Influence of a three-dimensional, microarray environment on human Cell culture in drug screening systems

Biomaterials

Volumn 33, Issue 35, 2012, Pages 9087-9096

  Meli, Luciana ^a   Jordan, Eric T ^b   Clark, Douglas S ^d   Linhardt, Robert J ^a,b,c   Dordick, Jonathan S ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c Research Rensselaer Polytechnic Institute   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3D cell culture; Drug resistance; High throughput; Microarray

Indexed keywords

3-D CELL CULTURE; 3-D ENVIRONMENTS; 3-D MICROARRAY; 5-FLUOROURACIL; AMITRIPTYLINE; ANGIOGENESIS; ANTIPROLIFERATIVE EFFECT; CELL NUMBER; CELL-CELL CONTACT; CELLULAR MICROARRAYS; CHEMOSENSITIVITY; DOXORUBICIN; DRUG METABOLISMS; DRUG RESISTANCE; DRUG SCREENING; EXPRESSION PROFILE; HEPATOCELLULAR CARCINOMA CELL; HEPG2 CELLS; HIGH-THROUGHPUT; HIGH-THROUGHPUT ANALYSIS; IMMUNOFLUORESCENCE ASSAY; NUTRIENT AVAILABILITY; ON CHIPS; PROTEIN EXPRESSION PROFILES; QUANTITATIVE DATA; SEEDING DENSITY; TAMOXIFEN; TARGET PROTEINS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELLS; FLOW MEASUREMENT; MICROARRAYS; PROTEINS; THREE DIMENSIONAL COMPUTER GRAPHICS;

CELL CULTURE;

ALGINIC ACID; AMITRIPTYLINE; BETA1 INTEGRIN; CYTOCHROME P450; DOXORUBICIN; FLUOROURACIL; TAMOXIFEN; VASCULOTROPIN;

ANGIOGENESIS; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL CULTURE; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CELL STRAIN HEPG2; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE TEST; IN VIVO STUDY; LIVER CELL CARCINOMA; MICROARRAY ANALYSIS; MICROTITER PLATE ASSAY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS;

ALGINATES; AMITRIPTYLINE; ANTIGENS, CD29; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENT ANTIBODY TECHNIQUE; FLUOROURACIL; GLUCURONIC ACID; HEP G2 CELLS; HEXURONIC ACIDS; HUMANS; LIVER; MICROARRAY ANALYSIS; MICROSCOPY, CONFOCAL; PHENOTYPE; TAMOXIFEN; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84867142135     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.08.065     Document Type: Article

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