PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target

Journal of Clinical Investigation

Volumn 121, Issue 12, 2011, Pages 4655-4669

  Li, Jiarong ^a   Karaplis, Andrew C ^b   Huang, Dao C ^a   Siegel, Peter M ^c   Camirand, Anne ^a,b   Yang, Xian Fang ^a   Muller, William J ^c   Kremer, Richard ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; BLOOD CLOTTING FACTOR 8; CHEMOKINE RECEPTOR CXCR4; CYCLIN D1; HUMAN MONOCLONAL ANTIBODY; KI 67 ANTIGEN; MOLECULAR MARKER; NEUTRALIZING ANTIBODY; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN MONOCLONAL ANTIBODY; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL ADHESION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFICACY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PLEIOTROPY; PRIMARY TUMOR; PRIORITY JOURNAL; SOLID TUMOR; TUMOR GROWTH; TUMOR XENOGRAFT;

ANGIOGENIC PROTEINS; ANIMALS; ANTIBODIES, NEUTRALIZING; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL CYCLE PROTEINS; DISEASE PROGRESSION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PARATHYROID HORMONE-RELATED PROTEIN; RECEPTORS, CXCR4; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84055191098     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46134     Document Type: Article

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