PTHrP regulates epidermal differentiation in adult mice

Journal of Investigative Dermatology

Volumn 111, Issue 6, 1998, Pages 1122-1128

  Foley, John ^a,c   Longely, B Jack ^b   Wysolmerski, John J ^a   Dreyer, Barbara E ^a   Broadus, Arthur E ^a   Philbrick, William M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

Aging; Dermis; Keratinocyte; Sebaceous glands

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN;

ACANTHOSIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CHONDRODYSPLASIA; EPIDERMIS; GENE DISRUPTION; HYPERKERATOSIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PAPILLOMATOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEBACEOUS GLAND DISEASE; TRANSGENIC MOUSE;

EID: 0032456895     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00428.x     Document Type: Article

References (47)

1. Amizuka N, Warshawsky H, Henderson JE, Goltzman D, Karaplis AC: Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J Cell Biol 126:1611-1623, 1994
2. Andreasen E: Cyclic changes in the skin of the mouse. Acta Pathol Microbiol Immunol, Scand A 32:157-164, 1953
3. Atillasoy EJ, Burtis WJ, Milstone LM: Immunochemical localization of parathyroid hormone-related protein in normal human skin. J Invest Dermatol 96:277-280, 1991
4. Blessing M, Schrimacher P, Kaiser S: Overexpression of bone Morphogenic Protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and fromation of psoriatic lesions. J Cell Biol 135:227-239, 1996
5. Broadus AE, Stewart AF: Parathyroid hormone-related protein structure, processing and physiological actions. In: Marcus R (ed.). The Parathyroids. New York: Raven Press, 1996, pp. 259-294
6. Broadus AE, Mangin M, Ikeda K, Insogna KL, Weir EC, Burtis WJ, Stewart AF: Humoral hypercalcemia of cancer: identification of a novel parathyroid hormone-like peptide. N Engl J Med 319:556-563, 1998
7. Ebling FJG, Eady RAJ, Leigh IM: Anatomy and organization of human skin. In: Textbook of Dermatology. London: Blackwell Scientific Publications, 1992, pp. 49-124
8. Eckert RL, Criosh JF, Robinson NA: The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Phys Rev 77:397-423, 1997
9. Falzon M: DNA sequences in the rat parathyroid hormone-related peptide gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression. Mol Endo 10:672-681, 1996
10. Freire-Maia N, Pinheiro M: Ectodermal Dysplaias: A Clinical and Genetic Study. New York: Alan R. Liss, 1984
11. Guo L, Yu G-C, Fuchs E: Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J 12:973-986, 1993
12. Henderson JE, Kremer R, Rhim JS, Goltzman D: Identification and functional characterization of adenylate cyclase-linked receptors for parathyroid hormone-like peptides on immortalized keratinocytes. Endocrinology 130:449-457, 1992
13. Heyden A, Lützow-Holm C, Clausen OPF, et al: Application of cantharidin or 12-0-tetradecanoylphorbol-13-acetate on mouse epidermis induces a cell population shift that causes altered keratin distribution. Differentiation 57:187-193, 1994
14. Holick MF, Ray S, Chen TC, Persons KSA: parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice. Proc Natl Acad Sci USA 91:8014-8016, 1994
15. Holick MF, Chen ML, Kong XF, Sanan DK: Clinical uses for calciotropic hormones 1,25-dihydroxyvitamin D3 and parathyroid hormone-related peptide in dermatology: a new perspective. J Invest Derm Symp Proc 1:1-9, 1996
16. Kaiser ST, Laneuville P, Bernier SM, Rhim JS, Kremer R, Goltzman D: Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem 267:13623-13528, 1991
17. Kaiser SM, Sebag M, Rhim JS, Kremer R, Goltzman D: Antisense-mediated inhibition of parathyroid hormone-related peptide production in a keratinocyte cell line impedes differentiation. Mol Endo 8:139-147, 1994
18. Karaplis A, Luz A, Glowacki J, Bronson RJ, Tybolewicz VLJ, Kronenberg HM, Mulligan RC: Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes and Dev 8:277-289, 1994
19. Key G, Becker MH, Baron B, Duchrow M, Schluter C, Flad HD, Gerdes J: New Ki. -67-equivalent murine monoclonal antibodies (M1B 1-3) against bacterially expressed parts of the Ki-67 cDNA containing three base pair repetitive elements encoding for the Ki-67 epitope. Lab Invest 68:629-636, 1993
20. Kraplis AC, Kroneberg HM: Physiological roles for parathyroid hormone related-protein. Vitamins Hormones 52:177-193, 1996
21. Kremer R, Karaplis AC, Henderson J, Gulliver W, Banville D, Hendy GN, Goltzman D: Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. J Clin Invest 87:884-893, 1991
22. Kremer R, Sebag M, Champigny C, Meerovitch K, Hendy GN, White J, Goltzman D: Identification and characterization of 1,25-dihydroxyvitamin D3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene. J Biol Chem 271:16310-16316, 1996
23. Lanske B, Karaplis AC, Lee K, et al: PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science (Wash DC) 273:663-666, 1996
24. Lee K, Deeds JD, Segre GV: Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 136:453-463, 1995
25. Lee K, Lanske B, Karaplis AC, et al: Parathyroid hormone-related peptide delays terminal differentiation of chodrocytes during endochondral bone development. Endocrinology 137:5109-5118, 1996
26. Löwik CWGM, Hockman K, Offringa R, Groot CG, Hendy GN, Papapoulos SE, Ponec M: Regulation of parathyroid hormonelike protein production in cultured normal and malignant keratinocytes. J Invest Derm 98:198-203, 1992
27. Massfelder T, Wu T, Dann P, Plotkin R, Vasavada R, Helwig JJ, Stewart AF: Opposing mitogenic and anti-mitogenic actions of PTHrP in vascular smooth muscle (VSM) cells: a critical role for nuclear targeting. Proc Natl Acad Sci USA 94:13630-13635, 1997
28. Merendino JJ, Insogna KL, Milstone LM, Broadus AE, Stewart AF: Cultured human keratinocytes produce a parathyroid hormone-like protein. Science (Wash DC) 231:388-390, 1986
29. Murillas RF, Larcher CJ, Conti M, Santos A, Ullrich A, Jorcano JL: Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J 14:5216-5223, 1995
30. Philbrick WM, Wysolmerski JJ, Galbraith S, et al: Defining the roles of Parathyroid hormone-related protein in normal physiology. Physiological Rev 76:127-173, 1996
31. Philbrick WM, Dreyer BE, Nakchbandi IA, Karaplis AC: Parathyroid hormone-related protein is required for tooth eruption. Proc Natl Acad Sci USA 95:11846-11851, 1998
32. Rosenthal DS, Griffiths CEM, Yuspa SH, Roop DR, Voorhees JJ: Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. J Invest Derm 98:343-350, 1992
33. Schilli MC, Ray S, Pau R, Obi-Tabot E, Holick MF: Control of hair growth with parathyroid hormone (7-34). J Invest Derm 108:928-932, 1997
34. Schipani E, Lanske B, Hunzelman J, et al: Targeted expression of constitutively active PTH/PTHrP receptors delays endochondral bone formation and rescues PTHrP-less mice. Proc Natl Acad Sci USA 94:13689-13694, 1997
35. Schweizer J: Murine epidermal keratins. In: Bloomberg M (ed.). Molecular Biology of the Skin. The Keratinocyte. New York: Academic Press, 1993, pp. 33-78
36. Segre GV: Receptors for parathyroid hormone and parathyroid hormone-related protein. In: Levine MA (ed.). The Parathyroids. New York: Raven Press, 1994, pp. 213-229
37. Senior PV, Heath DA, Beck F: Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Molec Endocrinol 6:281-290, 1991
38. Strauss J, Downing PT, Ebling FJ, Stewart ME: Sebaceous glands. In: Goldsmith LA (ed.). Physiology Biochemistry and Molecular Biology of Skin. Oxford: Oxford University Press, 1991
39. Urena P, Kong X, Abou-Samra A, Jüppner H, Kronenberg HM, Potts JT, Segre GV: Parathyroid hormone (PTH/PTH-related peptide) messenger ribonucleic acids are widely distributed in rat tissues. Endocrinology 133:617-623, 1993
40. Vassar R, Fuchs E: Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation. Genes Dev 5:714-727, 1991
41. Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE: Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci USA 93:10240-10245, 1996
42. Werkmeister JR, Merryman JI, McCauley LK, Horton JE, Capen CC, Rosol TJ: Parathyroid hormone-related protein production by normal human keratinocytes in vitro. Exp Cell Res 208:68-74, 1993
43. Werner S, Weinberg W, Liao X, et al: Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. EMBO J 7:2635-2643, 1993
44. Whitfield JF, Isaacs RJ, Jouishomme H, et al: C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes. J Cell Physiol 166:1-11, 1996
45. Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM: Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proc Natl Acad Sci USA 91:1133-1137, 1994
46. Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM: Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 121:3539-3547, 1995
47. Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Karaplis A, Broadus AE: Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125:1285-1294, 1998