Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ

Cancer Research

Volumn 69, Issue 18, 2009, Pages 7473-7479

  Fleming, Nicholas I ^a,b   Trivett, Melanie K ^a   George, Joshy ^a   Slavin, John L ^b   Murray, William K ^a   Moseley, Jane M ^b   Anderson, Robin L ^a   Thomas, David M ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CARCINOGENESIS; CELL INFILTRATION; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEMALE; GENE DELETION; GENE EXPRESSION PROFILING; HUMANS; LUNG NEOPLASMS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MONOCYTES; PARATHYROID HORMONE-RELATED PROTEIN; RECEPTOR, ERBB-2;

EID: 70349731659     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0194     Document Type: Article

References (47)

1. Swarthout JT, D'Alonzo RC, Selvamurugan N, Partridge NC. Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene 2002;282:1-17. (Pubitemid 34117557)
2. Southby J, Kissin MW, Danks JA, et al. Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res 1990;50:7710-7716 (Pubitemid 20173378)
3. Karaplis AC, Luz A, Glowacki J, et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 1994;8:277-289 (Pubitemid 24065970)
4. Lanske B, Karaplis AC, Lee K, et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 1996;273:663-666 (Pubitemid 26262123)
5. Miao D, He B, Karaplis AC, Goltzman D. Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 2002;109:1173-1182 (Pubitemid 34496595)
6. Dunbar ME, Young P, Zhang JP, et al. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein. Dev Biol 1998;203:75-89. (Pubitemid 28506664)
7. Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998;125:1285-1294 (Pubitemid 28203943)
8. Bundred NJ, Walker RA, Ratcliffe WA, Warwick J, Morrison JM, Ratcliffe JG. Parathyroid hormone related protein and skeletal morbidity in breast cancer. Eur J Cancer 1992;28:690-692
9. Powell GJ, Southby J, Danks JA, et al. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 1991;51:3059-3061
10. Kohno N, Kitazawa S, Fukase M, et al. The expression of parathyroid hormone-related protein in human breast cancer with skeletal metastases. Surg Today 1994;24:215-220 (Pubitemid 24120221)
11. Yoshida A, Nakamura Y, Shimizu A, et al. Significance of the parathyroid hormone-related protein expression in breast carcinoma. Breast Cancer 2000;7:215-220
12. Thomas RJ, Guise TA, Yin JJ, et al. Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology 1999;140:4451-4458 (Pubitemid 30666108)
13. Guise TA. Parathyroid hormone-related protein and bone metastases. Cancer 1997;80:1572-1580 (Pubitemid 27444029)
14. Kitazawa S, Kitazawa R. RANK ligand is a prerequisite for cancer-associated osteolytic lesions. J Pathol 2002;198:228-236 (Pubitemid 35243881)
15. Linforth R, Anderson N, Hoey R, et al. Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival. Clin Cancer Res 2002;8:3172-3177 (Pubitemid 35155027)
16. Henderson MA, Danks JA, Slavin JL, et al. Parathyroid hormone-related protein localization in breast cancers predict improved prognosis. Cancer Res 2006;66:2250-2256
17. Liapis H, Crouch EC, Grosso LE, Kitazawa S, Wick MR. Expression of parathyroid-like protein in normal, proliferative, and neoplastic human breast tissues. Am J Pathol 1993;143:1169-1178 (Pubitemid 24070559)
18. Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A 1992;89:10578-10582
19. Chen H, Lee JS, Liang X, et al. Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis. Cancer Res 2008;68:3637-3644
20. Davies MP, Rudland PS, Robertson L, Parry EW, Jolicoeur P, Barraclough R. Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours. Oncogene 1996;13:1631-1637 (Pubitemid 26377494)
21. Muraoka RS, Koh Y, Roebuck LR, et al. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1. Mol Cell Biol 2003;23:8691-8703 (Pubitemid 37433371)
22. Wagner KU, Wall RJ, St-Onge L, et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 1997;25:4323-4330 (Pubitemid 27485212)
23. He B, Deckelbaum RA, Miao D, et al. Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles. Endocrinology 2001;142:2070-2077 (Pubitemid 32405966)
24. O'Connell FC, Martin F. Laminin-rich extracellular matrix association with mammary epithelial cells suppresses Brca1 expression. Cell Death Differ 2000;7:360-367 (Pubitemid 30209663)
25. Glass AG, Donis-Keller H, Mies C, et al. The Cooperative Breast Cancer Tissue Resource: archival tissue for the investigation of tumor markers. Clin Cancer Res 2001;7:1843-1849 (Pubitemid 32994815)
26. Richard V, Luchin A, Brena RM, Plass C, Rosol TJ. Quantitative evaluation of alternative promoter usage and 3′ splice variants for parathyroid hormone-related protein by real-time reverse transcription-PCR. Clin Chem 2003;49:1398-1402 (Pubitemid 36900628)
27. Wellmann S, Taube T, Paal K, et al. Specific reverse transcription-PCR quantification of vascular endothelial growth factor (VEGF) splice variants by LightCycler technology. Clin Chem 2001;47:654-660 (Pubitemid 32275807)
28. Dennis G, Jr., Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4:P3.
29. VanHouten J, Dann P, McGeoch G, et al. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest 2004;113:598-608. (Pubitemid 38542509)
30. VanHouten JN, Yu N, Rimm D, et al. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. J Clin Endocrinol Metab 2006;91:580-583 (Pubitemid 43236929)
31. Shepherd TG, Kockeritz L, Szrajber MR, Muller WJ, Hassell JA. The pea3su bfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol 2001;11:1739-1748 (Pubitemid 33092162)
32. Rowse GJ, Ritland SR, Gendler SJ. Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis. Cancer Res 1998;58:2675-2679
33. Cardiff RD, Anver MR, Gusterson BA, et al. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 2000;19:968-988
34. Hoogendam J, Parlevliet E, Miclea R, Lowik CW, Wit JM, Karperien M. Novel early target genes of parathyroid hormone-related peptide in chondrocytes. Endocrinology 2006;147:3141-3152 (Pubitemid 43764650)
35. Hoogendam J, Farih-Sips H, van Beek E, Lowik CW, Wit JM, Karperien M. Novel late response genes of PTHrP in chondrocytes. Horm Res 2007;67:159-170 (Pubitemid 46452443)
36. Lee AH, Happerfield LC, Bobrow LG, Millis RR. Angiogenesis and inflammation in invasive carcinoma of the breast. J Clin Pathol 1997;50:669-673 (Pubitemid 27396070)
37. Miller LD, Smeds J, George J, et al. An expression signature for p53status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A 2005;102:13550-13555 (Pubitemid 41420886)
38. Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 1996;56:4625-4629 (Pubitemid 26338061)
39. Leek RD, Hunt NC, Landers RJ, Lewis CE, Royds JA, Harris AL. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J Pathol 2000;190:430-436 (Pubitemid 30163582)
40. Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438:820-827 (Pubitemid 41753060)
41. Yang L, Huang J, Ren X, et al. Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 2008;13:23-35. (Pubitemid 350309741)
42. Stockmann C, Doedens A, Weidemann A, et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008;456:814-818
43. Derhovanessian E, Solana R, Larbi A, Pawelec G. Immunity, ageing and cancer. Immun Ageing 2008;5:11.
44. Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 1995;121:3539-3547
45. Ferrari S, Rizzoli R, Chaponnier C, Gabbiani G, Bonjour JP. Parathyroid hormone-related protein increases cAMP production in mammary epithelial cells. Am J Physiol 1993;264:E471-5. (Pubitemid 23103962)
46. Cataisson C, Lieberherr M, Cros M, et al. Parathyroid hormone-related peptide stimulates proliferation of highly tumorigenic human SV40-immortalized breast epithelial cells. J Bone Miner Res 2000;15:2129-2139 (Pubitemid 30800828)
47. Dittmer A, Vetter M, Schunke D, et al. Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells. J Biol Chem 2006;281:14563-14572 (Pubitemid 43855159)