Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation

Endocrine Reviews

Volumn 18, Issue 6, 1997, Pages 832-872

  Kovacs, Christopher S ^a,b   Kronenberg, Henry M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CALCITRIOL; CALCIUM; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATE;

ADULT; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CALCIUM METABOLISM; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FETOPLACENTAL UNIT; FETUS; HUMAN; LACTATION; NEWBORN; NONHUMAN; OSTEOPOROSIS; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; RAT; REVIEW;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BONE AND BONES; CALCIUM; FEMALE; FETUS; HUMANS; INFANT, NEWBORN; LACTATION; MATERNAL-FETAL EXCHANGE; POSTPARTUM PERIOD; PREGNANCY;

EID: 0031471679     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.18.6.832     Document Type: Review

References (567)

1. Albright F, Reifenstein EC 1948 Parathyroid Glands and Metabolic Bone Disease. Williams & Wilkins, Baltimore
2. Chesney RW, Specker BL, Mimouni F, McKay CP 1992 Mineral metabolism during pregnancy and lactation. In: Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Raven Press, New York, pp 383-393
3. Martin MC, Taylor RN, Kitzmiller JL 1994 The endocrinology of pregnancy. In: Greenspan FS, Baxter JD (eds) Basic & Clinical Endocrinology. Appleton & Lange, Norwalk, CT, pp 525-550
4. Givens MH, Macy IC 1933 The chemical composition of the human fetus. J Biol Chem 102:7-17
5. Trotter M, Hixon BB 1974 Sequential changes in weight, density, and percentage ash weight of human skeletons from an early fetal period through old age. Anat Rec 179:1-18
6. Comar CL 1956 Radiocalcium studies in pregnancy. Ann NY Acad Sci 64:281-298
7. Mull JW, Bill AH 1934 Variations in serum calcium and phosphorus during pregnancy. Am J Obstet Gynecol 27:510-517
8. Oberst WF, Plass ED 1932 The variations in serum calcium, protein, and inorganic phosphorus in early and late pregnancy, during parturition and the puerperium, and in non-pregnant women. J Clin Invest 11:123-127
9. Pitkin RM, Gebhardt MP 1977 Serum calcium concentrations in human pregnancy. Am J Obstet Gynecol 127:775-778
10. Kerr C, Loken HF, Glendening MB, Gordon CS, Page EW 1962 Calcium and phosphorus dynamics in pregnancy. Am J Obstet Gynecol 83:2-8
11. Davis OK, Hawkins DS, Rubin LP, Posillico JT, Brown EM, Schiff I 1988 Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J Clin Endocrinol Metab 67:850-852
12. Gertner JM, Coustan DR, Kliger AS, Mallette LE, Ravin N, Broadus AE 1986 Pregnancy as state of physiologic absorptive hypercalciuria. Am J Med 81:451-456
13. Cruikshank DP, Pitkin RM, Reynolds WA, Williams GA, Hargis GK 1980 Calcium-regulating hormones and ions in amniotic fluid. Am J Obstet Gynecol 136:621-625
14. Dahlman T, Sjoberg HE, Bucht E 1994 Calcium homeostasis in normal pregnancy and puerperium. A longitudinal study. Acta Obstet Gynecol Scand 73:393-398
15. Seki K, Makimura N, Mitsui C, Hirata J, Nagata I 1991 Calcium-regulating hormones and osteocalcin levels during pregnancy: a longitudinal study. Am J Obstet Gynecol 164:1248-1252
16. Rasmussen N, Frolich A, Hornnes PJ, Hegedus L 1990 Serum ionized calcium and intact parathyroid hormone levels during pregnancy and postpartum. Br J Obstet Gynaecol 97:857-859
17. Saggese G, Baroncelli GI, Bertelloni S, Cipolloni C 1991 Intact parathyroid hormone levels during pregnancy, in healthy term neonates and in hypocalcemic preterm infants. Acta Paediatr Scand 80:36-41
18. Pitkin RM, Reynolds WA, Williams GA, Hargis GK 1979 Calcium metabolism in normal pregnancy: a longitudinal study. Am J Obstet Gynecol 133:781-790
19. Frolich A, Rudnicki M, Fischer-Rasmussen W, Olofsson K 1991 Serum concentrations of intact parathyroid hormone during late human pregnancy: a longitudinal study. Eur J Obstet Gynecol Reprod Biol 42:85-87
20. Seely EW, Brown EM, DeMaggio DM, Weldon DK, Graves SW 1997 A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Obstet Gynecol 176: 214-217
21. Garner SC, Peng TC, Toverud SU 1988 Modulation of serum parathyroid hormone and ionized calcium concentrations during reproduction in rats fed a low calcium diet. J Bone Miner Res 3:319-323
22. Boass A, Garner SC, Schultz VL, Toverud SU 1997 Regulation of serum calcitriol by serum ionized calcium in rats during pregnancy and lactation. J Bone Miner Res 12:909-914
23. Chao CC, Brown RD, Deftos LJ 1985 Metabolism of calcium and phosphorus during pregnancy and lactation in white-tailed deer. Acta Endocrinol (Copenh) 109:269-275
24. Allen WM, Sansom BF 1986 Metabolic disorders. In: Howard JL (ed) Current Veterinary Therapy: Food Animal Practice. W.B. Saunders, Philadelphia, vol 2:311-322
25. Elias E, Shainkin-Kestenbaum R 1990 Hypocalcaemia and serum levels of inorganic phosphorus, magnesium parathyroid and calcitonin hormones in the last month of pregnancy in Awassi fat-tail ewes. Reprod Nutr Dev 30:693-699
26. Gillette ME, Insogna KL, Lewis AM, Baran DT 1982 Influence of pregnancy on immunoreactive parathyroid hormone levels. Calcif Tissue Int 34:9-12
27. Cross NA, Hillman LS, Allen SH, Krause GF, Vieira NE 1995 Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr 61:514-523
28. Kent GN, Price RI, Gutteridge DH, Allen JR, Rosman KJ, Smith M, Bhagat CI, Wilson SG, Retallack RW 1993 Effect of pregnancy and lactation on maternal bone mass and calcium metabolism. Osteoporos Int 3 [Suppl 1]:44-47
29. Brommage R, DeLuca HF 1984 Placental transport of calcium and phosphorus is not regulated by vitamin D. Am J Physiol 246:F526-F529
30. Cushard Jr WG, Creditor MA, Canterbury JM, Reiss E 1972 Physiological hyperparathyroidism in pregnancy. J Clin Endocrinol Metab 34:767-771
31. Watney PJ, Rudd BT 1974 Calcium metabolism in pregnancy and in the newborn. J Obstet Gynaecol Br Commonw 81:210-219
32. Reitz RE, Daane TA, Woods JR, Weinstein RL 1977 Calcium, magnesium, phosphorus, and parathyroid hormone interrelation-ships in pregnancy and newborn infants. Obstet Gynecol 50:701-705
33. Cruikshank DP, Pitkin RM, Reynolds WA, Williams GA, Hargis GK 1980 Altered maternal calcium homeostasis in diabetic pregnancy. J Clin Endocrinol Metab 50:264-267
34. Drake TS, Kaplan RA, Lewis TA 1979 The physiologic hyperparathyroidism of pregnancy. Is it primary or secondary? Obstet Gynecol 53:746-749
35. Hillman LS, Slatopolsky E, Haddad JG 1978 Perinatal vitamin D metabolism. IV. Maternal and cord serum 24,25-dihydroxyvitamin D concentrations. J Clin Endocrinol Metab 47:1073-1077
36. Whitehead M, Lane G, Young O, Campbell S, Abeyasekera G, Hillyard CJ, Maclntyre I, Phang KG, Stevenson JC 1981 Interrelations of calcium-regulating hormones during normal pregnancy. Br Med J 283:10-12
37. Wieland P, Fischer JA, Trechsel U, Roth HR, Vetter K, Schneider H, Huch A 1980 Perinatal parathyroid hormone, vitamin D metabolites, and calcitonin in man. Am J Physiol 239:E385-E390
38. Allgrove J, Adami S, Manning RM, O'Riordan JL 1985 Cytochemical bioassay of parathyroid hormone in maternal and cord blood. Arch Dis Child 60:110-115
39. Reynolds WA, Williams GA, Pitkin RM 1981 Calcitropic hormone responsiveness during pregnancy. Am J Obstet Gynecol 139:855-862
40. Steichen JJ, Tsang RC, Gratton TL, Hamstra A, DeLuca HF 1980 Vitamin D homeostasis in the perinatal period: 1,25-dihydroxyvitamin D in maternal, cord, and neonatal blood. N Engl J Med 302:315-319
41. Verhaeghe J, Bouillon R 1992 Calciotropic hormones during reproduction. J Steroid Biochem Mol Biol 41:469-477
42. Potts Jr JT, Bringhurst FR, Gardella T, Nussbaum S, Segre G, Kronenberg HM 1995 Parathyroid hormone: physiology, chemistry, biosynthesis, secretion, metabolism, and mode of action. In: DeGroot LJ (ed) Endocrinology. W.B. Saunders, Philadelphia, pp 920-966
43. Thiébaud D, Janisch S, Koelbl H, Hanzal E, Jacquet AF, Leodolter S, Burckhardt P, Pecherstorfer M 1993 Direct evidence of a parathyroid related protein gradient between the mother and the newborn in humans. Bone Miner 23:213-221
44. Gallacher SJ, Fraser WD, Owens OJ, Dryburgh FJ, Logue FC, Jenkins A, Kennedy J, Boyle IT 1994 Changes in calciotrophic hormones and biochemical markers of bone turnover in normal human pregnancy. Eur J Endocrinol 131:369-374
45. Quan-Sheng D, Miller SC 1989 Calciotrophic hormone levels and calcium absorption during pregnancy in rats. Am J Physiol 257: E118-E123
46. Bourdeau A, Manganella G, Thil-Trubert CL, Sachs C, Cournot G 1990 Bioactive parathyroid hormone in pregnant rats and fetuses. Am J Physiol 258: E549-E554
47. Sinclair JG 1942 Fetal rat parathyroids as affected by changes in maternal serum calcium and phosphorus through parathyroidectomy and dietary control. J Nutr 23:141-152
48. Rucart G, Gagnon PM 1959 Modifications des parathyroides sous l'influence de la gestation. C R Seances Soc Biol Fil 153:1102-1103
49. Schultz VL, Boass A, Garner SC, Toverud SU 1997 Altered regulation of parathyroid hormone secretion by calcium in pregnant and lactating rats. J Bone Miner Res 12:903-908
50. Garner SC, Peng TC, Hirsch PF, Boass A, Toverud SU 1987 Increase in serum parathyroid hormone concentration in the lactating rat: effects of dietary calcium and lactational intensity. J Bone Miner Res 2:347-352
51. Bodansky M, Duff VB 1939 Regulation of the level of calcium in the serum during pregnancy. J Am Med Assoc 112:223-229
52. 3 injections into thyroparathyroidectomized pregnant rats. Reprod Nutr Dev 21:961-968
53. Chalon S, Garel JM 1985 Plasma calcium control in the rat fetus. I. Influence of maternal hormones. Biol Neonate 48:313-322
54. 3 metabolites on fetal growth and fetal liver glycogen stores in thyro-parathyroidectomized pregnant rats. Biomedicine 32:93-99
55. Lund B, Selnes A 1979 Plasma 1,25-dihydroxyvitamin D levels in pregnancy and lactation. Acta Endocrinol (Copenh) 92:330-335
56. Fleischman AR, Rosen JF, Cole J, Smith CM, DeLuca HF 1980 Maternal and fetal serum 1,25-dihydroxyvitamin D levels at term. J Pediatr 97:640-642
57. Bikle DD, Gee E, Halloran B, Haddad JG 1984 Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 74:1966-1971
58. Wilson SG, Retallack RW, Kent JC, Worth GK, Gutteridge DH 1990 Serum free 1,25-dihydroxyvitamin D and the free 1,25-dihydroxyvitamin D index during a longitudinal study of human pregnancy and lactation. Clin Endocrinol (Oxf) 32:613-622
59. Gray TK, Lowe W, Lester GE 1981 Vitamin D and pregnancy: the maternal-fetal metabolism of vitamin D. Endocr Rev 2:264-274
60. Paulson SK, Ford KK, Langman CB 1990 Pregnancy does not alter the metabolic clearance of 1,25-dihydroxyvitamin D in rats. Am J Physiol 258:E158-E162
61. Delvin EE, Gilbert M, Pere MC, Garel JM 1988 In vivo metabolism of calcitriol in the pregnant rabbit doe. J Dev Physiol 10:451-459
62. 3 in the pregnant sheep and its chronically catheterized fetus by primed infusion technique. Pediatr Res 26:633-638
63. 3 production rate in multiple ovine pregnancy are independent of changes in the metabolic clearance rate. Pediatr Res 27:192A (Abstract)
64. 3. Endocrinology 110:1950-1956
65. Fenton E, Britton HG 1980 25-hydroxycholecalciferol 1 alpha-hydroxylase activity in the kidney of the fetal, neonatal and adult guinea pig. Biol Neonate 37:254-256
66. Ross R, Care AD, Robinson JS, Pickard DW, Weatherley AJ 1980 Perinatal 1,25-dihydroxycholecalciferol in the sheep and its role in the maintenance of the transplacental calcium gradient. J Endocrinol 87:17P-18P
67. Baksi SN, Kenny AD 1978 Acute effect of estradiol on the renal vitamin D hydroxylases in Japanese quail. Biochem Pharmacol 27:2765-2768
68. Spanos E, Colston KW, Evans IM, Galante LS, Macauley SJ, MacIntyre I 1976 Effect of prolactin on vitamin D metabolism. Mol Cell Endocrinol 5:163-167
69. Spanos E, Brown DJ, Stevenson JC, MacIntyre I 1981 Stimulation of 1,25-dihydroxycholecalciferol production by prolactin and related peptides in intact renal cell preparations in vitro. Biochim Biophys Acta 672:7-15
70. Takeuchi K, Morikawa H, Ueda Y, Mochizuki M 1988 Studies on the effects of placental lactogen on calcium metabolism during pregnancy]. Nippon Naibunpi Gakkai Zasshi 64:1175-1186
71. Cheema C, Grant BF, Marcus R 1989 Effects of estrogen on circulating free and total 1,25-dihydroxyvitamin D and on the parathyroid-vitamin D axis in postmenopausal women. J Clin Invest 83:537-542
72. Kumar R, Abboud CF, Riggs BL 1980 The effect of elevated prolactin levels on plasma 1,25-dihydroxyvitamin D and intestinal absorption of calcium. Mayo Clin Proc 55:51-53
73. Reddy GS, Norman AW, Willis DM, Goltzman D, Guyda H, Solomon S, Philips DR, Bishop JE, Mayer E 1983 Regulation of vitamin D metabolism in normal human pregnancy. J Clin Endocrinol Metab 56:363-370
74. Weisman Y, Vargas A, Duckett G, Reiter E, Root AW 1978 Synthesis of 1,25-dihydroxyvitamin D in the nephrectomized pregnant rat. Endocrinology 103:1992-1996
75. 3 by rat placental tissue. Proc Natl Acad Sci USA 76:5033-5035
76. Weisman Y, Sapir R, Harell A, Edelstein S 1976 Maternal-perinatal interrelationships of vitamin D metabolism in rats. Biochim Biophys Acta 428:388-395
77. Glorieux FH, Arabian A, Delvin EE 1995 Pseudo-vitamin D deficiency: absence of 25-hydroxyvitamin D 1 alpha-hydroxylase activity in human placenta decidual cells. J Clin Endocrinol Metab 80:2255-2258
78. 3 in pregnancy. Science 204:1311-1313
79. Lachenmaier-Currle U, Harmeyer J 1989 Placental transport of calcium and phosphorus in pigs. J Perinat Med 17:127-136
80. Turner M, Barre PE, Benjamin A, Goltzman D, Gascon-Barre M 1988 Does the maternal kidney contribute to the increased circulating 1,25-dihydroxyvitamin D concentrations during pregnancy? Miner Electrolyte Metab 14:246-252
81. Pike JW, Parker JB, Haussler MR, Boass A, Toverud SV 1979 Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats. Science 204:1427-1429
82. Halloran BP, Barthell EN, DeLuca HF 1979 Vitamin D metabolism during pregnancy and lactation in the rat. Proc Natl Acad Sci USA 76:5549-5553
83. Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS 1986 Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr 109:328-334
84. Halloran BP, De Luca HF 1981 Effect of vitamin D deficiency on skeletal development during early growth in the rat. Arch Biochem Biophys 209:7-14
85. Halloran BP, DeLuca HF 1979 Vitamin D deficiency and reproduction in rats. Science 204:73-74
86. Samaan NA, Anderson GD, Adam-Mayne ME 1975 Immunore-active calcitonin in the mother, neonate, child and adult. Am J Obstet Gynecol 121:622-625
87. Silva OL, Titus-Dillon P, Becker KL, Snider RH, Moore CF 1981 Increased serum calcitonin in pregnancy. J Natl Med Assoc 73: 649-652
88. Kovarik J, Woloszczuk W, Linkesch W, Pavelka R 1980 Calcitonin in pregnancy (letter). Lancet 1:199-200
89. Woloszczuk W, Kovarik J, Pavelka P 1981 Calcitonin in pregnant women and in cord blood. Gynecol Obstet Invest 12:272-276
90. Garel JM, Savajol H, Barlet JP 1976 Plasma immunoreactive calcitonin levels in pregnant ewes and their lambs. Biol Neonate 28:207-218
91. Barlet JP, Garel JM 1975 Physiological role of calcitonin in pregnant goats and ewes, In: Talmage RV, Owen M, Parsons A (eds) Calcium Regulating Hormones: Proceedings of the Fifth Parathyroid Conference, Oxford, U.K., July 21-26, 1974. Excerpta Medica, Amsterdam, pp 119-121
92. Garel JM, Jullienne A 1977 Plasma calcitonin levels in pregnant and newborn rats. J Endocrinol 75:373-382
93. Bucht E, Telenius-Berg M, Lundell G, Sjoberg HE 1986 Immunoextracted calcitonin in milk and plasma from totally thyroidectomized women. Evidence of monomeric calcitonin in plasma during pregnancy and lactation. Acta Endocrinol (Copenh) 113:529-535
94. Balabanova S, Kruse B, Wolf AS 1987 Calcitonin secretion by human placental tissue. Acta Obstet Gynecol Scand 66:323-326
95. Deftos LJ 1993 Calcitonin. In: Favus MJ (ed) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Raven Press, New York, pp 70-76
96. Taylor TG, Lewis PE, Balderstone O 1975 Role of calcitonin in protecting the skeleton during pregnancy and lactation. J Endocrinol 66:297-298
97. Lewis P, Rafferty B, Shelley M, Robinson CJ 1971 A suggested physiological role of calcitonin: the protection of the skeleton during pregnancy and lactation. J Endocrinol 49:9-10
98. Barlet JP 1974 Role physiologique de la calcitonine chez la chèvre gestante ou allaitante. Ann Biol Anim Biochim Biophys 14:447-457
99. de Papp AE, Stewart AF 1993 Parathyroid hormone-related protein: a peptide of diverse physiologic functions. Trends Endocrinol Metab 4:181-187
100. Orloff JJ, Reddy D, de Papp AE, Yang KH, Soifer NE, Stewart AF 1994 Parathyroid hormone-related protein as a prohormone: post-translational processing and receptor interactions. Endocr Rev 15: 40-60
101. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD, Martin TJ 1987 Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 84:5048-5052
102. Mangin M, Webb AC, Dreyer BE, Posillico JT, Ikeda K, Weir EC, Stewart AF, Bander NH, Milstone L, Barton DE, Francke U, Broadus AE 1988 Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 85: 597-601
103. Suva LJ, Winslow GA, Wettenhall RE, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen EY, Hudson PJ, Martin TJ, Wood WI 1987 A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 237:893-896
104. Martin TJ, Moseley JM 1995 Parathyroid hormone-related protein. In: DeGroot LJ (ed) Endocrinology. W.B. Saunders, Philadelphia, pp 967-977
105. Barri ME, Abbas SK, Care AD 1992 The effects in the rat of two fragments of parathyroid hormone-related protein on uterine contractions in situ. Exp Physiol 77:481-490
106. Ferguson II JE, Gorman JV, Bruns DE, Weir EC, Burtis WJ, Martin TJ, Bruns ME 1992 Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor. Proc Natl Acad Sci USA 89:8384-8388
107. Fenton AJ, Kemp BE, Hammonds Jr RG, Mitchelhill K, Moseley JM, Martin TJ, Nicholson GC 1991 A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology 129:3424-3426
108. Fenton AJ, Kemp BE, Kent GN, Moseley JM, Zheng MH, Rowe DJ, Britto JM, Martin TJ, Nicholson GC 1991 A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts. Endocrinology 129:1762-1768
109. Cornish J, Gallon KE, Nicholson GC, Reid IR 1997 Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo. Endocrinology 138:1299-1304
110. Khosla S, Johansen KL, Dry SJ, O'Brien PC, Kao PC 1990 Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc 65:1408-1414
111. Bertelloni S, Baroncelli GI, Pelletti A, Battini R, Saggese G 1994 Parathyroid hormone-related protein in healthy pregnant women. Calcif Tissue Int 54:195-197
112. Ratcliffe WA, Abbas SK, Care AD 1993 Clearance of exogenous parathyroid hormone-related protein in pregnant, non-pregnant and fetal sheep, goats and pigs. J Endocrinol 138:459-465
113. Ratcliffe WA, Thompson GE, Abbas SK, Care AD 1992 Studies on the metabolic clearance of parathyroid hormone-related protein in pregnant, nonpregnant and fetal animals. In: Cohn DV, Gennari C, Tashjian Jr AH (eds) Calcium Regulating Hormones and Bone Metabolism: Basic and Clinical Aspects. Elsevier Science Publishers, New York, pp 69-75
114. Senior PV, Heath DA, Beck F 1991 Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Mol Endocrinol 6:281-290
115. Ferguson JE, Seaner R, Bruns DE, Redick JA, Mills SE, Jüppner H, Segre GV, Bruns ME 1994 Expression of parathyroid hormone-related protein and its receptor in human umbilical cord: evidence for a paracrine system involving umbilical vessels. Am J Obstet Gynecol 170:1018-1024
116. MacIsaac RJ, Caple IW, Danks JA, Diefenbach-Jagger H, Grill V, Moseley JM, Southby J, Martin TJ 1991 Ontogeny of parathyroid hormone-related protein in the ovine parathyroid gland. Endocrinology 129:757-764
117. Budayr AA, Halloran BP, King JC, Diep D, Nissenson RA, Strewler GJ 1989 High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci USA 86:7183-7185
118. Rakopoulos M, Vargas SJ, Gillespie MT, Ho PW, Diefenbach-Jagger H, Leaver DD, Grill V, Moseley JM, Danks JA, Martin TJ 1992 Production of parathyroid hormone-related protein by the rat mammary gland in pregnancy and lactation. Am J Physiol 263: E1077-E1085
119. Van Heerden JA, Gharib H, Jackson IT 1988 Pseudohyperparathyroidism secondary to gigantic mammary hypertrophy. Arch Surg 123:80-82
120. Pahuja DN, DeLuca HF 1981 Stimulation of intestinal calcium transport and bone calcium mobilization by prolactin in vitamin D-deficient rats. Science 214:1038-1039
121. Mainoya JR 1975 Effects of bovine growth hormone, human placental lactogen and ovine prolactin on intestinal fluid and ion transport in the rat. Endocrinology 96:1165-1170
122. Burstyn PG, Lloyd IJ, McKillop W 1975 The effect of human placental lactogen on the renal excretion of calcium in the rabbit. IRCS J Med Sci 3:30
123. Burstyn PG, McKillop W, Lloyd IJ 1974 The effects of prolactin on the renal excretion of water, sodium, potassium and calcium in the rabbit. J Int Res Commun 2:1474
124. Dvir R, Golander A, Jaccard N, Yedwab G, Otremski I, Spirer Z, Weisman Y 1995 Amniotic fluid and plasma levels of parathyroid hormone-related protein and hormonal modulation of its secretion by amniotic fluid cells. Eur J Endocrinol 133:277-282
125. Bringhurst FR 1995 Calcium and phosphate distribution, turnover, and metabolic actions. In: DeGroot LJ (ed) Endocrinology. W.B. Saunders, Philadelphia, pp 1015-1043
126. Heaney RP, Skillman TG 1971 Calcium metabolism in normal human pregnancy. J Clin Endocrinol Metab 33:661-670
127. Kent GN, Price RI, Gutteridge DH, Rosman KJ, Smith M, Allen JR, Hickling CJ, Blakeman SL 1991 The efficiency of intestinal calcium absorption is increased in late pregnancy but not in established lactation. Calcif Tissue Int 48:293-295
128. Kent GN, Price RI, Gutteridge DH, Allen JR, Blakeman SL, Bhagat CI, St.John A, Barnes MP, Smith M, Evans DV 1991 Acute effects of an oral calcium load in pregnancy and lactation: findings on renal calcium conservation and biochemical indices of bone turnover. Miner Electrolyte Metab 17:1-7
129. Delorme AC, Marche P, Garel JM 1979 Vitamin D-dependent calcium-binding protein. Changes during gestation, prenatal and postnatal development in rats. J Dev Physiol 1:181-194
130. Delorme AC, Danan JL, Ripoche MA, Mathieu H 1982 Biochemical characterization of mouse vitamin D-dependent calcium-binding protein. Evidence for its presence in embryonic life. Biochem J 205:49-57
131. Bruns ME, Vollmer S, Wallshein V, Bruns DE 1981 Vitamin D-dependent calcium-binding protein. Immunochemical studies and synthesis by placental tissue in vitro. J Biol Chem 256:4649-4653
132. Marche P, Delorme A, Cuisinier-Gleizes P 1978 Intestinal and placental calcium-binding proteins in vitamin D-deprived or -supplemented rats. Life Sci 23:2555-2561
133. Bruns ME, Wallshein V, Bruns DE 1982 Regulation of calcium-binding protein in mouse placenta and intestine. Am J Physiol 242:E47-E52
134. Ibrahim MM, Thomas ML, Forte LR 1984 Maternal-fetal relationships in the parathyroidectomized rat. Intestinal calcium transport, serum calcium, immunoreactive parathyroid hormone and calcitonin. Biol Neonate 46:89-97
135. Wasserman RH, Comar CL, Nold MM, Lengemann FW 1957 Placental transfer of calcium and strontium in the rat and rabbit. Am J Physiol 189:91-97
136. Ellinger GM, Duckworth J 1952 Skeletal changes during pregnancy and lactation in the rat: effect of different levels of dietary calcium. Br J Nutr 6:235-253
137. Halloran BP, DeLuca HF 1980 Skeletal changes during pregnancy and lactation: the role of vitamin D. Endocrinology 107:1923-1929
138. 45Ca during pregnancy under conditions of calcium deficiency in rats. J Dent Res 43:563-567
139. Rasmussen P 1977 Calcium deficiency, pregnancy, and lactation in rats. Some effects on blood chemistry and the skeleton. Calcif Tissue Res 23:87-94
140. Miller SC, Halloran BP, DeLuca HF, Jee WS 1982 Role of vitamin D in maternal skeletal changes during pregnancy and lactation: a histomorphometric study. Calcif Tissue Int 34:245-252
141. Halloran BP, DeLuca HF 1980 Calcium transport in small intestine during pregnancy and lactation. Am J Physiol 239:E64-E68
142. Brommage R, Baxter DC, Gierke LW 1990 Vitamin D-independent intestinal calcium and phosphorus absorption during reproduction. Am J Physiol 259:G631-G638
143. Thomas ML, Forte LR 1982 Serum calcium and parathyroid hormone during the reproductive cycle in normal and vitamin D-deficient rats. Endocrinology 110:703-707
144. Gaboury CL, Woods LL 1995 Renal reserve in pregnancy. Semin Nephrol 15:449-453
145. Baylis C 1994 Glomerular filtration and volume regulation in gravid animal models. Baillieres Clin Obstet Gynaecol 8:235-264
146. Allen J, Kent N, Price R, Gutteridge D, Blakeman S, Rosman K, Bhagat C, Smith M 1990 Calcium and phosphate metabolism in human pregnancy and lactation. Bone Miner 10:S317
147. Pedersen EB, Johannesen P, Kristensen S, Rasmussen AB, Emmertsen K, Moller J, Lauritsen JG, Wohlert M 1984 Calcium, parathyroid hormone and calcitonin in normal pregnancy and preeclampsia. Gynecol Obstet Invest 18:156-164
148. Chef R 1969 Metabolisme du calcium chez la ratte en gestation. Etude cinetique par le 45Ca. C R Seances Soc Biol Fil 163:541-545
149. Frenkel Y, Barkai G, Mashiach S, Dolev E, Zimlichman R, Weiss M 1991 Hypocalciuria of preeclampsia is independent of parathyroid hormone level. Obstet Gynecol 77:689-691
150. August P, Marcaccio B, Gertner JM, Druzin ML, Resnick LM, Laragh JH 1992 Abnormal 1,25-dihydroxyvitamin D metabolism in preeclampsia. Am J Obstet Gynecol 166:1295-1299
151. Seely EW, Wood RJ, Brown EM, Graves SW 1992 Lower serum ionized calcium and abnormal calciotropic hormone levels in preeclampsia. J Clin Endocrinol Metab 74:1436-1440
152. Lalau JD, Jans I, el Esper N, Bouillon R, Fournier A 1993 Calcium metabolism, plasma parathyroid hormone, and calcitriol in transient hypertension of pregnancy. Am J Hypertens 6:522-527
153. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, DerSimonian R, Esterlitz JR, Raymond EG, Bild DE, Clemens JD, Cutler JA 1997 Trial of calcium to prevent preeclampsia. N Engl J Med 337:69-76
154. Marie PJ, Cancela L, Le Boulch N, Miravet L 1986 Bone changes due to pregnancy and lactation: influence of vitamin D status. Am J Physiol 251: E400-E406
155. Fukuda S, Iida H 1993 Histomorphometric changes in iliac trabecular bone during pregnancy and lactation in beagle dogs. J Vet Med Sci 55:565-569
156. Warnock GM, Duckworth J 1944 Changes in the skeleton during gestation and lactation in the rat. Biochem J 38:220-224
157. Braithwaite GD, Glascock RF, Riazuddin S 1970 Calcium metabolism in pregnant ewes. Br J Nutr 24:661-670
158. Delmas PD 1993 Markers of bone formation and resorption. In: Favus MJ (ed) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Raven Press, New York, pp 108-112
159. Calvo MS, Eyre DR, Gundberg CM 1996 Molecular basis and clinical application of biological markers of bone turnover. Endocr Rev 17:333-368
160. Cross NA, Hillman LS, Allen SH, Krause GF 1995 Changes in bone mineral density and markers of bone remodeling during lactation and postweaning in women consuming high amounts of calcium. J Bone Miner Res 10:1312-1320
161. Yamaga A, Taga M, Minaguchi H, Sato K 1996 Changes in bone mass as determined by ultrasound and biochemical markers of bone turnover during pregnancy and puerperium: a longitudinal study. J Clin Endocrinol Metab 81:752-756
162. Rodin A, Duncan A, Quartero HW, Pistofidis G, Mashiter G, Whitaker K, Crook D, Stevenson JC, Chapman MG, Fogelman I 1989 Serum concentrations of alkaline phosphatase isoenzymes and osteocalcin in normal pregnancy. J Clin Endocrinol Metab 68:1123-1127
163. Karlsson R, Eden S, Eriksson L, von Schoultz B 1992 Osteocalcin 24-hour profiles during normal pregnancy. Gynecol Obstet Invest 34:197-201
164. Chesnut CH 1992 The imaging and quantitation of bone by radiographic and scanning methodologies. In: Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Raven Press, New York, pp 443-454
165. Genant HK, Engelke K, Fuerst T, Glüer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M 1996 Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 11:707-730
166. Lamke B, Brundin J, Moberg P 1977 Changes of bone mineral content during pregnancy and lactation. Acta Obstet Gynecol Scand 56:217-219
167. Christiansen C, Rodbro P, Heinild B 1976 Unchanged total body calcium in normal human pregnancy. Acta Obstet Gynecol Scand 55:141-143
168. Sowers M, Crutchfield M, Jannausch M, Updike S, Corton G 1991 A prospective evaluation of bone mineral change in pregnancy. Obstet Gynecol 77:841-845
169. Drinkwater BL, Chesnut III CH 1991 Bone density changes during pregnancy and lactation in active women: a longitudinal study. Bone Miner 14:153-160
170. Paparella P, Giorgino R, Maglione A, Lorusso D, Scirpa P, Del Bosco A, Mancuso S 1995 Maternal ultrasound bone density in normal pregnancy. Clin Exp Obstet Gynecol 22:268-278
171. Gambacciani M, Spinetti A, Gallo R, Cappagli B, Teti GC, Facchini V 1995 Ultrasonographic bone characteristics during normal pregnancy: longitudinal and cross-sectional evaluation. Am J Obstet Gynecol 173:890-893
172. van Hemert AM, Vandenbroucke JP, Birkenhager JC, Valkenburg HA 1990 Prediction of osteoporotic fractures in the general population by a fracture risk score. A 9-year follow-up among middle-aged women. Am J Epidemiol 132:123-135
173. Johansson C, Mellstrom D, Milsom I 1993 Reproductive factors as predictors of bone density and fractures in women at the age of 70. Maturitas 17:39-50
174. Kritz-Silverstein D, Barrett-Connor E, Hollenbach KA 1992 Pregnancy and lactation as determinants of bone mineral density in postmenopausal women. Am J Epidemiol 136:1052-1059
175. Armamento-Villareal R, Villareal DT, Avioli LV, Civitelli R 1992 Estrogen status and heredity are major determinants of premenopausal bone mass. J Clin Invest 90:2464-2471
176. Alderman BW, Weiss NS, Daling JR, Ure CL, Ballard JH 1986 Reproductive history and postmenopausal risk of hip and forearm fracture. Am J Epidemiol 124:262-267
177. Walker AR, Richardson B, Walker F 1972 The influence of numerous pregnancies and lactations on bone dimensions in South African Bantu and Caucasian mothers. Clin Sci 42:189-196
178. Sowers MR, Clark MK, Hollis B, Wallace RB, Jannausch M 1992 Radial bone mineral density in pre- and perimenopausal women: a prospective study of rates and risk factors for loss. J Bone Miner Res 7:647-657
179. Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, Dilsen G, Gennari C, Lopes Vaz A, Lyritis G, Mazzuoli G, Miravet L, Passen M, Perez Cano R, Rapado A, Ribot C 1995 Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res 10:1802-1815
180. Melton III LJ, Bryant SC, Wahner HW, O'Fallon WM, Malkasian GD, Judd HL, Riggs BL 1993 Influence of breastfeeding and other reproductive factors on bone mass later in life. Osteoporos Int 3:76-83
181. Cox ML, Khan SA, Gau DW, Cox SA, Hodkinson HM 1991 Determinants of forearm bone density in premenopausal women: a study in one general practice. Br J Gen Pract 41:194-196
182. Picard D, Ste-Marie LG, Coutu D, Carrier L, Chartrand R, Lepage R, Fugere P, D'Amour P 1988 Premenopausal bone mineral content relates to height, weight and calcium intake during early adulthood. Bone Miner 4:299-309
183. Bauer DC, Browner WS, Cauley JA, Orwoll ES, Scott JC, Black DM, Tao JL, Cummings SR 1993 Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Ann Intern Med 118:657-665
184. Kreiger N, Kelsey JL, Holford TR, O'Connor T 1982 An epidemiologic study of hip fracture in postmenopausal women. Am J Epidemiol 116:141-148
185. Kreiger N, Gross A, Hunter G 1992 Dietary factors and fracture in postmenopausal women: a case-control study. Int J Epidemiol 21: 953-958
186. Ribot C, Tremollieres F, Pouilles JM, Albarede JL, Mansat M, Utheza G, Bonneu M, Bonnissent P, Ricoeur C 1993 Risk factors for hip fracture. MEDOS study: results of the Toulouse Centre. Bone 14[Suppl 1]:S77-S80
187. Cumming RG, Klineberg RJ 1993 Breastfeeding and other reproductive factors and the risk of hip fractures in elderly women, Int J Epidemiol 22:684-691
188. Johnell O, Nilsson BE 1984 Life-style and bone mineral mass in perimenopausal women. Calcif Tissue Int 36:354-356
189. Sowers MR, Wallace RB, Lemke JH 1985 Correlates of mid-radius bone density among postmenopausal women: a community study. Am J Clin Nutr 41:1045-1053
190. Sowers M, Wallace RB, Lemke JH 1985 Correlates of forearm bone mass among women during maximal bone mineralization, Prev Med 14:585-596
191. Sinigaglia L, Varenna M, Binelli L, Gallazzi M, Calori G, Ranza R 1996 Effect of lactation on postmenopausal bone mineral density of the lumbar spine. J Reprod Med 41:439-443
192. Laitinen K, Valimaki M, Keto P 1991 Bone mineral density measured by dual-energy X-ray absorptiometry in healthy Finnish women. Calcif Tissue Int 48:224-231
193. Stevenson JC, Lees B, Devenport M, Cust MP, Ganger KF 1989 Determinants of bone density in normal women: risk factors for future osteoporosis? Br Med J 298:924-928
194. Nilsson BE 1969 Parity and osteoporosis. Surg Gynecol Obstet 129:27-28
195. Fox KM, Magaziner J, Sherwin R, Scott JC, Plato CC, Nevitt M, Cummings S 1993 Reproductive correlates of bone mass in elderly women. Study of Osteoporotic Fractures Research Group. J Bone Miner Res 8:901-908
196. Goldsmith NF, Johnston JO 1975 Bone mineral: effects of oral contraceptives, pregnancy, and lactation. J Bone Joint Surg [Am] 57:657-668
197. Huffman S, Grisso JA, Kelsey JL, Gammon MD, O'Brien LA 1993 Parity, lactation and hip fracture. Osteoporos Int 3:171-176
198. Paganini-Hill A, Chao A, Ross RK, Henderson BE 1991 Exercise and other factors in the prevention of hip fracture: the Leisure World study. Epidemiology 2:16-25
199. Lissner L, Bengtsson C, Hansson T 1991 Bone mineral content in relation to lactation history in pre- and postmenopausal women. Calcif Tissue Int 48:319-325
200. Biberoglu KO, Yildiz A, Kandemir O 1993 Bone mineral density in Turkish postmenopausal women. Int J Gynaecol Obstet 41:153-157
201. Parra-Cabrera S, Hernandez-Avila M, Tamayo-y-Orozco J, Lopez-Carrillo L, Meneses-González F 1996 Exercise and reproductive factors as predictors of bone density among Osteoporotic women in Mexico City. Calcif Tissue Int 59:89-94
202. Fujiwara S, Kasagi F, Yamada M, Kodama K 1997 Risk factors for hip fracture in a Japanese cohort. J Bone Miner Res 12:998-1004
203. Hreshchyshyn MM, Hopkins A, Zylstra S, Anbar M 1988 Associations of parity, breast-feeding, and birth control pills with lumbar spine and femoral neck bone densities. Am J Obstet Gynecol 159:318-322
204. Jones OV 1953 Crush fracture of the dorsal spine in eclampsia. J Obstet Gynaecol Br Emp 60:259-262
205. Nordin BE, Roper A 1955 Postpregnancy osteoporosis: a syndrome? Lancet 1:431-434
206. Jackson WP 1958 Osteoporosis of unknown cause in younger people: idiopathic osteoporosis. J Bone Joint Surg [Br] 40:420-441
207. Dent CE, Friedman M 1965 Pregnancy and idiopathic osteoporosis. Q J Med 34:341-357
208. Smith R, Stevenson JC, Winearls CC, Woods CG, Wordsworth BP 1985 Osteoporosis of pregnancy. Lancet 1:1178-1180
209. Dunne F, Walters B, Marshall T, Heath DA 1993 Pregnancy associated osteoporosis. Clin Endocrinol (Oxf) 39:487-490
210. Rillo OL, Di Stefano CA, Bermudez J, Maldonado Cocco JA 1994 Idiopathic osteoporosis during pregnancy. Clin Rheumatol 13:299-304
211. Chung HC, Lim SK, Lee MK, Lee MH, Huh KB 1988 Pregnancy-associated osteoporosis. Yonsei Med J 29:286-294
212. Smith R, Athanasou NA, Ostlere SJ, Vipond SE 1995 Pregnancy-associated osteoporosis. Q J Med 88:865-878
213. Carbone LD, Palmieri GM, Graves SC, Smull K 1995 Osteoporosis of pregnancy: long-term follow-up of patients and their offspring. Obstet Gynecol 86:664-666
214. Goldman GA, Friedman S, Hod M, Ovadia J 1994 Idiopathic transient osteoporosis of the hip in pregnancy. Int J Gynaecol Obstet 46:317-320
215. Longstreth PL, Malinak LR, Hill Jr CS 1973 Transient osteoporosis of the hip in pregnancy. Obstet Gynecol 41:563-569
216. Brodell JD, Burns Jr JE, Heiple KG 1989 Transient osteoporosis of the hip of pregnancy. Two cases complicated by pathological fracture. J Bone Joint Surg [Am] 71:1252-1257
217. Guerra JJ, Steinberg ME 1995 Distinguishing transient osteoporosis from avascular necrosis of the hip. J Bone Joint Surg [Am] 77:616-624
218. Funk JL, Shoback DM, Genant HK 1995 Transient osteoporosis of the hip in pregnancy: natural history of changes in bone mineral density. Clin Endocrinol (Oxf) 43:373-382
219. Lose G, Lindholm P 1986 Transient painful osteoporosis of the hip in pregnancy. Int J Gynaecol Obstet 24:13-16
220. Curtiss Jr PH, Kincaid WE 1959 Transitory demineralization of the hip in pregnancy: a report of three cases. J Bone Joint Surg [Am] 41:1327-1333
221. Takatori Y, Kokubo T, Ninomiya S, Nakamura T, Okutsu I, Kamogawa M 1991 Transient osteoporosis of the hip. Magnetic resonance imaging. Clin Orthop 271:190-194
222. Beaulieu JG, Razzano CD, Levine RB 1976 Transient osteoporosis of the hip in pregnancy. Clin Orthop 115:165-168
223. Gruber HE, Gutteridge DH, Baylink DJ 1984 Osteoporosis associated with pregnancy and lactation: bone biopsy and skeletal features in three patients. Metab Bone Dis Relat Res 5:159-165
224. Payne RB, Little AJ, Evans RT 1990 Albumin-adjusted calcium concentration in serum increases during normal pregnancy. Clin Chem 36:142-144
225. Ludwig GD 1962 Hyperparathyroidism in relation to pregnancy. N Engl J Med 267:637-642
226. Shangold MM, Dor N, Welt SI, Fleischman AR, Crenshaw Jr MC 1982 Hyperparathyroidism and pregnancy: a review. Obstet Gynecol Surv 37:217-228
227. Wagner G, Transhol L, Melchior JC 1964 Hyperparathyroidism and pregnancy. Acta Endocrinol (Copenh) 47:549-564
228. Bruce J, Strong JA 1955 Maternal hyperparathyroidism and parathyroid deficiency in the child, with account of effect of parathyroidectomy on renal function, and of attempt to transplant part of tumor. Q J Med 24:307-319
229. Better OS, Levi J, Grief E, Tuma S, Gellei B, Erlik D 1973 Prolonged neonatal parathyroid suppression. A sequel to asymptomatic maternal hyperparathyroidism. Arch Surg 106:722-724
230. Garel JM, Dumont C 1972 Distribution and inactivation of labeled parathyroid hormone in rat fetus. Horm Metab Res 4:217-221
231. Garel JM 1972 Distribution of labeled parathyroid hormone in rat fetus. Horm Metab Res 4:131-132
232. Northrop G, Misenhimer HR, Becker FO 1977 Failure of parathyroid hormone to cross the nonhuman primate placenta. Am J Obstet Gynecol 129:449-453
233. Kaplan EL, Burrington JD, Klementschitsch P, Taylor J, Deftos L 1984 Primary hyperparathyroidism, pregnancy, and neonatal hypocalcemia. Surgery 96:717-722
234. Delmonico FL, Neer RM, Cosimi AB, Barnes AB, Russell PS 1976 Hyperparathyroidism during pregnancy. Am J Surg 131:328-337
235. Johnstone RE, Kreindler T 1972 Hyperparathyroidism during pregnancy. Obstet Gynecol 40:580-585
236. Wilson DT, Martin T, Christensen R, Yee AH, Reynolds C 1983 Hyperparathyroidism in pregnancy: case report and review of the literature. Can Med Assoc J 129:986-989
237. Rubin A, Chaykin L, Ludwig GD 1968 Maternal hyperparathyroidism and pregnancy. J Am Med Assoc 206:128-130
238. Higgins RV, Hisley JC 1988 Primary hyperparathyroidism in pregnancy. A report of two cases. J Reprod Med 33:726-730
239. Lueg MC, Dawkins WE 1983 Primary hyperparathyroidism and pregnancy. South Med J 76:1389-1392
240. Lowe DK, Orwoll ES, McClung MR, Cawthon ML, Peterson CG 1983 Hyperparathyroidism and pregnancy. Am J Surg 145:611-614
241. Thomas BR, Bennett JD 1995 Symptomatic hypocalcemia and hypoparathyroidism in two infants of mothers with hyperparathyroidism and familial benign hypercalcemia. J Perinatol 15:23-26
242. Marx SJ, Attie MF, Levine MA, Spiegel AM, Downs Jr RW, Lasker RD 1981 The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds. Medicine (Baltimore) 60:397-412
243. Powell BR, Buist NR 1990 Late presenting, prolonged hypocalcemia in an infant of a woman with hypocalciuric hypercalcemia. Clin Pediatr (Phila) 29:241-243
244. Rude RK, Haussler MR, Singer FR 1984 Postpartum resolution of hypocalcemia in a lactating hypoparathyroid patient. Endocrinol Jpn 31:227-233
245. Cundy T, Haining SA, Guilland-Cumming DF, Butler J, Kanis JA 1987 Remission of hypoparathyroidism during lactation: evidence for a physiological role for prolactin in the regulation of vitamin D metabolism. Clin Endocrinol (Oxf) 26:667-674
246. Bronsky D, Kiamko RT, Moncada R, Rosenthal IM 1968 Intrauterine hyperparathyroidism secondary to maternal hypoparathyroidism. Pediatrics 42:606-613
247. Grant DK 1953 Papilloedema and fits in hypoparathyroidism. Q J Med 22:243-259
248. Wright AD, Joplin GF, Dixon HG 1969 Post-partum hypercalcaemia in treated hypoparathyroidism. Br Med J 1:23-25
249. Blickstein I, Kessler I, Lancet M 1985 Idiopathic hypoparathyroidism with gestational diabetes. Am J Obstet Gynecol 153:649-650
250. Redell G 1946 Parathyroprival tetany and pregnancy. Acta Obstet Gynecol Scand 26:1-10
251. Blohm RW, Wurl OA, Gillespie JO, Escamilla RF 1953 Refractoriness to antitetanic therapy in a case of surgical hypoparathyroidism. J Clin Endocrinol Metab 13:519-533
252. Graham III WP, Gordon CS, Loken HF, Blum A, Halden A 1964 Effect of pregnancy and of the menstrual cycle on hypoparathyroidism. J Clin Endocrinol Metab 24:512-516
253. Markestad T, Ulstein M, Bassoe HH, Aksnes L, Aarskog D 1983 Vitamin D metabolism in normal and hypoparathyroid pregnancy and lactation. Case report. Br J Obstet Gynaecol 90:971-976
254. Caplan RH, Beguin EA 1990 Hypercalcemia in a calcitriol-treated hypoparathyroid woman during lactation. Obstet Gynecol 76:485-489
255. Sadeghi-Nejad A, Wolfsdorf JI, Senior B 1980 Hypoparathyroidism and pregnancy. Treatment with calcitriol. J Am Med Assoc 243:254-255
256. Salle BL, Berthezene F, Glorieux FH, Delvin EE, Berland M, David L, Varenne JP, Putet G 1981 Hypoparathyroidism during pregnancy: treatment with calcitriol. J Clin Endocrinol Metab 52: 810-813
257. Kurzel RB, Hagen GA 1990 Use of thiazide diuretics to reduce the hypercalciuria of hypoparathyroidism during pregnancy. Am J Perinatol 7:333-336
258. Caplan RH, Wickus GG 1993 Reduced calcitriol requirements for treating hypoparathyroidism during lactation. A case report. J Reprod Med 38:914-918
259. Levine MA, Spiegel AM 1995 Pseudohypoparathyroidism. In: DeGroot LJ (ed) Endocrinology. W.B. Saunders, Philadelphia, pp 1136-1150
260. Breslau NA, Zerwekh JE 1986 Relationship of estrogen and pregnancy to calcium homeostasis in pseudohypoparathyroidism. J Clin Endocrinol Metab 62:45-51
261. 3: biochemical characterization and production in normal subjects and patients with pseudohypoparathyroidism. J Clin Endocrinol Metab 62:192-196
262. Vidailhet M, Monin P, Andre M, Suty Y, Marchai C, Vert P 1980 [Neonatal hyperparathyroidism secondary to maternal hypoparathyroidism]. Arch Fr Pediatr 37:305-312
263. Glass EJ, Barr DG 1981 Transient neonatal hyperparathyroidism secondary to maternal pseudohypoparathyroidism. Arch Dis Child 56:565-568
264. Kirby DR, Bardbury S 1965 The hemo-chorial mouse placenta. Anat Rec 152:279-282
265. Enders AC 1965 A comparative study of the fine structures of the trophoblast in several hemochorial placentas. Am J Anat 116:29-68
266. Ramsey EM 1982 The Placenta: Human and Animal. Praeger, New York, p 187
267. Robinson NR, Atkinson DE, Jones CJ, Sibley CP 1988 Permeability of the near-term rat placenta to hydrophilic solutes. Placenta 9:361-372
268. David L, Anast CS 1974 Calcium metabolism in newborn infants. The interrelationship of parathyroid function and calcium, magnesium, and phosphorus metabolism in normal, sick, and hypocalcemic newborns. J Clin Invest 54:287-296
269. Garel JM, Barlet JP 1976 Calcium metabolism in newborn animals: the interrelationship of calcium, magnesium, and inorganic phosphorus in newborn rats, foals, lambs, and calves. Pediatr Res 10: 749-754
270. Schauberger CW, Pitkin RM 1979 Maternal-perinatal calcium relationships. Obstet Gynecol 53:74-76
271. Fleischman AR, Lerman S, Oakes GK, Epstein MF, Chez RA, Mintz DH 1975 Perinatal primate parathyroid hormone metabolism. Biol Neonate 27:40-49
272. Schedewie HK, Odell WD, Fisher DA, Krutzik SR, Dodge M, Cousins L, Fiser WP 1979 Parathormone and perinatal calcium homeostasis. Pediatr Res 13:1-6
273. Pitkin RM, Cruikshank DP, Schauberger CW, Reynolds WA, Williams GA, Hargis GK 1980 Fetal calcitropic hormones and neonatal calcium homeostasis. Pediatrics 66:77-82
274. Delivoria-Papadopoulos M, Battaglia FC, Bruns PD, Meschia G 1967 Total, protein-bound, and ultrafilterable calcium in maternal and fetal plasmas. Am J Physiol 213:363-366
275. Wadsworth JC, Kronfeld DS, Ramberg Jr CF 1982 Parathyrin and calcium homeostasis in the fetus. Biol Neonate 41:101-109
276. Math F, Davrainville JL 1979 Postnatal variations of extracellular free calcium levels in the rat. Influence of undernutrition. Experientia 35:1355-1356
277. Thomas ML, Anast CS, Forte LR 1981 Regulation of calcium homeostasis in the fetal and neonatal rat. Am J Physiol 240:E367-E372
278. Krukowski M, Smith JJ 1976 pH and the level of calcium in the blood of fetal and neonatal albino rats. Biol Neonate 29:148-161
279. Krukowski M, Smith JJ 1979 Acidosis, hypercalcemia, and hyperphosphatemia in rat fetuses near term and effects of maternal acid/base loading. Proc Soc Exp Biol Med 162:359-364
280. Caple IW, Heath JA, Care AD, Heaton C, Farrugia W, Wark JD 1988 The regulation of osteoblast activity in fetal lambs by placental calcium transport and the fetal parathyroid glands. In: Jones CT (ed) Fetal and Neonatal Development. Perinatal Press, Ithaca, NY, pp 90-93
281. MacIsaac RJ, Heath JA, Rodda CP, Moseley JM, Care AD, Martin TJ, Caple IW 1991 Role of the fetal parathyroid glands and parathyroid hormone-related protein in the regulation of placental transport of calcium, magnesium and inorganic phosphate. Reprod Fertil Dev 3:447-457
282. Moniz CF, Nicolaides KH, Tzannatos C, Rodeck CH 1986 Calcium homeostasis in second trimester fetuses. J Clin Pathol 39:838-841
283. Delvin EE, Glorieux FH, Salle BL, David L, Varenne JP 1982 Control of vitamin D metabolism in preterm infants: feto-maternal relationships. Arch Dis Child 57:754-757
284. Lima MS, Kallfelz F, Krook L, Nathanielsz PW 1993 Humeral skeletal development and plasma constituent changes in fetuses of ewes maintained on a low calcium diet from 60 days of gestation. Calcif Tissue Int 52:283-290
285. Miller SC, Halloran BP, DeLuca HF, Jee WS 1983 Studies on the role of vitamin D in early skeletal development, mineralization, and growth in rats. Calcif Tissue Int 35:455-460
286. Chalon S, Garel JM 1985 Plasma calcium control in the rat fetus. II. Influence of fetal hormones. Biol Neonate 48:323-328
287. Pic P 1968 [Maintenance of an elevated fetal blood calcium in the absence of maternal and fetal parathyroid glands in rats]. C R Seances Soc Biol Fil 162:1043-1047
288. Kovacs CS, Ho C, Seidman CE, Seidman JG, Kronenberg HM 1996 Parathyroid calcium sensing receptor regulates fetal blood calcium and fetal-maternal calcium gradient independently of the maternal calcium level. J Bone Miner Res 11[Suppl 1]:S121 (Abstract)
289. Burnette JC, Simpson DM, Chandler Jr DC, Bawden JW 1968 Fetal blood calcium response to maternal parathyroid and vitamin D administration in guinea pigs. J Dent Res 47:444-446
290. Krukowski M, Lehr D 1963 Parathyroid hormone and the placental barrier. Arch Int Pharmacodyn Ther 146:245-265
291. Garel JM, Pic P, Jost A 1971 Action de la parathormone chez de foetus de rat. Ann Endocrinol (Paris) 32:253-262
292. Reynolds WA, Pitkin RM, Wezeman FH 1975 Calcitonin effects in primate pregnancy. Am J Obstet Gynecol 122:212-218
293. Stulc J, Stulcova B 1996 Placental transfer of phosphate in anaesthetized rats. Placenta 17:487-493
294. Barlet JP, Davicco MJ, Rouffet J, Coxam V, Lefaivre J 1994 Short communication: parathyroid hormone-related peptide does not stimulate phosphate placental transport. Placenta 15:441-444
295. Moore ES, Langman CB, Favus MJ, Coe FL 1985 Role of fetal 1,25-dihydroxyvitamin D production in intrauterine phosphorus and calcium homeostasis. Pediatr Res 19:566-569
296. Leroyer-Alizon E, David L, Anast CS, Dubois PM 1981 Immunocytological evidence for parathyroid hormone in human fetal parathyroid glands. J Clin Endocrinol Metab 52:513-516
297. Weatherley AJ, Ross R, Pickard DW, Care AD 1983 The transfer of calcium during perfusion of the placenta and intact and thyroparathyroidectomized sheep. Placenta 4:271-277
298. Care AD, Caple IW, Abbas SK, Pickard DW 1986 The effect of fetal thyroparathyroidectomy on the transport of calcium across the ovine placenta to the fetus. Placenta 7:417-424
299. Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM 1996 Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc Natl Acad Sci USA 93:15233-15238
300. Smith Jr FG, Alexander DP, Buckle RM, Britton HG, Nixon DA 1972 Parathyroid hormone in foetal and adult sheep: the effect of hypocalcaemia. J Endocrinol 53:339-348
301. Pitkin RM, Reynolds WA, Williams GA, Kawahara W, Bauman AF, Hargis GK 1980 Maternal and fetal parathyroid hormone responsiveness in pregnant primates. J Clin Endocrinol Metab 51: 1044-1047
302. Dorey LG, Gell JW 1975 Primary hyperparathyroidism during the third trimester of pregnancy. Obstet Gynecol 45:469-472
303. Rubin LP, Posillico JT, Anast CS, Brown EM 1991 Circulating levels of biologically active and immunoreactive intact parathyroid hormone in human newborns. Pediatr Res 29:201-207
304. Seki K, Furuya K, Makimura N, Mitsui C, Hirata J, Nagata I 1994 Cord blood levels of calcium-regulating hormones and osteocalcin in premature infants. J Perinat Med 22:189-194
305. Fairney A, Jackson D, Clayton BE 1973 Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia. Arch Dis Child 48:419-424
306. Tsang RC, Chen IW, Friedman MA, Chen I 1973 Neonatal parathyroid function: role of gestational age and postnatal age. J Pediatr 83:728-738
307. Seino Y, Ishida M, Yamaoka K, Ishii T, Hiejima T, Ikehara C, Tanaka Y, Matsuda S, Shimotsuji T, Yabuuchi H, Morimoto S, Onishi T 1982 Serum calcium regulating hormones in the perinatal period. Calcif Tissue Int 34:131-135
308. Papantoniou NE, Papapetrou PD, Antsaklis AJ, Kontoleon PE, Mesogitis SA, Aravantinos D 1996 Circulating levels of immunoreactive parathyroid hormone-related protein and intact parathyroid hormone in human fetuses and newborns. Eur J Endocrinol 134:437-442
309. Collignon H, Davicco MJ, Barlet JP 1996 Calcitonin mRNA expression and plasma calciotropic hormones in fetal lambs. Domest Anim Endocrinol 13:269-276
310. Seki K, Wada S, Nagata N, Nagata I 1994 Parathyroid hormone-related protein during pregnancy and the perinatal period. Gynecol Obstet Invest 37:83-86
311. 3. Pediatr Res 37:720-725
312. 1 and Ca-binding protein in fetal rats: relationship to the maternal vitamin D status. Am J Physiol 254:E505-E512
313. Yoshizawa T, Handa Y, Uematsu Y, Sekine K, Takeda S, Yoshihara Y, Kawakami T, Sato H, Alioka K, Tanimoto K, Fukamizu A, Masushige S, Matsumoto T, Kato S 1996 Disruption of the vitamin D receptor (VDR) in the mouse [abstract]. J Bone Miner Res 11[Suppl 1]:S124
314. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB 1997 Targeted ablation of the vitamin D receptor: an animal model of vitamin D dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835
315. Campbell DE, Fleischman AR 1988 Rickets of prematurity: controversies in causation and prevention. Clin Perinatol 15:879-890
316. Pereira GR, Zucker AH 1986 Nutritional deficiencies in the neonate. Clin Perinatol 13:175-189
317. Specker BL 1994 Do North American women need supplemental vitamin D during pregnancy or lactation? Am J Clin Nutr 59[Suppl]:484S-490S
318. 3 receptor in fetal rat bone. J Bone Miner Res 11:56-61
319. Durand D, Barlet JP, Braithwaite GD 1983 The influence of 1,25-dihydroxycholecalciferol on the mineral content of foetal guinea pigs. Reprod Nutr Dev 23:235-244
320. Noff D, Edelstein S 1978 Vitamin D and its hydroxylated metabolites in the rat. Placental and lacteal transport, subsequent metabolic pathways and tissue distribution. Horm Res 9:292-300
321. Hollis BW, Pittard WB 1984 Evaluation of the total fetomaternal vitamin D relationships at term: evidence for racial differences. J Clin Endocrinol Metab 59:652-657
322. 3 and 25-hydroxycholecalciferol in the rat. J Lab Clin Med 77:908-915
323. Leroyer-Alizon E, David L, Dubois PM 1980 Evidence for calcitonin in the thyroid gland of normal and anencephalic human fetuses: immunocytological localization, radioimmunoassay, and gel filtration of thyroid extracts. J Clin Endocrinol Metab 50:316-321
324. Garel JM, Care AD, Barlet JP 1974 A radioimmunoassay for ovine calcitonin: an evaluation of calcitonin secretion during gestation, lactation and foetal life. J Endocrinol 62:497-509
325. Garel JM, Milhaud G, Sizonenko P 1969 [Thyrocalcitonin and the placental barrier in rats]. C R Acad Sci Hebd Seances Acad Sci D 269:1785-1787
326. Garel JM, Barlet JP 1978 Calcitonin in the mother, fetus and newborn. Ann Biol Anim Biochim Biophys 18:53-68
327. Garel JM, Milhaud G, Jost A 1968 [Hypocalcemic and hypophosphatemic action of thyrocalcitonin in fetal rats]. C R Acad Sci Hebd Seances Acad Sci D 267:344-347
328. Allgrove J, Manning RM, Adami S, Chayen J, O'Riordan JL 1981 Biologically active parathyroid hormone in foetal and maternal plasma. Clin Sci 60:11P (Abstract)
329. Abbas SK, Ratcliffe WA, Moniz C, Dixit M, Caple IW, Silver M, Fowden A, Care AD 1994 The role of parathyroid hormone-related protein in calcium homeostasis in the fetal pig. Exp Physiol 79: 527-536
330. Care AD 1989 Development of endocrine pathways in the regulation of calcium homeostasis. Baillieres Clin Endocrinol Metab 3:671-688
331. Abbas SK, Pickard DW, Illingworth D, Storer J, Purdie DW, Moniz C, Dixit M, Caple IW, Ebeling PR, Rodda CP 1990 Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes. J Endocrinol 124:319-325
332. Lee K, Deeds JD, Segre GV 1995 Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 136:453-463
333. Karmali R, Schiffmann SN, Vanderwinden JM, Hendy GN, Nys-DeWolf N, Corvilain J, Bergmann P, Vanderhaeghen JJ 1992 Expression of mRNA of parathyroid hormone-related peptide in fetal bones of the rat. Cell Tissue Res 270:597-600
334. Bowden SJ, Emly JF, Hughes SV, Powell G, Ahmed A, Whittle MJ, Ratcliffe JG, Ratcliffe WA 1994 Parathyroid hormone-related protein in human term placenta and membranes. J Endocrinol 142:217-224
335. Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF 1996 Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev 76:127-173
336. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC 1994 Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 8:277-289
337. Wysolmerski JJ, Dunbar M, Karaplis AC, Broadus AE, Philbrick WM 1996 PTHrP is necessary for mammary epithelial development. J Bone Miner Res 11:S113 (Abstract)
338. Rodda CP, Kubota M, Heath JA, Ebeling PR, Moseley JM, Care AD, Caple IW, Martin TJ 1988 Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy. J Endocrinol 117:261-271
339. Care AD 1991 The placental transfer of calcium. J Dev Physiol 15:253-257
340. Garel JM 1987 Hormonal control of calcium metabolism during the reproductive cycle in mammals. Physiol Rev 67:1-66
341. Fisher GJ, Kelley LK, Smith CH 1987 ATP-dependent calcium transport across basal plasma membranes of human placental trophoblast. Am J Physiol 252:C38-C46
342. Borke JL, Caride A, Verma AK, Kelley LK, Smith CH, Penniston JT, Kumar R 1989 Calcium pump epitopes in placental trophoblast basal plasma membranes. Am J Physiol 257:C341-C346
343. Bruns ME, Fausto A, Avioli LV 1978 Placental calcium binding protein in rats. Apparent identity with vitamin D-dependent calcium binding protein from rat intestine. J Biol Chem 253:3186-3190
344. Symonds HW, Sansom BF, Twardock AR 1972 The measurement of the transfer of calcium and phosphorus from foetus to dam in the sheep using a whole body counter. Res Vet Sci 13:272-275
345. Ramberg Jr CF, Delivoria-Papadopoulos M, Crandall ED, Kronfeld DS 1973 Kinetic analysis of calcium transport across the placenta. J Appl Physiol 35:682-688
346. Care AD, Dutton A, Mott JC, Robinson JS, Ross R 1979 Studies of the transplacental calcium gradient in sheep [abstract]. J Physiol (Lond) 290:19P-20P
347. Care AD 1980 Calcium homeostasis in the fetus. J Dev Physiol 2:85-99
348. Chalon S, Garel JM 1985 Plasma calcium control in the rat fetus. III. Influence of alterations in maternal plasma calcium on fetal plasma calcium level. Biol Neonate 48:329-335
349. Barlet JP 1985 Calcitonin may modulate placental transfer of calcium in ewes. J Endocrinol 104:17-21
350. Durand D, Barlet JP 1981 Influence de la calcitonine maternelle sur la calcémie foetale chez la brebis. Ann Endocrinol (Paris) 42:8C
351. Barlet JP 1985 Prolactin and calcium metabolism in pregnant ewes. J Endocrinol 107:171-175
352. 9K but not the vitamin D receptor. J Endocrinol 150:25-32
353. 3 in the sheep placenta. Placenta 10:553-567
354. 3 receptor from human placenta. J Obstet Gynaecol 21:631-639
355. 3 in rat placenta and yolk sac. Horm Res 18:215-220
356. 3 injections into rat fetuses: effects on fetal plasma calcium, plasma phosphate and mineral content. Reprod Nutr Dev 23:567-573
357. Durand D, Braithwaite GD, Barlet JP 1983 The effect of 1α-hydroxycholecalciferol on the placental transfer of calcium and phosphate in sheep. Br J Nutr 49:475-480
358. Barlet JP, Davicco MJ, Coxam V 1992 Calcitonin modulates parathyroid hormone related peptide-stimulated calcium placental transfer. In: Cohn DV, Gennari C (eds) Calcium Regulating Hormones and Bone Metabolism. Elsevier, Amsterdam, pp 124-128
359. Robinson NR, Sibley CP, Mughal MZ, Boyd RD 1989 Fetal control of calcium transport across the rat placenta. Pediatr Res 26:109-115
360. Shaw AJ, Mughal MZ, Maresh MJ, Sibley CP 1991 Effects of two synthetic parathyroid hormone-related protein fragments on maternofetal transfer of calcium and magnesium and release of cyclic AMP by the in-situ perfused rat placenta. J Endocrinol 129:399-404
361. Barri M, Abbas SK, Pickard DW, Hammonds RG, Wood WI, Caple IW, Martin TJ, Care AD 1990 Fetal magnesium homeostasis in the sheep. Exp Physiol 75:681-688
362. Abbas SK, Pickard DW, Rodda CP, Heath JA, Hammonds RG, Wood WI, Caple IW, Martin TJ, Care AD 1989 Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (FTHrP) preparations. Q J Exp Physiol 74:549-552
363. Care AD, Abbas SK, Pickard DW, Barri M, Drinkhill M, Findlay JB, White IR, Caple IW 1990 Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Exp Physiol 75:605-608
364. Wu TL, Vasavada RC, Yang K, Massfelder T, Ganz M, Abbas SK, Care AD, Stewart AF 1996 Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein. J Biol Chem 271:24371-24381
365. Davicco MJ, Coxam V, Lefaivre J, Barlet JP 1992 Parathyroid hormone-related peptide increases urinary phosphate excretion in fetal lambs. Exp Physiol 77:377-383
366. MacIsaac RJ, Horne RS, Caple IW, Martin TJ, Wintour EM 1993 Effects of thyroparathyroidectomy, parathyroid hormone, and PTHrP on kidneys of ovine fetuses. Am J Physiol 264:E37-E44
367. Brace RA 1994 Amniotic fluid dynamics. In: Creasy RK, Resnik R (eds) Maternal-Fetal Medicine: Principles and Practice. W.B. Saunders, Philadelphia, pp 106-114
368. Rebut-Bonneton C, Garel JM, Delbarre F 1983 Parathyroid hormone, calcitonin, 1,25-dihydroxycholecalciferol, and basal bone resorption in the rat fetus. Calcif Tissue Int 35:183-189
369. Rebut-Bonneton C, Demignon J, Amor B, Miravet L 1983 Effect of calcitonin in pregnant rats on bone resorption in fetuses. J Endocrinol 99:347-353
370. Garel JM, Geloso-Meyer A 1971 [Fetal hyperparathyroidism in rats following maternal hypoparathyroidism]. Rev Eur Etud Clin Biol 16:174-178
371. Aaron JE, Makins NB, Caple IW, Abbas SK, Pickard DW, Care AD 1989 The parathyroid glands in the skeletal development of the ovine foetus. Bone Miner 7:13-22
372. Aaron JE, Abbas SK, Colwell A, Eastell R, Oakley BA, Russell RG, Care AD 1992 Parathyroid gland hormones in the skeletal development of the ovine foetus: the effect of parathyroidectomy with calcium and phosphate infusion. Bone Miner 16:121-129
373. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize L, Ho C, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM 1996 PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273: 663-666
374. Page LA, Haddow JE 1987 Self-limited neonatal hyperparathyroidism in familial hypocalciuric hypercalcemia. J Pediatr 111:261-264
375. Stuart C, Aceto Jr T, Kuhn JP, Terplan K 1979 Intrauterine hyperparathyroidism. Postmortem findings in two cases. Am J Dis Child 133:67-70
376. Loughead JL, Mughal Z, Mimouni F, Tsang RC, Oestreich AE 1990 Spectrum and natural history of congenital hyperparathyroidism secondary to maternal hypocalcemia. Am J Perinatol 7: 350-355
377. Sann L, David L, Thomas A, Frederich A, Chapuy MC, Francois R 1976 Congenital hyperparathyroidism and vitamin D deficiency secondary to maternal hypoparathyroidism. Acta Paediatr Scand 65:381-385
378. Aceto Jr T, Batt RE, Bruck E, Schultz RB, Perz YR 1966 Intrauterine hyperparathyroidism: a complication of untreated maternal hypoparathyroidism. J Clin Endocrinol Metab 26:487-492
379. Eastell R, Edmonds CJ, de Chayal RC, McFadyen IR 1985 Prolonged hypoparathyroidism presenting eventually as second trimester abortion. Br Med J (Clin Res Ed) 291:955-956
380. Anderson GW, Musselman L 1942 The treatment of tetany in pregnancy. Am J Obstet Gynecol 43:547-567
381. Kehrer E 1913 Die geburtschilflich-gynäkologische bedeutung der tetanie. Arch Gynaek 99:372-447
382. Savani RC, Mimouni F, Tsang RC 1993 Maternal and neonatal hyperparathyroidism as a consequence of maternal renal tubular acidosis. Pediatrics 91:661-663
383. Levin TL, States L, Greig A, Goldman HS 1992 Maternal renal insufficiency: a cause of congenital rickets and secondary hyper-parathyroidism. Pediatr Radiol 22:315-316
384. Hammond VE, Senior PV, Tucci J, Beck F 1996 Functional analysis of the parathyroid hormone related protein by gene targeting. J Bone Miner Res 11 [Suppl 1]:S199 (Abstract)
385. Brown EM, Pollak M, Seidman CE, Seidman JG, Chou YH, Riccardi D, Hebert SC 1995 Calcium-ion-sensing cell-surface receptors. N Engl J Med 333:234-240
386. Chattopadhyay N, Mithal A, Brown EM 1996 The calcium-sensing receptor: a
387. Bagnoli F, Bruchi S, Garosi G, Pecciarini L, Bracci R 1990 Relationship between mode of delivery and neonatal calcium homeostasis. Eur J Pediatr 149:800-803
388. Kovacs CS, Lanske B, Byrne M, Krane SM, Kronenberg HM 1997 Altered interstitial collagenase expression in the tibias of PTHrP gene-ablated and PTH/PTHrP receptor gene-ablated fetal mice. J Bone Miner Res 12[Suppl 1]:S116 (Abstract)
389. Macy I, Kelly H, Sloan R 1953 The Composition of Milks; Publication No. 254. National Research Council, Washington, D.C., p 63
390. Sowers M 1996 Pregnancy and lactation as risk factors for subsequent bone loss and osteoporosis. J Bone Miner Res 11:1052-1060
391. Hunscher HA 1930 Metabolism of women during the reproductive cycle. II. Calcium and phosphorus utilization in two successive lactation periods. J Biol Chem 86:37-57
392. Laskey MA, Prentice A, Shaw J, Zachou T, Ceesay SM, Vasquez-Velasquez L, Fraser DR 1990 Breast-milk calcium concentrations during prolonged lactation in British and rural Gambian mothers. Acta Paediatr Scand 79:507-512
393. Neville MC, Keller RP, Seacat J, Casey CE, Allen JC, Archer P 1984 Studies on human lactation. I. Within-feed and between-breast variation in selected components of human milk. Am J Clin Nutr 40:635-646
394. Vaughan LA, Weber CW, Kemberling SR 1979 Longitudinal changes in the mineral content of human milk. Am J Clin Nutr 32:2301-2306
395. Karra MV, Udipi SA, Kirksey A, Roepke JL 1986 Changes in specific nutrients in breast milk during extended lactation. Am J Clin Nutr 43:495-503
396. Donelson E, Nims B, Hunscher HA, Macy IG 1931 Metabolism of women during the reproductive cycle. IV. Calcium and phosphorus utilization in late lactation and during subsequent reproductive rest. J Biol Chem 91:675-686
397. Hillman L, Sateesha S, Haussler M, Wiest W, Slatopolsky E, Haddad J 1981 Control of mineral homeostasis during lactation: interrelationships of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, calcitonin, prolactin, and estradiol. Am J Obstet Gynecol 139:471-476
398. Specker BL, Tsang RC, Ho ML 1991 Changes in calcium homeostasis over the first year postpartum: effect of lactation and weaning. Obstet Gynecol 78:56-62
399. Grill V, Hillary J, Ho PM, Law FM, MacIsaac RJ, MacIsaac IA, Moseley JM, Martin TJ 1992 Parathyroid hormone-related protein: a possible endocrine function in lactation. Clin Endocrinol (Oxf) 37:405-410
400. Dobnig H, Kainer F, Stepan V, Winter R, Lipp R, Schaffer M, Kahr A, Nocnik S, Patterer G, Leb G 1995 Elevated parathyroid hormone-related peptide levels after human gestation: relationship to changes in bone and mineral metabolism. J Clin Endocrinol Metab 80:3699-3707
401. Kovacs CS, Chik CL 1995 Hyperprolactinemia caused by lactation and pituitary adenomas is associated with altered serum calcium, phosphate, parathyroid hormone (PTH), and PTH-related peptide levels. J Clin Endocrinol Metab 80:3036-3042
402. Greer FR, Lane J, Ho M 1984 Elevated serum parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D in lactating women nursing twins. Am J Clin Nutr 40:562-568
403. Lepre F, Grill V, Ho PW, Martin TJ 1993 Hypercalcemia in pregnancy and lactation associated with parathyroid hormone-related protein [letter]. N Engl J Med 328:666-667
404. Toverud SU, Harper C, Munson PL 1976 Calcium metabolism during lactation: enhanced effects of thyrocalcitonin. Endocrinology 99:371-378
405. Wong KM, Singer L, Ophaug RH 1980 Metabolic aspects of bone resorption in calcium-deficient lactating rats. Calcif Tissue Int 32: 213-219
406. Blahosova A, Neradilova M, Velicky J, Titlbach M, Marsikova L, Reisenauer R 1974 Dynamics of changes of calcium and phosphorus metabolism in relation to the morphology of parafollicular thyroid cells in rats during lactation and forced weaning. Endokrinologie 63:122-136
407. 2D in rats. Am J Physiol 262:E840-E844
408. Peng TC, Garner SC, Kusy RP, Hirsch PF 1988 Effect of number of suckling pups and dietary calcium on bone mineral content and mechanical properties of femurs of lactating rats. Bone Miner 3: 293-304
409. Hodnett DW, DeLuca HF, Jorgensen NA 1992 Intestine, bone, and mammary gland contributions to maternal plasma calcium increase after abrupt weaning. Proc Soc Exp Biol Med 199:332-336
410. Kent GN, Price RI, Gutteridge DH, Smith M, Allen JR, Bhagat CI, Barnes MP, Hickling CJ, Retallack RW, Wilson SG 1990 Human lactation: forearm trabecular bone loss, increased bone turnover, and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning. J Bone Miner Res 5: 361-369
411. Lippuner K, Zehnder HJ, Casez JP, Takkinen R, Jaeger P 1996 PTH-related protein is released into the mother's bloodstream during location: evidence for beneficial effects on maternal calcium-phosphate metabolism. J Bone Miner Res 11:1394-1399
412. Kalkwarf HJ, Specker BL, Heubi JE, Vieira NE, Yergey AL 1996 Intestinal calcium absorption of women during lactation and after weaning. Am J Clin Nutr 63:526-531
413. Retallack RW, Jeffries M, Kent GN, Hitchcock NE, Gutteridge DH, Smith M 1977 Physiological hyperparathyroidism in human lactation. Calcif Tissue Res 22[Suppl]:142-146
414. GreerFR, Tsang RC, Searcy JE, Levin RS, Steichen JJ 1982 Mineral homeostasis during lactation - relationship to serum 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D, parathyroid hormone, and calcitonin. Am J Clin Nutr 36:431-437
415. Affinito P, Tommaselli GA, di Carlo C, Guida F, Nappi C 1996 Changes in bone mineral density and calcium metabolism in breastfeeding women: a one year follow-up study. J Clin Endocrinol Metab 81:2314-2318
416. Zinaman MJ, Hickey M, Tomai TP, Albertson BD, Simon JA 1990 Calcium metabolism in postpartum lactation: the effect of estrogen status. Fertil Steril 54:465-469
417. Krebs NF, Reidinger CJ, Robertson AD, Brenner M 1997 Bone mineral density changes during lactation: maternal, dietary, and biochemical correlates. Am J Clin Nutr 65:1738-1746
418. Fry JM, Curnow DH, Gutteridge DH, Retallack RW 1979 Effect of chronic parathyroidectomy on calcium metabolism in the lactating rat. J Endocrinol 82:323-330
419. 3 in lactating rats. Am J Physiol 259:E665-E671
420. Stevenson JC, Hillyard CJ, MacIntyre I, Cooper H, Whitehead MI 1979 A physiological role for calcitonin: protection of the maternal skeleton. Lancet 2:769-770
421. Toverud SU, Cooper CW, Munson PL 1978 Calcium metabolism during lactation: elevated blood levels of calcitonin. Endocrinology 103:472-479
422. Toverud SU, Boass A 1979 Hormonal control of calcium metabolism in lactation. In: Munson PL, Glover J, Diczfalusy E, Olson RE (eds) Vitamins and Hormones. Academic Press, New York, pp 303-347
423. Uemura H, Yasui T, Yoneda N, Irahara M, Aono T 1997 Measurement of N- and C-terminal-region fragments of parathyroid hormone-related peptide in milk from lactating women and investigation of the relationship of their concentrations to calcium in milk. J Endocrinol 153:445-451
424. Law FM, Moate PJ, Leaver DD, Diefenbach-Jagger H, Grill V, Ho PW, Martin TJ 1991 Parathyroid hormone-related protein in milk and its correlation with bovine milk calcium. J Endocrinol 128: 21-26
425. Yamamoto M, Fisher JE, Thiede MA, Caulfield MP, Rosenblatt M, Duong LT 1992 Concentrations of parathyroid hormone-related protein in rat milk change with duration of lactation and interval from previous suckling, but not with milk calcium. Endocrinology 130:741-747
426. Ratcliffe WA, Thompson GE, Care AD, Peaker M 1992 Production of parathyroid hormone-related protein by the mammary gland of the goat. J Endocrinol 133:87-93
427. Thiede MA, Grasser WA, Petersen DN 1992 Regulated expression of parathyroid hormone-related protein in mammary blood supply supports a role in mammary blood flow. In: Cohn DV, Gennari C, Tashjian Jr AH (eds) Calcium Regulating Hormones and Bone Metabolism: Basic and Clincal Aspects. Elsevier Science Publishers, New York, pp 62-66
428. Thiede MA 1994 Parathyroid hormone-related protein: a regulated calcium-mobilizing product of the mammary gland. J Dairy Sci 77:1952-1963
429. Thiede MA 1989 The mRNA encoding a parathyroid hormone-like peptide is produced in mammary tissue in response to elevations in serum prolactin. Mol Endocrinol 3:1443-1447
430. Thompson GE, Ratcliffe WA, Hughes S, Abbas SK, Care AD 1994 Local control of parathyroid hormone-related protein secretion by the mammary gland of the goat. Comp Biochem Physiol A 108: 485-490
431. Bucht E, Carlqvist M, Hedlund B, Bremme K, Torring O 1992 Parathyroid hormone-related peptide in human milk measured by a mid-molecule radioimmunoassay. Metabolism 41:11-16
432. Yamamoto M, Duong LT, Fisher JE, Thiede MA, Caulfield MP, Rosenblatt M 1991 Suckling-mediated increases in urinary phosphate and 3′,5′-cyclic adenosine monophosphate excretion in lactating rats: possible systemic effects of parathyroid hormone-related protein. Endocrinology 129:2614-2622
433. Barlet JP, Abbas SK, Care AD, Davicco MJ, Rouffet J 1993 Parathyroid hormone-related peptide and milking-induced phosphaturia in dairy cows. Acta Endocrinol (Copenh) 129:332-336
434. Melton ME, D'Anza JJ, Wimbiscus SA, Grill V, Martin TJ, Kukreja SC 1990 Parathyroid hormone-related protein and calcium homeostasis in lactating mice. Am J Physiol 259:E792-E796
435. Sowers MF, Hollis BW, Shapiro B, Randolph J, Janney CA, Zhang D, Schork A, Crutchfield M, Stanczyk F, Russell-Aulet M 1996 Elevated parathyroid hormone-related peptide associated with lactation and bone density loss. J Am Med Assoc 276:549-554
436. Lippuner K, Zehnder HJ, Casez JP, Takkinen R, Jaeger P 1995 Effects of PTH-related protein (PTH-rP) on calcium-phosphate metabolism in nursing mothers. Bone 16[Suppl 1]:209S (Abstract)
437. Caplan RH, Wickus GG, Sloane K, Sliva PD 1995 Serum parathyroid hormone-related protein levels during lactation. J Reprod Med 40:216-218
438. Reid IR, Wattie DJ, Evans MC, Budayr AA 1992 Post-pregnancy osteoporosis associated with hypercalcaemia. Clin Endocrinol (Oxf) 37:298-303
439. Siskind MS, Popovtzer MM 1991 Postpartum hypercalcemia in a patient with medullary sponge kidneys. Am J Kidney Dis 17:588-590
440. Khosla S, van Heerden JA, Gharib H, Jackson IT, Danks J, Hayman JA, Martin TJ 1990 Parathyroid hormone-related protein and hypercalcemia secondary to massive mammary hyperplasia (letter). N Engl J Med 322:1157
441. Specker BL, Vieira NE, O'Brien KO, Ho ML, Heubi JE, Abrams SA, Yergey AL 1994 Calcium kinetics in lactating women with low and high calcium intakes. Am J Clin Nutr 59:593-599
442. Prentice A, Jarjou LM, Cole TJ, Stirling DM, Dibba B, Fairweather-Tait S 1995 Calcium requirements of lactating Gambian mothers: effects of a calcium supplement on breast-milk calcium concentration, maternal bone mineral content, and urinary calcium excretion. Am J Clin Nutr 62:58-67
443. Prentice A 1994 Maternal calcium requirements during pregnancy and lactation. Am J Clin Nutr 59[Suppl]:477S-482S
444. Boass A, Toverud SU, Pike JW, Haussler MR 1981 Calcium metabolism during lactation: enhanced intestinal calcium absorption in vitamin D-deprived, hypocalcemic rats. Endocrinology 109:900-907
445. Anderson JJ, Garner SC, Mar MH, Boass A, Toverud SU, Parikh I 1990 The ovariectomized, lactating rat as an experimental model for osteopenia: calcium metabolism and bone changes. Bone Miner 11:43-53
446. Fournier P, Susbielle H 1952 Les échanges de calcium chez le rat au cours de la gestation, de la lactation et du sevrage. I. Influence du régime riche en calcium. J Physiol Paris 44:123-134
447. Komárková A, Záhor Z, Czabanová V 1967 The effect of lactation on the composition of long bones in rats. J Lab Clin Med 69:102-109
448. Miller MA, Omura TH, Miller SC 1989 Increased cancellous bone remodeling during lactation in beagles. Bone 10:279-285
449. Sowers M, Eyre D, Hollis BW, Randolph JF, Shapiro B, Jannausch ML, Crutchfield M 1995 Biochemical markers of bone turnover in lactating and nonlactating postpartum women. J Clin Endocrinol Metab 80:2210-2216
450. Hirsch PF, Hagaman JR 1986 Reduced bone mass in calcitonin-deficient rats whether lactating or not. J Bone Miner Res 1:199-206
451. Gruber HE, Stover SJ 1994 Maternal and weanling bone: the influence of lowered calcium intake and maternal dietary history. Bone 15:167-176
452. Hagaman JR, Ambrose WW, Hirsch PF 1990 A scanning electron microscopic and photon absorptiometric study of the development, prolongation, and pattern of recovery from lactation-induced osteopenia in rats. J Bone Miner Res 5:123-132
453. Hodnett DW, DeLuca HF, Jorgensen NA 1992 Bone mineral loss during lactation occurs in absence of parathyroid tissue. Am J Physiol 262:E230-E233
454. Garner SC, Boass A, Toverud SU 1990 Parathyroid hormone is not required for normal milk composition or secretion or lactation-associated bone loss in normocalcemic rats. J Bone Miner Res 5: 69-75
455. Brommage R, DeLuca HF 1985 Regulation of bone mineral loss during lactation. Am J Physiol 248:E182-E187
456. Atkinson PJ, West RR 1970 Loss of skeletal calcium in lactating women. J Obstet Gynaecol Br Commonw 77:555-560
457. Sorenson JA, Cameron JR 1967 A reliable in vivo measurement of bone mineral content. J Bone Joint Surg [Am] 49:481-497
458. Hayslip CC, Klein TA, Wray HL, Duncan WE 1989 The effects of lactation on bone mineral content in healthy postpartum women. Obstet Gynecol 73:588-592
459. Chan GM, Slater P, Ronald N, Roberts CC, Thomas MR, Folland D, Jackson R 1982 Bone mineral status of lactating mothers of different ages. Am J Obstet Gynecol 144:438-441
460. Chan GM, Ronald N, Slater P, Hollis J, Thomas MR 1982 Decreased bone mineral status in lactating adolescent mothers. J Pediatr 101:767-770
461. Chan GM, Roberts CC, Folland D, Jackson R 1982 Growth and bone mineralization of normal breast-fed infants and the effects of lactation on maternal bone mineral status. Am J Clin Nutr 36:438-443
462. Caird LE, Reid-Thomas V, Hannan WJ, Gow S, Glasier AF 1994 Oral progestogen-only contraception may protect against loss of bone mass in breast-feeding women. Clin Endocrinol (Oxf) 41:739-745
463. Laskey MA, Prentice A 1997 Effect of pregnancy on recovery of lactational bone loss (letter). Lancet 349:1518-1519
464. Kalkwarf HJ, Specker BL 1995 Bone mineral loss during lactation and recovery after weaning. Obstet Gynecol 86:26-32
465. Chan GM, McMurry M, Westover K, Engelbert-Fenton K, Thomas MR 1987 Effects of increased dietary calcium intake upon the calcium and bone mineral status of lactating adolescent and adult women. Am J Clin Nutr 46:319-323
466. Laskey MA, Prentice A, Jarjou LM, Beavan S 1996 Lactational changes in bone mineral of the lumbar spine are influenced by breast-milk output but not calcium intake, breast-milk calcium concentration, or vitamin-D receptor genotype. J Bone Miner Res 11:1815 (Abstract)
467. Sowers M, Corton G, Shapiro B, Jannausch ML, Crutchfield M, Smith ML, Randolph JF, Hollis B 1993 Changes in bone density with lactation. J Am Med Assoc 269:3130-3135
468. Revilla R, Revilla M, Hernandez ER, Villa LF, Varela L, Rico H 1995 Evidence that the loss of bone mass induced by GnRH agonists is not totally recovered. Maturitas 22:145-150
469. Roux C, Pelissier C, Listrat V, Kolta S, Simonetta C, Guignard M, Dougados M, Amor B 1995 Bone loss during gonadotropin releasing hormone agonist treatment and use of nasal calcitonin. Osteoporos Int 5:185-190
470. Fogelman I, Fentiman I, Hamed H, Studd JW, Leather AT 1994 Goserelin (Zoladex) and the skeleton. Br J Obstet Gynaecol 101[Suppl 10]:19-23
471. Mukherjee T, Barad D, Turk R, Freeman R 1996 A randomized, placebo-controlled study on the effect of cyclic intermittent etidronate therapy on the bone mineral density changes associated with six months of gonadotropin-releasing hormone agonist treatment. Am J Obstet Gynecol 175:105-109
472. Taga M, Minaguchi H 1996 Reduction of bone mineral density by gonadotropin-releasing hormone agonist, nafarelin, is not completely reversible at 6 months after the cessation of administration. Acta Obstet Gynecol Scand 75:162-165
473. Newhall-Perry K, Holloway L, Osburn L, Monroe SE, Heinrichs L, Henzl M, Marcus R 1995 Effects of a gonadotropin-releasing hormone agonist on the calcium-parathyroid axis and bone turnover in women with endometriosis. Am J Obstet Gynecol 173:824-829
474. Orwoll ES, Yuzpe AA, Burry KA, Heinrichs L, Buttram Jr VC, Hornstein MD 1994 Nafarelin therapy in endometriosis: long-term effects on bone mineral density. Am J Obstet Gynecol 171:1221-1225
475. Rico H, Arnanz F, Revilla M, Perera S, Iritia M, Villa LF, Arribas I 1993 Total and regional bone mineral content in women treated with GnRH agonists. Calcif Tissue Int 52:354-357
476. Paoletti AM, Serra GG, Cagnacci A, Vacca AM, Guerriero S, Solla E, Melis GB 1996 Spontaneous reversibility of bone loss induced by gonadotropin-releasing hormone analog treatment. Fertil Steril 65:707-710
477. Howell R, Edmonds DK, Dowsett M, Crook D, Lees B, Stevenson JC 1995 Gonadotropin-releasing hormone analogue (goserelin) plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial. Fertil Steril 64:474-481
478. Uemura T, Mohri J, Osada H, Suzuki N, Katagiri N, Minaguchi H 1994 Effect of gonadotropin-releasing hormone agonist on the bone mineral density of patients with endometriosis. Fertil Steril 62:246-250
479. Eckstein N, Feldes J, Feinstein Y, Vagman I, Eshel A, Steinberg R, Statter M, Limor R, Ayalon D 1992 Calcium homeostasis, bone metabolism and safety aspects during long-term treatment with a GnRH agonist. Maturitas 15:25-32
480. Stiegler C, Leb G, Kleinen R, Warnkross H, Ramschak-Schwarzer S, Lipp R, Clarici G, Krejs GJ, Dobnig H 1995 Plasma levels of parathyroid hormone-related pepride are elevated in hyperprolactinemia and correlated to bone density status. J Bone Miner Res 10:751-759
481. Sowers M, Randolph J, Shapiro B, Jannausch M 1995 A prospective study of bone density and pregnancy after an extended period of lactation with bone loss. Obstet Gynecol 85:285-289
482. Koetting CA, Wardlaw GM 1988 Wrist, spine, and hip bone density in women with variable histories of lactation. Am J Clin Nutr 48:1479-1481
483. Feldblum PJ, Zhang J, Rich LE, Fortney JA, Talmage RV 1992 Lactation history and bone mineral density among perimenopausal women. Epidemiology 3:527-531
484. Dequeker J, Tobing L, Rutten V, Geusens P 1991 Relative risk factors for osteoporotic fracture: a pilot study of the MEDOS questionnaire. Clin Rheumatol 10:49-53
485. Aloia JF, Cohn SH, Vaswani A, Yeh JK, Yuen K, Ellis K 1985 Risk factors for postmenopausal osteoporosis. Am J Med 78:95-100
486. Aloia JF, Vaswani AN, Yeh JK, Ross P, Ellis K, Cohn SH 1983 Determinants of bone mass in postmenopausal women. Arch Intern Med 143:1700-1704
487. Berning B, van Kuijk C, Schutte HE, Kuiper JW, Drogendijk AC, Fauser BC 1993 Determinants of lumbar bone mineral density in normal weight, non-smoking women soon after menopause. A study using clinical data and quantitative computed tomography. Bone Miner 21:129-139
488. Wardlaw GM, Pike AM 1986 The effect of lactation on peak adult shaft and ultra-distal forearm bone mass in women. Am J Clin Nutr 44:283-286
489. Glasier A, McNeilly AS, Howie PW 1984 The prolactin response to suckling. Clin Endocrinol (Oxf) 21:109-116
490. Wasnich R, Yano K, Vogel J 1983 Postmenopausal bone loss at multiple skeletal sites: relationship to estrogen use. J Chronic Dis 36:781-790
491. Hiyaoka A, Yoshida T, Cho F, Yoshikawa Y 1996 Changes in bone mineral density of lumbar vertebrae after parturition in African green monkeys (Cercopithecus aethiops). Exp Anim 45:257-259
492. Yamamoto N, Takahashi HE, Tanizawa T, Kawashima T, Endo N 1994 Bone mineral density and bone histomorphometric assessments of postpregnancy osteoporosis: a report of five patients. Calcif Tissue Int 54:20-25
493. Ratcliffe WA 1992 Role of parathyroid hormone-related protein in lactation. Clin Endocrinol (Oxf) 37:402-404
494. Cathebras P, Cartry O, Sassolas G, Rousset H 1996 [Hypercalcemia induced by lactation in 2 patients with treated hypoparathyroidism]. Rev Med Interne 17:675-676
495. Nishioka T, Yasuda T, Niimi H, Nakajima H 1988 Evidence that calcitonin plays a role in the postnatal increase of serum 1α,25-dihydroxyvitamin D. Eur J Pediatr 147:148-152
496. Loughead JL, Mimouni F, Tsang RC 1988 Serum ionized calcium concentrations in normal neonates. Am J Dis Child 142:516-518
497. Martinez ME, Catalan P, Lisbona A, Sanchez-Cabezudo MJ, Pallardo F, Jans I, Bouillon R 1994 Serum osteocalcin concentrations in diabetic pregnant women and their newborns. Horm Metab Res 26:338-342
498. Nishioka T, Yasuda T, Niimi H 1991 A discordant movement in urine calcium excretion in relation to serum calcium and parathyroid function occurring immediately after birth. Acta Paediatr Scand 80:590-595
499. Loughead JL, Mimouni F, Tsang RC, Khoury JC 1991 A role for magnesium in neonatal parathyroid gland function? J Am Coll Nutr 10:123-126
500. Mimouni F, Loughead JL, Tsang RC, Khoury J 1990 Postnatal surge in serum calcitonin concentrations: no contribution to neonatal hypocalcemia in infants of diabetic mothers. Pediatr Res 28: 493-495
501. Loughead JL, Mimouni F, Ross R, Tsang RC 1990 Postnatal changes in serum osteocalcin and parathyroid hormone concentrations. J Am Coll Nutr 9:358-362
502. Tsang RC, Light IJ, Sutherland JM, Kleinman LI 1973 Possible pathogenetic factors in neonatal hypocalcemia of prematurity. The role of gestation, hyperphosphatemia, hypomagnesemia, urinary calcium loss, and parathormone responsiveness. J Pediatr 82: 423-429
503. Romagnoli C, Zecca E, Tortorolo G, Diodato A, Fazzini G, Sorcini-Carta M 1987 Plasma thyrocalcitonin and parathyroid hormone concentrations in early neonatal hypocalcaemia. Arch Dis Child 62:580-584
504. Venkataraman PS, Blick KE, Fry HD, Rao RK 1985 Postnatal changes in calcium-regulating hormones in very-low-birth-weight infants. Effect of early neonatal hypocalcemia and intravenous calcium infusion on serum parathyroid hormone and calcitonin homeostasis. Am J Dis Child 139:913-916
505. Strewler GJ, Nissenson RA 1993 Parathyroid hormone-related protein. In: Favus MJ (ed) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Raven Press, New York, pp 61-63
506. Major BJ, Ho PM, Moseley JM, Martin TJ, Leaver DD 1995 Circulating levels of parathyroid hormone related protein in neonates. Bone 16[Suppl]:204S (Abstract)
507. Rong H, Hydbring E, Olsson K, Burtis WJ, Rankin W, Grill V, Bucht E 1997 Parathyroid hormone-related protein in neonatal and reproductive goats determined by a sensitive time-resolved immunofluorometric assay. Eur J Endocrinol 136:546-551
508. Kukreja SC, D'Anza JJ, Melton ME, Wimbiscus SA, Grill V, Martin TJ 1991 Lack of effects of neutralization of parathyroid hormone-related protein on calcium homeostasis in neonatal mice. J Bone Miner Res 6:1197-1201
509. Halbert KE, Tsang RC 1992 Neonatal calcium, phosphorus, and magnesium homeostasis. In: Polin RA, Fox WW (eds) Fetal and Neonatal Physiology. W.B. Saunders, Philadelphia, pp 1745-1761
510. Ghishan FK, Parker P, Nichols S, Hoyumpa A 1984 Kinetics of intestinal calcium transport during maturation in rats. Pediatr Res 18:235-239
511. Ghishan FK, Jenkins JT, Younoszai MK 1980 Maturation of calcium transport in the rat small and large intestine. J Nutr 110: 1622-1628
512. Halloran BP, DeLuca HF 1980 Calcium transport in small intestine during early development: role of vitamin D. Am J Physiol 239: G473-G479
513. Buchowski MS, Miller DD 1991 Lactose, calcium source and age affect calcium bioavailability in rats. J Nutr 121:1746-1754
514. Pansu D, Chapuy MC, Milani M, Bellaton C 1976 Transepithelial calcium transport enhanced by xylose and glucose in the rat jejunal ligated loop. Calcif Tissue Res 21[Suppl]:45-52
515. Leichter J, Tolensky AF 1975 Effect of dietary lactose on the absorption of protein, fat and calcium in the postweaning rat. Am J Clin Nutr 28:238-241
516. 3 during neonatal development in the rat. J Biol Chem 256:7338-7342
517. Bruns ME, Bruns DE, Avioli L 1979 Vitamin D-dependent calcium-binding protein of rat intestine: changes during postnatal development and sensitivity to 1,25-dihydroxycholecalciferol. Endocrinology 105:934-938
518. Giles MM, Fenton MH, Shaw B, Elton RA, Clarke M, Lang M, Hume R 1987 Sequential calcium and phosphorus balance studies in preterm infants. J Pediatr 110:591-598
519. Shaw JC 1976 Evidence for defective skeletal mineralization in low-birthweight infants: the absorption of calcium and fat. Pediatrics 57:16-25
520. Senterre J, Salle B 1982 Calcium and phosphorus economy of the preterm infant and its interaction with vitamin D and its metabolites. Acta Paediatr Scand Suppl 296:85-92
521. Barltrop D, Mole RH, Sutton A 1977 Absorption and endogenous faecal excretion of calcium by low birthweight infants on feeds with varying contents of calcium and phosphate. Arch Dis Child 52: 41-49
522. Kobayashi A, Kawai S, Obe Y, Nagashima Y 1975 Effects of dietary lactose and lactase preparation on the intestinal absorption of calcium and magnesium in normal infants. Am J Clin Nutr 28:681-683
523. Kocian J, Skala I, Bakos K 1973 Calcium absorption from milk and lactose-free milk in healthy subjects and patients with lactose intolerance. Digestion 9:317-324
524. 2 in the term human infant. J Clin Endocrinol Metab 81:1385-1388
525. Karlén J, Aperia A, Zetterstrüm R 1985 Renal excretion of calcium and phosphate in preterm and term infants. J Pediatr 106:814-819
526. Ghazali S, Barratt TM 1974 Urinary excretion of calcium and magnesium in children. Arch Dis Child 49:97-101
527. Guignard JP, Torrado A, Da Cunha O, Gautier E 1975 Glomerular filtration rate in the first three weeks of life. J Pediatr 87:268-272
528. Linarelli LG 1972 Newborn urinary cyclic AMP and developmental renal responsiveness to parathyroid hormone. Pediatrics 50:14-23
529. Mallet E, Basuyau JP, Brunelle P, Devaux AM, Fessard C 1978 Neonatal parathyroid secretion and renal receptor maturation in premature infants. Biol Neonate 33:304-308
530. Widdowson EM, McCance RA 1965 The metabolism of phosphorus, calcium, magnesium and strontium. Pediatr Clin North Am 12:595-614
531. Ziegler EE, O'Donnell AM, Nelson SE, Fomon SJ 1976 Body composition of the reference fetus. Growth 40:329-341
532. Sparks JW 1984 Human intrauterine growth and nutrient accretion. Semin Perinatol 8:74-93
533. Cockburn F, Belton NR, Purvis RJ, Giles MM, Brown JK, Turner TL, Wilkinson EM, Forfar JO, Barrie WJ, McKay GS, Pocock SJ 1980 Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants. Br Med J 281:11-14
534. Brooke OG, Brown IR, Bone CD, Carter ND, Cleeve HJ, Maxwell JD, Robinson VP, Winder SM 1980 Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J 280:751-754
535. Reif S, Katzir Y, Eisenberg Z, Weisman Y 1988 Serum 25-hydroxyvitamin D levels in congenital craniotabes. Acta Paediatr Scand 77:167-168
536. Specker BL, Ho ML, Oestreich A, Yin TA, Shui QM, Chen XC, Tsang RC 1992 Prospective study of vitamin D supplementation and rickets in China. J Pediatr 120:733-739
537. Brunvand L, Quigstad E, Urdal P, Haug E 1996 Vitamin D deficiency and fetal growth. Early Hum Dev 45:27-33
538. Garel JM 1983 Parathyroid hormone, calcitonin and mineral metabolism in the mammalian fetus and neonate. In: Hollick MF, Anast CS, Gray TK (eds) Perinatal Calcium and Phosphorus Metabolism. Excerpta Medica, Amsterdam, pp 71-104
539. Krukowski M, Kahn AJ 1980 The role of parathyroid hormone in mineral homeostasis and bone modeling in suckling rat pups. Metab Bone Dis Relat Res 2:257-260
540. Minton SD, Steichen JJ, Tsang RC 1979 Bone mineral content in term and preterm appropriate-for-gestational-age infants. J Pediatr 95:1037-1042
541. Steichen JJ, Asch PA, Tsang RC 1988 Bone mineral content measurement in small infants by single-photon absorptiometry: current methodologic issues. J Pediatr 113:181-187
542. Greer FR, McCormick A 1986 Bone growth with low bone mineral content in very low birth weight premature infants. Pediatr Res 20:925-928
543. Greer FR 1988 Determination of radial bone mineral content in low birth weight infants by photon absorptiometry. J Pediatr 113:213-219
544. Steichen JJ, Gratton TL, Tsang RC 1980 Osteopenia of prematurity: the cause and possible treatment. J Pediatr 96:528-534
545. Koo WW, Sherman R, Succop P, Ho M, Buckley D, Tsang RC 1989 Serum vitamin D metabolites in very low birth weight infants with and without rickets and fractures. J Pediatr 114:1017-1022
546. McIntosh N, De Curtis M, Williams J 1986 Failure of mineral supplementation to reduce incidence of rickets in very-low-birth-weight infants (letter). Lancet 2:981-982
547. Steichen JJ, Tsang RC, Greer FR, Ho M, Hug G 1981 Elevated serum 1,25 dihydroxyvitamin D concentrations in rickets of very low-birth-weight infants. J Pediatr 99:293-298
548. Gradus D, Le Roith D, Karplus M, Zmora E, Grief M, Bar-Ziv J 1981 Congenital hyperparathyroidism and rickets: secondary to maternal hypoparathyroidism and vitamin D deficiency. Isr J Med Sei 17:705-708
549. Key Jr LL, Thorne M, Pitzer B, Volberg F, Turner C 1990 Management of neonatal hyperparathyroidism with parathyroidectomy and autotransplantation. J Pediatr 116:923-926
550. Tsang RC, Venkataraman P, Ho M, Steichen JJ, Whitsett J, Greer F 1984 The development of pseudohypoparathyroidism. Involvement of progressively increasing serum parathyroid hormone concentrations, increased 1,25-dihydroxyvitamin D concentrations, and 'migratory' subcutaneous calcifications. Am J Dis Child 138: 654-658
551. Minagawa M, Yasuda T, Kobayashi Y, Niimi H 1995 Transient pseudohypoparathyroidism of the neonate. Eur J Endocrinol 133: 151-155
552. Mimouni F, Tsang RC 1992 Pathophysiology of neonatal hypocalcemia. In: Polin RA, Fox WW (eds) Fetal and Neonatal Physiology. W.B. Saunders, Philadelphia, pp 1761-1767
553. Specker BL, Tsang RC, Ho ML, Landi TM, Gratton TL 1991 Low serum calcium and high parathyroid hormone levels in neonates fed 'humanized' cow's milk-based formula. Am J Dis Child 145: 941-945
554. Noguchi A, Eren M, Tsang RC 1980 Parathyroid hormone in hypocalcemic and normocalcemic infants of diabetic mothers. J Pediatr 97:112-114
555. Strand CE, Ehrenkranz RA 1994 Infants of diabetic mothers. In: Lebovitz HE (ed) Therapy for Diabetes Mellitus and Related Disorders. American Diabetes Association, Alexandria, VA, pp 32-37
556. Freinkel N, Ogata E, Metzger BE 1990 The offspring of the mother with diabetes. In: Rifkin H, Porte Jr D (eds) Diabetes Mellitus: Theory and Practice. Elsevier, New York, pp 651-659
557. Demarini S, Mimouni F, Tsang RC, Khoury J, Hertzberg V 1994 Impact of metabolic control of diabetes during pregnancy on neonatal hypocalcemia: a randomized study. Obstet Gynecol 83:918-922
558. Tsang RC, Chen I, Friedman MA, Gigger M, Steichen J, Koffler H, Fenton L, Brown D, Pramanik A, Keenan W, Strub R, Joyce T 1975 Parathyroid function in infants of diabetic mothers. J Pediatr 86:399-404
559. Tsang RC, Strub R, Brown DR, Steichen J, Hartman C, Chen IW 1976 Hypomagnesemia in infants of diabetic mothers: perinatal studies. J Pediatr 89:115-119
560. Mimouni F, Tsang RC, Hertzberg VS, Miodovnik M 1986 Polycythemia, hypomagnesemia, and hypocalcemia in infants of diabetic mothers. Am J Dis Child 140:798-800
561. Martinez ME, Catalan P, Balaguer G, Lisbona A, Quero J, Reque A, Pallardo LF 1991 25(OH)D levels in diabetic pregnancies relation with neonatal hypocalcemia. Horm Metab Res 23:38-41
562. Salle B, David L, Glorieux F, Delvin EE, Louis JJ, Troncy G 1982 Hypocalcemia in infants of diabetic mothers. Studies in circulating calciotropic hormone concentrations. Acta Paediatr Scand 71:573-577
563. Donatelli M, Bucalo ML, Russo V, Cerasola GA 1984 Calcium hormones in diabetic pregnancy. Boll Soc Ital Biol Sper 60:1503-1508
564. Sgambato S, Passariello N, Buoninconti R, Caserta R, Paolisso G 1986 Plasma calcitonin variations in normal women and in women with family history of diabetes during pregnancy. Diabete Metab 12:297-301
565. Mimouni F, Tsang RC, Hertzberg VS, Neumann V, Ellis K 1989 Parathyroid hormone and calcitriol changes in normal and insulin-dependent diabetic pregnancies. Obstet Gynecol 74:49-54
566. Birdsey TJ, Husain SM, Garland HO, Sibley CP 1995 The effect of diabetes mellitus on urinary calcium excretion in pregnant rats and their offspring. J Endocrinol 145:11-18
567. 9K mRNA expression in rat placenta. Pediatr Res 35:376-381