Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

Journal of Biological Chemistry

Volumn 284, Issue 41, 2009, Pages 28382-28391

  Pioszak, Augen A ^a   Parker, Naomi R ^a   Gardella, Thomas J ^b   Xu, H Eric ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPATHIC; BINDING MODES; BINDING STUDIES; BONE DEVELOPMENT; BONE FORMATION; CLASS B; EXTRACELLULAR DOMAINS; G PROTEIN; G PROTEIN COUPLED RECEPTORS; HIGH RESOLUTION CRYSTAL STRUCTURE; HYBRID LIGAND; HYBRID PEPTIDES; MOLECULAR MODELS; PARATHYROID HORMONE RECEPTORS; PARATHYROID HORMONES; PROTEIN BINDING; ROTAMERS; SIDE CHAINS; STRUCTURAL BASIS; TOGGLE SWITCH;

AMINES; BINDING ENERGY; BIOCHEMISTRY; BONE; CONFORMATIONS; CRYSTAL STRUCTURE; ELECTROCHEMICAL SENSORS; ELECTROCHROMIC DEVICES; LIGANDS; POLYPEPTIDES; REDUCTION;

PEPTIDES;

G PROTEIN COUPLED RECEPTOR; ISOLEUCINE; LEUCINE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXTRACELLULAR SPACE; HUMAN; HYDROPHOBICITY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PARATHYROID HORMONE-RELATED PROTEIN; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70350504319     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.022905     Document Type: Article

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