Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs

Journal of Biological Chemistry

Volumn 286, Issue 2, 2011, Pages 1618-1626

  Nagai, So ^a   Okazaki, Makoto ^a   Segawa, Hiroko ^a   Bergwitz, Clemens ^a   Dean, Thomas ^a   Potts Jr , John T ^a   Mahon, Matthew J ^a   Gardella, Thomas J ^a   Jüppner, Harald ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRUSH BORDER MEMBRANES; CELL TYPES; CLONAL CELL LINES; CO-TRANSPORTERS; DOWN-REGULATION; IN-CELL; INTRACELLULAR CALCIUM; OPOSSUM KIDNEYS; PARATHYROID HORMONES; PHOSPHATE TRANSPORTERS; PHOSPHOLIPASE C; PHOSPHOLIPASES; SIGNALING MECHANISMS; SIGNALING PATHWAYS; WILD TYPES;

BLOOD; CELL CULTURE; CELL MEMBRANES; FETAL MONITORING; LIGANDS; PIGMENTS; PLANTS (BOTANY); SIGNALING; SODIUM;

CLONE CELLS;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE[1-34]; PHOSPHATE P 32; SODIUM PHOSPHATE COTRANSPORTER 2A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOWN REGULATION; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NONHUMAN; OPOSSUM; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; OPOSSUMS; OSTEOBLASTS; PARATHYROID HORMONE; PHOSPHORUS; PSEUDOHYPOPARATHYROIDISM; RATS; SIGNAL TRANSDUCTION; SODIUM; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA;

DIDELPHIDAE; MUS;

EID: 78651381799     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.198416     Document Type: Article

References (31)

1. Gardella, T. J., Jüppner, H., Brown, E. M., Kronenberg, H. M., and Potts, J. T., Jr. (2010) in Endocrinology (DeGroot, L. J., and Jameson, J. L., eds) 6th Ed., pp. 1040-1073, W. B. Saunders, Philadelphia, PA
2. Lupp, A., Klenk, C., Röcken, C., Evert, M., Mawrin, C., and Schulz, S. (2010) Eur. J. Endocrinol. 162, 979-986
3. Tenenhouse, H. S. (2007) J. Steroid Biochem. Mol. Biol. 103, 572-577
4. Segawa, H., Yamanaka, S., Onitsuka, A., Tomoe, Y., Kuwahata, M., Ito, M., Taketani, Y., and Miyamoto, K. (2007) Am. J. Physiol. Renal Physiol. 292, F395-F403
5. Bergwitz, C., Roslin, N. M., Tieder, M., Loredo-Osti, J. C., Bastepe, M., Abu-Zahra, H., Frappier, D., Burkett, K., Carpenter, T. O., Anderson, D., Garabedian, M., Sermet, I., Fujiwara, T. M., Morgan, K., Tenenhouse, H. S., and Jüppner, H. (2006) Am. J. Hum. Genet. 78, 179-192
6. Lorenz-Depiereux, B., Benet-Pages, A., Eckstein, G., Tenenbaum-Rakover, Y., Wagenstaller, J., Tiosano, D., Gershoni-Baruch, R., Albers, N., Lichtner, P., Schnabel, D., Hochberg, Z., and Strom, T. M. (2006) Am. J. Hum. Genet. 78, 193-201
7. Ichikawa, S., Sorenson, A. H., Imel, E. A., Friedman, N. E., Gertner, J. M., and Econs, M. J. (2006) J. Clin. Endocrinol. Metab. 91, 4022-4027
8. Jankowski, M., Hilfiker, H., Biber, J., and Murer, H. (2001) Kidney Blood Press Res. 24, 1-4
9. Cole, J. A., Eber, S. L., Poelling, R. E., Thorne, P. K., and Forte, L. R. (1987) Am. J. Physiol. 253, E221-E227
10. Cole, J. A., Forte, L. R., Eber, S., Thorne, P. K., and Poelling, R. E. (1988) Endocrinology 122, 2981-2989
11. Mahon, M. J., Cole, J. A., Lederer, E. D., and Segre, G. V. (2003) Mol. Endocrinol. 17, 2355-2364
12. Forster, I. C., Hernando, N., Biber, J., and Murer, H. (2006) Kidney Int. 70, 1548-1559
13. Takasu, H., Baba, H., Inomata, N., Uchiyama, Y., Kubota, N., Kumaki, K., Matsumoto, A., Nakajima, K., Kimura, T., Sakakibara, S., Fujita, T., Chihara, K., and Nagai, I. (1996) Endocrinology 137, 5537-5543
14. Whitfield, J. F., Isaacs, R. J., Chakravarthy, B., Maclean, S., Morley, P., Willick, G., Divieti, P., and Bringhurst, F. R. (2001) J. Bone Miner. Res. 16, 441-447
15. Jan de Beur, S. M., and Levine, M. A. (2001) in The Parathyroids: Basic and Clinical Concepts (Bilezikian, J. P., Markus, R., and Levine, M. A., eds) pp. 807-825, Academic Press, New York
16. Weinstein, L. S., Yu, S., Warner, D. R., and Liu, J. (2001) Endocr. Rev. 22, 675-705
17. Bastepe, M., and Jüppner, H. (2005) Horm. Res. 63, 65-74
18. Shimizu, M., Carter, P. H., Khatri, A., Potts, J. T., Jr., and Gardella, T. J. (2001) Endocrinology 142, 3068-3074
19. Shimizu, M., Shimizu, N., Tsang, J. C., Petroni, B. D., Khatri, A., Potts, J. T., Jr., and Gardella, T. J. (2002) Biochemistry 41, 13224-13233
20. Shimizu, N., Dean, T., Khatri, A., and Gardella, T. J. (2004) J. Bone Miner. Res. 19, 2078-2086
21. Dean, T., Linglart, A., Mahon, M. J., Bastepe, M., Jüppner, H., Potts, J. T., Jr., and Gardella, T. J. (2006) Mol. Endocrinol. 20, 931-943
22. Dean, T., Vilardaga, J. P., Potts, J. T., Jr., and Gardella, T. J. (2008) Mol. Endocrinol. 22, 156-166
23. Okazaki, M., Ferrandon, S., Vilardaga, J. P., Bouxsein, M. L., Potts, J. T., Jr., and Gardella, T. J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 16525-16530
24. Jouishomme, H., Whitfield, J. F., Chakravarthy, B., Durkin, J. P., Gagnon, L., Isaacs, R. J., MacLean, S., Neugebauer, W., Willick, G., and Rixon, R. H. (1992) Endocrinology 130, 53-60
25. Jouishomme, H., Whitfield, J. F., Gagnon, L., Maclean, S., Isaacs, R., Chakravarthy, B., Durkin, J., Neugebauer, W., Willick, G., and Rixon, R. H. (1994) J. Bone Miner Res. 9, 943-949
26. Ferrandon, S., Feinstein, T. N., Castro, M., Wang, B., Bonley, R., Potts, J. T., Jr., Gardella, T. J., and Vilardaga, J. P. (2009) Nat. Chem. Biol. 10, 734-742
27. Bisello, A., Chorev, M., Rosenblatt, M., Monticelli, L., Mierke, D. F., and Ferrari, S. L. (2002) J. Biol. Chem. 277, 38524-38530
28. Gesty-Palmer, D., Chen, M., Reiter, E., Ahn, S., Nelson, C. D., Wang, S., Eckhardt, A. E., Cowan, C. L., Spurney, R. F., Luttrell, L. M., and Lefkowitz, R. J. (2006) J. Biol. Chem. 281, 10856-10864
29. Wang, D., Christensen, K., Chawla, K., Xiao, G., Krebsbach, P. H., and Franceschi, R. T. (1999) J. Bone Miner. Res. 14, 893-903
30. Mahon, M. J., Donowitz, M., Yun, C. C., and Segre, G. V. (2002) Nature 417, 858-861
31. Bell, N. H., Avery, S., Sinha, T., Clark, C. M., Jr., Allen, D. O., and Johnston, C., Jr. (1972) J. Clin. Invest. 51, 816-823