Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: Selectivity of a modified PTH(1-15) radioligand for GαS-coupled receptor conformations

Molecular Endocrinology

Volumn 20, Issue 4, 2006, Pages 931-943

  Dean, Thomas ^a   Linglart, Agnes ^a   Mahon, Matthew J ^a   Bastepe, Murat ^a   Jüppner, Harald ^a   Potts Jr , John T ^a   Gardella, Thomas J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IODINE 125; PARATHYROID HORMONE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; PARATHYROID HORMONE[1-15]; PARATHYROID HORMONE[1-34]; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL MEMBRANE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HORMONE RECEPTOR INTERACTION; HYPOTHESIS; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SWINE; WILD TYPE;

ANIMALS; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; KINETICS; LIGANDS; LLC-PK1 CELLS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECOMBINANT PROTEINS; SWINE;

ANIMALIA; SUS SCROFA;

EID: 33645408784     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2005-0349     Document Type: Article

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