Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways

Development

Volumn 127, Issue 3, 2000, Pages 543-548

  Karp, Seth J ^a   Schipani, Ernestina ^b   St Jacques, Benoit ^a,c   Hunzelman, Joy ^b   Kronenberg, Henry ^b   McMahon, Andrew P ^a  

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Ontogeny Inc   (United States)

Author keywords

Cartilage; Chondrocyte; Endochondral bone; Indian hedgehog (Ihh); Parathyroid hormone related protein (PTHrP)

Indexed keywords

COLLAGEN TYPE 2; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; ENCHONDRAL OSSIFICATION; GENE FUNCTION; HYPERTROPHY; MORPHOGENESIS; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALS; BONE AND BONES; CARTILAGE, ARTICULAR; CROSSES, GENETIC; DWARFISM; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC INDUCTION; GENE DELETION; HEDGEHOG PROTEINS; HYPERTROPHY; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHOGENESIS; OSTEOGENESIS; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

ANIMALIA; ERINACEIDAE; VERTEBRATA;

EID: 0033950445     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Amizuka, N., Henderson J. E., Hoshi, K., Warshawsky, H., Ozawa, H., Goltzman, D. and Karaplis, A. C. (1996). Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for Parathyroid Hormone-related Peptide gene deletion. Endocrinology 137, 5055-5067.
2. Bitgood, M. J. and McMahon, A. P. (1995). Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172, 126-138.
3. Cheah, K. S., Lau, E. T., Au, P. K. and Tam, P. P. (1991). Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development. Development 111, 945-53.
4. Echelard Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P. (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-30.
5. Elima, K., Eerola, I., Rosati, R., Metsaranta, M., Garofalo, S., Perala, M., De Crombrugghe, B. and Vuorio, E. (1993). The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern. Biochem. J. 289, 247-253.
6. Erlebacher, A., Filvaroff, E. H., Gitelman, S. E. and Derynck, R. (1995). Toward a molecular understanding of skeletal development. Cell 80, 371-378.
7. Hunziker, E. B. (1988). Growth plate structure and function. Pathol. Immunopathol. Res. 7, 9-13.
8. Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L., Kronenberg, H. M. and Mulligan, R. C. (1994). Lethal skeletal dysplasia from targeted disruption of the Parathyroid Hormone-related Peptide gene. Genet Dev. 8, 277-289.
9. Kosher, R. A., Kulyk, W. M. and Gay, S. W. (1986). Collagen gene expression during cartilage differentiation. J. Cell Biol. 102, 1151-1156.
10. Lanske, B., Karaplis, A. C., Lee, K., Luz, A., Vortkamp, A., Pirro, A., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., Abou-Samra, A. B., Juppner, H., Segre, G. V. and Kronenberg, H. M. (1996). PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273, 663-666.
11. Lee, K., Deeds, J. D. and Segre, G. V. (1995). Expression of Parathyroid Hormone-related Peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 136, 453-463.
12. Lee, K., Lanske, B., Karaplis, A. C., Deeds, J. D., Kohno, H., Nissenson, R. A., Kronenberg, H. M. and Segre, G. V. (1996). Parathyroid hormone-related Peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137, 5109-5118.
13. Metsaranta M., Garofalo, S., Smith, C., Niederreither, K., de Crombrugghe, B. and Vuorio, E. (1995). Developmental expression of a type II collagen/ beta-galactosidase fusion gene in transgenic mice. Dev. Dyn. 204, 202-10.
14. McLeod, M. J. (1980) Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22, 299-301.
15. Nowakowski, R. S., Lewin, S. B. and Miller, M. W. (1989). Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J. Neurocytol. 18, 311-318.
16. Schipani, E., Kruse, K. and Juppner, H. (1995). A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268, 98-100
17. Schipani, E., Lanske, B., Hunzelman, J., Luz, A., Kovacs, C. S., Lee, K., Pirro, A., Kronenberg, H. M. and Juppner, H. (1997). Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc. Natl. Acad. Sci. USA 94, 13689-13694.
18. St-Jacques, B., Hammerschmidt, M., McMahon, A. P. (1999). Indian hedgehog signaling regulates proliferation and differentiation of the chondrocytes and is essential for osteoblast differentiation during skeletal development. Genes Dev. 13, 2072-2086.
19. Suva, L. J., Winslow, G. A., Wettenhall, R. E. H., Hammonds, R. G., Moseley, J. M., Diefenbach-Jagger, H., Rodda, C., Kemp, P. B. E., Rodriguez, H., Chen, E. Y., Hudson, P. J., Martin, T. J. and Wood, W. I. (1987). A Parathyroid Hormone-related Protein implicated in malignant hypercalcemia: cloning and expression. Science 237, 893-896.
20. Swalla, B. J., Upholt, W. B. and Solursh. M. (1988). Analysis of type II collagen RNA localization in chick wing buds by in situ hybridization. Dev. biol. 125, 51-58.
21. Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. J. (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.
22. Weir, E. C., Philbrick, W. M., Amling, M., Neff, L. A., Baron, R. and Broadus, A. E. (1996). Targeted overexpression of Parathyroid Hormone-related Peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc. Natl. Acad. Sci. USA 93, 10240-10245.
23. Wilkinson, D. G. (1992). Whole mount in situ hybridization to vertebrate embryos. In In Situ Hybridization: A Practical Approach (ed. D. G. Wilkinson), pp. 75-83. IRL Press, Oxford, UK.
24. Yamada, Y., Miyashita, T., Savagner, P., Horton, W., Brown, K. S., Amramczuk, J., Xie, H. X., Kohno, K., Bolander, M. and Bruggeman, L. (1990). Regulation of the collagen II gene in vitro and in transgenic mice. Ann. N. Y. Acad. Sci. 580, 81-87.