Controlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responses

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Håkanson, Maria ^a   Kobel, Stefan ^b   Lutolf, Matthias P ^b   Textor, Marcus ^a   Cukierman, Edna ^c   Charnley, Mirren ^a  

^a ETH ZURICH   (Switzerland)

^b EPFL   (Switzerland)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; MATRIX PROTEIN; PACLITAXEL;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL ADHESION; CELL CYCLE REGULATION; CELL DENSITY; CELL PROLIFERATION; CELLULAR PARAMETERS; CONTROLLED STUDY; DRUG RESPONSE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYDROGEL; MATERIAL COATING; MICROARRAY ANALYSIS; MULTILAYER CELL CLUSTER; TUMOR MICROENVIRONMENT;

ANTIGENS, CD29; APOPTOSIS; BREAST NEOPLASMS; CADHERINS; CELL ADHESION; CELL COUNT; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; HYDROGEL; PACLITAXEL; POLYETHYLENE GLYCOLS; TUMOR CELLS, CULTURED; TUMOR MICROENVIRONMENT;

EID: 84863094439     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040141     Document Type: Article

References (59)

1. Xu R, Boudreau A, Bissell MJ, (2009) Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer and metastasis reviews 28: 167-176.
2. Cukierman E, Bassi DE, (2010) Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol 20: 139-145.
3. Beacham D, Cukierman E, (2005) The changing face of fibroblastic microenvironments during tumor progression. Semin Cancer Biol 15: 329-341.
4. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, et al. (2009) Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling. Cell 139: 891-906.
5. Goetz J, Minguet S, Navarro-Lerida I, Samaniego R, Calvo E, et al. (2011) Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell 146: 148-163.
6. Butcher DT, Alliston T, Weaver VM, (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9: 108-122.
7. Meads M, Gatenby R, Dalton W, (2009) Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 9: 665-674.
8. Hazlehurst LA, Landowski TH, Dalton WS, (2003) Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death. Oncogene 22: 7396-7402.
9. Sherman-Baust C, Weeraratna A, Rangel L, Pizer E, Cho K, et al. (2003) Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell 3: 377-386.
10. Yao E, Zhang H, Chen Y, Lee B, Chew K, (2007) Increased ß1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer. Cancer Res 67: 659-664.
11. Aoudjit F, Vuori K, (2001) Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 20: 4995-5004.
12. Dhiman H, Ray AR, Panda AK, (2005) Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen. Biomaterials 26: 979-986.
13. St Croix B, Florenes V, Rak J, Flanagan M, Bhattacharya N, et al. (1996) Impact of the cyclin-dependent kinase inhibitor p27(Kip1) on resistance of tumor cells to anticancer agents. Nature Medicine 2: 1204-1210.
14. Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, et al. (2007) Engineering tumors with 3D scaffolds. Nat Meth 4: 855-860.
15. Gudjonsson T, Rønnov-Jessen L, Villadsen R, (2003) To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Methods 30: 247-255.
16. Griffith LG, Schwartz MA, (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7: 211-224.
17. Yamada K, Cukierman E, (2007) Modeling tissue morphogenesis and cancer in 3D. Cell 130: 601-610.
18. Grantab R, Sivananthan S, Tannock I, (2006) The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells. Cancer Res 66: 1033-1039.
19. Zahir N, Weaver V, (2004) Death in the third dimension: apoptosis regulation and tissue architecture. Current opinion in genetics & development 14: 71-80.
20. Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JCR, et al. (2002) B4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2: 205-216.
21. St Croix B, Sheehan C, Rak JW, Flørenes VA, Slingerland JM, et al. (1998) E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). The Journal of Cell Biology 142: 557-571.
22. Desgrosellier JS, Cheresh DA, (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10: 9-22.
23. Patel S, Jenkins J, Papadopolous N, Burgess M, Plager C, et al. (2001) Pilot study of Vitaxin- An angiogenesis inhibitor- In patients with advanced leiomyosarcomas. Cancer 92: 1347-1348.
24. Cukierman E, Daniel E B, (2012) The mesenchymal tumor microenvironment: a drug resistant niche. Cell Adhesion & Migration 6(3): x-x Epub ahead of print.
25. Goicoechea S, Bednarski B, Stack C, Cowan D, Volmar K, et al. (2010) Isoform-specific upregulation of palladin in human and murine pancreas tumors. PloS One 5: e10347.
26. Gupta V, Bassi D, Simons J, Devarajan K, Al-Saleem T, et al. (2011) Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma. PLoS One 6: e21494.
27. Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, et al. (2008) The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma. Clin Gastroenterol Hepatol 6: 1155-1161.
28. Ivascu A, Kubbies M, (2006) Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis. J Biomol Screening 11: 922-932.
29. Friedrich J, Seidel C, Ebner R, Kunz-Schughart L, (2009) Spheroid-based drug screen: considerations and practical approach. Nature Protocols 4: 309-324.
30. Campbell JS, Davidenko N, Caffarel MM, Cameron RE, Watson, C J, (2011) A Multifunctional 3D Co-Culture System for Studies of Mammary Tissue Morphogenesis and Stem Cell Biology. PLoS One 6: e25661.
31. Lee GY, Kenny PA, Lee EH, Bissell MJ, (2007) Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Meth 4: 359-365.
32. Castelló-Cros R, Khan DR, Simons J, Valianou M, Cukierman E, (2009) Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins. BMC Cancer 9: 94.
33. Serebriiskii I, Castelló-Cros R, Lamb A, Golemis E, Cukierman E, (2008) Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol 27: 573-585.
34. Lang P, Yeow K, Nichols A, Scheer A, (2006) Cellular imaging in drug discovery. Nat Rev Drug Discov 5: 343-356.
35. Charnley M, Textor M, Khademohosseini A, Lutolf M, (2009) Integration column: microwell arrays for mammalian cell culture. Integr Biol 1: 625-634.
36. Ochsner M, Dusseiller MR, Grandin HM, Luna-Morris S, Textor M, et al. (2007) Micro-well arrays for 3D shape control and high resolution analysis of single cells. Lab Chip 7: 1074-1077.
37. Håkanson M, Textor M, Charnley M, (2011) Engineered 3D environments to elucidate the effect of environmental parameters on drug response in cancer. Integr Biol pp. 1-8.
38. Lutolf M, Doyonnas R, Havenstrite K, Koleckar K, Blau HM, (2009) Perturbation of single hematopoietic stem cell fates in artificial niches. Integr Biol 1: 59-69.
39. Heino J, (2000) The collagen receptor integrins have distinct ligand recognition and signaling functions. Matrix Biol 19: 319-323.
40. Park CC, Zhang H, Pallavicini M, Gray JW, Baehner F, et al. (2006) β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo. Cancer Res 66: 1526-1535.
41. Zutter MM, (2007) Integrin-mediated adhesion: Tipping the balance between chemosensitivity and chemoresistance. Adv Exp Med Biol 608: 87-100.
42. Akiyama SK, Yamada SS, Chen W-T, Yamada KM, (1989) Analysis of fibronectin receptor function with monoclonal antibodies: Roles in Cell Adhesion, Migration, Matrix Assembly, and Cytoskeletal Organization. J Cell Biol 109: 863-875.
43. Teicher BA, (2009) Acute and chronic in vivo therapeutic resistance. Biochemical pharmacology 77: 1665-1673.
44. Denys H, Braems G, Lambein K, Pauwels P, Hendrix A, et al. (2009) The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment. Curr Pharm Des 15: 1373-1384.
45. Horning JL, Sahoo SK, Vijayaraghavalu S, Dimitrijevic S, Vasir JK, et al. (2008) 3-D Tumor Model for In Vitro Evaluation of Anticancer Drugs. Mol Pharmaceutics 5: 849-862.
46. Benton G, Crooke E, George J, (2009) Laminin-1 induces E-cadherin expression in 3-dimensional cultured breast cancer cells by inhibiting DNA methyltransferase 1 and reversing promoter methylation status. FASEB J 23: 3884-3895.
47. Yao C, Ziober B, Squillace R, Kramer R, (1996) alpha 7 integrin mediates cell adhesion and migration on specific laminin isoforms. Journal of Biological Chemistry 271: 25598-25603.
48. Hirtenlehner K, Pec M, Kubista E, Singer CF, (2002) Extracellular matrix proteins influence phenotype and cytokine expression in human breast cancer cell lines. Eur Cytokine Network 13: 234-240.
49. Ohbayashi M, Yasuda M, Kawakami I, Kohyama N, Kobayashi Y, et al. (2008) Effect of interleukins response to ECM-induced acquisition of drug resistance in MCF-7 cells. Exp Oncol 30: 276-282.
50. Lee H-O, Mullins SR, Franco-Barraza J, Valianou M, Cukierman E, et al. (2011) FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer 11: 245.
51. Sharma S, Lee D, Li B, Quinlan M, Takahashi F, et al. (2010) A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141: 69-80.
52. Kim J-H, Kushiro K, Graham NA, Asthagiri AR, (2009) Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth. Proc Natl Acad Sci USA 106: 11149-11153.
53. Park CC, Zhang HJ, Yao ES, Park CJ, Bissell MJ, (2008) β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts. Cancer Res 68: 4398-4405.
54. Folgiero V, Avetrani P, Bon G, Di Carlo SE, Fabi A, et al. (2008) Induction of ErbB-3 Expression by α6β4 Integrin Contributes to Tamoxifen Resistance in ERβ1-Negative Breast Carcinomas. PLoS ONE 3.
55. Vargas GA, (2009) Personalized healthcare: how to improve outcomes by increasing benefit and decreasing risk through the use of biomarkers. Biomarkers in Medicine 3: 701-709.
56. Naumov G, Townson J, MacDonald I, Wilson S, Bramwell V, et al. (2003) Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast cancer research and treatment 82: 199-206.
57. Aas T, Geisler S, Eide GE, Haugen DF, Varhaug JE, et al. (2003) Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy. Eur J Cancer 39: 438-446.
58. De Azambuja E, Cardoso F, De Castro G, Colozza M, Mano MS, et al. (2007) Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12, 155 patients. British journal of cancer 96: 1504-1513.
59. Pasche De Paul S, Voros J, Spencer N, Textor M, (2003) Poly (L-lysine)-graft-poly (ethylene glycol) Assembled Monolayers on Niobium Oxide Surfaces: A Quantitative Study of the Influence of Polymer Interfacial Architecture on Resistance to Protein Adsorption by ToF-SIMS and in Situ OWLS. Langmuir 19: 9216-9225.