메뉴 건너뛰기




Volumn 30, Issue 10, 2009, Pages 1789-1795

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 70349985246     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp180     Document Type: Article
Times cited : (94)

References (28)
  • 1
    • 34547660321 scopus 로고    scopus 로고
    • A spatially and temporally restricted mouse model of soft tissue sarcoma
    • Kirsch,D.G. et al. (2007) A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat. Med., 13, 992-997.
    • (2007) Nat. Med , vol.13 , pp. 992-997
    • Kirsch, D.G.1
  • 2
    • 0038312141 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
    • Sommer,G. et al. (2003) Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc. Natl Acad. Sci. USA, 100, 6706-6711.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 6706-6711
    • Sommer, G.1
  • 3
    • 23044467277 scopus 로고    scopus 로고
    • A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E
    • Rubin,B.P. et al. (2005) A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E. Cancer Res., 65, 6631-6639.
    • (2005) Cancer Res , vol.65 , pp. 6631-6639
    • Rubin, B.P.1
  • 4
    • 38949125814 scopus 로고    scopus 로고
    • A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy
    • Nakai,N. et al. (2008) A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J. Pathol., 214, 302-311.
    • (2008) J. Pathol , vol.214 , pp. 302-311
    • Nakai, N.1
  • 5
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks,T. et al. (1994) Tumor spectrum analysis in p53-mutant mice. Curr. Biol., 4, 1-7.
    • (1994) Curr. Biol , vol.4 , pp. 1-7
    • Jacks, T.1
  • 6
    • 0030265337 scopus 로고    scopus 로고
    • The p53-deficient mouse: A model for basic and applied cancer studies
    • Donehower,L.A. (1996) The p53-deficient mouse: A model for basic and applied cancer studies. Semin. Cancer Biol., 7, 269-278.
    • (1996) Semin. Cancer Biol , vol.7 , pp. 269-278
    • Donehower, L.A.1
  • 7
    • 0023715595 scopus 로고
    • A cancer family syndrome in twenty-four kindreds
    • Li,F.P. et al. (1988) A cancer family syndrome in twenty-four kindreds. Cancer Res., 48, 5358-5362.
    • (1988) Cancer Res , vol.48 , pp. 5358-5362
    • Li, F.P.1
  • 8
    • 0026702996 scopus 로고
    • Effects of an Rb mutation in the mouse, see comments
    • Jacks,T. et al. (1992) Effects of an Rb mutation in the mouse. Nature, 359, 295-300[see comments].
    • (1992) Nature , vol.359 , pp. 295-300
    • Jacks, T.1
  • 9
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis, see comment
    • Lee,E.Y. et al. (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature, 359 288-294[see comment].
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1
  • 10
    • 0026760426 scopus 로고
    • Requirement for a functional Rb-1 gene in murine development, see comment
    • Clarke,A.R. et al. (1992) Requirement for a functional Rb-1 gene in murine development. Nature, 359, 328-330[see comment].
    • (1992) Nature , vol.359 , pp. 328-330
    • Clarke, A.R.1
  • 11
    • 0022623369 scopus 로고
    • Second primary neoplasms in patients with retinoblastoma
    • Draper,G.J. et al. (1986) Second primary neoplasms in patients with retinoblastoma. Br. J. Cancer, 53, 661-671.
    • (1986) Br. J. Cancer , vol.53 , pp. 661-671
    • Draper, G.J.1
  • 12
    • 0028174064 scopus 로고
    • Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
    • Hu,N. et al. (1994) Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene, 9, 1021-1027.
    • (1994) Oncogene , vol.9 , pp. 1021-1027
    • Hu, N.1
  • 13
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino,S. et al. (2000) Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev., 14, 994-1004.
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1
  • 14
    • 0034084930 scopus 로고    scopus 로고
    • Identification of a prx1 limb enhancer
    • Martin,J.F. et al. (2000) Identification of a prx1 limb enhancer. Genesis J. Genet. Dev., 26, 225-229.
    • (2000) Genesis J. Genet. Dev , vol.26 , pp. 225-229
    • Martin, J.F.1
  • 15
    • 0036076389 scopus 로고    scopus 로고
    • Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer
    • Logan,M. et al. (2002) Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis J. Genet. Dev., 33, 77-80.
    • (2002) Genesis J. Genet. Dev , vol.33 , pp. 77-80
    • Logan, M.1
  • 16
    • 38549157655 scopus 로고    scopus 로고
    • Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass
    • Nakanishi,R. et al. (2008) Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J. Bone Miner. Res., 23, 271-277.
    • (2008) J. Bone Miner. Res , vol.23 , pp. 271-277
    • Nakanishi, R.1
  • 17
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano,P. (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet., 21, 70-71.
    • (1999) Nat. Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 18
    • 4444246433 scopus 로고    scopus 로고
    • Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity
    • Zamurovic,N. et al. (2004) Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. J. Biol. Chem., 279, 37704-37715.
    • (2004) J. Biol. Chem , vol.279 , pp. 37704-37715
    • Zamurovic, N.1
  • 19
    • 33644879150 scopus 로고    scopus 로고
    • Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling
    • Lengner,C.J. et al. (2006) Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J. Cell Biol., 172, 909-921.
    • (2006) J. Cell Biol , vol.172 , pp. 909-921
    • Lengner, C.J.1
  • 20
    • 50149110590 scopus 로고    scopus 로고
    • Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
    • Berman,S.D. et al. (2008) Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc. Natl Acad. Sci. USA, 105, 11851-11856.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 11851-11856
    • Berman, S.D.1
  • 21
    • 45349086509 scopus 로고    scopus 로고
    • Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease
    • Walkley,C.R. et al. (2008) Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev., 22, 1662-1676.
    • (2008) Genes Dev , vol.22 , pp. 1662-1676
    • Walkley, C.R.1
  • 22
    • 2942548981 scopus 로고    scopus 로고
    • Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
    • Stein,G.S. et al. (2004) Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene, 23, 4315-4329.
    • (2004) Oncogene , vol.23 , pp. 4315-4329
    • Stein, G.S.1
  • 23
    • 20144371011 scopus 로고    scopus 로고
    • The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts
    • Galindo,M. et al. (2005) The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J. Biol. Chem., 280 20274-20285.
    • (2005) J. Biol. Chem , vol.280 , pp. 20274-20285
    • Galindo, M.1
  • 24
    • 0026471778 scopus 로고
    • MHox: A mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer
    • Cserjesi,P. et al. (1992) MHox: A mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development, 115, 1087-1101.
    • (1992) Development , vol.115 , pp. 1087-1101
    • Cserjesi, P.1
  • 25
    • 0029086672 scopus 로고
    • Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain
    • Leussink,B. et al. (1995) Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain. Mech. Dev., 52, 51-64.
    • (1995) Mech. Dev , vol.52 , pp. 51-64
    • Leussink, B.1
  • 26
    • 0015043748 scopus 로고    scopus 로고
    • Knudson,A.G.Jr (1971) Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA, 68, 820-823.
    • Knudson,A.G.Jr (1971) Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA, 68, 820-823.
  • 27
    • 53349141349 scopus 로고    scopus 로고
    • The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development
    • Berman,S.D. et al. (2008) The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol. Cancer Res., 6, 1440-1451.
    • (2008) Mol. Cancer Res , vol.6 , pp. 1440-1451
    • Berman, S.D.1
  • 28
    • 57449095858 scopus 로고    scopus 로고
    • Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice
    • Gutierrez,G.M. et al. (2008) Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice. Proc. Natl Acad. Sci. USA, 105, 18402-18407.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 18402-18407
    • Gutierrez, G.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.