Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

Journal of Endocrinology

Volumn 209, Issue 1, 2011, Pages 21-32

  Powell Jr , William F ^a   Barry, Kevin J ^a   Tulum, Irena ^a   Kobayashi, Tatsuya ^a   Harris, Stephen E ^b   Bringhurst, F Richard ^a   Pajevic, Paola Divieti ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CRE RECOMBINASE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; SCLEROSTIN; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE STRUCTURE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DISEASE SEVERITY; GENE DELETION; HISTOPATHOLOGY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOCYTE; OSTEOPENIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRABECULAR BONE;

ANIMALS; BONE REMODELING; CALCIUM, DIETARY; HOMEOSTASIS; HYPERPARATHYROIDISM, SECONDARY; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; OSTEOCYTES; RECEPTOR, PARATHYROID HORMONE, TYPE 1;

EID: 79953701946     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-10-0308     Document Type: Article

References (40)

1. Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC & Bellido T 2006 Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. Journal of Bone and Mineral Research 21 605-615. (doi:10.1359/jbmr.060107)
2. Ai M, Holmen SL, Van Hul W, Williams BO & Warman ML 2005 Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Molecular and Cellular Biology 25 4946-4955. (doi:10.1128/MCB.25.12.4946-4955.2005)
3. van Bezooijen RL, Roelen BA, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P & Lowik CW 2004 Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. Journal of Experimental Medicine 199 805-814. (doi:10.1084/jem.20031454)
4. van Bezooijen RL, ten Dijke P, Papapoulos SE & Lowik CW 2005 SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine and Growth Factor Reviews 16 319-327. (doi:10.1016/j.cytogfr.2005.02.005)
5. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ & Muller R 2010 Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. Journal of Bone and Mineral Research 25 1468-1486. (doi:10.1002/jbmr.141)
6. Calvi LM, Sims NA, Hunzelman JL, Knight MC, Giovannetti A, Saxton JM, Kronenberg HM, Baron R & Schipani E 2001 Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. Journal of Clinical Investigation 107 277-286. (doi:10.1172/JCI11296)
7. Cullinane DM 2002 The role of osteocytes in bone regulation: mineral homeostasis versus mechanoreception. Journal of Musculoskeletal and Neuronal Interactions 2 242-244.
8. Divieti P, Inomata N, Chapin K, Singh R, Juppner H & Bringhurst FR 2001 Receptors for the carboxyl-terminal region of pth(1-84) are highly expressed in osteocytic cells. Endocrinology 142 916-925. (doi:10.1210/en.142.2.916)
9. Divieti P, Geller AI, Suliman G, Juppner H & Bringhurst FR 2005 Receptors specific for the carboxyl-terminal region of parathyroid hormone on bonederived cells: determinants of ligand binding and bioactivity. Endocrinology 146 1863-1870. (doi:10.1210/en.2004-1262)
10. Ehrlich PJ, Noble BS, Jessop HL, Stevens HY, Mosley JR & Lanyon LE 2002 The effect of in vivo mechanical loading on estrogen receptor α expression in rat ulnar osteocytes. Journal of Bone and Mineral Research 17 1646-1655. (doi:10.1359/jbmr.2002.17.9.1646)
11. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S et al. 2006 Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nature Genetics 38 1310-1315. (doi:10.1038/ng1905)
12. Fermor B & Skerry TM 1995 PTH/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats. Journal of Bone and Mineral Research 10 1935-1943. (doi:10.1002/jbmr.5650101213)
13. George A, Gui J, Jenkins NA, Gilbert DJ, Copeland NG & Veis A 1994 In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. Journal of Histochemistry and Cytochemistry 42 1527-1531. (doi:10.1177/42.12.7983353)
14. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D et al. 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 513-523. (doi:10.1016/S0092-8674(01)00571-2)
15. Gowen LC, Petersen DN, Mansolf AL, Qi H, Stock JL, Tkalcevic GT, Simmons HA, Crawford DT, Chidsey-Frink KL, Ke HZ et al. 2003 Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass. Journal of Biological Chemistry 278 1998-2007. (doi:10.1074/jbc.M203250200)
16. Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, Mankani M, Robey PG, Poole AR, Pidoux I et al. 1999 MT1-MMPdeficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 99 81-92. (doi:10.1016/S0092-8674(00)80064-1)
17. Holmbeck K, Bianco P, Pidoux I, Inoue S, Billinghurst RC, Wu W, Chrysovergis K, Yamada S, Birkedal-Hansen H & Poole AR 2005 The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone. Journal of Cell Science 118 147-156. (doi:10.1242/jcs.01581)
18. Jessop HL, Suswillo RF, Rawlinson SC, Zaman G, Lee K, Das-Gupta V, Pitsillides AA & Lanyon LE 2004 Osteoblast-like cells from estrogen receptor ( knockout mice have deficient responses to mechanical strain. Journal of Bone and Mineral Research 19 938-946. (doi:10.1359/jbmr.2004.19.6.938)
19. Jilka RL, Weinstein RS, Bellido T, Parfitt AM & Manolagas SC 1998 Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. Journal of Bone and Mineral Research 13 793-802. (doi:10.1359/jbmr.1998.13.5.793)
20. Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM & Manolagas SC 1999 Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. Journal of Clinical Investigation 104 439-446. (doi:10.1172/JCI6610)
21. Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts JT Jr, Kronenberg HM et al. 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254 1024-1026. (doi:10.1126/science.1658941)
22. Knothe Tate ML 2003 "Whither flows the fluid in bone?" An osteocyte's perspective Journal of Biomechanics 36 1409-1424. (doi:10.1016/S0021-9290(03)00123-4)
23. Kobayashi T, Chung UI, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B & Kronenberg HM 2002 PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development 129 2977-2986.
24. Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP & Kronenberg HM 2005 Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. Journal of Clinical Investigation 115 1734-1742. (doi:10.1172/JCI24397)
25. Lanyon L, Armstrong V, Ong D, Zaman G & Price J 2004 Is estrogen receptor ( key to controlling bones' resistance to fracture? Journal of Endocrinology 182 183-191. (doi:10.1677/joe.0.1820183)
26. Lee KC, Jessop H, Suswillo R, Zaman G & Lanyon LE 2004 The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-( and -β. Journal of Endocrinology 182 193-201. (doi:10.1677/joe.0.1820193)
27. Liu S, Zhou J, Tang W, Jiang X, Rowe DW & Quarles LD 2006 Pathogenic role of Fgf23 in Hyp mice. American Journal of Physiology. Endocrinology and Metabolism 291 E38-E49. (doi:10.1152/ajpendo.00008.2006)
28. Lorenz-Depiereux B, Bastepe M, Benet-Pages A, Amyere M, Wagenstaller J, Muller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH et al. 2006 DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nature Genetics 38 1248-1250. (doi:10.1038/ng1868)
29. O'Brien CA, Plotkin LI, Vyas K, Cazer PE, Gortazar AR, Goellner JJ, Chen J, Shelton R, Weinstein RS, Schipani E et al. 2006 Activation of PTH receptor 1 specifically in osteocytes suppresses sost expression and increases bone mass in transgenic mice. In American Society for Bone and Mineral Research. Ed JoBaM Research. Philadelphia, PA 21 S4.
30. O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH et al. 2008 Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS ONE 3 e2942. (doi:10.1371/journal.pone.0002942)
31. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R & Brown TA 2000 Identification of osteoblast/osteocyte factor 45 (OF45), a bonespecific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. Journal of Biological Chemistry 275 36172-36180. (doi:10.1074/jbc.M003622200)
32. Schipani E, Kruse K & Juppner H 1995 A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268 98-100. (doi:10.1126/science.7701349)
33. Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM & Juppner H 1997 Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. PNAS 94 13689-13694. (doi:10.1073/pnas.94.25.13689)
34. Soriano P 1999 Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genetics 21 70-71. (doi:10.1038/5007)
35. Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S & Ikeda K 2007 Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metabolism 5 464-475. (doi:10.1016/j.cmet.2007.05.001)
36. Westbroek I, De Rooij KE & Nijweide PJ 2002 Osteocyte-specific monoclonal antibody MAb OB7.3 is directed against Phex protein. Journal of Bone and Mineral Research 17 845-853. (doi:10.1359/jbmr.2002.17.5.845)
37. Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D, Jonas M, Kovacevich BR, Staehling-Hampton K et al. 2003 Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO Journal 22 6267-6276. (doi:10.1093/emboj/cdg599)
38. Yadav VK, Ryu J-H, Suda N, Tanka K, Gingrich JA, Shutz G, Glorieux FH, Chaing CY, Zajac JD, Insogna KI et al. 2008 Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135 825-837. (doi:10.1016/j.cell.2008.09.059)
39. Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DWet al. 2005 Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. Journal of Biological Chemistry 280 20680-20690.
40. Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y & Feng JQ 2004 Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Journal of Biological Chemistry 279 19141-19148. (doi:10.1074/jbc.M400490200)