    • Constitutively active 5-hydroxytryptamine2c receptors reveal novel inverse agonist activity of receptor ligands
    • Barker E, Westphal R, Schmidt D, Sanders-Bush E 1994 Constitutively active 5-hydroxytryptamine2c receptors reveal novel inverse agonist activity of receptor ligands. J Biol Chem 269:11687-11690
    • (1994) J Biol Chem , vol.269 , pp. 11687-11690
    • Barker, E.1    Westphal, R.2    Schmidt, D.3    Sanders-Bush, E.4
  • 7
    • 0028838954 scopus 로고
    • Truncation of the thyrotropin-releasing hormone receptor carboxyl tail causes constitutive activity and leads to impaired responsiveness in Xenopus oocytes and AtT20 cells
    • Matus LN, Nussenzveig DR, Gershengorn MC, Oron Y 1995 Truncation of the thyrotropin-releasing hormone receptor carboxyl tail causes constitutive activity and leads to impaired responsiveness in Xenopus oocytes and AtT20 cells. J Biol Chem 270:1041-1047
    • (1995) J Biol Chem , vol.270 , pp. 1041-1047
    • Matus, L.N.1    Nussenzveig, D.R.2    Gershengorn, M.C.3    Oron, Y.4
  • 8
    • 0028886577 scopus 로고
    • A constitutively active mutant thyrotropin-releasing hormone recptor is chronically down-regulated in pituitary cells: Evidence using chlordiazepoxide as a negative antagonist
    • Heinflink M, Nussenzveig D, Grimberg H, Lupo-Meiri M, Oron Y, Gershengorn M 1995 A constitutively active mutant thyrotropin-releasing hormone recptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist. Mol Endocrinol 9:1455-1460
    • (1995) Mol Endocrinol , vol.9 , pp. 1455-1460
    • Heinflink, M.1    Nussenzveig, D.2    Grimberg, H.3    Lupo-Meiri, M.4    Oron, Y.5    Gershengorn, M.6
  • 10
    • 0028861330 scopus 로고
    • Inverse agonism: Pharmacological curiosity or potential therapeutic strategy
    • Milligan G, Bond R, Lee M 1995 Inverse agonism: pharmacological curiosity or potential therapeutic strategy. Trends Pharmacol Sci 16:10-13
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 10-13
    • Milligan, G.1    Bond, R.2    Lee, M.3
  • 11
    • 0026598246 scopus 로고
    • Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium
    • Abou-Samra AB, Jüppner H, Force T, Freeman M, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT Jr, Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2732-2736
    • Abou-Samra, A.B.1    Jüppner, H.2    Force, T.3    Freeman, M.4    Kong, X.F.5    Schipani, E.6    Urena, P.7    Richards, J.8    Bonventre, J.V.9    Potts Jr., J.T.10    Kronenberg, H.M.11    Segre, G.V.12
  • 18
    • 0016861429 scopus 로고
    • Analysis of the requirements for parathyroid hormone action in renal membranes with the use of inhibiting analogues
    • Goltzman D, Peytremann A, Callahan E, Tregear GW, Potts Jr JT 1975 Analysis of the requirements for parathyroid hormone action in renal membranes with the use of inhibiting analogues. J Biol Chem 250:3199-3203
    • (1975) J Biol Chem , vol.250 , pp. 3199-3203
    • Goltzman, D.1    Peytremann, A.2    Callahan, E.3    Tregear, G.W.4    Potts Jr., J.T.5
  • 19
    • 0020531235 scopus 로고
    • A parathyroid hormone inhibitor in vivo: Design and biologic evaluation of a hormone analog
    • Horiuchi N, Holick MF, Potts JT Jr, Rosenblatt M 1983 A parathyroid hormone inhibitor in vivo: design and biologic evaluation of a hormone analog. Science 220:1053-1055
    • (1983) Science , vol.220 , pp. 1053-1055
    • Horiuchi, N.1    Holick, M.F.2    Potts Jr., J.T.3    Rosenblatt, M.4
  • 23
    • 0025286359 scopus 로고
    • Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists
    • McKee RL, Caulfield MP, Rosenblatt M 1990 Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists. Endocrinology 127:76-82
    • (1990) Endocrinology , vol.127 , pp. 76-82
    • McKee, R.L.1    Caulfield, M.P.2    Rosenblatt, M.3
  • 25
    • 0028943780 scopus 로고
    • A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
    • Schipani E, Kruse K, Jüppner H 1995 A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268:98-100
    • (1995) Science , vol.268 , pp. 98-100
    • Schipani, E.1    Kruse, K.2    Jüppner, H.3
  • 28
    • 0000820364 scopus 로고
    • Molecular Cloning of the CD2 Antigen, the T-cell Erythrocyte Receptor
    • Seed B, Aruffo A 1987 Molecular Cloning of the CD2 Antigen, the T-cell Erythrocyte Receptor. Proc Natl Acad Sci USA 84:3365-3369
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3365-3369
    • Seed, B.1    Aruffo, A.2
  • 29
    • 0029165117 scopus 로고
    • Homolog-scanning mutagenesis of the parathyroid hormone receptor reveals PTH-(1-34)-binding determinants in the third extracellular loop
    • Lee C, Luck M, Juppner H, Potts J, Kronenberg H, Gardella T 1995 Homolog-scanning mutagenesis of the parathyroid hormone receptor reveals PTH-(1-34)-binding determinants in the third extracellular loop. Mol Endocrinol 9:1269-1278
    • (1995) Mol Endocrinol , vol.9 , pp. 1269-1278
    • Lee, C.1    Luck, M.2    Juppner, H.3    Potts, J.4    Kronenberg, H.5    Gardella, T.6
  • 30
    • 0028845059 scopus 로고
    • Nonlinear regression using spreadsheets
    • Bowen W, Jerman J 1995 Nonlinear regression using spreadsheets. Trends Pharmacol Sci 16:413-417
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 413-417
    • Bowen, W.1    Jerman, J.2
  • 31
    • 0028840145 scopus 로고
    • The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis
    • Huang Z, Chen Y, Nissenson RA 1995 The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem 270:151-156
    • (1995) J Biol Chem , vol.270 , pp. 151-156
    • Huang, Z.1    Chen, Y.2    Nissenson, R.A.3
  • 32
    • 0027296623 scopus 로고
    • Constitutively active mutants of the α2-adrenergic receptor
    • Ren Q, Kurose H, Lefkowitz RJ, Cotecchia S 1993 Constitutively active mutants of the α2-adrenergic receptor. J Biol Chem 268:16483-16487
    • (1993) J Biol Chem , vol.268 , pp. 16483-16487
    • Ren, Q.1    Kurose, H.2    Lefkowitz, R.J.3    Cotecchia, S.4
  • 33
    • 0028331771 scopus 로고
    • A constitutively active mutant b2-adrenergic receptor is Constitutively desensitized and phosphorylated
    • Pei G, Samama P, Lohse M, Wang M, Codina J, Lefkowitz R 1994 A constitutively active mutant b2-adrenergic receptor is Constitutively desensitized and phosphorylated. Proc Natl Acad Sci USA 91:2699-2702
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2699-2702
    • Pei, G.1    Samama, P.2    Lohse, M.3    Wang, M.4    Codina, J.5    Lefkowitz, R.6
  • 34
    • 0019137579 scopus 로고
    • A Ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
    • De Lean A, Stadel J, Lefkowitz R 1980 A Ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J Biol Chem 255:7108-7117
    • (1980) J Biol Chem , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.2    Lefkowitz, R.3
  • 35
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the β2-adrenergic receptor: Extending the ternary complex model
    • Samama P, Cotecchia S, Costa T, Lefkowitz R 1993 A mutation-induced activated state of the β2-adrenergic receptor: extending the ternary complex model. J Biol Chem 268:4625-4636
    • (1993) J Biol Chem , vol.268 , pp. 4625-4636
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.4
  • 38
    • 0028909975 scopus 로고
    • Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty
    • Kosugi S, Van DC, Geffner ME, Rabl W, Carel JC, Chaussain JL, Mori T, Merendino JJ, Shenker A 1995 Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. Hum Mol Genet 4:183-188
    • (1995) Hum Mol Genet , vol.4 , pp. 183-188
    • Kosugi, S.1    Van, D.C.2    Geffner, M.E.3    Rabl, W.4    Carel, J.C.5    Chaussain, J.L.6    Mori, T.7    Merendino, J.J.8    Shenker, A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.