Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research

Journal of Biomolecular Screening

Volumn 17, Issue 8, 2012, Pages 1005-1017

  Towne, Danli L ^a   Nicholl, Emily E ^a   Comess, Kenneth M ^a   Galasinski, Scott C ^a   Hajduk, Philip J ^a   Abraham, Vivek C ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

automated microscopy; high content screening; mechanism of action; oncology

Indexed keywords

4 (8 CYCLOPENTYL 7 ETHYL 5,6,7,8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL)BENZAMIDE; ANTINEOPLASTIC AGENT; BARASERTIB; BENDAMUSTINE; BLEOMYCIN SULFATE; CAMPTOTHECIN; DACTINOMYCIN; ETOPOSIDE; FLAVOPIRIDOL; HYDROXYUREA; MELPHALAN; MENADIONE; MLNM 8054; NOCODAZOLE; PACLITAXEL; STAUROSPORINE; TACRINE; TOZASERTIB; UNCLASSIFIED DRUG; VINBLASTINE;

ALGORITHM; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL STRUCTURE; DATA ANALYSIS; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; DRUG SCREENING; HIGH CONTENT SCREENING ASSAY; IMAGE ANALYSIS; MEASUREMENT; MITOCHONDRION; OUTCOME ASSESSMENT; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA;

EID: 84864970321     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112450050     Document Type: Article

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