Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues

Biotechnology Journal

Volumn 6, Issue 12, 2011, Pages 1488-1496

  Drewitz, Maren ^a   Helbling, Marianne ^a   Fried, Nicole ^a   Bieri, Manuela ^a   Moritz, Wolfgang ^a   Lichtenberg, Jan ^a   Kelm, Jens M ^a  

^a InSphero AG   (Switzerland)

Author keywords

Cell based assays; Drug discovery; Drug screening; High throughput; Tissue engineering

Indexed keywords

3D MODELS; 96-WELL; 96-WELL FORMAT; ACADEMIC LEVEL; AUTOMATED PRODUCTIONS; CELL LINES; CELL-BASED ASSAYS; COLON CANCER CELLS; DRUG DISCOVERY; DRUG DISCOVERY PROCESS; DRUG SCREENING; DRUG SENSITIVITY; DRUG TESTING; EFFICACY TESTING; HIGH THROUGHPUT; HIGH-DENSITY; HIGH-THROUGHPUT TECHNOLOGIES; INDUSTRIAL IMPLEMENTATION; PRODUCTION BATCHES; REFERENCE COMPOUNDS; REPRODUCIBILITIES; ROBOTIC PLATFORMS; SIZE VARIATION; STAUROSPORINES; TIME POINTS;

ASSAYS; CELL CULTURE; CELLS; INDUSTRIAL APPLICATIONS; TISSUE; TISSUE ENGINEERING;

THREE DIMENSIONAL;

CHLORAMBUCIL; STAUROSPORINE;

ARTICLE; CELL STRAIN HCT116; CELL STRAIN HEPG2; CELL STRAIN HT29; DRUG DEVELOPMENT; DRUG SCREENING; HANGING DROP VAPOR DIFFUSION METHOD; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MICROTITER PLATE ASSAY; PRIORITY JOURNAL; QUALITY CONTROL; RELIABILITY; REPRODUCIBILITY; TISSUE GROWTH;

CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; SPHEROIDS, CELLULAR; TISSUE CULTURE TECHNIQUES;

EID: 83455236148     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201100290     Document Type: Article

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