메뉴 건너뛰기




Volumn 5, Issue 4, 2015, Pages 768-790

High content imaging (HCI) on miniaturized three-dimensional (3D) cell cultures

Author keywords

High content imaging; Miniaturized cell based assay; Predictive toxicology; Three dimensional (3D) cell culture

Indexed keywords

ASSAYS; CELL CULTURE; CELLS; DRUG PRODUCTS; HISTOLOGY; THROUGHPUT; TISSUE;

EID: 84983099937     PISSN: None     EISSN: 20796374     Source Type: Journal    
DOI: 10.3390/bios5040768     Document Type: Review
Times cited : (43)

References (109)
  • 1
    • 77951975169 scopus 로고    scopus 로고
    • High content screening: Seeing is believing
    • Zanella, F.; Lorens, J.B.; Link, W. High content screening: Seeing is believing. Trends Biotechnol. 2010, 28, 237-245, doi:10.1016/j.tibtech.2010.02.005.
    • (2010) Trends Biotechnol , vol.28 , pp. 237-245
    • Zanella, F.1    Lorens, J.B.2    Link, W.3
  • 4
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni, F.; Reynaud, E.G.; Stelzer, E.H.K. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 2007, 8, 839-845, doi:10.1038/nrm2236.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.K.3
  • 5
    • 84894475006 scopus 로고    scopus 로고
    • 3D cell culture: A review of current approaches and techniques
    • Humana Press: New York, NY, USA
    • Haycock, J. 3D cell culture: A review of current approaches and techniques. In 3D Cell Culture: Methods and Protocols; Humana Press: New York, NY, USA; 2011; Volume 695, pp. 243-259.
    • (2011) 3D Cell Culture: Methods and Protocols , vol.695 , pp. 243-259
    • Haycock, J.1
  • 6
    • 44949166671 scopus 로고    scopus 로고
    • Three-dimensional cell culture matrices: State of the art
    • Lee, J.; Cuddihy, M.J.; Kotov, N.A. Three-dimensional cell culture matrices: State of the art. Tissue Eng. Part B Rev. 2008, 14, 61-86, doi:10.1089/teb.2007.0150.
    • (2008) Tissue Eng. Part B Rev , vol.14 , pp. 61-86
    • Lee, J.1    Cuddihy, M.J.2    Kotov, N.A.3
  • 7
    • 84903433798 scopus 로고    scopus 로고
    • The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells
    • Wei, J.; Han, J.; Zhao, Y.; Cui, Y.; Wang, B.; Xiao, Z.; Chen, B.; Dai, J. The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells. Biomaterials 2014, 35, 7724-7733, doi:10.1016/j.biomaterials.2014.05.060.
    • (2014) Biomaterials , vol.35 , pp. 7724-7733
    • Wei, J.1    Han, J.2    Zhao, Y.3    Cui, Y.4    Wang, B.5    Xiao, Z.6    Chen, B.7    Dai, J.8
  • 8
    • 84867225972 scopus 로고    scopus 로고
    • Synthetic 3D multicellular systems for drug development
    • Rimann, M.; Graf-Hausner, U. Synthetic 3D multicellular systems for drug development. Curr. Opin. Biotechnol. 2012, 23, 803-809, doi:10.1016/j.copbio.2012.01.011.
    • (2012) Curr. Opin. Biotechnol , vol.23 , pp. 803-809
    • Rimann, M.1    Graf-Hausner, U.2
  • 9
    • 84874700631 scopus 로고    scopus 로고
    • Three-dimensional cell culture: The missing link in drug discovery
    • Breslin, S.; O'Driscoll, L. Three-dimensional cell culture: The missing link in drug discovery. Drug Discov. Today 2013, 18, 240-249, doi:10.1016/j.drudis.2012.10.003.
    • (2013) Drug Discov. Today , vol.18 , pp. 240-249
    • Breslin, S.1    O'Driscoll, L.2
  • 11
    • 84858448828 scopus 로고    scopus 로고
    • 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids
    • Hsiao, A.Y.; Tung, Y.-C.; Qu, X.; Patel, L.R.; Pienta, K.J.; Takayama, S. 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids. Biotechnol. Bioeng. 2012, 109, 1293-1304, doi:10.1002/bit.24399.
    • (2012) Biotechnol. Bioeng , vol.109 , pp. 1293-1304
    • Hsiao, A.Y.1    Tung, Y.-C.2    Qu, X.3    Patel, L.R.4    Pienta, K.J.5    Takayama, S.6
  • 12
    • 84896305360 scopus 로고    scopus 로고
    • Transfer, Imaging, and Analysis Plate for Facile Handling of 384 Hanging Drop 3D Tissue Spheroids
    • Cavnar, S.P.; Salomonsson, E.; Luker, K.E.; Luker, G.D.; Takayama, S. Transfer, Imaging, and Analysis Plate for Facile Handling of 384 Hanging Drop 3D Tissue Spheroids. J. Lab. Autom. 2014, 19, 208-214, doi:10.1177/2211068213504296.
    • (2014) J. Lab. Autom , vol.19 , pp. 208-214
    • Cavnar, S.P.1    Salomonsson, E.2    Luker, K.E.3    Luker, G.D.4    Takayama, S.5
  • 13
    • 84921937067 scopus 로고    scopus 로고
    • Microscale screening systems for 3D cellular microenvironments: Platforms, advances, and challenges
    • Montanez-Sauri, S.I.; Beebe, D.J.; Sung, K.E. Microscale screening systems for 3D cellular microenvironments: Platforms, advances, and challenges. Cell. Mol. Life Sci. 2015, 72, 237-249, doi:10.1007/s00018-014-1738-5.
    • (2015) Cell. Mol. Life Sci , vol.72 , pp. 237-249
    • Montanez-Sauri, S.I.1    Beebe, D.J.2    Sung, K.E.3
  • 14
    • 84871913777 scopus 로고    scopus 로고
    • Plastic pillar inserts for three-dimensional (3D) cell cultures in 96-well plates
    • Lee, D.W.; Yi, S.H.; Jeong, S.H.; Ku, B.; Kim, J.; Lee, M.-Y. Plastic pillar inserts for three-dimensional (3D) cell cultures in 96-well plates. Sens. Actuators B Chem. 2013, 177, 78-85, doi:10.1016/j.snb.2012.10.129.
    • (2013) Sens. Actuators B Chem , vol.177 , pp. 78-85
    • Lee, D.W.1    Yi, S.H.2    Jeong, S.H.3    Ku, B.4    Kim, J.5    Lee, M.-Y.6
  • 15
    • 33645464806 scopus 로고    scopus 로고
    • Cellular imaging in drug discovery
    • Lang, P.; Yeow, K.; Nichols, A.; Scheer, A. Cellular imaging in drug discovery. Nat. Rev. Drug Discov. 2006, 5, 343-356, doi:10.1053/j.gastro.2006.06.028.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 343-356
    • Lang, P.1    Yeow, K.2    Nichols, A.3    Scheer, A.4
  • 17
    • 84938878004 scopus 로고    scopus 로고
    • The smart and gentle microscope
    • Scherf, N.; Huisken, J. The smart and gentle microscope. Nat. Biotechnol. 2015, 33, 815-818, doi:10.1038/nbt.3310.
    • (2015) Nat. Biotechnol , vol.33 , pp. 815-818
    • Scherf, N.1    Huisken, J.2
  • 18
    • 84925033174 scopus 로고    scopus 로고
    • Guide to light-sheet microscopy for adventurous biologists
    • Reynaud, E.G.; Peychl, J.; Huisken, J.; Tomancak, P. Guide to light-sheet microscopy for adventurous biologists. Nat. Methods 2015, 12, 30-34, doi:10.1038/nmeth.3222.
    • (2015) Nat. Methods , vol.12 , pp. 30-34
    • Reynaud, E.G.1    Peychl, J.2    Huisken, J.3    Tomancak, P.4
  • 19
    • 84899993200 scopus 로고    scopus 로고
    • Miniaturized pre-clinical cancer models as research and diagnostic tools
    • Håkanson, M.; Cukierman, E.; Charnley, M. Miniaturized pre-clinical cancer models as research and diagnostic tools. Adv. Drug Deliv. Rev. 2014, 69-70, 52-66, doi:10.1016/j.addr.2013.11.010.
    • (2014) Adv. Drug Deliv. Rev , vol.69-70 , pp. 52-66
    • Håkanson, M.1    Cukierman, E.2    Charnley, M.3
  • 21
    • 84874172945 scopus 로고    scopus 로고
    • Development of high content imaging methods for cell death detection in human pluripotent stem cell-derived cardiomyocytes
    • Mioulane, M.; Foldes, G.; Ali, N.N.; Schneider, M.D.; Harding, S.E. Development of high content imaging methods for cell death detection in human pluripotent stem cell-derived cardiomyocytes. J. Cardiovasc. Transl. Res. 2012, 5, 593-604, doi:10.1007/s12265-012-9396-1.
    • (2012) J. Cardiovasc. Transl. Res , vol.5 , pp. 593-604
    • Mioulane, M.1    Foldes, G.2    Ali, N.N.3    Schneider, M.D.4    Harding, S.E.5
  • 22
    • 49249103327 scopus 로고    scopus 로고
    • Cellular imaging predictions of clinical drug-induced liver injury
    • Xu, J.J.; Henstock, P.V.; Dunn, M.C.; Smith, A.R.; Chabot, J.R.; de Graaf, D. Cellular imaging predictions of clinical drug-induced liver injury. Toxicol. Sci. 2008, 105, 97-105, doi:10.1093/toxsci/kfn109.
    • (2008) Toxicol. Sci , vol.105 , pp. 97-105
    • Xu, J.J.1    Henstock, P.V.2    Dunn, M.C.3    Smith, A.R.4    Chabot, J.R.5    de Graaf, D.6
  • 23
    • 84896696047 scopus 로고    scopus 로고
    • High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells
    • Sirenko, O.; Hesley, J.; Rusyn, I.; Cromwell, E.F. High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. Assay Drug Dev. Technol. 2014, 12, 43-54, doi:10.1089/adt.2013.520.
    • (2014) Assay Drug Dev. Technol , vol.12 , pp. 43-54
    • Sirenko, O.1    Hesley, J.2    Rusyn, I.3    Cromwell, E.F.4
  • 24
    • 84907216713 scopus 로고    scopus 로고
    • High Content Analysis Provides Mechanistic Insights on the Pathways of Toxicity Induced by Amine-Modified Polystyrene Nanoparticles
    • Anguissola, S.; Garry, D.; Salvati, A.; Brien, P.J.O.; Dawson, K.A. High Content Analysis Provides Mechanistic Insights on the Pathways of Toxicity Induced by Amine-Modified Polystyrene Nanoparticles. PLoS ONE 2014, 9, doi:10.1371/journal.pone.0108025.
    • (2014) PLoS ONE , vol.9
    • Anguissola, S.1    Garry, D.2    Salvati, A.3    Brien, P.J.O.4    Dawson, K.A.5
  • 25
    • 78650080357 scopus 로고    scopus 로고
    • High-content screening of drug-induced cardiotoxicity using quantitative single cell imaging cytometry on microfluidic device
    • Kim, M.J.; Lee, S.C.; Pal, S.; Han, E.; Song, J.M. High-content screening of drug-induced cardiotoxicity using quantitative single cell imaging cytometry on microfluidic device. Lab Chip 2011, 11, 104-114, doi:10.1039/c0lc00110d.
    • (2011) Lab Chip , vol.11 , pp. 104-114
    • Kim, M.J.1    Lee, S.C.2    Pal, S.3    Han, E.4    Song, J.M.5
  • 26
    • 84890566643 scopus 로고    scopus 로고
    • Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants
    • Krug, A.K.; Balmer, N.V.; Matt, F.; Schönenberger, F.; Merhof, D.; Leist, M. Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants. Arch. Toxicol. 2013, 87, 2215-2231, doi:10.1007/s00204-013-1072-y.
    • (2013) Arch. Toxicol , vol.87 , pp. 2215-2231
    • Krug, A.K.1    Balmer, N.V.2    Matt, F.3    Schönenberger, F.4    Merhof, D.5    Leist, M.6
  • 27
    • 84870357944 scopus 로고    scopus 로고
    • Use of high content image analyses to detect chemical-mediated effects on neurite sub-populations in primary rat cortical neurons
    • Harrill, J.A.; Robinette, B.L.; Freudenrich, T.; Mundy, W.R. Use of high content image analyses to detect chemical-mediated effects on neurite sub-populations in primary rat cortical neurons. Neurotoxicology 2013, 34, 61-73, doi:10.1016/j.neuro.2012.10.013.
    • (2013) Neurotoxicology , vol.34 , pp. 61-73
    • Harrill, J.A.1    Robinette, B.L.2    Freudenrich, T.3    Mundy, W.R.4
  • 28
    • 84930923987 scopus 로고    scopus 로고
    • High Content Imaging and Analysis Enable Quantitative in Situ Assessment of CYP3A4 Using Cryopreserved Differentiated HepaRG Cells
    • Ranade, A.R.; Wilson, M.S.; Mcclanahan, A.M.; Ball, A.J. High Content Imaging and Analysis Enable Quantitative in Situ Assessment of CYP3A4 Using Cryopreserved Differentiated HepaRG Cells. J. Toxicol. 2014, 2014, 1-12, doi:10.1155/2014/291054.
    • (2014) J. Toxicol , vol.2014 , pp. 1-12
    • Ranade, A.R.1    Wilson, M.S.2    Mcclanahan, A.M.3    Ball, A.J.4
  • 29
    • 84859057446 scopus 로고    scopus 로고
    • High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay
    • Donato, M.T.; Tolosa, L.; Jiménez, N.; Castell, J.V.; Gómez-Lechón, M.J. High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay. J. Biomol. Screen. 2012, 17, 394-400, doi:10.1177/1087057111427586.
    • (2012) J. Biomol. Screen , vol.17 , pp. 394-400
    • Donato, M.T.1    Tolosa, L.2    Jiménez, N.3    Castell, J.V.4    Gómez-Lechón, M.J.5
  • 30
    • 84896698541 scopus 로고    scopus 로고
    • High-Content pSTAT3/1 Imaging Assays to Screen for Selective Inhibitors of STAT3 Pathway Activation in Head and Neck Cancer Cell Lines
    • Johnston, P.A.; Sen, M.; Hua, Y.; Camarco, D.; Shun, T.Y.; Lazo, J.S.; Grandis, J.R. High-Content pSTAT3/1 Imaging Assays to Screen for Selective Inhibitors of STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Assay Drug Dev. Technol. 2014, 12, 55-79, doi:10.1089/adt.2013.524.
    • (2014) Assay Drug Dev. Technol , vol.12 , pp. 55-79
    • Johnston, P.A.1    Sen, M.2    Hua, Y.3    Camarco, D.4    Shun, T.Y.5    Lazo, J.S.6    Grandis, J.R.7
  • 31
    • 84928237102 scopus 로고    scopus 로고
    • High-content Analysis of Antibody Phage-display Library Selection Outputs Identifies Tumor Selective Macropinocytosis-Dependent Rapidly Internalizing Antibodies
    • Ha, K.D.; Bidlingmaier, S.M.; Zhang, Y.; Su, Y.; Liu, B. High-content Analysis of Antibody Phage-display Library Selection Outputs Identifies Tumor Selective Macropinocytosis-Dependent Rapidly Internalizing Antibodies. Mol. Cell. Proteom. 2014, 13, 3320-3331, doi:10.1074/mcp.M114.039768.
    • (2014) Mol. Cell. Proteom , vol.13 , pp. 3320-3331
    • Ha, K.D.1    Bidlingmaier, S.M.2    Zhang, Y.3    Su, Y.4    Liu, B.5
  • 32
    • 84868125584 scopus 로고    scopus 로고
    • High content image based analysis identifies cell cycle inhibitors as regulators of ebola virus infection
    • Kota, K.P.; Benko, J.G.; Mudhasani, R.; Retterer, C.; Tran, J.P.; Bavari, S.; Panchal, R.G. High content image based analysis identifies cell cycle inhibitors as regulators of ebola virus infection. Viruses 2012, 4, 1865-1877, doi:10.3390/v4101865.
    • (2012) Viruses , vol.4 , pp. 1865-1877
    • Kota, K.P.1    Benko, J.G.2    Mudhasani, R.3    Retterer, C.4    Tran, J.P.5    Bavari, S.6    Panchal, R.G.7
  • 34
    • 84895535497 scopus 로고    scopus 로고
    • High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers
    • Martin, H.L.; Adams, M.; Higgins, J.; Bond, J.; Morrison, E.E.; Bell, S.M.; Warriner, S.; Nelson, A.; Tomlinson, D.C. High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers. PLoS ONE 2014, 9, 1-8, doi:10.1371/journal.pone.0088338.
    • (2014) PLoS ONE , vol.9 , pp. 1-8
    • Martin, H.L.1    Adams, M.2    Higgins, J.3    Bond, J.4    Morrison, E.E.5    Bell, S.M.6    Warriner, S.7    Nelson, A.8    Tomlinson, D.C.9
  • 35
    • 84894368834 scopus 로고    scopus 로고
    • Evaluation of YO-PRO-1 as an early marker of apoptosis following radiofrequency ablation of colon cancer liver metastases
    • Fujisawa, S.; Romin, Y.; Barlas, A.; Petrovic, L.M.; Turkekul, M.; Fan, N.; Xu, K.; Garcia, A.R.; Monette, S.; Klimstra, D.S.; et al. Evaluation of YO-PRO-1 as an early marker of apoptosis following radiofrequency ablation of colon cancer liver metastases. Cytotechnology 2014, 66, 259-273, doi:10.1007/s10616-013-9565-3.
    • (2014) Cytotechnology , vol.66 , pp. 259-273
    • Fujisawa, S.1    Romin, Y.2    Barlas, A.3    Petrovic, L.M.4    Turkekul, M.5    Fan, N.6    Xu, K.7    Garcia, A.R.8    Monette, S.9    Klimstra, D.S.10
  • 36
    • 84864970321 scopus 로고    scopus 로고
    • Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research
    • Towne, D.L.; Nicholl, E.E.; Comess, K.M.; Galasinski, S.C.; Hajduk, P.J.; Abraham, V.C. Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research. J. Biomol. Screen. 2012, 17, 1005-1017, doi:10.1177/1087057112450050.
    • (2012) J. Biomol. Screen , vol.17 , pp. 1005-1017
    • Towne, D.L.1    Nicholl, E.E.2    Comess, K.M.3    Galasinski, S.C.4    Hajduk, P.J.5    Abraham, V.C.6
  • 37
    • 84895811941 scopus 로고    scopus 로고
    • A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities
    • Joy, M.E.; Vollmer, L.L.; Hulkower, K.; Stern, A.M.; Peterson, C.K.; Boltz, R.C.; Roy, P.; Vogt, A. A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities. PLoS ONE 2014, 9, 1-12, doi:10.1371/journal.pone.0088350.
    • (2014) PLoS ONE , vol.9 , pp. 1-12
    • Joy, M.E.1    Vollmer, L.L.2    Hulkower, K.3    Stern, A.M.4    Peterson, C.K.5    Boltz, R.C.6    Roy, P.7    Vogt, A.8
  • 38
    • 84922785429 scopus 로고    scopus 로고
    • High Content Image-Based Screening of a Protease Inhibitor Library Reveals Compounds Broadly Active against Rift Valley Fever Virus and Other Highly Pathogenic RNA Viruses
    • Mudhasani, R.; Kota, K.P.; Retterer, C.; Tran, J.P.; Whitehouse, C.A.; Bavari, S. High Content Image-Based Screening of a Protease Inhibitor Library Reveals Compounds Broadly Active against Rift Valley Fever Virus and Other Highly Pathogenic RNA Viruses. PLoS Negl. Trop. Dis. 2014, 8, 1-16, doi:10.1371/journal.pntd.0003095.
    • (2014) PLoS Negl. Trop. Dis , vol.8 , pp. 1-16
    • Mudhasani, R.1    Kota, K.P.2    Retterer, C.3    Tran, J.P.4    Whitehouse, C.A.5    Bavari, S.6
  • 39
    • 84901197044 scopus 로고    scopus 로고
    • A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages
    • Pegoraro, G.; Eaton, B.P.; Ulrich, R.L.; Lane, D.J.; Ojeda, J.F.; Bavari, S.; DeShazer, D.; Panchal, R.G. A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages. BMC Microbiol. 2014, 14, 98, doi:10.1186/1471-2180-14-98.
    • (2014) BMC Microbiol , vol.14 , pp. 98
    • Pegoraro, G.1    Eaton, B.P.2    Ulrich, R.L.3    Lane, D.J.4    Ojeda, J.F.5    Bavari, S.6    DeShazer, D.7    Panchal, R.G.8
  • 40
    • 84897434413 scopus 로고    scopus 로고
    • Identification of OmpA, a Coxiella burnetii Protein Involved in Host Cell Invasion, by Multi-Phenotypic High-Content Screening
    • Martinez, E.; Cantet, F.; Fava, L.; Norville, I.; Bonazzi, M. Identification of OmpA, a Coxiella burnetii Protein Involved in Host Cell Invasion, by Multi-Phenotypic High-Content Screening. PLoS Pathog. 2014, 10, doi:10.1371/journal.ppat.1004013.
    • (2014) PLoS Pathog , vol.10
    • Martinez, E.1    Cantet, F.2    Fava, L.3    Norville, I.4    Bonazzi, M.5
  • 41
    • 84860479779 scopus 로고    scopus 로고
    • Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors
    • Mulji, A.; Haslam, C.; Brown, F.; Randle, R.; Karamshi, B.; Smith, J.; Eagle, R.; Munoz-Muriedas, J.; Taylor, J.; Sheikh, A.; et al. Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors. J. Biomol. Screen. 2012, 17, 108-120, doi:10.1177/1087057111418229.
    • (2012) J. Biomol. Screen , vol.17 , pp. 108-120
    • Mulji, A.1    Haslam, C.2    Brown, F.3    Randle, R.4    Karamshi, B.5    Smith, J.6    Eagle, R.7    Munoz-Muriedas, J.8    Taylor, J.9    Sheikh, A.10
  • 42
    • 84886769795 scopus 로고    scopus 로고
    • HCS-Neurons: Identifying phenotypic changes in multi-neuron images upon drug treatments of high-content screening
    • Charoenkwan, P.; Hwang, E.; Cutler, R.W.; Lee, H.-C.; Ko, L.-W.; Huang, H.-L.; Ho, S.-Y. HCS-Neurons: Identifying phenotypic changes in multi-neuron images upon drug treatments of high-content screening. BMC Bioinform. 2013, 14, 1-15, doi:10.1186/1471-2105-14-S16-S12.
    • (2013) BMC Bioinform , vol.14 , pp. 1-15
    • Charoenkwan, P.1    Hwang, E.2    Cutler, R.W.3    Lee, H.-C.4    Ko, L.-W.5    Huang, H.-L.6    Ho, S.-Y.7
  • 43
    • 33747084103 scopus 로고    scopus 로고
    • High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
    • O'Brien, P.J.; Irwin, W.; Diaz, D.; Howard-Cofield, E.; Krejsa, C.M.; Slaughter, M.R.; Gao, B.; Kaludercic, N.; Angeline, A.; Bernardi, P.; et al. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch. Toxicol. 2006, 80, 580-604, doi:10.1007/s00204-006-0091-3.
    • (2006) Arch. Toxicol , vol.80 , pp. 580-604
    • O'Brien, P.J.1    Irwin, W.2    Diaz, D.3    Howard-Cofield, E.4    Krejsa, C.M.5    Slaughter, M.R.6    Gao, B.7    Kaludercic, N.8    Angeline, A.9    Bernardi, P.10
  • 44
    • 84878722744 scopus 로고    scopus 로고
    • HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: Identification of bioactivable drugs and the potential mechanism of toxicity involved
    • Tolosa, L.; Gómez-Lechón, M.J.; Pérez-Cataldo, G.; Castell, J.V.; Donato, M.T. HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: Identification of bioactivable drugs and the potential mechanism of toxicity involved. Arch. Toxicol. 2013, 87, 1115-1127, doi:10.1007/s00204-013-1012-x.
    • (2013) Arch. Toxicol , vol.87 , pp. 1115-1127
    • Tolosa, L.1    Gómez-Lechón, M.J.2    Pérez-Cataldo, G.3    Castell, J.V.4    Donato, M.T.5
  • 45
    • 84893041165 scopus 로고    scopus 로고
    • Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases
    • Schildknecht, S.; Karreman, C.; Pöltl, D.; Efrémova, L.; Kullmann, C.; Gutbier, S.; Krug, A.; Scholz, D.; Gerding, H.R.; Leist, M. Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. ALTEX 2013, 30, 427-444, doi:10.14573/altex.2013.4.427.
    • (2013) ALTEX , vol.30 , pp. 427-444
    • Schildknecht, S.1    Karreman, C.2    Pöltl, D.3    Efrémova, L.4    Kullmann, C.5    Gutbier, S.6    Krug, A.7    Scholz, D.8    Gerding, H.R.9    Leist, M.10
  • 46
    • 79960986078 scopus 로고    scopus 로고
    • High-content screening in infectious diseases
    • Brodin, P.; Christophe, T. High-content screening in infectious diseases. Curr. Opin. Chem. Biol. 2011, 15, 534-539, doi:10.1016/j.cbpa.2011.05.023.
    • (2011) Curr. Opin. Chem. Biol , vol.15 , pp. 534-539
    • Brodin, P.1    Christophe, T.2
  • 47
    • 77951023954 scopus 로고    scopus 로고
    • Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex
    • Berke, J.M.; Fenistein, D.; Pauwels, F.; Bobbaers, R.; Lenz, O.; Lin, T.I.; Krausz, E.; Fanning, G. Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex. J. Virol. Methods 2010, 165, 268-276, doi:10.1016/j.jviromet.2010.02.007.
    • (2010) J. Virol. Methods , vol.165 , pp. 268-276
    • Berke, J.M.1    Fenistein, D.2    Pauwels, F.3    Bobbaers, R.4    Lenz, O.5    Lin, T.I.6    Krausz, E.7    Fanning, G.8
  • 48
    • 84880772898 scopus 로고    scopus 로고
    • High Content Screening as High Quality Assay for Biological Evaluation of Photosensitizers In Vitro
    • Vaz, G.M.F.; Paszko, E.; Davies, A.M.; Senge, M.O. High Content Screening as High Quality Assay for Biological Evaluation of Photosensitizers In Vitro. PLoS ONE 2013, 8, 1-17, doi:10.1371/journal.pone.0070653.
    • (2013) PLoS ONE , vol.8 , pp. 1-17
    • Vaz, G.M.F.1    Paszko, E.2    Davies, A.M.3    Senge, M.O.4
  • 49
    • 84875252390 scopus 로고    scopus 로고
    • Three-dimensional tissue cultures: Current trends and beyond
    • Page, H.; Flood, P.; Reynaud, E.G. Three-dimensional tissue cultures: Current trends and beyond. Cell Tissue Res. 2013, 352, 123-131, doi:10.1007/s00441-012-1441-5.
    • (2013) Cell Tissue Res , vol.352 , pp. 123-131
    • Page, H.1    Flood, P.2    Reynaud, E.G.3
  • 51
    • 58149178486 scopus 로고    scopus 로고
    • 3D cell culture opens new dimensions in cell-based assays
    • Justice, B.A.; Badr, N.A.; Felder, R.A. 3D cell culture opens new dimensions in cell-based assays. Drug Discov. Today 2009, 14, 102-107, doi:10.1016/j.drudis.2008.11.006.
    • (2009) Drug Discov. Today , vol.14 , pp. 102-107
    • Justice, B.A.1    Badr, N.A.2    Felder, R.A.3
  • 52
    • 84899897771 scopus 로고    scopus 로고
    • Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments
    • Astashkina, A.; Grainger, D.W. Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments. Adv. Drug Deliv. Rev. 2014, 69-70, 1-18, doi:10.1016/j.addr.2014.02.008.
    • (2014) Adv. Drug Deliv. Rev , vol.69-70 , pp. 1-18
    • Astashkina, A.1    Grainger, D.W.2
  • 53
    • 84897799049 scopus 로고    scopus 로고
    • Stem cells in a three-dimensional scaffold environment
    • Meng, X.; Leslie, P.; Zhang, Y.; Dong, J. Stem cells in a three-dimensional scaffold environment. Springerplus 2014, 3, 80, doi:10.1186/2193-1801-3-80.
    • (2014) Springerplus , vol.3 , pp. 80
    • Meng, X.1    Leslie, P.2    Zhang, Y.3    Dong, J.4
  • 54
    • 78650162975 scopus 로고    scopus 로고
    • An automated high-content assay for tumor cell migration through 3-dimensional matrices
    • Echeverria, V.; Meyvantsson, I.; Skoien, A.; Worzella, T.; Lamers, C.; Hayes, S. An automated high-content assay for tumor cell migration through 3-dimensional matrices. J. Biomol. Screen. 2010, 15, 1144-1151, doi:10.1177/1087057110378890.
    • (2010) J. Biomol. Screen , vol.15 , pp. 1144-1151
    • Echeverria, V.1    Meyvantsson, I.2    Skoien, A.3    Worzella, T.4    Lamers, C.5    Hayes, S.6
  • 55
    • 79952000716 scopus 로고    scopus 로고
    • 3D models of epithelial-mesenchymal transition in breast cancer metastasis: High-throughput screening assay development, validation, and pilot screen
    • Li, Q.; Chen, C.; Kapadia, A.; Zhou, Q.; Harper, M.K.; Schaack, J.; LaBarbera, D.V. 3D models of epithelial-mesenchymal transition in breast cancer metastasis: High-throughput screening assay development, validation, and pilot screen. J. Biomol. Screen. 2011, 16, 141-154, doi:10.1177/1087057110392995.
    • (2011) J. Biomol. Screen , vol.16 , pp. 141-154
    • Li, Q.1    Chen, C.2    Kapadia, A.3    Zhou, Q.4    Harper, M.K.5    Schaack, J.6    LaBarbera, D.V.7
  • 56
    • 84892697565 scopus 로고    scopus 로고
    • An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models
    • Celli, J.P.; Rizvi, I.; Blanden, A.R.; Massodi, I.; Glidden, M.D.; Pogue, B.W.; Hasan, T. An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Sci. Rep. 2014, 4, 3751, doi:10.1038/srep03751.
    • (2014) Sci. Rep , vol.4 , pp. 3751
    • Celli, J.P.1    Rizvi, I.2    Blanden, A.R.3    Massodi, I.4    Glidden, M.D.5    Pogue, B.W.6    Hasan, T.7
  • 57
    • 84863005114 scopus 로고    scopus 로고
    • RAIN-Droplet: A novel 3D in vitro angiogenesis model
    • Zeitlin, B.D.; Dong, Z.; Nör, J.E. RAIN-Droplet: A novel 3D in vitro angiogenesis model. Lab. Investig. 2012, 92, 988-998, doi:10.1038/labinvest.2012.77.
    • (2012) Lab. Investig , vol.92 , pp. 988-998
    • Zeitlin, B.D.1    Dong, Z.2    Nör, J.E.3
  • 58
    • 84897872570 scopus 로고    scopus 로고
    • Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models
    • Chwalek, K.; Tsurkan, M.V.; Freudenberg, U.; Werner, C. Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models. Sci. Rep. 2014, 4, 1-8, doi:10.1038/srep04414.
    • (2014) Sci. Rep , vol.4 , pp. 1-8
    • Chwalek, K.1    Tsurkan, M.V.2    Freudenberg, U.3    Werner, C.4
  • 61
    • 84876802415 scopus 로고    scopus 로고
    • 3D organotypic cultures of human heparg cells: A tool for in vitro toxicity studies
    • Gunness, P.; Mueller, D.; Shevchenko, V.; Heinzle, E.; Ingelman-Sundberg, M.; Noor, F. 3D organotypic cultures of human heparg cells: A tool for in vitro toxicity studies. Toxicol. Sci. 2013, 133, 67-78, doi:10.1093/toxsci/kft021.
    • (2013) Toxicol. Sci , vol.133 , pp. 67-78
    • Gunness, P.1    Mueller, D.2    Shevchenko, V.3    Heinzle, E.4    Ingelman-Sundberg, M.5    Noor, F.6
  • 62
    • 84888290491 scopus 로고    scopus 로고
    • 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
    • Mueller, D.; Krämer, L.; Hoffmann, E.; Klein, S.; Noor, F. 3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies. Toxicol. Vitro 2014, 28, 104-112, doi:10.1016/j.tiv.2013.06.024.
    • (2014) Toxicol. Vitro , vol.28 , pp. 104-112
    • Mueller, D.1    Krämer, L.2    Hoffmann, E.3    Klein, S.4    Noor, F.5
  • 63
    • 84887869938 scopus 로고    scopus 로고
    • A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications
    • Thoma, C.R.; Stroebel, S.; Rösch, N.; Calpe, B.; Krek, W.; Kelm, J.M. A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications. J. Biomol. Screen. 2013, 18, 1330-1337, doi:10.1177/1087057113499071.
    • (2013) J. Biomol. Screen , vol.18 , pp. 1330-1337
    • Thoma, C.R.1    Stroebel, S.2    Rösch, N.3    Calpe, B.4    Krek, W.5    Kelm, J.M.6
  • 66
    • 52649121981 scopus 로고    scopus 로고
    • The three-dimensional cultivation of the carcinoma cell line HepG2 in a perfused chip system leads to a more differentiated phenotype of the cells compared to monolayer culture
    • Altmann, B.; Giselbrecht, S.; Weibezahn, K.-F.; Welle, A.; Gottwald, E. The three-dimensional cultivation of the carcinoma cell line HepG2 in a perfused chip system leads to a more differentiated phenotype of the cells compared to monolayer culture. Biomed. Mater. 2008, 3, 1-10, doi:10.1088/1748-6041/3/3/034120.
    • (2008) Biomed. Mater , vol.3 , pp. 1-10
    • Altmann, B.1    Giselbrecht, S.2    Weibezahn, K.-F.3    Welle, A.4    Gottwald, E.5
  • 67
    • 34648837293 scopus 로고    scopus 로고
    • Culture of HepG2 liver cells on three dimensional polystyrene scaffolds enhances cell structure and function during toxicological challenge
    • Bokhari, M.; Carnachan, R.J.; Cameron, N.R.; Przyborski, S.A. Culture of HepG2 liver cells on three dimensional polystyrene scaffolds enhances cell structure and function during toxicological challenge. J. Anat. 2007, 211, 567-576, doi:10.1111/j.1469-7580.2007.00778.x.
    • (2007) J. Anat , vol.211 , pp. 567-576
    • Bokhari, M.1    Carnachan, R.J.2    Cameron, N.R.3    Przyborski, S.A.4
  • 68
    • 78751560396 scopus 로고    scopus 로고
    • High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
    • Tung, Y.-C.; Hsiao, A.Y.; Allen, S.G.; Torisawa, Y.; Ho, M.; Takayama, S. High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 2011, 136, 473-478, doi:10.1039/c0an00609b.
    • (2011) Analyst , vol.136 , pp. 473-478
    • Tung, Y.-C.1    Hsiao, A.Y.2    Allen, S.G.3    Torisawa, Y.4    Ho, M.5    Takayama, S.6
  • 69
    • 59249106851 scopus 로고    scopus 로고
    • Survival advantages of multicellular spheroids vs. monolayers of HepG2 cells in vitro
    • Li, C.-L.; Tian, T.; Nan, K.-J.; Zhao, N.; Guo, Y.-H.; Cui, J.; Wang, J.; Zhang, W.-G. Survival advantages of multicellular spheroids vs. monolayers of HepG2 cells in vitro. Oncol. Rep. 2008, 20, 1465-1471.
    • (2008) Oncol. Rep , vol.20 , pp. 1465-1471
    • Li, C.-L.1    Tian, T.2    Nan, K.-J.3    Zhao, N.4    Guo, Y.-H.5    Cui, J.6    Wang, J.7    Zhang, W.-G.8
  • 70
    • 77956187576 scopus 로고    scopus 로고
    • Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells
    • Loessner, D.; Stok, K.S.; Lutolf, M.P.; Hutmacher, D.W.; Clements, J.A.; Rizzi, S.C. Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials 2010, 31, 8494-8506, doi:10.1016/j.biomaterials.2010.07.064.
    • (2010) Biomaterials , vol.31 , pp. 8494-8506
    • Loessner, D.1    Stok, K.S.2    Lutolf, M.P.3    Hutmacher, D.W.4    Clements, J.A.5    Rizzi, S.C.6
  • 71
    • 83455236148 scopus 로고    scopus 로고
    • Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues
    • Drewitz, M.; Helbling, M.; Fried, N.; Bieri, M.; Moritz, W.; Lichtenberg, J.; Kelm, J.M. Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues. Biotechnol. J. 2011, 6, 1488-1496, doi:10.1002/biot.201100290.
    • (2011) Biotechnol. J , vol.6 , pp. 1488-1496
    • Drewitz, M.1    Helbling, M.2    Fried, N.3    Bieri, M.4    Moritz, W.5    Lichtenberg, J.6    Kelm, J.M.7
  • 73
  • 75
    • 84875055289 scopus 로고    scopus 로고
    • High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO)
    • Ertürk, A.; Bradke, F. High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO). Exp. Neurol. 2013, 242, 57-64, doi:10.1016/j.expneurol. 2012.10.018.
    • (2013) Exp. Neurol , vol.242 , pp. 57-64
    • Ertürk, A.1    Bradke, F.2
  • 77
    • 84925082320 scopus 로고    scopus 로고
    • Optical clearing in collagen-and proteoglycan-rich osteochondral tissues
    • Neu, C.P.; Novak, T.; Gilliland, K.F.; Marshall, P.; Calve, S. Optical clearing in collagen-and proteoglycan-rich osteochondral tissues. Osteoarthr. Cartil. 2014, 23, 405-413, doi:10.1016/j.joca.2014.11.021.
    • (2014) Osteoarthr. Cartil , vol.23 , pp. 405-413
    • Neu, C.P.1    Novak, T.2    Gilliland, K.F.3    Marshall, P.4    Calve, S.5
  • 78
    • 84937218109 scopus 로고    scopus 로고
    • Tissue clearing for confocal imaging of native and bio-artificial skeletal muscle
    • Decroix, L.; van Muylder, V.; Desender, L.; Sampaolesi, M.; Thorrez, L. Tissue clearing for confocal imaging of native and bio-artificial skeletal muscle. Biotech. Histochem. 2015, 90, 424-431, doi:10.3109/10520295.2015.1019564.
    • (2015) Biotech. Histochem , vol.90 , pp. 424-431
    • Decroix, L.1    van Muylder, V.2    Desender, L.3    Sampaolesi, M.4    Thorrez, L.5
  • 80
    • 78649499977 scopus 로고    scopus 로고
    • Overview of single-cell analyses: Microdevices and applications
    • Lindström, S.; Andersson-Svahn, H. Overview of single-cell analyses: Microdevices and applications. Lab Chip 2010, 10, 3363-3372, doi:10.1039/c0lc00150c.
    • (2010) Lab Chip , vol.10 , pp. 3363-3372
    • Lindström, S.1    Andersson-Svahn, H.2
  • 81
    • 77949321194 scopus 로고    scopus 로고
    • Perturbation of single hematopoietic stem cell fates in artificial niches
    • Lutolf, M.P.; Doyonnas, R.; Havenstrite, K.; Koleckar, K.; Blau, H.M. Perturbation of single hematopoietic stem cell fates in artificial niches. Integr. Biol. Camb. 2009, 1, 59-69, doi:10.1039/b815718a.
    • (2009) Integr. Biol. Camb , vol.1 , pp. 59-69
    • Lutolf, M.P.1    Doyonnas, R.2    Havenstrite, K.3    Koleckar, K.4    Blau, H.M.5
  • 82
    • 84863094439 scopus 로고    scopus 로고
    • Controlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responses
    • Håkanson, M.; Kobel, S.; Lutolf, M.P.; Textor, M.; Cukierman, E.; Charnley, M. Controlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responses. PLoS ONE 2012, 7, doi:10.1371/journal.pone.0040141.
    • (2012) PLoS ONE , vol.7
    • Håkanson, M.1    Kobel, S.2    Lutolf, M.P.3    Textor, M.4    Cukierman, E.5    Charnley, M.6
  • 85
    • 84891780785 scopus 로고    scopus 로고
    • High-throughput screening (HTS) of anticancer drug efficacy on a micropillar/microwell chip platform
    • Lee, D.W.; Choi, Y.S.; Seo, Y.J.; Lee, M.Y.; Jeon, S.Y.; Ku, B.; Kim, S.; Yi, S.H.; Nam, D.H. High-throughput screening (HTS) of anticancer drug efficacy on a micropillar/microwell chip platform. Anal. Chem. 2014, 86, doi:10.1021/ac402546b.
    • (2014) Anal. Chem , vol.86
    • Lee, D.W.1    Choi, Y.S.2    Seo, Y.J.3    Lee, M.Y.4    Jeon, S.Y.5    Ku, B.6    Kim, S.7    Yi, S.H.8    Nam, D.H.9
  • 86
    • 51549106300 scopus 로고    scopus 로고
    • On-Chip, Cell-Based Microarray Immunofluorescence Assay for High-Throughput Analysis of Target Proteins
    • Fernandes, T.G.; Kwon, S.-J.; Lee, M.-Y.; Clark, D.S.; Cabral, J.M.S.; Dordick, J.S. On-Chip, Cell-Based Microarray Immunofluorescence Assay for High-Throughput Analysis of Target Proteins. Anal. Chem. 2008, 80, 6633-6639.
    • (2008) Anal. Chem , vol.80 , pp. 6633-6639
    • Fernandes, T.G.1    Kwon, S.-J.2    Lee, M.-Y.3    Clark, D.S.4    Cabral, J.M.S.5    Dordick, J.S.6
  • 87
    • 84867142135 scopus 로고    scopus 로고
    • Influence of a three-dimensional, microarray environment on human Cell culture in drug screening systems
    • Meli, L.; Jordan, E.T.; Clark, D.S.; Linhardt, R.J.; Dordick, J.S. Influence of a three-dimensional, microarray environment on human Cell culture in drug screening systems. Biomaterials 2012, 33, 9087-9096, doi:10.1016/j.biomaterials.2012.08.065.
    • (2012) Biomaterials , vol.33 , pp. 9087-9096
    • Meli, L.1    Jordan, E.T.2    Clark, D.S.3    Linhardt, R.J.4    Dordick, J.S.5
  • 88
    • 84893920523 scopus 로고    scopus 로고
    • Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro
    • Lee, D.W.; Lee, M.-Y.; Ku, B.; Yi, S.H.; Ryu, J.-H.; Jeon, R.; Yang, M. Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro. Arch. Toxicol. 2014, 88, 283-290, doi:10.1007/s00204-013-1102-9.
    • (2014) Arch. Toxicol , vol.88 , pp. 283-290
    • Lee, D.W.1    Lee, M.-Y.2    Ku, B.3    Yi, S.H.4    Ryu, J.-H.5    Jeon, R.6    Yang, M.7
  • 90
    • 77649213213 scopus 로고    scopus 로고
    • Integration column: Microwell arrays for mammalian cell culture
    • Charnley, M.; Textor, M.; Khademhosseini, A.; Lutolf, M.P. Integration column: Microwell arrays for mammalian cell culture. Integr. Biol. (Camb.) 2009, 1, 625-634, doi:10.1039/b918172p.
    • (2009) Integr. Biol. (Camb.) , vol.1 , pp. 625-634
    • Charnley, M.1    Textor, M.2    Khademhosseini, A.3    Lutolf, M.P.4
  • 91
    • 20444400222 scopus 로고    scopus 로고
    • An inverted microcontact printing method on topographically structured polystyrene chips for arrayed micro-3-D culturing of single cells
    • Dusseiller, M.R.; Schlaepfer, D.; Koch, M.; Kroschewski, R.; Textor, M. An inverted microcontact printing method on topographically structured polystyrene chips for arrayed micro-3-D culturing of single cells. Biomaterials 2005, 26, 5917-5925, doi:10.1016/j.biomaterials.2005.02.032.
    • (2005) Biomaterials , vol.26 , pp. 5917-5925
    • Dusseiller, M.R.1    Schlaepfer, D.2    Koch, M.3    Kroschewski, R.4    Textor, M.5
  • 92
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • Lin, R.Z.; Chang, H.Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol. J. 2008, 3, 1172-1184, doi:10.1002/biot.200700228.
    • (2008) Biotechnol. J , vol.3 , pp. 1172-1184
    • Lin, R.Z.1    Chang, H.Y.2
  • 93
    • 84900021928 scopus 로고    scopus 로고
    • Quasi-spherical microwells on superhydrophobic substrates for long term culture of multicellular spheroids and high throughput assays
    • Liu, T.; Winter, M.; Thierry, B. Quasi-spherical microwells on superhydrophobic substrates for long term culture of multicellular spheroids and high throughput assays. Biomaterials 2014, 35, 6060-6068, doi:10.1016/j.biomaterials.2014.04.047.
    • (2014) Biomaterials , vol.35 , pp. 6060-6068
    • Liu, T.1    Winter, M.2    Thierry, B.3
  • 95
    • 33646839924 scopus 로고    scopus 로고
    • Cell adhesion profiling using extracellular matrix protein microarrays
    • Kuschel, C.; Steuer, H.; Maurer, A.N.; Kanzok, B.; Stoop, R.; Angres, B. Cell adhesion profiling using extracellular matrix protein microarrays. Biotechniques 2006, 40, 523-531, doi:10.2144/000112134.
    • (2006) Biotechniques , vol.40 , pp. 523-531
    • Kuschel, C.1    Steuer, H.2    Maurer, A.N.3    Kanzok, B.4    Stoop, R.5    Angres, B.6
  • 97
    • 65549112285 scopus 로고    scopus 로고
    • High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research
    • Fernandes, T.G.; Diogo, M.M.; Clark, D.S.; Dordick, J.S.; Cabral, J.M.S. High-throughput cellular microarray platforms: Applications in drug discovery, toxicology and stem cell research. Trends Biotechnol. 2009, 27, 342-349, doi:10.1016/j.tibtech.2009.02.009.
    • (2009) Trends Biotechnol , vol.27 , pp. 342-349
    • Fernandes, T.G.1    Diogo, M.M.2    Clark, D.S.3    Dordick, J.S.4    Cabral, J.M.S.5
  • 99
    • 63049111520 scopus 로고    scopus 로고
    • High content cell screening in a microfluidic device
    • Cheong, R.; Wang, C.J.; Levchenko, A. High content cell screening in a microfluidic device. Mol. Cell. Proteom. 2009, 8, 433-442, doi:10.1074/mcp.M800291-MCP200.
    • (2009) Mol. Cell. Proteom , vol.8 , pp. 433-442
    • Cheong, R.1    Wang, C.J.2    Levchenko, A.3
  • 100
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • Toh, Y.-C.; Lim, T.C.; Tai, D.; Xiao, G.; van Noort, D.; Yu, H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab Chip 2009, 9, 2026-2035, doi:10.1039/b900912d.
    • (2009) Lab Chip , vol.9 , pp. 2026-2035
    • Toh, Y.-C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    van Noort, D.5    Yu, H.6
  • 101
    • 36349024270 scopus 로고    scopus 로고
    • Cell-based high content screening using an integrated microfluidic device
    • Ye, N.; Qin, J.; Shi, W.; Liu, X.; Lin, B. Cell-based high content screening using an integrated microfluidic device. Lab Chip 2007, 7, 1696-1704, doi:10.1039/b711513j.
    • (2007) Lab Chip , vol.7 , pp. 1696-1704
    • Ye, N.1    Qin, J.2    Shi, W.3    Liu, X.4    Lin, B.5
  • 102
    • 84867319585 scopus 로고    scopus 로고
    • Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts
    • Su, G.; Sung, K.E.; Beebe, D.J.; Friedl, A. Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts. PLoS ONE 2012, 7, 1-12, doi:10.1371/journal.pone.0046685.
    • (2012) PLoS ONE , vol.7 , pp. 1-12
    • Su, G.1    Sung, K.E.2    Beebe, D.J.3    Friedl, A.4
  • 103
    • 77954794130 scopus 로고    scopus 로고
    • High-content screening in microfluidic devices
    • Cheong, R.; Paliwal, S.; Levchenko, A. High-content screening in microfluidic devices. Expert Opin. Drug Discov. 2010, 5, 715-720, doi:10.1517/17460441.2010.495116.
    • (2010) Expert Opin. Drug Discov , vol.5 , pp. 715-720
    • Cheong, R.1    Paliwal, S.2    Levchenko, A.3
  • 105
  • 106
  • 107
    • 84890589120 scopus 로고    scopus 로고
    • Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment
    • Chan, H.F.; Zhang, Y.; Ho, Y.-P.; Chiu, Y.-L.; Jung, Y.; Leong, K.W. Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment. Sci. Rep. 2013, 3, 1-8, doi:10.1038/srep03462.
    • (2013) Sci. Rep , vol.3 , pp. 1-8
    • Chan, H.F.1    Zhang, Y.2    Ho, Y.-P.3    Chiu, Y.-L.4    Jung, Y.5    Leong, K.W.6
  • 108
    • 84905376221 scopus 로고    scopus 로고
    • Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
    • Halldorsson, S.; Lucumi, E.; Gómez-Sjöberg, R.; Fleming, R.M.T. Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. Biosens. Bioelectron. 2015, 63, 218-231, doi:10.1016/j.bios.2014.07.029.
    • (2015) Biosens. Bioelectron , vol.63 , pp. 218-231
    • Halldorsson, S.1    Lucumi, E.2    Gómez-Sjöberg, R.3    Fleming, R.M.T.4
  • 109
    • 84887532397 scopus 로고    scopus 로고
    • Microfluidic cell culture
    • Mehling, M.; Tay, S. Microfluidic cell culture. Curr. Opin. Biotechnol. 2014, 25, 95-102, doi:10.1016/j.copbio.2013.10.005.
    • (2014) Curr. Opin. Biotechnol , vol.25 , pp. 95-102
    • Mehling, M.1    Tay, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.