Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: Association with serum-induced cell proliferation

Bone

Volumn 26, Issue 3, 2000, Pages 221-225

  Watson, P H ^a   Fraher, L J ^a   Natale, B V ^a   Kisiel, M ^a   Hendy, G N ^b   Hodsman, A B ^a  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Immunocytochemistry; Localization; MC3T3 E1; Osteoblasts; Parathyroid hormone receptor

Indexed keywords

PARATHYROID HORMONE RECEPTOR;

ARTICLE; CELL CULTURE; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CULTURE MEDIUM; DNA SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; OSTEOCLAST; SERUM;

3T3 CELLS; ANIMALS; BLOOD; CELL DIVISION; CELL NUCLEUS; IMMUNOHISTOCHEMISTRY; MICE; PARATHYROID HORMONE; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, PARATHYROID HORMONE; TUMOR CELLS, CULTURED;

EID: 0033974978     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(99)00264-1     Document Type: Article

References (33)

1. Aarts M.M., Levy D., He B., Stregger S., Chen T., Richard S., Henderson J.E. Parathyroid hormone-related protein interacts with RNA. J Biol Chem. 274:1999;4832-4838.
2. Abou-Samra A.B., Juppner H., Force T., Freeman M.W., Kong X.F., Schipani E., Urena P., Richards J., Bonventre J.V., Potts J.T. Jr, Kronenberg H.M., Segre G.V. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium . Proc Natl Acad Sci USA. 89:1992;2732-2736.
3. Bader T., Witzerbin J. Nuclear accumulation of interferon γ Proc Natl Acad Sci USA. 91:1994;11831-11835.
4. Burwen S.J., Jones A.L. The association of polypeptide hormones and growth factors with the nuclei of target cells. Trends Biochem Sci. 12:1987;159-162.
5. Burysek L., Houstek J. Multifactorial induction of gene expression and nuclear localization of mouse interleukin 1α Cytokine. 6:1996;70-78.
6. Csaba G., Hegyesi H. Immunocytochemical verification of the insulin receptor's specificity in the nuclear envelope of Tetrahymena. Comparison with receptors of the plasma membrane. Biosci Rep. 14:1994;25-31.
7. Collins T., Bonthon D.T., Orkin S.H. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. Nature. 328:1987;621-624.
8. Curtis B.M., Widner M.B., de Roos P., Qwarnstorm E.E. IL-1 and its receptor are translocated to the nucleus. J Immunol. 144:1990;1295-1303.
9. Henderson J.E., Amizuka N., Warshawsky H., Biasotto D., Lanske B.M.K., Goltzman D., Karaplis A.C. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol. 15:1995;4064-4075.
10. Jans D.A., Briggs L.J., Gustin S.E., Jans P., Ford S., Young I.G. A functional bipartite nuclear localization signal in the cytokine interleukin-5. FEBS Lett. 406:1997;315-320.
11. Jans D.A., Hassan G. Nuclear targeting by growth factors, cytokines, and their receptors a role in signaling? Bioessays. 20:1998;400-411.
12. Jans D.A., Huebner S. Regulation of protein transport to the nucleus central role of phosphorylation . Physiol Rev. 76:1996;651-685.
13. Joune H., Lanske B., Karperien M., Qian F., Defize L., Abou-Samra A. Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor gene a new PTH/PTHrP receptor splice variant that lacks the signal peptide . Endocrinology. 138:1997;1742-1749.
14. Johnson H.M., Torres B.A., Green M.M., Szente B.E., Siler K.I., Larkin J. III, Subramaniam P.S. Cytokine-receptor complexes as chaperones for nuclear translocation of signal transducers. Biochem Biophys Res Commun. 244:1998;607-614.
15. Kaiser S.M., Laneuville P., Bernier S.M., Rhim J.S., Kremer R., Goltzman D. Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem. 267:1992;13623-13628.
16. Kilkenny D.M., Hill D.J. Perinuclear localization of an intracellular binding protein related to the fibroblast growth factor (FGF) receptor 1 is temporally associated with the nuclear trafficking of FGF-2 in proliferating epiphyseal growth plate chondrocytes. Endocrinology. 137:1996;5078-5089.
17. Kronenberg H.M., Lanske B., Kovacs C.S., Chung U.-I., Lee K., Segre G.V., Schipani E., Juppner H. Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res. 53:1998;283-303.
18. Lam M.H.C., Briggs L.J., Hu W., Martin T.J., Gillespie M.T., Jans D.A. Extracellular PTHrP can be internalized by the PTH/PTHrP receptor and attain a nuclear location via importin β Bone. 23:(Suppl.):1998;197.
19. Lam M.H.C., Briggs L.J., Hu W., Martin T.J., Gillespie M.T., Jans D.A. Importin (beta) recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin (alpha). J Biol Chem. 274:1999;7391-7397.
20. Largo R., Gomez-Garre D., Santos S., Penaranda C., Blanco J., Esbrit P., Egido J. Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage. Kidney Int. 55:1999;82-90.
21. Leaman D.W., Leung S., Li X., Stark G.R. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J. 10:1996;1578-1588.
22. Lee B.A., Maher D.W., Hannink M., Donoghue D.J. Identification of a signal for nuclear targeting in platelet-derived growth-factor-related molecules. Mol Cell Biol. 7:1987;3527-3537.
23. Nguyen M.T.A., Karaplis A.C. The nucleus a target site for parathyroid hormone-related peptide (PTHrP) action . J Cell Biochem. 70:1998;193-199.
24. Pausova Z., Bourdon J., Clayton D., Mattei M.-G., Seldin M.F., Janicic N., Riviere M., Szpirer J., Levan G., Szpirer C., Goltzman D., Hendy G.N. Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR106) cell line chromosomal assignment of the gene in the human, mouse and rat genomes . Genomics. 20:1994;20-26.
25. 2-terminal extension of high molecular weight bFGF is a nuclear targeting signal. J Cell Physiol. 147:1991;311-318.
26. Radulescu R.T. Insulin receptor α-subunit a putative gene regulatory molecule . Med Hypotheses. 45:1995;107-111.
27. Vasavada R.C., Garcia-Ocana A., Massfelder T., Dann P., Stewart A.F. Parathyroid hormone-related protein in the pancreatic islet and the cardiovascular system. Recent Prog Horm Res. 53:1998;305-340.
28. Watson, P. H., Fraher, L. J., Hendy, G. N., Chung, U.-I., Kisiel, M., Natale, B. V., and Hodsman, A. B. Nuclear localization of the type 1 PTH/PTHrP receptor in rat tissues. J Bone Miner Res 2000.
29. Watson, P. H., Kisiel, M. A., Natale, B. V., Hendy, G. N., Fraher, L. J., and Hodsman, A. B. Co-localization of PTH/PTHrP receptor protein and mRNA in kidney and non-traditional PTH target tissues. Bone 23(Suppl. 1):567.
30. Watson P., Lazowski D., Han V., Fraher L., Steer B., Hodsman A. Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor I gene expression in ovariectomized rats. Bone. 16:1995;357-365.
31. Wessendorf J.H., Garfinkel S., Zhan X., Brown S., Maciag T. Identification of nuclear localization sequence within the structure of the human interleukin-1α precursor. J Biol Chem. 268:1993;22100-22104.
32. Zhan, X., Hu, H., Friedman, S., and Maciag, T. Analysis of endogenous and exogenous nuclear translocation of fibroblast growth factor-1 in NIH 3T3 cells. Biochem Biophys Res Commun 188:982-981; 1992.
33. 1 functional epitope of the human interferon γ is a nuclear targeting signal-like element. J Biol Chem. 266:1991;6023-6026.