Physiological Roles for Parathyroid Hormone-Related Protein: Lessons from Gene Knockout Mice

Vitamins and Hormones

Volumn 52, Issue C, 1996, Pages 177-193

  Karaplis, Andrew C ^a   Kronenberg, Henry M ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN; PROTEIN;

ANIMAL; BONE; CHIMERA; CONGENITAL MALFORMATION; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; MUTATION; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW;

ANIMALS; BONE AND BONES; CHIMERA; MICE; MICE, KNOCKOUT; MUTATION; PARATHYROID HORMONE-RELATED PROTEIN; PHENOTYPE; PROTEINS;

EID: 0029681280     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(08)60411-2     Document Type: Chapter

References (24)

1. Abou-Samra A.-B., Jüppner H., Force T., Freeman M.W., Kong X.F., Schipani E., Ureña P., Richards J., Bonventre J.V., Potts Jr. J.T., Kronenberg H.M., and Segre G.V. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 2732-2736
2. Amizuka N., Warshawsky H., Henderson J.E., Goltzman D., and Karaplis A.C. Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J. Cell Biol. 126 (1994) 1611-1623
3. Bradley A. Production and analysis of chimeric mice. In: Robertson E.J. (Ed). "Teratocarcinomas and Embryonic Stem Cells: A Practical Approach" (1987), IRL Press, Washington, DC 113
4. Broadus A.E., and Stewart A.F. Parathyroid hormone-related protein. Structure, processing, and physiological actions. In: Bilezikian J.P., Marcus R., and Levine M.A. (Eds). "The Parathyroids" (1994), Raven Press, New York 259
5. Campos R.V., Asa S.L., and Drucker D.J. Immunocytochemical localization of parathyroid hormone-like peptide in the rat fetus. Cancer Res. 51 (1991) 6351-6357
6. Capecchi M.R. Altering the genome by homologous recombination. Science 244 (1989) 1288-1292
7. Doetschman T.C., Eistetter H., Katz M., Schmidt W., and Kemler R. The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol. 87 (1985) 27-45
8. Jüppner H., Abou-Samra A.-B., Freeman M., Kong X.-F., Schipani E., Richards J., Kolakowski Jr. L.F., Hock J., Potts Jr. J.T., Kronenberg H.M., and Segre G.V. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254 (1991) 1024-1026
9. Karaplis A.C., Luz A., Glowacki J., Bronson R.T., Tybulewicz V.L.J., Kronenberg H.M., and Mulligan R.C. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8 (1994) 277-289
10. Lee K., Karaplis A., Deeds J., Lanske B., Kronenberg H.M., and Segre G.V. Molecular analysis of abnormal endochondral bone formation in PTHrP-less mice. J. Bone Miner. Res. 9 Suppl 1 (1994) S159
11. Mangin M., Ikeda K., Dreyer B.E., and Broadus A.E. Isolation and characterization of the human parathyroid hormone-like peptide gene. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 2408-2412
12. Mangin M., Ikeda K., and Broadus A.E. Structure of the mouse gene encoding parathyroid hormone-related peptide. Gene 95 (1990) 195-202
13. Mangin M., Ikeda K., Dreyer B.E., and Broadus A.E. Identification of an upstream promoter of the human parathyroid hormone-related peptide gene. Mol. Endocrinol. 4 (1990) 851-858
14. Moniz C., Burton P.B.J., Malik A.N., Dixit M., Banga J.P., Nicolaides K., Quirke P., Knight D.E., and McGregor A.M. Parathyroid hormone-related peptide in normal human fetal development. J. Mol. Endocrinol. 5 (1990) 259-266
15. Schipani E., Kruse K., and Jüppner H. A constitutively active PTH/PTHrP receptor in Jansen type metaphyseal chondrodysplasia. Science 268 (1995) 98-100
16. Senior P.V., Heath D.A., and Beck F. Expression of parathyroid hormone-related protein mRNA in the rat before birth: Demonstration by hybridization histochemistry. J. Mol. Endocrinol. 6 (1991) 281-290
17. Stolpe A.v.d., Karperien M., Lowik C.W.G.M., Jüppner H., Segre G.V., Abou-Samra A.-B., Laat S.W.D., and Defize L.H.K. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. J. Cell Biol. 120 (1993) 235-243
18. Thiede M.A., and Rodan G.A. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science 242 (1988) 278-280
19. Tybulewicz V.L.J., Crawford C.E., Jackson P.K., Bronson R.T., and Mulligan R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65 (1991) 1153-1163
20. Vasavada R.C., Wysolmerski J.J., Broadus A.E., and Philbrick W.M. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Mol. Endocrinol. 7 (1993) 273-282
21. Weir E., Philbrick W., Neff L., Amling M., Baron R., and Broadus A. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes skeletal dysplasia and delayed osteogenesis. J. Bone Miner. Res. 10 Suppl 1 (1995) S157
22. Wysolmerski J., Daifotis A., Broadus A., Milstone L., and Philbrick W. Over-expression of PTHrP in transgenic mice results in breast hypoplasia. J. Bone Miner. Res. 8 Suppl. 1 (1993) S149
23. Wysolmerski J.J., Broadus A.E., Zhou J., Fuchs E., Milstone L., and Philbrick W.M. Overexpression of parathyroid hormone-related protein in skin of transgenic mice interferes with hair follicle development. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 1133-1137
24. Yasuda T., Banville D., Rabbani S.A., Hendy G.N., and Goltzman D. Rat parathyroid hormone-like peptide: Comparison with the human homologue and expression in malignant and normal tissue. Mol. Endocrinol. 3 (1989) 518-525